Interaction of 22 risk SNPs with Helicobacter pylori infection and risk of gastric cardia adenocarcinoma

2019 ◽  
Vol 15 (31) ◽  
pp. 3579-3585 ◽  
Author(s):  
Fan-Kai Xiao ◽  
Jian Xue Yang ◽  
Xin Min Li ◽  
Xue Ke Zhao ◽  
Peng Yuan Zheng ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Helicobacter Pylori Infection ◽  
Gastric Cardia ◽  
Gastric Cardia Adenocarcinoma ◽  
Susceptibility Loci ◽  
Single Nucleotide ◽  
Increased Risk ◽  
Risk Snps ◽  
H Pylori ◽  
The Relationship

Aim: To determine the prevalence of Helicobacter pylori infection and correlation between H. pylori infection and single nucleotide polymorphism (SNPs) identified in gastric cardia adenocarcinoma (GCA) patients. Methods: A case control study was performed. 22 risks of GCA-related SNPs were identified by genotyping assay and the relationship between susceptibility loci for GCA and H. pylori infection was further analyzed. Results: Helicobacter pylori infection was associated with GCA significantly (odds ratio: 1.40; 95% CI: 1.29–1.53 p < 0.01). Five GCA risk SNPs had their genotypes significantly different between H. pylori positive patients and H. pylori negative patients. Conclusion: The interaction between SNPs susceptibility loci and H. pylori infection is associated with an increased risk of GCA.

scholarly journals Sex differences in the relationship among alcohol, smoking, and Helicobacter pylori infection in asymptomatic individuals

2020 ◽  
Vol 48 (5) ◽  
pp. 030006052092603
Author(s):  
Wenzhi Wu ◽  
Marcis Leja ◽  
Vladislav Tsukanov ◽  
Zarrin Basharat ◽  
Dong Hua ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Alcohol Consumption ◽  
Logistic Regression Analysis ◽  
Helicobacter Pylori Infection ◽  
Multivariable Logistic Regression Analysis ◽  
H Pylori ◽  
Relationship Of ◽  
The Relationship

Objective We aimed to investigate the relationship of Helicobacter pylori infection with alcohol and smoking. Methods We conducted a cross-sectional study among participants who underwent health check-ups for H. pylori infection between January 2013 and March 2017. We subsequently investigated the relationship of H. pylori infection with alcohol and smoking. Results A total of 7169 participants were enrolled in this study. The overall prevalence of H. pylori infection was 55.2%. Participants with H. pylori infection were more likely to be older than those without H. pylori infection. For male participants with H. pylori infection, multivariable logistic regression analysis indicated that both smoking (odds ratio (OR): 1.61; 95% confidence interval (CI): 1.41–1.83) and alcohol consumption (OR: 1.30; 95% CI: 1.10–1.52) were independently positively associated with H. pylori infection. For female participants, multivariable logistic regression analysis indicated that both smoking (OR: 0.03; 95% CI: 0.02–0.07) and alcohol consumption (OR: 0.20; 95% CI: 0.12–0.33) were inversely significantly associated with H. pylori infection after adjustment for age. Conclusions Smoking and alcohol consumption were risk factors for male participants but these were protective factors for female individuals with H. pylori infection.

scholarly journals Relationship of interleukin-1B gene promoter region polymorphism with Helicobacter pylori infection and gastritis

2015 ◽  
Vol 9 (10) ◽  
pp. 1108-1116 ◽  
Author(s):  
Ivy Bastos Ramis ◽  
Júlia Silveira Vianna ◽  
Priscila Cristina Bartolomeu Halicki ◽  
Caroline Lara ◽  
Thássia Fernanda Tadiotto ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Promoter Region ◽  
Gene Promoter ◽  
Helicobacter Pylori Infection ◽  
Caga Gene ◽  
Gastric Diseases ◽  
Ulcer Disease ◽  
Increased Risk ◽  
H Pylori ◽  
Relationship Of

