scholarly journals Formulation and evaluation of effervescent tablets: a review

2018 ◽  
Vol 8 (6) ◽  
pp. 296-303 ◽  
Author(s):  
Salim G Patel ◽  
M Siddaiah
Keyword(s):  
Drug Delivery Systems ◽  
Dosage Form ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Liquid Form ◽  
Pulsatile Drug Delivery ◽  
Oral Dosage Forms ◽  
Effervescent Tablet ◽  
Liquid Dosage Form ◽  
Slow Absorption

Oral dosage forms are the most popular way of taking medication, despite having some disadvantages compared with other methods like risk of slow absorption of the medicament, which can be overcome by administering the drug in liquid form, therefore, possibly allowing the use of a lower dosage. However, instability of many drugs in liquid dosage form limits its use. Effervescent technique can be used as alternate to develop a dosage form which can accelerate drug disintegration and dissolution, is usually applied in quick release preparations. Along with the development of new pharmaceutical technique, effervescent tablet are more and more extensively to adjust the behaviour of drug release, such as in sustained and controlled release preparations, pulsatile drug delivery systems, and so on. This review demonstrated the new applying of effervescent technique in effervescent tablets. Keywords: Effervescent Tablet, Sustained release, Floating Delivery System

scholarly journals Dry syrup: An overview

2018 ◽  
Vol 6 (03) ◽  
pp. 30-38
Author(s):  
M. Ola ◽  
R. Bhaskar ◽  
Priya Patil
Keyword(s):  
Gastrointestinal Tract ◽  
Dosage Form ◽  
Drug Stability ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Technological Advancement ◽  
Ich Guidelines ◽  
Reconstituted System ◽  
Oral Dosage Forms ◽  
High Bioavailability

The advantages of oral dosage form that are responsible for its popularity are its ease of administration, patient compliance and stability of formulation. The most popular oral dosage forms beings tablets and capsules, but one important drawback of the dosage forms however is the difficulty to swallow especially when a dosage form is developed for pediatric and geriatric patient. The modern scientific and technological advancement in the pharmaceutical field had created bank of interest in reconstitutable oral suspension dosage form in the recent year. The reconstituted system is the formulation of choice when the drug stability is a major concern. Reconstitutable oral systems show the adequate chemical stability of the drug during shelf life and also reduce the weight of the final product. Dry syrup form of the drug is also useful in case of bioavailability as it has high bioavailability rather than tablets and capsules as it disintegrates in water outside of the oral cavity and directly the suspension is gone through the gastrointestinal tract. So the suspension easily absorbs in the GIT. The present review gives an account of the excipients used, methods of preparation of dry syrups along with their evaluations, their packaging, ICH guidelines.

Biopolymeric matrices based on chitosan for medical applications

e-Polymers ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria Mucha ◽  
Jacek Balcerzak ◽  
Iwona Michalak ◽  
Michał Tylman
Keyword(s):  
Drug Delivery Systems ◽  
Release Kinetics ◽  
Controlled Drug Delivery ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Poly Lactic Acid ◽  
Medical Applications ◽  
Freeze Dried ◽  
Excellent Adhesion ◽  
Oral Dosage Forms

AbstractChitosan (CS) based materials in a form of composite with poly(lactic acid) (PLA) granules, films and freeze-dried scaffolds also with blend form with hydroxypropylocellulose (HPC), as well as dibutyrylchitin films were obtained. These structures are intended especially for controlled drug delivery systems, including transdermal and oral dosage forms. Excellent adhesion of biopolymer matrices to PLA microspheres or hydroxyapatite (HAp) particles was proven. The Iorder drug (ibuprofen (IBU)) release kinetics from obtained films is stated.

scholarly journals AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS

2018 ◽  
Vol 6 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Pravin Kumar Sharma ◽  
Pankaj Kumar Sharma ◽  
Gajanan N Darwhekar ◽  
Birendra Shrivastava
Keyword(s):  
Dosage Form ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Drug Dissolution ◽  
Solid Dosage Forms ◽  
Onset Of Action ◽  
Cold Sore ◽  
Solid Dosage ◽  
Oral Films ◽  
Oral Dosage Forms

Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of action, bypassing the first pass metabolism of drugs and thus enhance their oral bioavailability with reduced dosing frequency. These formulations are suitable for cough, cold, sore throat, allergenic conditions, nausea, pain, hypertension and CNS disorders. The present review provides the details about the recent advancement in design and development of oral fast dissolving film.

