First Case of Isolated Cystic Brain Metastasis from Endometrial Adenocarcinoma Treated by Surgery

Introduction: Lung cancer, breast cancer, renal cell cancer, gastrointestinal carcinoma, and melanoma are common sources of cerebral metastasis. Brain metastasis from malignant gynecological tumors are considered rare. According to the literature, fewer than 3% of all brain metastases originate from gynecological lesions. The primary mechanism of metastatic spread from genital tract cancers to the brain is through the hematogenous rout. The endometrial carcinoma metastasis to the brain is a very rare event. The objective of this study is to describe this rare event and conduct a brief review of the literature. Case description: We report on a unique case of a cystic endometrial adenocarcinoma metastasis treated by neurosurgical procedure. The patient underwent “en bloc” tumor resection guided by neuronavigation and there were no complications during surgery. After discharge, she underwent whole brain radiation therapy, currently makes quarterly outpatient follow-up and showed no signals of tumor recurrence. Conclusion: In this article we present a case of cystic brain metastasis from an endometrial adenocarcinoma that was successfully treated by neurosurgery tumoral resection. To our knowledge, this condition has not been reported previously in the literature.

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Brain metastasis of Wilms tumor with diffuse anaplasia and complex cytogenetic phenotype in a child with neurofibromatosis Type 1

Journal of Neurosurgery Pediatrics ◽

10.3171/2011.7.peds1119 ◽

2011 ◽

Vol 8 (4) ◽

pp. 353-356

Author(s):

Marianna Shvartsbeyn ◽

Luigi Bassani ◽

Irina Mikolaenko ◽

Jeffrey H. Wisoff

Keyword(s):

Brain Metastasis ◽

Neurofibromatosis Type 1 ◽

Wilms Tumor ◽

Metastatic Tumor ◽

Neurofibromatosis Type ◽

Radiological Features ◽

First Case ◽

History Of ◽

The Brain

The authors report the first case of a Wilms tumor (WT) with diffuse anaplasia metastatic to the brain in a 13-year-old girl with a history of neurofibromatosis Type 1. At presentation, the metastatic tumor had radiological features that suggested a meningioma. Histologically it was characterized by striking anaplasia and features similar to the patient's previously resected WT with diffuse anaplasia.

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COMPARATIVE RISK OF LEPTOMENINGEAL DISSEMINATION OF CANCER AFTER SURGERY OR STEREOTACTIC RADIOSURGERY FOR A SINGLE SUPRATENTORIAL SOLID TUMOR METASTASIS

Neurosurgery ◽

10.1227/01.neu.0000341535.53720.3e ◽

2009 ◽

Vol 64 (4) ◽

pp. 664-676 ◽

Cited By ~ 71

Author(s):

Dima Suki ◽

Mustafa Aziz Hatiboglu ◽

Akash J. Patel ◽

Jeffrey S. Weinberg ◽

Morris D. Groves ◽

...

Keyword(s):

Brain Metastasis ◽

Stereotactic Radiosurgery ◽

Tumor Resection ◽

En Bloc Resection ◽

Bloc Resection ◽

Cancer Center ◽

Leptomeningeal Disease ◽

En Bloc ◽

University Of Texas ◽

The Difference

Abstract OBJECTIVE To test the hypothesis that differential risks of developing leptomeningeal disease (LMD) exist in patients having a single supratentorial brain metastasis resected via a piecemeal or en bloc approach or treated with stereotactic radiosurgery (SRS). METHODS Between 1993 and 2006, 827 patients with a supratentorial brain metastasis underwent resection or SRS at The University of Texas M.D. Anderson Cancer Center. The primary outcome was the incidence of LMD. RESULTS Resection was performed piecemeal in 191 patients and en bloc in 351 patients; 285 patients received SRS. LMD occurred in 33 patients, 29 in the resection group and 4 in the SRS group. Risk of LMD was significantly higher with piecemeal tumor resection than with other procedures (SRS: hazard ratio [HR] for piecemeal, 5.8; 95% confidence interval [CI], 1.9–17.2; P = 0.002; en bloc, HR for piecemeal, 2.7; 95% CI, 1.3–5.6; P = 0.009). The difference between piecemeal and en bloc was particularly pronounced in patients with a melanoma primary (HR, 8.4; 95% CI, 1.8–39.2; P = 0.007). The risk of LMD was not significantly different between en bloc resection and SRS (HR for en bloc, 2.1; 95% CI, 0.7–6.4; P = 0.21). Similar results were obtained when comparing effects of SRS and both resection approaches after limiting the sample to patients with tumors in a specific volume range. CONCLUSION Piecemeal resection of a supratentorial brain metastasis carries a higher risk of LMD than en bloc resection or SRS. Further assessment of the role of the 2 surgical resection approaches and SRS in a controlled prospective setting with large numbers of patients is warranted.