Introduction: Helicobacter pylori infection is associated with gastritis, peptic ulcer disease and gastric carcinoma. The severity of damage is determined by the interplay between environmental/behavioral factors, bacterial pathogenicity genes and host genetic polymorphisms that can influence the secretion levels of inflammatory cytokines. Accordingly, this study aimed to identify polymorphisms in the IL-1B and IL-1RN genes and their associations with H. pylori infection, cagA gene of H. pylori, and gastroduodenal diseases. Methodology: Gastric biopsy samples from 151 patients infected with H. pylori and 76 uninfected individuals were analyzed. H. pylori infection was diagnosed by histology and PCR. Polymorphisms at positions -511, -31 and +3954 of the IL-1B gene were detected by PCR-RFLP, and an analysis of the VNTR polymorphism of the IL-1RN gene was performed by PCR. Results: It was observed that the presence of the T/T genotype at position -511 and the C/C genotype at position -31 were associated with H. pylori infection and with an increased risk of gastritis in H. pylori-positive patients. Additionally, strains from patients H. pylori-positive carrying the cagA gene was significantly related with the T/T genotype at position -511 of IL-1B.  No association of polymorphisms at position +3954 of IL-1B and in the IL-1RN with H. pylori infection and with risk of severe gastric diseases was found. Conclusions: We demonstrated that polymorphisms in the promoter region of the IL-1B gene (at positions -511 and -31) are associated with an enhanced risk of H. pylori infection as well as gastritis in H. pylori-positive patients.

scholarly journals Experimental Study of the Effect of Helicobacter pylori Infection on Barrett Esophagus and Its Correlation with Immune Function

2020 ◽  
Vol 13 (6) ◽  
Author(s):  
Jing Zhang ◽  
Xiao-Ping Tan ◽  
Xin-Zhang Sun ◽  
Qing Zhang
Keyword(s):  
Helicobacter Pylori ◽  
Immune Function ◽  
Lower Esophageal Sphincter Pressure ◽  
Helicobacter Pylori Infection ◽  
Barrett Esophagus ◽  
Control Group ◽  
Sphincter Pressure ◽  
Esophageal Function ◽  
H Pylori ◽  
The Relationship

Background: Helicobacter pylori is an important pathogen in the upper digestive tract. It is of great significance to properly understand the risk factors for the transformation of Barrett esophagus into esophageal carcinoma. However, the relationship between H. pylori and gastroesophageal reflux disease (GERD) and Barrett esophagus remains controversial, and the correlation with immune function has been rarely reported. Objectives: This study investigated the effect of H. pylori infection on Barrett esophagus and its correlation with immune function. Methods: We recruited 40 patients with Barrett esophagus (Barrett esophagus group) and 40 patients with GERD (GERD group). In addition, 40 healthy controls were selected for the control group. Esophageal function and its correlation with immune function were measured in each group. Results: The positivity rate of H. pylori (P < 0.05) and sphincter pressure were lower in both Barrett esophagus and GERD groups than in the control group, while the levels of PGI, PGII, PGI/II, and G-17 were higher (P < 0.05). The levels of CD3+, CD4+, and CD4+/CD8+ were lower in the Barrett esophagus group than in the GERD group, but they were negatively correlated (P < 0.05) with H. pylori infection. The level of CD8+ was higher in the Barrett esophagus group, and it was positively correlated (P < 0.05) with H. pylori infection. Conclusions: Helicobacter pylori infection may protect against Barrett esophagus by reducing gastric acid secretion and increasing lower esophageal sphincter pressure. Besides, it has a certain correlation with immune function.

scholarly journals The Evolving Epidemiology ofHelicobacter pyloriInfection and Gastric Cancer

2003 ◽  
Vol 17 (suppl b) ◽  
pp. 18B-20B ◽  
Author(s):  
Jia-Qing Huang ◽  
Richard H Hunt
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Increased Risk ◽  
H Pylori ◽  
The Relationship

The relationship betweenHelicobacter pyloriinfection and the risk of gastric cancer has been well established in the last decade. Four metaanalyses have found that the infection increases the risk of noncardia gastric cancer by 2- to 6-fold compared with noninfected control populations. However, the role ofcagAstrains ofH pyloriin relation to gastric cancer has not been evaluated systematically. We undertook a meta-analysis of epidemiological studies examining the relationship between infection withcagA-positive strains ofH pyloriand the risk of gastric cancer, and found that patients who are seropositive forcagAstrains ofH pyloriare at an increased risk for developing noncardia gastric cancer compared with those withH pyloriinfection alone. Therefore, searching forcagA-positive strains ofH pylorimay help identify populations at a greater risk for developing gastric cancer.

scholarly journals The Relationship between Helicobacter pylori Infection of the Gallbladder and Chronic Cholecystitis and Cholelithiasis: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Liang Wang ◽  
Junyin Chen ◽  
Wenxi Jiang ◽  
Li Cen ◽  
Jiaqi Pan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Helicobacter Pylori ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Chronic Cholecystitis ◽  
Cochrane Library ◽  
Positive Correlation ◽  
Increased Risk ◽  
H Pylori ◽  
The Relationship

