The feasibility of phage therapy for periodontitis

Periodontitis, a chronic progressive inflammation caused by plaque biofilm, is the main cause of tooth loss in adults. For certain refractory periodontitis cases, it is difficult to achieve a good curative effect using the existing periodontal treatment approaches, which may be due to periodontal pathogenic mechanism in the affected periodontal tissue that the host cannot resist and eliminate. Various pieces of evidence collectively revealed that most studies are focusing on phages in periodontal disease. Several studies have reported periodontitis treatment using phage therapy, highlighting its features including specificity, rapid propagation, and effectiveness on bacteriophage biofilms. In this study, we focus on these reports, aiming to lay the foundation for improved periodontal treatment approaches.

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The role of maintenance in periodontal disease

Dental Update ◽

10.12968/denu.2019.46.10.959 ◽

2019 ◽

Vol 46 (10) ◽

pp. 959-965

Author(s):

Joanna Batt ◽

Phil Ower ◽

Praveen Sharma

Keyword(s):

Periodontal Disease ◽

Clinical Relevance ◽

Tooth Loss ◽

Initial Therapy ◽

Periodontal Therapy ◽

Periodontal Treatment ◽

New Classification ◽

Periodontal Health ◽

Periodontal Breakdown

There is increasing recognition, made explicit in the new classification for periodontitis, that periodontitis is a lifelong disease that is not ‘cured’ but rather ‘managed’. This paper focuses on how the response to periodontal treatment is ideally measured and how decisions are made as to whether the treatment has been ‘successful’ or not. The roles of both the patient and practitioner in the maintenance of periodontal health for those patients who respond to initial therapy are crucial. Patients not responding to initial, non-surgical periodontal therapy also need to be appropriately managed, as outlined in this paper. CPD/Clinical Relevance: This paper highlights the importance of maintenance of periodontal health, as an integral part of the overall management of patients with periodontitis, in order to minimize further periodontal breakdown and eventual tooth loss.

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Status jaringan periodontal dan kebutuhan perawatan jaringan periodontal pada manula Suku Bugis dan Suku Mandar

Journal of Dentomaxillofacial Science ◽

10.15562/jdmfs.v6i1.137 ◽

2007 ◽

Vol 6 (1) ◽

pp. 51

Author(s):

Bahruddin Thalib ◽

Dian Angriani

Keyword(s):

Periodontal Disease ◽

Disease Prevalence ◽

Periodontal Treatment ◽

World Population ◽

Periodontal Tissue ◽

Biologic Process ◽

Aging People

Being old is a biologic process that can not be avoided, where degeneration occurs inmany ways, which finally decreases the function. These cause aging people prone tovarious diseases; including periodontal disease. Prevalence and severity of periodontaldiseases vary in world population. These differences seem to be related with age, sex,socioeconomic, education, and also ethnic and geography. This study was aimed toinvestigate the periodontal tissue of aging Buginese and Mandarnese. Total samples are390 persons (195 Buginese dan 195 Mandarnese). The condition of periodontal tissuewere checked using CPITN from WHO. Of 195 samples, 88 samples of Buginese and 55samples of Mandarnese were edentulous. The result showed periodontal disease ofBuginese were bleeding 2.8%, tartar 39.25%, pocket of 4-5 mm depth, 50.47%, andpocket of 6 mm depth, 7.48%. Periodontal disease of Mandarnese ethnic were bleeding2.14%, tartar 53.57%, pocket of 4-5 mm depth 21.43%, and pocket of 6 mm depth22.86%. Therefore, the need for periodontal treatment for aging Buginese were brushingteeth instruct 100%, prophylaxis 97.19%, and restorative 7.46%. Aging Mandarnese;were brushing teeth instruction 100%, prophylaxis 97.85%, and restorative 22.86%.

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Clindamycin as an Alternative Option in Optimizing Periodontal Therapy

Antibiotics ◽

10.3390/antibiotics10070814 ◽

2021 ◽

Vol 10 (7) ◽

pp. 814

Author(s):

Ionut Luchian ◽

Ancuta Goriuc ◽

Maria Alexandra Martu ◽

Mihai Covasa

Keyword(s):

