The antioxidant effect of beta-alanine or carnosine supplementation on exercise- induced oxidative stress: a systematic review and meta-analysis

O objetivo deste estudo foi realizar uma revisão sistemática e meta-análise dos artigos que abordaram o efeito da suplementação de BA ou carnosina sobre o estresse oxidativo (TE) induzido pelo exercício físico (EF). Antes de maio de 2018, pesquisamos em todo PubMed, CAPES Periodic e SPORTDiscus modelo humano de revisão por pares, estudos randomizados de controle com suplementação crônica de BA ou carnosina em SO induzida por PE. Um total de 128 citações foram encontradas. Apenas quatro artigos preencheram critérios para inclusão. Todos os quatro estudos utilizaram jovens saudáveis, sedentários, recreativos ou atléticos. Após uma suplementação crônica com BA ou carnosina, os estudos avaliaram a SG induzida por PE imediatamente e várias horas após o exercício (0,5 a 48 h). Em resposta ao SO induzido por PE, quando comparado ao placebo, a suplementação com BA / carnosina aumentou a capacidade antioxidante total [TAC; Tamanho do Efeito (ES) = 0,35, Intervalo de Confiança 95% (CI) 0,06 a 0,65, p = 0,02] e concentrações de glutationa (GSH; ES = 0,75, IC 95% 0,32 a 1,19, p = 0,0007) enquanto diminuiu os marcadores OS diretos ( ES = -1,19, IC 95% -1,48 a -0,80, p

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The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

10.20944/preprints201811.0189.v1 ◽

2018 ◽

Author(s):

Elias de França ◽

Fábio Santos Lira ◽

Marcio Flávio Ruaro ◽

Vinicius Barroso Hirota ◽

Paula A. Faria Waziry ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Meta Analysis ◽

Protein Carbonyl ◽

Human Model ◽

Sod Activity ◽

Beta Alanine ◽

Total Antioxidant ◽

Acute Increase ◽

Exercise Induced

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect beta-alanine (BA) or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). We searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. We search papers published before May 2018.  A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young (21y) sedentary, recreationally active or athletic participants. After a chorionic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, BA/carnosine supplementation increased total antioxidant capacity (TAC) and glutathione concentrations while decreased pro-oxidant markers and superoxide dismutase (SOD) activity. BA or carnosine supplementation did not prevent the increase in peroxidation markers (e.g., 8-isoprostane, protein carbonyl or malonaldehyde). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in pro-oxidants, treatment did not decrease measured values of peroxidation markers.

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The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

10.20944/preprints201811.0189.v3 ◽

2018 ◽

Author(s):

Elias de França ◽

Fábio Santos Lira ◽

Marcio Flávio Ruaro ◽

Vinicius Barroso Hirota ◽

Paula A. Faria Waziry ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Meta Analysis ◽

Human Model ◽

Sod Activity ◽

Beta Alanine ◽

Total Antioxidant ◽

Acute Increase ◽

Randomized Control ◽

Exercise Induced

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect BA or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). Before May 2018 we searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young sedentary, recreationally active or athletic participants. After a chronic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, when compared to placebo, BA/carnosine supplementation increased total antioxidant capacity [TAC; Effect Size (ES) = 0.35, 95% Confidence Interval (CI) 0.06 to 0.65, p = 0.02] and glutathione (GSH; ES = 0.75, 95% CI 0.32 to 1.19, p = 0.0007) concentrations while decreased direct OS markers (ES = −1.19, 95% CI −1.48 to −0.80, p < 0.01) and superoxide dismutase (SOD) activity (ES = −0.58, 95% CI −1.10 to −0.06, p = 0.03). BA or carnosine supplementation did not prevent the increase in indirect OS markers (ES: −0.20, 95% CI −0.59 to 0.20, p = 0.33). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in direct OS species (reactive nitrogen and oxygen species), treatment did not decrease measured values of indirect OS markers (peroxidation or molecule oxidation).

