scholarly journals Kinetic study of mushroom tyrosinase inhibition using naturally occurring bromophenols and comparison with related phenolic compounds

2021 ◽  
Vol 10 (6) ◽  
pp. 61-65
Author(s):  
MD. Reazul Islam ◽  
Hideyuki Kurihara
Keyword(s):  
Phenolic Compounds ◽  
Kinetic Study ◽  
Mushroom Tyrosinase ◽  
Tyrosinase Inhibition ◽  
Naturally Occurring

scholarly journals Germinated Riceberry Rice Enhanced Protocatechuic Acid and Vanillic Acid to Suppress Melanogenesis through Cellular Oxidant-Related Tyrosinase Activity in B16 Cells

Antioxidants ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 247 ◽  
Author(s):  
Teerapat Rodboon ◽  
Seiji Okada ◽  
Prasit Suwannalert
Keyword(s):  
Phenolic Compounds ◽  
Vanillic Acid ◽  
Protocatechuic Acid ◽  
Inhibitory Effect ◽  
Total Phenolic ◽  
Dependent Manner ◽  
Mushroom Tyrosinase ◽  
Tyrosinase Inhibition ◽  
Dose Dependent

The anti-melanogenic bioactivities of phytophenolic compounds have been well recognized. Riceberry rice contains a rich source of phenolic compounds that act as melanin inhibitors through their antioxidant and anti-tyrosinase properties. Germination has been shown to be an effective process to improve targeted phenolic compounds. In this study, germinated riceberry rice extract was tested for antioxidant activity. Total phenolic content was determined while the tyrosinase inhibitory effect was screened by the in vitro mushroom tyrosinase assay. Cytotoxicity of germinated riceberry rice extract was investigated in B16 cells before evaluating its activities on cellular tyrosinase, melanogenesis, melanin excretion, morphological appearance, and cellular oxidants. Germinated riceberry rice extract showed increased potency of antioxidants and was also twice as effective for mushroom tyrosinase inhibition when compared with ungerminated riceberry rice extract. In B16 cells, the extract inhibited cellular tyrosinase, melanogenesis, and cellular oxidants in a dose-dependent manner when compared with untreated cells. Germinated riceberry rice extract also displayed an effect on B16 cells morphology by reducing the number of melanin- containing cells and their dendriticity. Additionally, the germination of riceberry rice dominantly enhanced two phenolic acids, protocatechuic acid and vanillic acid, which have the potential for antioxidant-associated hyperpigmentation control. Thus, the restricted germination of riceberry rice tended to promote protocatechuic acid and vanillic acid, which dominantly displayed antioxidants and tyrosinase-related melanogenic inhibition.

Investigation of tyrosinase inhibition by some 1,2,4 triazole derivative compounds: in vitro and in silico mechanisms

2018 ◽  
Vol 44 (4) ◽  
pp. 473-481
Author(s):  
Elif Ayazoglu Demir ◽  
Ahmet Colak ◽  
Aylin Kalfa ◽  
Ahmet Yasar ◽  
Olcay Bekircan ◽  
...  
Keyword(s):  
Critical Role ◽  
Docking Studies ◽  
Biosynthesis Pathway ◽  
Mushroom Tyrosinase ◽  
Tyrosinase Inhibitor ◽  
Effective Inhibitor ◽  
Tyrosinase Inhibition ◽  
Triazole Derivative

Abstract Background Tyrosinase plays a central role in the biosynthesis pathway of melanin pigment. Melanin protects human skin against radiation and its unusual levels cause some skin disorders such as pregnancy scar, oldness spots and melanoma. Tyrosinase has also been linked to Parkinson’s and other neurodegenerative diseases. In addition, melanin plays a critical role as a defense molecule for insects during wound healing and is important for their life. Therefore, determination of inhibitor molecules for tyrosinase has a promising potential for therapies of some diseases and is an alternative method for keeping insects under control. Material and methods In this study, 1-hepthyl-3-(4-methoxybenzyl)-4H-1,2,4-triazole-5-one derivative (A6, A8, A15) and 3-(4-chlorophenyl)- 5-(4-methoxybenzyl)-4H-1,2,4-triazole (B5, B9, B13) derivative compounds were evaluated in terms of their potential for mushroom tyrosinase inhibition. IC50 values of these six molecules were determined. Results It was seen that B9 molecule was the most effective inhibitor. Docking studies also nearly supported this end result. Tyrosinase inhibition type and Ki value were found to be uncompetitive and 370.7±0.3 μM, respectively, in the presence of B9 compound. Conclusion These results suggest that B9 compound is a potential tyrosinase inhibitor.

scholarly journals Synthesis of Novel Compounds as New Potent Tyrosinase Inhibitors

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Hooshang Hamidian
Keyword(s):  
Kojic Acid ◽  
Azo Compounds ◽  
The Novel ◽  
Mushroom Tyrosinase ◽  
Reference Standard ◽  
Tyrosinase Inhibition ◽  
H Nmr ◽  
Ft Ir ◽  
Tyrosinase Inhibitors ◽  
C Nmr

In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, andN,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold. All synthesized compounds (5a–5f) showed the most potent mushroom tyrosinase inhibition (IC50values in the range of 4.39 ± 0.76–1.71 ± 0.49 µM), comparable to the kojic acid, as reference standard inhibitor. All the novel compounds were characterized by FT-IR,1H NMR,13C NMR, and elemental analysis.

scholarly journals Green resins from renewable resources

2021 ◽  
Author(s):  
Justin J. Kosalka
Keyword(s):  
Phenolic Compounds ◽  
High Resolution Mass Spectrometry ◽  
Dicarboxylic Acids ◽  
13C Nmr Spectroscopy ◽  
One Pot ◽  
1H And 13C Nmr ◽  
X Ray Crystallography ◽  
Naturally Occurring ◽  
One Step ◽  
Acid Catalyzed

This work was aimed at exploring bio-based materials for the purpose of toner production on an industrial scale. Polyester and polyether based resins were prepared in good yields from naturally occurring phenolic compounds with desired thermal and physical properties. Phenols with varying functionality such as guaiacol, eugenol and vanillin along with two synthetically produced phenolic compounds modelling the β-O-4 linkage found in softwood lignins were explored as suitable precursors to synthetic, "green", resins. Phenols were transformed into diols using glycerine carbonate and a base catalyzed reaction. Diols were then polymerized with dicarboxylic acids in an acid catalyzed, transesterfication, reaction. A novel, bio-based polyether was synthesized in one pot, one step polymerization using vanillin. Thermal properties ((Tg) and (Ts) of resulting resins were evaluated. Resulting compounds and polymers were characterized using 1H and 13C NMR spectroscopy, high resolution mass spectrometry, elemental analysis, X-ray crystallography, DSC and GPC.

Mushroom Tyrosinase Inhibition Activity of Some Chromones.

ChemInform ◽  
2010 ◽  
Vol 33 (35) ◽  
pp. 134-134
Author(s):  
Long Zhu Piao ◽  
Hyang Rae Park ◽  
Yun Kyung Park ◽  
Seung Ki Lee ◽  
Jeong Hill Park ◽  
...  
Keyword(s):  
Mushroom Tyrosinase ◽  
Inhibition Activity ◽  
Tyrosinase Inhibition
Sign in / Sign up

Export Citation Format

Share Document