Periodontal Disease ◽

Tooth Loss ◽

Periodontal Treatment ◽

Host Immune System ◽

Antibiotic Administration ◽

Bacteriostatic Effect ◽

Oral Biofilm ◽

Bacterial Proteins ◽

Periodontal Tissues ◽

Degrees Of Severity

Periodontal disease is an oral infectious and inflammatory disease caused by microorganisms that determine the host-mediated destruction of soft and hard periodontal tissues, which ultimately leads to tooth loss. Periodontitis affects a large part of the population, with various degrees of severity. Treatment consists of etiologic therapy: the removal of biofilm through mechanical debridement plus microbial elimination by supplementary measures. Antibiotic administration, either systemically or through local delivery, has been shown to improve clinical outcomes after mechanical periodontal treatment. Clindamycin is a lincosamide with a broad spectrum, being active against aerobic, anaerobic, and β-lactamase-producing bacteria. This antibiotic offers several advantages and some disadvantages and has been used in periodontal treatment both systemically and locally with various degrees of success. Among the properties that recommend it for periodontal treatment is the bacteriostatic effect, the inhibition of bacterial proteins synthesis, the enhancement of neutrophil chemotaxis, phagocytosis and the oxidative burst–oxidative stress storm. Furthermore, it is easily absorbed at the level of oral tissues in a considerable amount. This substantial tissue penetration, especially inside the bone, is synergistic with a stimulating effect on the host immune system. The aim of this review is to explore the applicability of this antibiotic agent and to evaluate its antimicrobial potential and limitations at the level of the oral biofilm associated with periodontal disease.

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Relationship of tooth loss and Implant related to periodontal treatment among periodontal disease patients with hypertension

Korean Journal of Dental Materials ◽

10.14815/kjdm.2015.42.3.249 ◽

2015 ◽

Vol 42 (3) ◽

pp. 249

Author(s):

Jeong-Min Hwang ◽

Jae-Mok Lee

Keyword(s):

Periodontal Disease ◽

Tooth Loss ◽

Periodontal Treatment ◽

Relationship Of

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Tooth Splinting for Severely Mobile Mandibular Incisor Teeth in a Dog

Journal of Veterinary Dentistry ◽

10.1177/089875649501200304 ◽

1995 ◽

Vol 12 (3) ◽

pp. 93-95 ◽

Cited By ~ 3

Author(s):

Gregg DuPont

Keyword(s):

Periodontal Disease ◽

Tooth Loss ◽

Tooth Movement ◽

Treatment Plan ◽

Disease Process ◽

Periodontal Treatment ◽

Mandibular Incisor ◽

Tooth Mobility ◽

Advanced Stages

Periodontal disease, in its advanced stages, causes tooth mobility. The tooth movement further damages the periodontium, accelerating the disease process leading to tooth loss. Dental splinting can provide coaptive stability to the teeth as an important component of a periodontal treatment plan. This report documents results four years following splinting of the mandibular incisor teeth in a 3 year old Miniature Schnauzer dog.

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Tooth Loss in Patients under Periodontal Maintenance in a Private Practice: A Retrospective Study

Brazilian Dental Journal ◽

10.1590/0103-6440201701476 ◽

2017 ◽

Vol 28 (4) ◽

pp. 440-446 ◽

Cited By ~ 5

Author(s):

Amanda Finger Stadler ◽

Marina Mendez ◽

Rui Vicente Oppermann ◽

Sabrina Carvalho Gomes

Keyword(s):

Periodontal Disease ◽

Disease Progression ◽

Private Practice ◽

Tooth Loss ◽

Cox Regression ◽

Survival Curve ◽

Survival Rates ◽

Periodontal Treatment ◽

Chi Square ◽

Student’S T

Abstract The aim of the present study was to evaluate the incidence and causes of tooth loss in periodontal subjects from a private practice in Brazil. Two trained examiners extracted data from the records of subjects who sought periodontal treatment from 1980 to 2013. Only records of patients who completed the non-surgical periodontal treatment and had at least one visit for maintenance were included. Data were analyzed by chi-square test, Student’s t-test, Kaplan-Meier survival curve and Cox regression. A total of 3,319 records were reviewed and 737 records included (58.6% women, mean age of 46.6±13.0 years at the beginning of the treatment). Maintenance period ranged from 1 to 33 years (7.4±6 years). During this period, 202 individuals (27.4%) lost 360 teeth, 47.5% of losses within the first five years (n=171). Non-compliers lost more teeth than compliers (p<0.001), respectively 211 and 149 teeth. Regarding reasons of tooth loss, 84 individuals lost 38% of the teeth from periodontal disease progression (n=137). Survival analysis showed that most patients lost only one tooth from periodontal disease, and differences in the survival rates between compliers and non-compliers were observed following the second tooth loss. Approximately one-third of tooth losses was related to periodontal disease progression, and there was stability in time of the proportion of losses from disease progression and other reasons. Therefore, it is possible to conclude that compliant patients in a private practice lose fewer teeth than do non-compliers. Among compliers, periodontal disease progression was not the main cause of tooth loss.