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Brain Metastasis In A Case Of Canine Transmissible Venereal Tumor After A Supposed Successful Treatment With Vincristine Sulfate

Acta veterinaria ◽

10.1515/acve-2015-0011 ◽

2015 ◽

Vol 65 (1) ◽

pp. 137-142

Author(s):

PINCZOWSKI Pedro ◽

GIMENO Marina ◽

ACEÑA Carmen ◽

VILLEGAS Ainara ◽

de MARTINO Alba ◽

...

Keyword(s):

Brain Metastasis ◽

Brain Metastases ◽

Blood Brain Barrier ◽

Successful Treatment ◽

Rare Event ◽

Brain Barrier ◽

Splenic Metastasis ◽

Vincristine Sulfate ◽

S 100 ◽

The Brain

Abstract A ten year old mongrel bitch was diagnosed with a primary vulvar transmissible venereal tumor (TVT) causing subcutaneous, mammary and splenic metastasis and it was successfully treated with vincristine. Four months later the animal presented neurological disturbances, brain metastases were suspected and the animal was euthanized. A TVT metastatic mass was found in the brain and confirmed with immunohistochemical results, being positive for vimentin and lysozyme and negative for S-100, CD3 and cytokeratin. TVT metastases in the brain are a rare event and cannot be treated with usual chemotherapy as vincristine does not cross the blood-brain barrier, thus allowing the re-emergence of the tumor after a period of time.

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Brachytherapy for Recurrent Single Brain Metastasis

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100040439 ◽

1995 ◽

Vol 22 (1) ◽

pp. 13-16 ◽

Cited By ~ 34

Author(s):

Mark Bernstein ◽

Alberto Cabantog ◽

Normand Laperriere ◽

Phil Leung ◽

Cindy Thomason

Keyword(s):

Brain Metastasis ◽

High Activity ◽

Tumor Resection ◽

Median Dose ◽

Whole Brain Radiation ◽

Single Brain Metastasis ◽

Iodine 125 ◽

Craniotomy For Tumor Resection ◽

Brain Radiation ◽

The Brain

ABSTRACT:Of 112 stereotactic high-activity iodine-125 implants for malignant brain tumors done as of July 1, 1994, ten have been done for recurrent single brain metastasis and constitute the study group described herein. All patients had initially undergone craniotomy for tumor resection followed by fractionated external beam whole brain radiation and recurred at the same site in the brain. The interval between initial cancer therapy and occurrence of the brain metastasis was 13 – 156 weeks (median: 63 weeks). The interval between initial treatment of the brain metastasis and its recurrence treated with brachytherapy was 13-69 weeks (median: 35 weeks). Minimum brachytherapy dose administered was 70 Gy at a median dose rate of 67 cGy/hour. Eight- patients have died. Two died suddenly at 2 and 13 weeks post-implant of presumed pulmonary embolus. Five died of recurrence of the brain metastasis at 20, 39, 52, 103, and 143 weeks post-implant, and one died of systemic metastases at 40 weeks post-implant. Two patients remain alive 183 and 324 weeks post-implant. High-activity iodine-125 brachytherapy appears to be of benefit for selected patients with recurrent single brain metastasis but larger, and preferably randomized studies are needed.

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En bloc resection of a thoracic chordoma is possible using minimally invasive anterior access: An 8-year follow-up

Journal of Neurosciences in Rural Practice ◽

10.4103/0976-3147.172171 ◽

2016 ◽

Vol 7 (01) ◽

pp. 138-140 ◽

Cited By ~ 1

Author(s):

Anand Goomany ◽

Jake Timothy ◽

Craig Robson ◽

Abhay Rao

Keyword(s):

Minimally Invasive ◽

Thoracic Spine ◽

Interbody Fusion ◽

Traditional Approach ◽

Tumor Resection ◽

En Bloc Resection ◽

Bloc Resection ◽

En Bloc ◽

Perioperative Morbidity ◽

First Case

ABSTRACTThoracic spine chordomas are a rare clinical entity and present several diagnostic and management challenges. Posterior debulking techniques are the traditional approach for the resection of thoracic tumors involving the vertebral body. Anterior approaches to the thoracic spine enable complete tumor resection and interbody fusion. However, this approach has previously required a thoracotomy incision, which is associated with significant perioperative morbidity, pain, and the potential for compromised ventilation and subsequent respiratory sequelae. The extreme lateral approach to the anterior spine has been used to treat degenerative disorders of the lower thoracic and lumbar spine, and reduces the potential complications compared with the anterior transperitoneal/transpleural approach. However, such an approach has not been utilized in the treatment of thoracic chordomas. We describe the first case of an en bloc resection of a thoracic chordoma via a minimally invasive eXtreme lateral interbody fusion approach.