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The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

10.20944/preprints201811.0189.v4 ◽

2018 ◽

Author(s):

Elias de França ◽

Fábio Santos Lira ◽

Marcio Flávio Ruaro ◽

Vinicius Barroso Hirota ◽

Paula A. Faria Waziry ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Meta Analysis ◽

Human Model ◽

Sod Activity ◽

Beta Alanine ◽

Total Antioxidant ◽

Acute Increase ◽

Randomized Control ◽

Exercise Induced

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect BA or carnosine supplementation on physical exercise (PE)-induced oxidative stress (OS). Before May 2018 we searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young sedentary, recreationally active or athletic participants. After a chronic BA or carnosine supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, when compared to placebo, BA/carnosine supplementation increased total antioxidant capacity [TAC; Effect Size (ES) = 0.35, 95% Confidence Interval (CI) 0.06 to 0.65, p = 0.02] and glutathione (GSH; ES = 0.75, 95% CI 0.32 to 1.19, p = 0.0007) concentrations while decreased direct OS markers (ES = −1.19, 95% CI −1.48 to −0.80, p < 0.01) and superoxide dismutase (SOD) activity (ES = − 0.58, 95% CI −1.10 to −0.06, p = 0.03). BA or carnosine supplementation did not prevent the increase in indirect OS markers (ES: 0.06, 95% CI −0.38 to 0.500, p = 0.80). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in direct OS markers (reactive nitrogen and oxygen species), treatment did not decrease measured values of indirect OS markers (peroxidation or molecule oxidation).

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The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

10.20944/preprints201811.0189.v2 ◽

2018 ◽

Author(s):

Elias de França ◽

Fábio Santos Lira ◽

Marcio Flávio Ruaro ◽

Vinicius Barroso Hirota ◽

Paula A. Faria Waziry ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Meta Analysis ◽

Human Model ◽

Sod Activity ◽

Beta Alanine ◽

Total Antioxidant ◽

Acute Increase ◽

Randomized Control ◽

Exercise Induced

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect BA or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). We searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. We search papers published before May 2018. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young (21y) sedentary, recreationally active or athletic participants. After a chorionic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, when compared to placebo, BA/carnosine supplementation increased total antioxidant capacity [TAC; Effect Size (ES) = 0.35, 95% Confidence Interval (CI) 0.06 to 0.65, p = 0.02] and glutathione (GSH; ES = 0.75, 95% CI 0.32 to 1.19, p = 0.0007) concentrations while decreased pro-oxidant markers (ES = −1.19, 95% CI −1.48 to -0.80, p < 0.01) and superoxide dismutase (SOD) activity (ES = −0.58, 95% CI −1.10 to −0.06, p = 0.03). BA or carnosine supplementation did not prevent the increase in peroxidation markers (ES: −0.20, 95% CI −0.59 to 0.20, p = 0.33). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in pro-oxidants, treatment did not decrease measured values of peroxidation markers.

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Impact of anthocyanin-rich whole fruit consumption on exercise-induced oxidative stress and inflammation: a systematic review and meta-analysis

Nutrition Reviews ◽

10.1093/nutrit/nuz018 ◽

2019 ◽

Vol 77 (9) ◽

pp. 630-645 ◽

Cited By ~ 2

Author(s):

Taylor K Bloedon ◽

Rock E Braithwaite ◽

Imogene A Carson ◽

Dorothy Klimis-Zacas ◽

Robert A Lehnhard

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Inflammatory Marker ◽

Data Extraction ◽

Meta Analysis ◽

Cochrane Collaboration ◽

Oxidative Stress Marker ◽

Exercise Induced ◽

The Impact ◽

And Oxidative Stress

Abstract Context Supplementing with fruits high in anthocyanins to reduce exercise-induced oxidative stress and inflammation has produced mixed results. Objective This systematic review and meta-analysis aims to discuss the impact of whole fruits high in anthocyanins, including processing methods and the type and amount of fruit, on inflammation and oxidative stress. Data Sources PICOS reporting guidelines and a customized coding scheme were used to search 5 databases (SPORTDiscus, Science Direct, Web of Science [BIOSIS], Medline [Pubmed], and the Cochrane Collaboration) with additional cross-referencing selection. Data Extraction A random-effects meta-analysis was used to measure effects of the fruit supplements with 3 statistics; the QTotal value based on a χ2 distribution, τ2 value, and I2 value were used to determine homogeneity of variances on 22 studies (out of 807). Outliers were identified using a relative residual value. Results A small significant negative summary effect across the sum of all inflammatory marker outcomes (P < 0.001) and a moderate negative effect for the sum of all oxidative stress marker outcomes (P = 0.036) were found. Moderator analyses did not reveal significant (P > 0.05) differences between subgrouping variables. Conclusions Results indicate that consumption of whole fruit high in anthocyanins can be beneficial for reducing inflammation and oxidative stress.