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Effects of periodontal therapy with topical antibiotics in the glycemic control of diabetic patients: systematic review.

Revista Estomatología ◽

10.25100/re.v27i1.8735 ◽

2019 ◽

Vol 27 (1) ◽

pp. 31-42

Author(s):

Gloria Cristina Aranzazu-Moya

Keyword(s):

Periodontal Disease ◽

Periodontal Therapy ◽

Periodontal Treatment ◽

Diabetic Patients ◽

Inclusion Criteria ◽

Topical Antibiotics ◽

Bias Risk ◽

Black Scale ◽

Glycated Hemoglobin A ◽

Modest Reduction

Background: Periodontal disease is considered as a diabetes complication and has been suggested that periodontal treatment plus antibiotics should reduce glycated hemoglobin A, by reducing local production of pro inflammatory substances. Objective: To evaluate diabetic patients with periodontal disease under periodontal treatment plus topical antibiotics and reduction of HbA1c, compared to diabetic patients under periodontal treatment without antibiotics. Materials and Methods: Using PUBMED, SCOPUS, WEB OF SCIENCE, EMBASE and Google Scholar data bases, were screened documents from 2008 to 2018. The documents included were the clinical studies, which included non-surgical periodontal treatment plus topical antibiotics, whose outcomes included the HbA1c report. Two independent researchers evaluate title; abstract and bias risk with Downs Black scale and Cochrane tool. Documents with a score higher than 15 on average by the two evaluators were included. Results: Five articles, which find inclusion criteria, were identified. Two documents failed to demonstrate statistically significant effect when compared to non-surgical periodontal therapy alone. Conclusion: In general a modest reduction of HbA1c was identified when using antibiotic therapy.

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The burden of periodontal disease

Dental Update ◽

10.12968/denu.2019.46.10.907 ◽

2019 ◽

Vol 46 (10) ◽

pp. 907-913

Author(s):

Kasim Butt ◽

Razia Butt ◽

Praveen Sharma

Keyword(s):

Quality Of Life ◽

Periodontal Disease ◽

Tooth Loss ◽

Chronic Inflammatory Disease ◽

Severe Form ◽

Health Concern ◽

Ageing Population ◽

Obesity And Diabetes ◽

The Uk

Periodontal disease is the most common chronic inflammatory disease seen in humans. It is a major public health concern, and in its severe form affects approximately 10.8% or 743 million people aged 15−99 worldwide. Trends such as the rise of smoking in developing countries, the obesity and diabetes epidemic, coupled with an ageing population with greater tooth retention, are all likely to increase the burden of periodontitis still further in the UK and worldwide. Consequences of periodontitis include hypermobility of teeth, tooth migration, drifting and eventual tooth loss. Tooth loss can directly affect the quality of life of a person in terms of reduced functional capacity, self-esteem and social relationships. CPD/Clinical Relevance: This article reports the prevalence of periodontal disease in the UK and worldwide, along with the consequences of periodontitis. The importance of timely diagnosis to avoid litigation is discussed, as is the importance of effective management of periodontitis in order to improve patients' oral health-related quality of life.

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Implant Treatment with 12-Year Follow-Up in a Patient with Severe Chronic Periodontitis: A Case Report and Literature Review

Case Reports in Dentistry ◽

10.1155/2019/3715159 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Keisuke Seki ◽

Yoshiyuki Hagiwara

Keyword(s):

Periodontal Disease ◽

Chronic Periodontitis ◽

Case Reports ◽

English Literature ◽

Supportive Therapy ◽

Periodontal Treatment ◽

Periodontal Tissues ◽

Severe Periodontitis ◽

And Control ◽

Implant Treatment

Tooth loss among adults is associated with progressive periodontitis. Implant prosthetic treatment has long been utilized in periodontal patients. Even when the implants are applied, ongoing management of periodontal disease and control of inflammation is necessary to maintain a healthy oral cavity. Lack of appropriate periodontal treatment can result in recurrence of periodontal disease during a maintenance period; loss of the supportive capacity of the periodontal tissues will increase the susceptibility of residual teeth to traumatic force. For this reason, it is worthwhile to improve oral function by applying implants as a fixed device. Here, we report that implant treatment in a patient with generalized severe chronic periodontitis helped maintain the periodontal and peri-implant tissue for a long term. We propose that initial periodontal treatment and ongoing supportive therapy can help maintain implants in patients with severe periodontitis. In addition, we reviewed case reports in the English literature so far.

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