Association of Helicobacter Pylori babA2 gene and Gastric Cancer Risk: A Meta-analysis

Abstract Background: The association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relationship between H. pylori babA2 gene and GC risk.Methods: Case-control studies involving the association between H. pylori babA2 gene and GC risk were systematically identified from PubMed databases. A meta-analysis was used to pool studies and to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of H. pylori babA2 gene associated with GC risk.Results: Twenty studies were identified with a total of 1289 GC cases and 1081 controls. H. pylori babA2 gene was associated with an increased risk of GC by 2.05 fold (95% CI: 1.30-3.24, P=0.002). In subgroup analysis, we found that H. pylori babA2 gene was significantly associated with GC risk in Asian population (OR=2.63, 95% CI: 1.36-5.09 P=0.004) but not in South American population (OR=1.35, 95% CI: 0.69-2.64, P=0.379).Conclusions: This meta-analysis indicates that H. pylori babA2 gene may be associated with increased risk of GC, especially in Asian population.

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Association of Helicobacter Pylori babA2 gene and Gastric Cancer Risk: A Meta-analysis

10.21203/rs.2.17506/v1 ◽

2019 ◽

Author(s):

Marce-Amara Kpoghomou ◽

jinchen Wang ◽

Tianpei Wang ◽

Guangfu Jin

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Meta Analysis ◽

Strong Association ◽

Asian Population ◽

Positive Association ◽

South American ◽

Case Control Studies ◽

Increased Risk ◽

H Pylori

Abstract Background The association of H. pylori babA2 gene with gastric cancer (GC) was proposed by several studies, but the results have been inconsistent. Objective of this meta-analysis was to investigate the association of Helicobacter pylori (H. pylori ) babA2 gene and gastric cancer (GC) risk.Methods Studies evaluated the association between H. pylori babA2 gene and GC risk were collected from PubMed databases. A meta-analysis of case-control studies was used. The pooled ORs with 95% CIs were used to calculate the effect of H. pylori babA2 gene effect on GC risk.Results Twenty studies were identified with a total of 747 GC and 1597 controls. Infection with H. pylori babA2 gene was associated with an increased risk of GC by 1.46 fold (95% CI: 1.19-1.77, P=0.001) . In subgroup analysis, borderline association was found among South American and strong association was found among Asian population, with pooled OR of 1.38 (95% CI: 0.97-1.95, P=0.068 ) and 1.50 (95% CI: 1.16-1.93, P=0.002 ) respectively.Conclusions This meta-analysis validated that H. pylori babA2 gene may be associated with increased risk of GC. And positive association was found among Asian population.

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The Evolving Epidemiology ofHelicobacter pyloriInfection and Gastric Cancer

Canadian Journal of Gastroenterology ◽

10.1155/2003/692808 ◽

2003 ◽

Vol 17 (suppl b) ◽

pp. 18B-20B ◽

Cited By ~ 20

Author(s):

Jia-Qing Huang ◽

Richard H Hunt

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Meta Analysis ◽

Epidemiological Studies ◽

Increased Risk ◽

H Pylori ◽

The Relationship

The relationship betweenHelicobacter pyloriinfection and the risk of gastric cancer has been well established in the last decade. Four metaanalyses have found that the infection increases the risk of noncardia gastric cancer by 2- to 6-fold compared with noninfected control populations. However, the role ofcagAstrains ofH pyloriin relation to gastric cancer has not been evaluated systematically. We undertook a meta-analysis of epidemiological studies examining the relationship between infection withcagA-positive strains ofH pyloriand the risk of gastric cancer, and found that patients who are seropositive forcagAstrains ofH pyloriare at an increased risk for developing noncardia gastric cancer compared with those withH pyloriinfection alone. Therefore, searching forcagA-positive strains ofH pylorimay help identify populations at a greater risk for developing gastric cancer.

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The Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17072524 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2524

Author(s):

Yun-A Kim ◽

Yoon Jeong Cho ◽

Sang Gyu Kwak

Keyword(s):

Helicobacter Pylori ◽

Irritable Bowel Syndrome ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Cross Sectional ◽