Preparation and Evaluation of Diclofenac Sodium Effervescent Tablet

2021 ◽  
pp. 305-311
Author(s):  
P.B. Savant ◽  
M.A. Qureshi ◽  
Kshirsagar N. ◽  
Manjusha Kareppa ◽  
Avinash B Thalkari ◽  
...  
Keyword(s):  
Diclofenac Sodium ◽  
Oral Dosage ◽  
Wet Granulation ◽  
Liquid Form ◽  
Onset Of Action ◽  
Weight Variation ◽  
Acid And Base ◽  
Acceptable Method ◽  
Oral Dosage Forms ◽  
Effervescent Tablet

The oral dosage forms are the most popular way of taking medicine although having some disadvantages like deliberate absorption and thus onset of action is extend. This can be overcome by administrating the drug in a liquid form i.e. effervescent tablet. The research is a formulation of diclofenac sodium as a effervescent tablet by wet granulation method. The bitter taste of the drug are masked by added sweetening agent (lactose, glucose etc.) In the present work we are prepared effervescent tablet in that we are used active drug diclofenac sodium and other active ingredient acid like tartaric acid and base sodium bicarbonate in different concentrations. The formulation of tablet was done by using wet granulation, wet granulation is found to be acceptable method of effervescent tablet formulation. The various pre-formulation studies was performed hardness, weight variation, disintegration, dissolution etc.

scholarly journals A comprehensive review on pharmaceutical mini tablets

2018 ◽  
Vol 8 (6) ◽  
pp. 382-390 ◽  
Author(s):  
Priyanka Priyanka ◽  
Kapil Kumar ◽  
Deepak Teotia
Keyword(s):  
Dosage Form ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Formulation Development ◽  
Coating Materials ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Therapeutic Benefits ◽  
Form Design ◽  
Oral Dosage Forms

Mini-tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less. Offering some therapeutic benefits such as dose flexibility and combined release patterns. They do not require any solvent for their production and also local irritation can be avoided by the use of mini tablet Mini tablet offer several advantages like they can be manufactured relatively easily, They are not require less coating materials and also there is a great flexibility during their formulation development. Mini tablet are more acceptable in children and elderly people as they are easy to swallow. The objective of controlled drug delivery systems is to reduce the frequency of the dosing and to increase the effectiveness of the drug by localization. Keywords: Mini-tablets, solid dosage form, oral dosage forms.

scholarly journals AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS

2018 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Pravin Kumar Sharma ◽  
Pankaj Kumar Sharma ◽  
Gajanan N Darwhekar ◽  
Birendra Shrivastava
Keyword(s):  
Dosage Form ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Drug Dissolution ◽  
Solid Dosage Forms ◽  
Onset Of Action ◽  
Cold Sore ◽  
Solid Dosage ◽  
Oral Films ◽  
Oral Dosage Forms

Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of action, bypassing the first pass metabolism of drugs and thus enhance their oral bioavailability with reduced dosing frequency. These formulations are suitable for cough, cold, sore throat, allergenic conditions, nausea, pain, hypertension and CNS disorders. The present review provides the details about the recent advancement in design and development of oral fast dissolving film.

scholarly journals Formulation and Evaluation of Pediatric Paracetamol Elixir Using Natural Colorant

2020 ◽  
Vol 13 (3) ◽  
pp. 180-185
Author(s):  
Mamatha Tirunagari ◽  
Nagadivya Nerella ◽  
Anupama Koneru ◽  
Madihah ◽  
Syed Sarfaraz ◽  
...  
Keyword(s):  
Dosage Form ◽  
Cost Effective ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Physical Parameters ◽  
Natural Colorant ◽  
Solid Dosage ◽  
Pediatric Age Group ◽  
Wide Range ◽  
Oral Dosage Forms

Oral dosage forms are most popular among other dosage forms. In terms of bioavailability liquid dosage form is better than that of solid dosage form. In the present scenario monophagic liquid dosage forms such as syrups, elixirs, throat paints, mouth washes, gargles have gained huge popularity. These are very basic preparations which involve brief processes, machineries and are cost effective also. They come in wide range colours and flavors so as to attract the pediatric age group. Currently colors derived from natural sources are given priority compared to synthetic ones. In this study we formulated paracetamol which is a bitter drug as an elixir using natural colorant from annatto seeds at three different concentrations in F1, F2, and F3. Ethanol. Propylene glycol, mixed fruit juice, chloroform spirit, sucrose syrup and glycerin were also used. These formulations were evaluated for different physical parameters and it showed good results.

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