Genetic association of polymorphisms inAXIN1gene with clear cell renal cell carcinoma in a Chinese population

2017 ◽  
Vol 11 (11) ◽  
pp. 947-955 ◽  
Author(s):  
Yan Pu ◽  
Xuhua Mi ◽  
Peng Chen ◽  
Bin Zhou ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Genetic Association ◽  
Renal Cell ◽  
Chinese Population ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

scholarly journals Transcriptomic characterization and innovative molecular classification of clear cell renal cell carcinoma in the Chinese population

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Qiang Zhao ◽  
Jia Xue ◽  
Baoan Hong ◽  
Wubin Qian ◽  
Tiezhu Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Population ◽  
Clear Cell ◽  
Expression Profiles ◽  
Molecular Classification ◽  
The Cancer Genome Atlas ◽  
Cell Renal Cell Carcinoma

Abstract Background Large-scale initiatives like The Cancer Genome Atlas (TCGA) performed genomics studies on predominantly Caucasian kidney cancer. In this study, we aimed to investigate genomics of Chinese clear cell renal cell carcinoma (ccRCC). Methods We performed whole-transcriptomic sequencing on 55 tumor tissues and 11 matched normal tissues from Chinese ccRCC patients. We systematically analyzed the data from our cohort and comprehensively compared with the TCGA ccRCC cohort. Results It found that PBRM1 mutates with a frequency of 11% in our cohort, much lower than that in TCGA Caucasians (33%). Besides, 31 gene fusions including 5 recurrent ones, that associated with apoptosis, tumor suppression and metastasis were identified. We classified our cohort into three classes by gene expression. Class 1 shows significantly elevated gene expression in the VEGF pathway, while Class 3 has comparably suppressed expression of this pathway. Class 2 is characterized by increased expression of extracellular matrix organization genes and is associated with high-grade tumors. Applying the classification to TCGA ccRCC patients revealed better distinction of tumor prognosis than reported classifications. Class 2 shows worst survival and Class 3 is a rare subtype ccRCC in the TCGA cohort. Furthermore, computational analysis on the immune microenvironment of ccRCC identified immune-active and tolerant tumors with significant increased macrophages and depleted CD4 positive T-cells, thus some patients may benefit from immunotherapies. Conclusion In summary, results presented in this study shed light into distinct genomic expression profiles in Chinese population, modified the stratification patterns by new molecular classification, and gave practical guidelines on clinical treatment of ccRCC patients.

scholarly journals Genetic Variants in RKIP Are Associated with Clear Cell Renal Cell Carcinoma Risk in a Chinese Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109285 ◽  
Author(s):  
Qiang Cao ◽  
Jian Wang ◽  
Mingcong Zhang ◽  
Pu Li ◽  
Jian Qian ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Genetic Variants ◽  
Renal Cell ◽  
Chinese Population ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Carcinoma Risk

scholarly journals Postoperative prognostic model for patients with clear cell renal cell carcinoma in a Chinese population

2019 ◽  
Vol 26 (6) ◽  
pp. 624-629 ◽  
Author(s):  
Yan Zhu ◽  
Yao‐Rui Zhao ◽  
Xian‐Fa Yang ◽  
Mao‐Ti Wei ◽  
Yuan‐Jie Niu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Population ◽  
Prognostic Model ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

scholarly journals Genetic Variants in Caveolin-1 and RhoA/ROCK1 Are Associated with Clear Cell Renal Cell Carcinoma Risk in a Chinese Population

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128771 ◽  
Author(s):  
Ruizhe Zhao ◽  
Kang Liu ◽  
Zhengkai Huang ◽  
Jun Wang ◽  
Yongsheng Pan ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Genetic Variants ◽  
Renal Cell ◽  
Chinese Population ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Caveolin 1 ◽  
Carcinoma Risk

scholarly journals CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Gang Feng ◽  
Hou-Bao Huang ◽  
Xiao-Bing Ye ◽  
Peng Zhang ◽  
Jian-Jun Huang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Population ◽  
Clear Cell ◽  
Promoter Polymorphism ◽  
Chinese Patients ◽  
Promoter Polymorphisms ◽  
Cell Renal Cell Carcinoma ◽  
Cd146 Expression