Cross Sectional Studies ◽

H Pylori ◽

Irritable Bowel ◽

The Relationship

The association of Helicobacter pylori (H. pylori) infection with functional dyspepsia has been well studied. However, the data on the relationship between H. pylori infection and irritable bowel syndrome (IBS) are conflicting. This study aims to elucidate the association between H. pylori infection and IBS. PubMed, Cochrane Library, CINAHL and SCOPUS databases were searched to identify eligible English articles published up to December 2019. Cross-sectional studies, case–control studies and cohort studies reporting both prevalence of H. pylori infection and IBS were selected for the detailed review. The pooled odds ratio (ORs) and their 95% confidence interval (CI) were calculated. A total of 7269 individuals in four cross-sectional studies and six case-control studies were included. The prevalence of H. pylori infection ranged from 12.8% to 73.4% in the control group, and 9.7% to 72.1% in the IBS group. The combined OR for H. pylori infection was 1.10 (95% CI: 0.93–1.29, I2: 37.5%). In a subgroup analysis of IBS defined according to Rome criteria, the OR for H. pylori infection was 1.10 (95% CI: 0.93–1.30, I2 = 31.7%). In this meta-analysis, H. pylori infection was not significantly associated with IBS. Well-designed studies are needed to identify the relationship between H. pylori infection and IBS.

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Correlation between the geographical origin of Helicobacter pylori homB-positive strains and their clinical outcomes: a systematic review and meta-analysis

10.21203/rs.3.rs-131264/v1 ◽

2021 ◽

Author(s):

Mohsen Karbalaei ◽

Masoud Keikha

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Peptic Ulcer ◽

Clinical Outcomes ◽

Meta Analysis ◽

Asian Population ◽

Positive Association ◽

Clinical Results ◽

Western Countries ◽

H Pylori

Abstract Background In general, all virulence factors of Helicobacter pylori (H. pylori) are involved in its infections. However, recent studies have shown that the homB gene is one of the virulence genes that affects the severity of the clinical results of this bacterium. Methods The main purpose of this study was to investigate the relationship between the presence of homB gene in H. pylori and the progression of its infection to peptic ulcer and gastric cancer. In the present study, we conducted a systematic search to collect all articles related to the effect of homB-positive strains on clinical outcomes. Finally 12 eligible studies according to our criteria were included in this meta-analysis and the effect of homB gene on gastric ulcer and gastric cancer diseases was evaluated by summary odds ratio. Results Current results showed that the homB-positive strains significantly increase the risk of peptic ulcer (OR: 1.36; 1.07–1.72 with 95% CIs), especially in western countries (OR: 1.61; 1.20–2.14 with 95% CIs). Moreover, we observed a positive association between the homB gene and risk of gastric cancer (OR: 2.10; 1.35–3.29 with 95% CIs). In addition, based on subgroup analysis, it was found that the presence of this gene in H. pylori strains increases the risk of gastric cancer in the Asian population (OR: 3.71; 1.85–7.45 with 95% CIs). Conclusions Overall, in the present study we found that homB gene is responsible for the progressing of primary infection to severe complications, in particular peptic ulcer in western countries and gastric cancer in Asian countries.

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The Relationship between Helicobacter pylori Infection of the Gallbladder and Chronic Cholecystitis and Cholelithiasis: A Systematic Review and Meta-Analysis

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2021/8886085 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Liang Wang ◽

Junyin Chen ◽

Wenxi Jiang ◽

Li Cen ◽

Jiaqi Pan ◽

...

Keyword(s):

Systematic Review ◽

Helicobacter Pylori ◽

Subgroup Analysis ◽

Meta Analysis ◽

Chronic Cholecystitis ◽

Cochrane Library ◽

Positive Correlation ◽

Increased Risk ◽

H Pylori ◽

The Relationship

Helicobacter pylori (H. pylori) is proved to be the main pathogenic agent of various diseases, including chronic gastritis, gastric ulcer, duodenal ulcer, and gastric cancer. In addition, chronic cholecystitis and cholelithiasis are common worldwide, which are supposed to increase the total mortality of patients. Epidemiologic evidence on the relationship between H. pylori infection of the gallbladder and chronic cholecystitis/cholelithiasis still remains unclear. We conducted a systematic review and meta-analysis of overall studies to investigate the relationship between H. pylori infection of the gallbladder and chronic cholecystitis/cholelithiasis. Two researchers searched PubMed, Embase, and Cochrane Library databases to obtain all related and eligible studies published before July 2020. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by the random-effects model. Subgroup analysis, heterogeneity, publication bias, and sensitivity analysis were also conducted. Twenty studies were included in the meta-analysis, involving 1735 participants and 1197 patients with chronic cholecystitis/cholelithiasis. Helicobacter species infection of the gallbladder was positively correlated with increased risk of chronic cholecystitis and cholelithiasis, especially H. pylori (OR = 3.05; 95% CI, 1.81–5.14; I2 = 23.5%). Besides, country-based subgroup analysis also showed a positive correlation between the gallbladder H. pylori positivity and chronic cholecystitis/cholelithiasis risk. For Asian and non-Asian country studies, the ORs were 4.30 (95% CI, 1.76–10.50; I2 = 37.4%) and 2.13 (95% CI, 1.23–3.70; I2 = 0.0%), respectively. The association was more obvious using the bile sample and urease gene primer. In conclusion, this meta-analysis provided evidence that there is a positive correlation between H. pylori infection in the gallbladder and increased risk of chronic cholecystitis and cholelithiasis.

