Polymer in Pharmaceutical Drug Delivery System

Abstract: The current review article focuses on polymers in pharmaceutical drug delivery of therapeutic agents. These dosage forms include tablets, patches, tapes, films, semisolids and powders. Polymers are the backbone of a pharmaceutical drug delivery system as they control the release of the drug from the device. Biodegradable polymers attracts the attention of its use as they can be degraded to non‐toxic monomers and most important, a constant rate of drug release can be achieved from a biodegradable polymer based controlled release device. Natural polymers can be used as the means of achieving predetermined rates of drug delivery and their physico‐chemical characteristics with the ease of availability provide a platform to use it as a polymer for drug delivery systems. Biodegradable polymers have been widely used in biomedical applications because of their known biocompatibility and biodegradability. In the biomedical area, polymers are generally used as implants and are expected to perform long term service. These improvements contribute to make medical treatment more efficient and to minimize side effects and other types of inconveniences for patients. The main role of polymer is to protect drug from physiological environment and prolong release of drug to improve its stability. The drug is release from polymer by diffusion, degradation and swelling. In addition to this review presents characteristics and behaviours of plant derived and mucoadhesive polymers which are currently used in drug delivery.

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EXTRACTION, MODIFICATION, AND CHARACTERIZATION OF NATURAL POLYMERS USED IN TRANSDERMAL DRUG DELIVERY SYSTEM: AN UPDATED REVIEW

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i7.37756 ◽

2020 ◽

pp. 10-20

Author(s):

DIPJYOTI BISWAS ◽

SUDIP DAS ◽

SOURAV MOHANTO ◽

SHUBHRAJIT MANTRY

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Transdermal Drug Delivery ◽

Biomedical Application ◽

The Body ◽

Fixed Dose ◽

Natural Polymers ◽

Transdermal Drug Delivery System

The modified/regulated drug delivery system helps to sustain the delivery of the drug for a prolonged period. The modified drug delivery system is primarily aimed at ensuring protection, the effectiveness of the drug, and patient compliance. The transdermal drug delivery system (TDDS) falls within the modified drug delivery system, in which the goal is to deliver the drug at a fixed dose and regulated rate through the skin. Polymers are the backbone of the framework for providing transdermal systems. The polymer should be stable, non-toxic, economical, and provide a sustainable release of the drug. In general, natural polymers used in the TDDS as rate-controlling agents, protective, and stabilizing agents and also used to minimize the frequency of dosing and improve the drug’s effectiveness by localizing at the site of action. Nowadays, manufacturers are likely to use natural polymers due to many issues associated with drug release and side effects with synthetic polymers. Drug release processes from natural polymers include oxidation, diffusion, and swelling. Natural polymers may be used as the basis to achieve predetermined drug distribution throughout the body. The use of natural materials for traditional and modern types of dosage forms are gums, mucilages, resins, and plant waste etc. Thus, the main objective of this review article is to give a brief knowledge about the extraction, modification, characterization, and biomedical application of conventional natural polymers used in the transdermal drug delivery system and their future prospective.

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Novel colon targeted drug delivery system using natural polymers

Indian Journal of Pharmaceutical Sciences ◽

10.4103/0250-474x.40346 ◽

2008 ◽

Vol 70 (1) ◽

pp. 111 ◽

Cited By ~ 15

Author(s):

TM Pramod Kumar ◽

Siddaramaiah ◽

V Ravi

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Drug Delivery ◽

Natural Polymers ◽

Targeted Drug ◽

Targeted Drug Delivery System

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A haematotoxicity evaluation of a natural polymer intended to be a nutraceutical and pharmaceutical drug delivery system.

10.1055/s-0041-1736932 ◽

2021 ◽

Author(s):

Ofosua Adi-Dako ◽

Doris Kumadoh ◽

AlexanderKwadwo Nyarko

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Natural Polymer ◽

Pharmaceutical Drug

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DEVELOPMENT AND CHARACTERIZATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM FOR RITONAVIR TABLETS USING NATURAL POLYMERS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i5.17266 ◽

2017 ◽

Vol 10 (5) ◽

pp. 318

Author(s):

Saritha Chukka

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Guar Gum ◽

Prolonged Release ◽

Natural Polymers ◽

Drug Bioavailability ◽

Floating Tablets ◽

Drug Concentrations

ABSTRACT Objective: The present study involves preparation and evaluation of floating tablets of ritonavir for improving the drug bioavailability by prolongation of gastric residence time.Ritonavir is an antiretroviral agent used in treatment of HIV and viral diseases has been taken as a model drug in the present investigation because of its low biological half life (3-5h). Moreover it is primarily absorbed from stomach. Materials and Methods: Ritonavir floating tablets were prepared by the dry granulation technique, using guar gum and xanthan gum as polymers, sodium bicarbonate as effervescent agent, PVP as binding agent, Di calcium phosphate as diluents, Crospovidone as swelling agent and magnesium stearate as lubricant. The prepared tablets were evaluated for various physico-chemical parameters. Results: Drug-excipient interaction studies were conducted by FTIR and DSC. The results suggested that there was no incompatibility between the drug and polymers. The prepared tablets were evaluated for their physical characteristics. All the parameters were within the pharmacopoeial limits. Further, tablets were also studied for their floating properties and in vitro drug release characteristics. The tablets exhibited controlled and prolonged drug release profiles. The developed formulation was found to be stable. Conclusion: The developed floating tablets of ritonavir exhibit prolonged release upto 12 h, and thus may improve bioavailability and minimize fluctuations in plasma drug concentrations. Key words: Ritonavir, floating tablets, gastric residence time, gastroretentive drug delivery system

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