Helicobacter pylori (H. pylori) is proved to be the main pathogenic agent of various diseases, including chronic gastritis, gastric ulcer, duodenal ulcer, and gastric cancer. In addition, chronic cholecystitis and cholelithiasis are common worldwide, which are supposed to increase the total mortality of patients. Epidemiologic evidence on the relationship between H. pylori infection of the gallbladder and chronic cholecystitis/cholelithiasis still remains unclear. We conducted a systematic review and meta-analysis of overall studies to investigate the relationship between H. pylori infection of the gallbladder and chronic cholecystitis/cholelithiasis. Two researchers searched PubMed, Embase, and Cochrane Library databases to obtain all related and eligible studies published before July 2020. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by the random-effects model. Subgroup analysis, heterogeneity, publication bias, and sensitivity analysis were also conducted. Twenty studies were included in the meta-analysis, involving 1735 participants and 1197 patients with chronic cholecystitis/cholelithiasis. Helicobacter species infection of the gallbladder was positively correlated with increased risk of chronic cholecystitis and cholelithiasis, especially H. pylori (OR = 3.05; 95% CI, 1.81–5.14; I2 = 23.5%). Besides, country-based subgroup analysis also showed a positive correlation between the gallbladder H. pylori positivity and chronic cholecystitis/cholelithiasis risk. For Asian and non-Asian country studies, the ORs were 4.30 (95% CI, 1.76–10.50; I2 = 37.4%) and 2.13 (95% CI, 1.23–3.70; I2 = 0.0%), respectively. The association was more obvious using the bile sample and urease gene primer. In conclusion, this meta-analysis provided evidence that there is a positive correlation between H. pylori infection in the gallbladder and increased risk of chronic cholecystitis and cholelithiasis.

scholarly journals Helicobacter pyloriInfection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Lin Li ◽  
Lingling Li ◽  
Xiaoying Zhou ◽  
Shuping Xiao ◽  
Huiyuan Gu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Helicobacter Pylori ◽  
Pregnant Women ◽  
Web Of Science ◽  
Hyperemesis Gravidarum ◽  
Meta Analysis ◽  
Control Group ◽  
Increased Risk ◽  
H Pylori ◽  
The Relationship

Background. Several studies have shown a possible involvement ofHelicobacter pylori(H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG andH. pyloriinfection.Methods. PubMed, Embase, and Web of Science databases up to March 20, 2014, were searched to select studies on the prevalence ofH. pyloriinfection between pregnant women with HG and the normal pregnant control subjects.Results. Of the HG cases, 1289 (69.6%) wereH. pylori-positive; however, 1045 (46.2%) wereH. pylori-positive in control group. Compared to the non-HG normal pregnant controls, infection rate ofH. pyloriwas significantly higher in pregnant women with HG (OR = 3.34, 95% CI: 2.32–4.81,P<0.001). Subgroup analysis indicated thatH. pyloriinfection was a risk factor of HG in Asia, Africa, and Oceania, especially in Africa (OR = 12.38, 95% CI: 7.12–21.54,P<0.001).Conclusions.H. pylorishould be considered one of the risk factors of HG, especially in the developing countries.H. pylorieradication could be considered to relieve the symptoms of HG in some intractable cases.

scholarly journals The Relationship of Food Insecurity and Quality of Life with Helicobacter Pylori Infection

2020 ◽  
Author(s):  
Soudeh Talezadeh Shirazi ◽  
Mohammad Hassan Eftekhari ◽  
Afsane Ahmadi ◽  
Zohreh Mazloom ◽  
Mohammad Fararouei ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Helicobacter Pylori ◽  
Food Insecurity ◽  
Human Infection ◽  
World Population ◽  
Increased Risk ◽  
H Pylori ◽  
Relationship Of ◽  
The Relationship