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MET-08 Air in cistern or ventricle after brain metastasis surgery is a predictor of early postoperative intracranial recurrence

Neuro-Oncology Advances ◽

10.1093/noajnl/vdaa143.084 ◽

2020 ◽

Vol 2 (Supplement_3) ◽

pp. ii19-ii19

Author(s):

Yusuke Ikeuchi ◽

Masamitsu Nishihara ◽

Noriaki Ashida ◽

Takashi Sasayama ◽

Kohkichi Hosoda

Keyword(s):

Brain Tumor ◽

Local Recurrence ◽

Brain Metastasis ◽

Tumor Resection ◽

Treatment Strategies ◽

En Bloc Resection ◽

Postoperative Recurrence ◽

Competing Risk ◽

En Bloc ◽

Significant Difference

Abstract INTRODUCTION: The operations of brain metastasis are on the increase as a result of more routine diagnostic imaging and improved extracranial systemic treatment strategies. Opening of the cistern or ventricle during tumor resection may promote local recurrence and cerebrospinal fluid dissemination. We investigated whether the air found in the cistern/ventricle on postoperative Computed tomography (CT) was a predictor of postoperative recurrence. METHODS: Between 2012 and 2019, 27 patients with single brain metastasis were treated with gross total resection at our hospital. The patients in which air was found in the cistern or ventricle of the head CT on the day after surgery was designated as air(+) group, and the patients without air was designated as air(-) group. The primary outcome was the local recurrence, as diagnosed with neuroimaging. The death due to other than brain metastasis was defined as competing risk. RESULTS: CT air(+) group was 17 patients, whereas CT air(-) group was 10 patients. There was no significant difference between the two groups, such as age and sex. Estimated 1-year brain tumor recurrence rate was 70% in the air(+) group and 5.9% in the air(-) group. (p = 0.004). On the other hand, no significant difference was observed in estimated 1-year competing risk between in the air(+) group (10%) and in the air(-) group (2.4%). CONCLUSION: En bloc resection of brain metastasis is effective, but there was no report on the risk of opening the cistern or ventricle. Our results indicate that postoperative air presence in the cistern or ventricle could be a predictor of early postoperative recurrence. In metastatic brain tumor removal, the cistern and ventricle should not be opened, and close follow-up should be done if air in the cistern or ventricle is detected on postoperative CT.

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Acute ICA occlusion due to pituitary apoplexy resulting In Internal Carotid Artery Occlusion and Stroke: Case Report, Review of The Literature, and Treatment Rationale

Psychology and Mental Health Care ◽

10.31579/2637-8892/002 ◽

2017 ◽

Vol 1 (1) ◽

pp. 01-03

Author(s):

Ramu Adepu

Keyword(s):

Tumor Resection ◽

Rare Event ◽

Treatment Strategies ◽

Pituitary Tumors ◽

Artery Occlusion ◽

Carotid Artery Occlusion ◽

Sudden Onset ◽

First Case ◽

Work Up ◽

Transsphenoidal Resection

We report the case of a 63 year-old man who presented with sudden-onset, severe headache. Work-up revealed a hemorrhagic pituitary macroadenoma. He then suffered sudden-onset aphasia and right hemiparesis. Further evaluation revealed left ICA occlusion. Emergent transsphenoidal resection of the tumor produced recanalization of the occluded ICA, but his neurological symptoms persisted. ICA occlusion following pituitary tumor apoplexy is a rare event that must be recognized early for optimal patient outcomes. We report the first case with demonstration of carotid recanalization after tumor resection, review the incidence of ICA occlusion due to pituitary tumors, describe the possible mechanisms, and recommend optimal treatment strategies.

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847 PREOPERATIVE BRAIN MRI/CT FOR PATIENTS WITH POTENTIALLY RESECTABLE ESOPHAGEAL SQUAMOUS CELL CANCER, TO BE OR NOT TO BE ROUTINELY?

Diseases of the Esophagus ◽

10.1093/dote/doab052.847 ◽

2021 ◽

Vol 34 (Supplement_1) ◽

Author(s):

Xiufeng Wei ◽

Yin Li ◽

Jianjun Qin ◽

Xiankai Chen ◽

Ruixiang Zhang ◽

...