Introduction. CD146 is a membrane signal receptor in tumor-induced angiogenesis. However, limited studies have focused on the CD146 promoter polymorphisms in clear cell renal cell carcinoma (ccRCC). Purpose. The purpose of this study was to investigate the association between polymorphisms located in the promoter region of the CD146 gene and characteristics of ccRCC in Chinese population. The association between the CD146 promoter polymorphisms and CD146 expression was also investigated in ccRCC. Materials and Methods. A total of 600 samples including 300 ccRCC patients and 300 healthy controls were collected for analysis of the CD146 promoter polymorphisms by direct sequence. The CD146 expressions were measured by qRT-PCR. Results. We had not found any significant differences in genotypic and allelic frequencies of CD146 promoter polymorphisms between ccRCC patients and controls. The rs3923594 was associated with stage and metastasis (300 cases) and recurrence (263 cases) of ccRCC in Chinese population. A significant association was also observed between the rs3923594 and CD146 expression (227 cases) in ccRCC. Conclusions. CD146 promoter polymorphisms were not associated with the risk of ccRCC in Chinese population. The rs3923594 was an independent predictor of recurrence in Chinese patients with localized ccRCC.

scholarly journals Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population

Oncotarget ◽  
2016 ◽  
Vol 8 (15) ◽  
pp. 24196-24201 ◽  
Author(s):  
Ning Zhang ◽  
Yishuo Wu ◽  
Jian Gong ◽  
Kaiwen Li ◽  
Xiaolin Lin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Population ◽  
Clear Cell ◽  
Genetic Variations ◽  
Cell Renal Cell Carcinoma

Risk factor for clear cell renal cell carcinoma in Chinese population: A case–control study

2012 ◽  
Vol 36 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Guoping Wang ◽  
Jianguo Hou ◽  
Liye Ma ◽  
Jiaxin Xie ◽  
Jianhua Yin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Risk Factor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Chinese Population ◽  
Case Control Study ◽  
Clear Cell ◽  
Case Control ◽  
Cell Renal Cell Carcinoma ◽  
Control Study

638: Macroscopic Tumor Necrosis is a Prognostic Indicator for Non-Metastatic Clear Cell Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 214-214
Author(s):  
Sung Kyu Hong ◽  
Byung Kyu Han ◽  
In Ho Chang ◽  
June Hyun Han ◽  
Ji Hyung Yu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Necrosis ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Cell Renal Cell Carcinoma ◽  
Macroscopic Tumor

Rare localization of renal cell carcinoma metastases in the paranasal sinuses and breast: a case report

2019 ◽  
Vol 22 (6) ◽  
pp. 13-22
Author(s):  
E. V. Kryaneva ◽  
N. A. Rubtsova ◽  
A. V. Levshakova ◽  
A. I. Khalimon ◽  
A. V. Leontyev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Paranasal Sinuses ◽  
Renal Cell ◽  
Clinical Case ◽  
Clear Cell ◽  
Malignant Tumors ◽  
Metastatic Potential ◽  
Cell Renal Cell Carcinoma ◽  
Metastatic Lesions

This article presents a clinical case demonsratinga high metastatic potential of clear cell renal cell carcinoma combined with atypical metastases to breast and paranasal sinuses. The prevalence of metastatic lesions to the breast and paranasal sinuses in various malignant tumors depending on their morphological forms is analyzed. The authors present an analysis of data published for the last 30 years. The optimal diagnostic algorithms to detect the progression of renal cell carcinoma and to evaluate the effectiveness of the treatment are considered.

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