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What is the Relationship Between Helicobacter Pylori CagA Genotypes and Gastrointestinal Diseases in the Iranian Population? A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-80096/v1 ◽

2020 ◽

Author(s):

Masoud Keikha ◽

Mohsen Karbalaei

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Meta Analysis ◽

Gastrointestinal Diseases ◽

Iranian Population ◽

Cancer Disease ◽

Gastrointestinal Complications ◽

Cytotoxin Associated Gene A ◽

H Pylori ◽

The Relationship

Abstract Background: Helicobacter pylori (H. pylori) is one of the most well-known risk factors for getting the gastric cancer disease. In recent studies, the relationship between its virulence factors, specially CagA (cytotoxin‐associated gene A) toxin and development into the gastrointestinal diseases is taken into consideration. According to review of literature, despite the presence of four motifs A, B, C, and D in CagA toxin, two motifs C and D are more associated with gastrointestinal complications in patients who are infected by H. pylori. Methods: In the present study, we researched about theses ambiguities using a comprehensive meta-analysis study. In this study, we assessed the information of 1762 Iranian patients for potential relationship between all genotypes of cagA gene and gastrointestinal diseases.Results: According to statistical analysis, the abundance of cagA genotypes AB, ABC, ABCC, ABCCC, and ABD in Iranian population is 5.52%, 80.18%, 22.81%, 2.76%, and 0% respectively. In addition, it was determined that there is a significant relationship between cagA genotypes ABCC and ABCCC on the one hand and cagA genotype ABCCC on the other hand with susceptibility to chronic gastritis and gastric cancer respectively.Conclusions: Overall, it can be concluded that the higher number of EPIYA-C copy numbers lead to the higher risk of gastric cancer. According to our results, it seems that the presence of EPIYA-ABCCC motif in strains of H. pylori should be considered as an appropriate marker in preventing the gastric cancer among the Iranian population.

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cagA-Seropositive Strains ofHelicobacter pyloriIncrease the Risk for Gastric Cancer more than the Presence ofH pyloriAlone

Canadian Journal of Gastroenterology ◽

10.1155/2004/424018 ◽

2004 ◽

Vol 18 (5) ◽

pp. 341-343

Author(s):

Naoki Chiba

Keyword(s):

Gastric Cancer ◽

Odds Ratio ◽

Meta Analysis ◽

Review Of The Literature ◽

Chain Reaction ◽

Positive Strain ◽

Increased Risk ◽

Polymerase Chain ◽

H Pylori ◽

The Relationship

Huang et al have performed a meta-analysis to determine the relationship betweencagA seropositivity (by serology and polymerase chain reaction) and the risk of gastric cancer. An extensive review of the literature identified no previous systematic overviews. The authors identified 16 studies involving 2284 cases and 2770 controls. The overall prevalence of Helicobacter pylori was 77.7% in cases and 63.1% in controls. Tests forcagA were positive in 62.8% of cases and 37.5% of controls. Thus,H pyloriandcagA seropositivity significantly increased the risk for gastric cancer, by 2.28 (95% CI 1.71 to 3.05) and 2.87 (95% CI 1.95 to 4.22), respectively. In patients withH pylori, those who were infected by acagA-positive strain had a slightly higher risk of gastric cancer, with an odds ratio of 1.64 (95% CI 1.21 to 2.24). The authors also found that patients infected withH pyloriwith or withoutcagA seropositivity had an increased risk of noncardia gastric cancer, but not of cancer of the gastric cardia. They concluded thatcagA-positive strains confer a greater risk of gastric cancer than does H pylori infection alone.

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Helicobacter pyloriInfection Is Associated with an Increased Risk of Hyperemesis Gravidarum: A Meta-Analysis

Gastroenterology Research and Practice ◽

10.1155/2015/278905 ◽

2015 ◽

Vol 2015 ◽

pp. 1-13 ◽

Cited By ~ 12

Author(s):

Lin Li ◽

Lingling Li ◽

Xiaoying Zhou ◽

Shuping Xiao ◽

Huiyuan Gu ◽

...