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Selected root plant supplementation reduces indices of exercise-induced muscle damage: A systematic review and meta-analysis

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000689 ◽

2020 ◽

pp. 1-21

Author(s):

Kenji Doma ◽

Baily Devantier-Thomas ◽

Daniel Gahreman ◽

Jonathan Connor

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Muscle Damage ◽

Performance Measures ◽

Muscle Soreness ◽

Meta Analysis ◽

Muscular Performance ◽

Anti Oxidant ◽

Exercise Induced ◽

Oxidant Status

Abstract. This systematic review and meta-analysis examined the effects of selected root plants (curcumin, ginseng, ginger and garlic) on markers of muscle damage and muscular performance measures following muscle-damaging protocols. We included 25 studies (parallel and crossover design) with 353 participants and used the PEDro scale to appraise each study. Forest plots were generated to report on standardised mean differences (SMD) and p-values at 24 and 48 hours following the muscle-damaging protocols. The meta-analysis showed that the supplemental (SUPP) condition showed significantly lower levels of indirect muscle damage markers (creatine kinase, lactate dehydrogenase and myoglobin) and muscle soreness at 24 hours and 48 hours (p < 0.01) than the placebo (PLA) condition. The inflammatory markers were significantly lower for the SUPP condition than the PLA condition at 24 hours (p = 0.02), although no differences were identified at 48 hours (p = 0.40). There were no significant differences in muscular performance measures between the SUPP and PLA conditions at 24 hours and 48 hours (p > 0.05) post-exercise. According to our qualitative data, a number of studies reported a reduction in oxidative stress (e.g., malondialdehyde, superoxide dismutase) with a concomitant upregulation of anti-oxidant status, although other studies showed no effects. Accordingly, selected root plants minimised the level of several biomarkers of muscle damage, inflammation and muscle soreness during periods of exercise-induced muscle damage. However, the benefits of these supplements in ameliorating oxidative stress, increasing anti-oxidant status and accelerating recovery of muscular performance appears equivocal, warranting further research in these outcome measures.

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Non-Invasive Measurement of Exercise-Induced Oxidative Stress in Response to Physical Activity. A Systematic Review and Meta-Analysis

Antioxidants ◽

10.3390/antiox10122008 ◽

2021 ◽

Vol 10 (12) ◽

pp. 2008

Author(s):

Giulia Squillacioti ◽

Fulvia Guglieri ◽

Nicoletta Colombi ◽

Federica Ghelli ◽

Paola Berchialla ◽

...

Keyword(s):

Oxidative Stress ◽

Physical Activity ◽

Systematic Review ◽

Meta Analysis ◽

Vigorous Physical Activity ◽

Oxidation Products ◽

Integrative Approach ◽

Oxidative Stress Biomarkers ◽

Exercise Interventions ◽

Exercise Induced

Physical activity may benefit health by modulating oxidative stress and inflammation. However, the selection of suitable exercise-induced oxidative stress biomarkers is still challenging. This study aimed at systematically summarizing the available evidence on exercise-induced oxidative stress measured in urine and/or saliva. Two meta-analyses including the most frequently quantified biomarkers of oxidative stress, namely, urinary isoprostane and DNA oxidation products, were performed. Three electronic databases (PubMed, EMBASE and Cochrane CENTRAL) were interrogated. Among 4479 records, 43 original articles were included in the systematic review and 11 articles were included in meta-analysis I and II, respectively. We observed a pooled trend of increase of urinary isoprostanes in response to physical activity (+0.95, 95% CI: −0.18; 2.09). In comparison with aerobic exercise, anaerobic training determined a greater induction of isoprostanes (+5.21, 95% CI: 2.76; 7.66, p < 0.0001), which were markedly increased after vigorous physical activity (+6.01, 95% CI: 1.18; 10.84, p < 0.001) and slightly decreased in response to exercise interventions protracted over time (e.g., months) (−1.19, 95% CI: −2.25; −0.12, p < 0.001). We recommend the most integrative approach of oxidative stress multi-marker panels in response to physical activity instead of selecting one preferential biomarker to quantify physical activity-induced oxidative stress in humans.

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