Background: Helicobacter pylori (H pylori) is the most prevalent human infection in half of the world population. Few studies investigated the reasons of infection to H pylori in societies. The current study was designed i to examine the relationship of food insecurity and quality of life with H pylori infection. Methods: In this case- control study, 200 candidates were selected among the people who referred to Shiraz Imam Reza Clinic. They were asked to complete the general questionnaire, food security, and quality of life questionnaires. The H pylori excremental diagnosis test was also taken from them.  Results: The prevalence of H pylori infection was 28%. No relationship was observed between H pylori and age, gender, household size, and body mass index. However, the prevalence of H pylori infection was significantly higher in married individuals and housewives and volunteers with lower educations and those who took digestive medications. In addition, food insecurity (P = 0.04) and low quality of life (P < 0.001) were significantly high in individuals with H pylori infection. However, the possibility of suffering from H pylori infection in individuals who consume digestive medicines was 3.97 times higher than other individuals (95% CI: 2.11-7.40). Furthermore, with reduction of quality of life, the possibility of suffering from H pylori infection increased 1.77 times (95% CI: 1.203-2.591). Conclusion: The data indicated a statistically significant increased risk of H pylori in marital status, occupation, educational level, quality of life, and food insecurity in the affected individuals. The association of food insecurity and quality of life with H pylori infection should be examined in future studies in different populations

scholarly journals Association of Helicobacter Pylori babA2 gene and Gastric Cancer Risk: A Meta-analysis

2020 ◽  
Author(s):  
Marce-Amara Kpoghomou ◽  
jinchen Wang ◽  
Tianpei Wang ◽  
Guangfu Jin
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Meta Analysis ◽  
Asian Population ◽  
South American ◽  
Case Control Studies ◽  
South American Population ◽  
Increased Risk ◽  
H Pylori ◽  
The Relationship

Abstract Background: The association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relationship between H. pylori babA2 gene and GC risk.Methods: Case-control studies involving the association between H. pylori babA2 gene and GC risk were systematically identified from PubMed databases. A meta-analysis was used to pool studies and to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of H. pylori babA2 gene associated with GC risk.Results: Twenty studies were identified with a total of 1289 GC cases and 1081 controls. H. pylori babA2 gene was associated with an increased risk of GC by 2.05 fold (95% CI: 1.30-3.24, P=0.002). In subgroup analysis, we found that H. pylori babA2 gene was significantly associated with GC risk in Asian population (OR=2.63, 95% CI: 1.36-5.09 P=0.004) but not in South American population (OR=1.35, 95% CI: 0.69-2.64, P=0.379).Conclusions: This meta-analysis indicates that H. pylori babA2 gene may be associated with increased risk of GC, especially in Asian population.

scholarly journals Impact of Helicobacter pylori Infection and Its Major Virulence Factor CagA on DNA Damage Repair

2020 ◽  
Vol 8 (12) ◽  
pp. 2007
Author(s):  
Eleftherios Kontizas ◽  
Spyros Tastsoglou ◽  
Timokratis Karamitros ◽  
Yiannis Karayiannis ◽  
Panagoula Kollia ◽  
...  
Keyword(s):  
Dna Damage ◽  
Helicobacter Pylori ◽  
Virulence Factor ◽  
Excision Repair ◽  
Dna Damage Repair ◽  
Helicobacter Pylori Infection ◽  
Dna Glycosylase ◽  
Damage Repair ◽  
Increased Risk ◽  
H Pylori

Helicobacter pylori infection induces a plethora of DNA damages. Gastric epithelial cells, in order to maintain genomic integrity, require an integrous DNA damage repair (DDR) machinery, which, however, is reported to be modulated by the infection. CagA is a major H. pylori virulence factor, associated with increased risk for gastric carcinogenesis. Its pathogenic activity is partly regulated by phosphorylation on EPIYA motifs. Our aim was to identify effects of H. pylori infection and CagA on DDR, investigating the transcriptome of AGS cells, infected with wild-type, ΔCagA and EPIYA-phosphorylation-defective strains. Upon RNA-Seq-based transcriptomic analysis, we observed that a notable number of DDR genes were found deregulated during the infection, potentially resulting to base excision repair and mismatch repair compromise and an intricate deregulation of nucleotide excision repair, homologous recombination and non-homologous end-joining. Transcriptome observations were further investigated on the protein expression level, utilizing infections of AGS and GES-1 cells. We observed that CagA contributed to the downregulation of Nth Like DNA Glycosylase 1 (NTHL1), MutY DNA Glycosylase (MUTYH), Flap Structure-Specific Endonuclease 1 (FEN1), RAD51 Recombinase, DNA Polymerase Delta Catalytic Subunit (POLD1), and DNA Ligase 1 (LIG1) and, contrary to transcriptome results, Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APE1) upregulation. Our study accentuates the role of CagA as a significant contributor of H. pylori infection-mediated DDR modulation, potentially disrupting the balance between DNA damage and repair, thus favoring genomic instability and carcinogenesis.

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