Keyword(s):

Brain Metastasis ◽

Treatment Regimen ◽

Squamous Cell ◽

Predictive Value ◽

Squamous Cell Cancer ◽

Brain Mri ◽

Cell Cancer ◽

Esophageal Squamous Cell Cancer ◽

Resectable Esophageal ◽

The Brain

Abstract There are few prospective studies of brain metastasis from esophageal squamous cell cancer (ESCC). The aim of this study was to investigate the necessity of the brain MRI/CT in the preoperative workup for patients with potentially resectable (cT1-4aN0-3) esophageal squamous cell cancer. Methods This was a prospective cross-section clinical trial (ChiCTR1800020304). There were a total of 468 patients who were diagnosed ESCC from October 2018 to August 2020. Of these 468 patients, 385 patients with cT1-4aN0-3 who were potentially candidates for surgical resection were consecutively enrolled into the study. Preoperative brain MRI/CT was performed preoperatively. The treatment regimen could be changed if the brain metastasis was confirmed. The primary endpoint was the incidence rate of the treatment regimen being changed because of brain metastasis. Results In all 385 patients, there are only 4 (1%) patients changed their treatment regimen because of brain metastasis proved by MRI/CT. The rate of positive brain MRI/CT findings is 1%. The MRI/CT diagnostic performance for brain metastasis was as follows: sensitivity, 100%; specificity, 100%; positive predictive value, 100%; negative predictive value, 100% and accuracy, 100%. There were no significant difference of bone metastasis among the Age, Sex, Tumor location and clinical stage. Conclusion Preoperative brain MRI/CT might help identify brain metastases in patients with esophageal cancer, but we do not recommend the brain MRI/CT in the preoperative workup for patients with potentially resectable esophageal squamous cell cancer.

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Anterior Impingement Syndrome of the Ankle Caused by Osteoid Osteoma in the Talar Neck Treated with Arthroscopy and 3D C-Arm-Based Imaging

Case Reports in Orthopedics ◽

10.1155/2017/2171627 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Masachika Ikegami ◽

Takumi Matsumoto ◽

Song Ho Chang ◽

Hiroshi Kobayashi ◽

Yusuke Shinoda ◽

...

Keyword(s):

Osteoid Osteoma ◽

Tumor Resection ◽

Percutaneous Treatment ◽

En Bloc Resection ◽

Impingement Syndrome ◽

Long Bone ◽

En Bloc ◽

Surgical Interventions ◽

Combination Methods ◽

First Case

Osteoid osteoma in periarticular lesions tends to have an unusual presentation that likely leads to a delayed or missed diagnosis compared with a typical osteoid osteoma in the metaphysis or diaphysis of the long bone. In cases that are unresponsive to conservative treatment, surgical interventions including en bloc resection, computed tomography-guided percutaneous treatment, and arthroscopic resection have been performed; however, these methods frequently result in inadequate tumor resection and recurrence. Here we present a case of a 16-year-old girl with osteoid osteoma in the talar neck presenting as anterior impingement syndrome due to marked synovitis in the ankle joint which was successfully treated without complications by arthroscopic synovectomy and tumor resection followed by intraoperative 3D C-arm-based imaging confirming complete tumor lesion removal. Her pain was relieved immediately after the surgery, and there was no recurrence at 12 months of follow-up. This is the first case report of the surgical treatment of the osteoid osteoma in the talar neck with the combination methods of arthroscopy and 3D C-arm-based imaging.

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INTRANEURAL PERINEURIOMA OF THE VIIITH CRANIAL NERVE

Neurosurgery ◽

10.1227/01.neu.0000290915.63094.55 ◽

2007 ◽

Vol 61 (3) ◽

pp. E652-E652 ◽

Cited By ~ 4

Author(s):

Mattheos Christoforidis ◽

Ralf Buhl ◽

Werner Paulus ◽

Abolghassem Sepehrnia

Keyword(s):

Cranial Nerve ◽

Tumor Resection ◽

Magnetic Resonance Imaging Scan ◽

En Bloc ◽

Tumor Mass ◽

Nerve Tumor ◽

First Case ◽

Intraneural Perineurioma ◽

History Of ◽

Viiith Cranial Nerve

Abstract OBJECTIVE The authors describe the clinical and pathological features of the second reported case of an intraneural perineurioma involving a major intracranial nerve and the first case of this entity involving the VIIIth cranial nerve. CLINICAL PRESENTATION A 59-year-old woman presented with a long history of dizziness, tinnitus, hearing loss, and unstable gait. A magnetic resonance imaging scan revealed a small intrameatal lesion, which showed no clear progression from 2000 to 2006. INTERVENTION As a result of worsening symptoms and a suspected vestibular schwannoma, an attempt of tumor resection through a retrosigmoid approach was performed. This revealed diffusely infiltrated and fusiform enlarged vestibular and cochlear nerves, with no identifiable border between the main tumor mass and normal nerve. An en bloc nerve-tumor mass excision was performed. The pathological findings confirmed the diagnosis of an intraneuronal perineurioma. CONCLUSION The experience with this unique case and the experience of others with the management of extracranial intraneural perineuriomas lead the authors to conclude that the most reasonable surgical management of this tumor at this location is a nerve-tumor cross-section resection.

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