scholarly journals AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS

2018 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Pravin Kumar Sharma ◽  
Pankaj Kumar Sharma ◽  
Gajanan N Darwhekar ◽  
Birendra Shrivastava
Keyword(s):  
Dosage Form ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Drug Dissolution ◽  
Solid Dosage Forms ◽  
Onset Of Action ◽  
Cold Sore ◽  
Solid Dosage ◽  
Oral Films ◽  
Oral Dosage Forms

Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of action, bypassing the first pass metabolism of drugs and thus enhance their oral bioavailability with reduced dosing frequency. These formulations are suitable for cough, cold, sore throat, allergenic conditions, nausea, pain, hypertension and CNS disorders. The present review provides the details about the recent advancement in design and development of oral fast dissolving film.

scholarly journals AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS

2018 ◽  
Vol 6 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Pravin Kumar Sharma ◽  
Pankaj Kumar Sharma ◽  
Gajanan N Darwhekar ◽  
Birendra Shrivastava
Keyword(s):  
Dosage Form ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Drug Dissolution ◽  
Solid Dosage Forms ◽  
Onset Of Action ◽  
Cold Sore ◽  
Solid Dosage ◽  
Oral Films ◽  
Oral Dosage Forms

Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of action, bypassing the first pass metabolism of drugs and thus enhance their oral bioavailability with reduced dosing frequency. These formulations are suitable for cough, cold, sore throat, allergenic conditions, nausea, pain, hypertension and CNS disorders. The present review provides the details about the recent advancement in design and development of oral fast dissolving film.

scholarly journals Superdisintegrant: crucial elements for mouth dissolving tablets

2019 ◽  
Vol 9 (2) ◽  
pp. 461-468
Author(s):  
Rada Santosh Kumar ◽  
Annu Kumari
Keyword(s):  
Fine Particles ◽  
Rapid Onset ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Solid Dosage Forms ◽  
Onset Of Action ◽  
Solid Dosage ◽  
Pharmacologic Effect ◽  
Solid Oral Dosage Forms ◽  
Oral Dosage Forms

Mouth dissolving tablets have gained more popularity among solid oral dosage forms. They perform better than conventional tablets because of its ease of administration and patient’s compliance. It facilitates water less administration and rapid onset of action. It also helps in improving oral bioavailability. The fast disintegration followed by dissolution leads to quick therapeutic activity makes these tablets superior over available tablets and capsules. Disintegration is an important key step for any solid dosage forms to show its pharmacologic effect as any solid dosage forms should disperse into its fine particles from which it is prepared. In mouth dissolving tablets superdisintegrants are incorporated in right amount for quick disintegration with improved bioavailability. Based on the source various types of superdisintegrants are available. They are synthetic, semi-synthetic, natural, and co-processed.  In this review, main emphasis is given on different types of superdisintegrants used in mouth dissolving tablets, their mechanisms and applications. Keywords: Superdisintegrants, Mouth dissolving, Disintegration, Bioavailability

Advances in solid dosage form manufacturing technology

2007 ◽  
Vol 365 (1861) ◽  
pp. 2935-2949 ◽  
Author(s):  
Gavin P Andrews
Keyword(s):  
Dosage Form ◽  
Powder Processing ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Pharmaceutical Companies ◽  
Solid Dosage Forms ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Manufacturing Technologies ◽  
Hot Melt

Currently, the pharmaceutical and healthcare industries are moving through a period of unparalleled change. Major multinational pharmaceutical companies are restructuring, consolidating, merging and more importantly critically assessing their competitiveness to ensure constant growth in an ever-more demanding market where the cost of developing novel products is continuously increasing. The pharmaceutical manufacturing processes currently in existence for the production of solid oral dosage forms are associated with significant disadvantages and in many instances provide many processing problems. Therefore, it is well accepted that there is an increasing need for alternative processes to dramatically improve powder processing, and more importantly to ensure that acceptable, reproducible solid dosage forms can be manufactured. Consequently, pharmaceutical companies are beginning to invest in innovative processes capable of producing solid dosage forms that better meet the needs of the patient while providing efficient manufacturing operations. This article discusses two emerging solid dosage form manufacturing technologies, namely hot-melt extrusion and fluidized hot-melt granulation.

scholarly journals REVIEW: FAST DISSOLVING TABLET

2018 ◽  
Vol 10 (2) ◽  
pp. 5
Author(s):  
Aher Smita S. ◽  
Saudagar R. B. ◽  
Shinde Mayuri S.
Keyword(s):  
Dosage Form ◽  
Geriatric Patients ◽  
Oral Route ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Tablet Disintegration ◽  
Physical And Chemical ◽  
Pass Metabolism

Fast dissolving tablets is one of the most widely accepted dosage forms and also most popular dosage form, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Some solid dosage forms like tablets and capsules are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitations like the first-pass metabolism. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. Some tablets are designed to dissolve fastly in saliva, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate.