Keyword(s):

Risk Factors ◽

Helicobacter Pylori ◽

Pregnant Women ◽

Web Of Science ◽

Hyperemesis Gravidarum ◽

Meta Analysis ◽

Control Group ◽

Increased Risk ◽

H Pylori ◽

The Relationship

Background. Several studies have shown a possible involvement ofHelicobacter pylori(H. pylori) infection in individuals with hyperemesis gravidarum (HG), but the relationship remains controversial. This meta-analysis was performed to validate and strengthen the association between HG andH. pyloriinfection.Methods. PubMed, Embase, and Web of Science databases up to March 20, 2014, were searched to select studies on the prevalence ofH. pyloriinfection between pregnant women with HG and the normal pregnant control subjects.Results. Of the HG cases, 1289 (69.6%) wereH. pylori-positive; however, 1045 (46.2%) wereH. pylori-positive in control group. Compared to the non-HG normal pregnant controls, infection rate ofH. pyloriwas significantly higher in pregnant women with HG (OR = 3.34, 95% CI: 2.32–4.81,P<0.001). Subgroup analysis indicated thatH. pyloriinfection was a risk factor of HG in Asia, Africa, and Oceania, especially in Africa (OR = 12.38, 95% CI: 7.12–21.54,P<0.001).Conclusions.H. pylorishould be considered one of the risk factors of HG, especially in the developing countries.H. pylorieradication could be considered to relieve the symptoms of HG in some intractable cases.

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Correlation between the geographical origin of Helicobacter pylori homB-positive strains and their clinical outcomes: a systematic review and meta-analysis

BMC Gastroenterology ◽

10.1186/s12876-021-01764-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Masoud Keikha ◽

Mohsen Karbalaei

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Peptic Ulcer ◽

Clinical Outcomes ◽

Meta Analysis ◽

Asian Population ◽

Positive Association ◽

Clinical Results ◽

Western Countries ◽

H Pylori

Abstract Background In general, all virulence factors of Helicobacter pylori (H. pylori) are involved in its infections. However, recent studies have shown that the homB gene is one of the virulence genes that affects the severity of the clinical results of this bacterium. Methods The main purpose of this study was to investigate the relationship between the presence of homB gene in H. pylori and the progression of its infection to peptic ulcer and gastric cancer. In the present study, we conducted a systematic search to collect all articles related to the effect of homB-positive strains on clinical outcomes. Finally, 12 eligible studies according to our criteria were included in this meta-analysis and the effect of homB gene on gastric ulcer and gastric cancer diseases was evaluated by summary odds ratio (OR). Results Current results showed that the homB-positive strains significantly increase the risk of peptic ulcer (OR 1.36; 1.07–1.72 with 95% CIs), especially in western countries (OR 1.61; 1.20–2.14 with 95% CIs). Moreover, we observed a positive association between the homB gene and risk of gastric cancer (OR 2.16; 1.37–3.40 with 95% CIs). In addition, based on subgroup analysis, it was found that the presence of this gene in H. pylori strains increases the risk of gastric cancer in the Asian population (OR 3.71; 1.85–7.45 with 95% CIs). Conclusions Overall, in the present study we found that homB gene is responsible for the progressing of primary infection to severe complications, in particular peptic ulcer in western countries and gastric cancer in Asian countries.

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The correlation between lncRNAs and Helicobacter pylori in gastric cancer

Pathogens and Disease ◽

10.1093/femspd/ftaa004 ◽

2019 ◽

Vol 77 (9) ◽

Author(s):

Narges Dastmalchi ◽

Seyed Mahdi Banan Khojasteh ◽

Mirsaed Miri Nargesi ◽

Reza Safaralizadeh

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Molecular Mechanisms ◽

Gastrointestinal Diseases ◽

Mechanisms Of Action ◽

Molecular Pathways ◽

Gastric Diseases ◽

Non Coding Rnas ◽

H Pylori ◽

The Relationship

ABSTRACT Helicobacter pylori infection performs a key role in gastric tumorigenesis. Long non-coding RNAs (lncRNAs) have demonstrated a great potential to be regarded as effective malignancy biomarkers for various gastrointestinal diseases including gastric cancer (GC). The present review highlights the relationship between lncRNAs and H. pylori in GC. Several studies have examined not only the involvement of lncRNAs in H. pylori-associated GC progression but also their molecular mechanisms of action. Among the pertinent studies, some have addressed the effects of H. pylori infection on modulatory networks of lncRNAs, while others have evaluated the effects of changes in the expression level of lncRNAs in H. pylori-associated gastric diseases, especially GC. The relationship between lncRNAs and H. pylori was found to be modulated by various molecular pathways.

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