In-Vitro Drug Dissolution Studies in Medicinal Compounds

2018 ◽  
Vol 25 (33) ◽  
pp. 4020-4036
Author(s):  
Burcin Bozal-Palabiyik ◽  
Bengi Uslu ◽  
Yalcin Ozkan ◽  
Sibel A. Ozkan
Keyword(s):  
Dosage Form ◽  
Dosage Forms ◽  
Drug Dissolution ◽  
Dissolution Testing ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
The Media ◽  
Recent Trends ◽  
Selection Of

After oral administration, drug absorption from solid dosage forms depends on the release of the drug active compounds from the dosage form, the dissolution or solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. Dissolution testing is an essential part of designing more effective solid dosage forms in pharmaceutical industry. Moreover, dissolution testing contributes to the selection of appropriate formulation excipients for improving the dosage form efficiency. This study aims to analyze in-vitro drug dissolution testing in solid dosage forms since 2010 in order to present a comprehensive outlook of recent trends. In doing that the previous studies in the literature are summarized in the form of a table to demonstrate the apparatuses used for dissolution testing, the media in which the solid dosage form is dissolved, the method preferred for analysis from dissolution media, the conditions of analyses and the results obtained.

scholarly journals A comprehensive review on pharmaceutical mini tablets

2018 ◽  
Vol 8 (6) ◽  
pp. 382-390 ◽  
Author(s):  
Priyanka Priyanka ◽  
Kapil Kumar ◽  
Deepak Teotia
Keyword(s):  
Dosage Form ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Formulation Development ◽  
Coating Materials ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Therapeutic Benefits ◽  
Form Design ◽  
Oral Dosage Forms

Mini-tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less. Offering some therapeutic benefits such as dose flexibility and combined release patterns. They do not require any solvent for their production and also local irritation can be avoided by the use of mini tablet Mini tablet offer several advantages like they can be manufactured relatively easily, They are not require less coating materials and also there is a great flexibility during their formulation development. Mini tablet are more acceptable in children and elderly people as they are easy to swallow. The objective of controlled drug delivery systems is to reduce the frequency of the dosing and to increase the effectiveness of the drug by localization. Keywords: Mini-tablets, solid dosage form, oral dosage forms.

scholarly journals Formulation and Evaluation of Pediatric Paracetamol Elixir Using Natural Colorant

2020 ◽  
Vol 13 (3) ◽  
pp. 180-185
Author(s):  
Mamatha Tirunagari ◽  
Nagadivya Nerella ◽  
Anupama Koneru ◽  
Madihah ◽  
Syed Sarfaraz ◽  
...  
Keyword(s):  
Dosage Form ◽  
Cost Effective ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Physical Parameters ◽  
Natural Colorant ◽  
Solid Dosage ◽  
Pediatric Age Group ◽  
Wide Range ◽  
Oral Dosage Forms

Oral dosage forms are most popular among other dosage forms. In terms of bioavailability liquid dosage form is better than that of solid dosage form. In the present scenario monophagic liquid dosage forms such as syrups, elixirs, throat paints, mouth washes, gargles have gained huge popularity. These are very basic preparations which involve brief processes, machineries and are cost effective also. They come in wide range colours and flavors so as to attract the pediatric age group. Currently colors derived from natural sources are given priority compared to synthetic ones. In this study we formulated paracetamol which is a bitter drug as an elixir using natural colorant from annatto seeds at three different concentrations in F1, F2, and F3. Ethanol. Propylene glycol, mixed fruit juice, chloroform spirit, sucrose syrup and glycerin were also used. These formulations were evaluated for different physical parameters and it showed good results.

scholarly journals Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 738 ◽  
Author(s):  
Jaemin Lee ◽  
Chanwoo Song ◽  
Inhwan Noh ◽  
Sangbyeong Song ◽  
Yun-Seok Rhee
Keyword(s):  
Dissolution Rate ◽  
Dosage Form ◽  
Amorphous State ◽  
Dosage Forms ◽  
Modified Release ◽  
Solid Dosage Forms ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Enhanced Solubility ◽  
Hot Melt

In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG) were printed by simultaneous HME and 3D deposition. Printed solid dosage forms were evaluated for their physicochemical properties, dissolution rates, and floatable behavior. Results revealed that IBF content in the solid dosage form could be individualized by adjusting the volume of solid dosage form. IBF was dispersed as amorphous state with enhanced solubility and dissolution rate in a polymer solid dosage form matrix. Due to absence of a disintegrant, sustained release of IBF from printed solid dosage forms was observed in phosphate buffer at pH 6.8. The dissolution rate of IBF was dependent on geometric properties of the solid dosage form. The dissolution rate of IBF could be modified by merging two different geometries into one solid dosage form. In this study, the 3D HME process showed high reproducibility and accuracy for preparing dosage forms. API dosage and release profile were found to be customizable by modifying or combining 3D modeling.

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