CEBSR: NTP Clinical Pathology Control Data

Background: Measurement Uncertainty (MU) can assist the interpretation and comparison of the laboratory results against international diagnostic protocols, facilitate a reduction in health care costs and also help protect laboratories against legal challenges. Determination of MU for quantitative testing in clinical pathology laboratories is also a requirement for ISO 15189. Methods: A practical and simple to use statistical model has been designed to make use of data readily available in a clinical laboratory to assess and establish MU for quantitative assays based on internal quality control data to calculate Random Error and external quality assurance scheme results to calculate Systematic Error. The model explained in this article has also been compared and verified against quality specifications based on Biological Variation. Results: Examples that explain and detail MU calculations for the proposed model are given where different components of MU are calculated with tabulated results. Conclusions: The designed model is cost-effective because it utilises readily available data in a clinical pathology laboratory. Data obtained from internal quality control programs and external quality assurance schemes are used to calculate the MU using a practical and convenient approach that will not require resources beyond what is available. Such information can additionally be useful not only in establishing limits for MU to satisfy ISO 15189 but also in selecting and/or improving methods and instruments in use. MU can as well play an important role in reducing health care costs as shown by examples in the article.

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On Future Directions in Pathology

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053991 ◽

1982 ◽

Vol 40 ◽

pp. 274-277

Author(s):

Benjamin F. Trump ◽

Irene K. Berezesky ◽

Raymond T. Jones

Keyword(s):

Electron Microscopy ◽

Transmission Electron Microscopy ◽

Clinical Pathology ◽

Future Directions ◽

Diagnostic Pathology ◽

The Past ◽

Transmission Electron ◽

Organ Systems ◽

The Many

The role of electron microscopy and associated techniques is assured in diagnostic pathology. At the present time, most of the progress has been made on tissues examined by transmission electron microscopy (TEM) and correlated with light microscopy (LM) and by cytochemistry using both plastic and paraffin-embedded materials. As mentioned elsewhere in this symposium, this has revolutionized many fields of pathology including diagnostic, anatomic and clinical pathology. It began with the kidney; however, it has now been extended to most other organ systems and to tumor diagnosis in general. The results of the past few years tend to indicate the future directions and needs of this expanding field. Now, in addition to routine EM, pathologists have access to the many newly developed methods and instruments mentioned below which should aid considerably not only in diagnostic pathology but in investigative pathology as well.

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The Adaptation of Medical Records to Epidemiological Use

Methods of Information in Medicine ◽

10.1055/s-0038-1636359 ◽

1965 ◽

Vol 04 (03) ◽

pp. 136-140

Author(s):

Cl Jeanty

Keyword(s):

Medical Records ◽

Clinical Pathology ◽

Time Variable ◽

Special Care ◽

General Description ◽

Causal Relations ◽

Laboratory Techniques ◽

Original Record ◽

Statistical Studies

A method is described in an attempt to make medical records suitable for epidemiologigri: purposes. Every case of a disease is recorded on an appropriate punched card with the object of working towards a general description of a disease through the collation of several cases of the same diagnosis. This punched card represents a very great condensation of the original record. Special care has been applied to state as precisely as possible the time variable, particularly as far as its origin and unit of measure are concerned, in order to demonstrate the existence of causal relations between diseases. Such cards are also intended to make easier statistical studies in clinical pathology, in evaluation of new laboratory techniques, and in therapeutical trials.

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Studies of Suloctidil in Experimental Thrombosis in Baboons

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661329 ◽

1985 ◽

Vol 53 (03) ◽

pp. 423-427 ◽

Cited By ~ 15

Author(s):

Stephen R Hanson ◽

Laurence A Harker

Keyword(s):

Oral Administration ◽

Thrombus Formation ◽

Vascular Grafts ◽

Scintillation Camera ◽

Control Data ◽

Experimental Thrombosis ◽

Arteriovenous Shunts ◽

Platelet Deposition ◽

Heparin Anticoagulation ◽

Antithrombotic Efficacy

SummarySuloctidil has been evaluated in the baboon for its antithrombotic efficacy using models of both acute and chronic arterial thrombogenesis. Acute thrombus formation was initiated by Dacron vascular grafts inserted as extension segments into chronic arteriovenous shunts. 111In-platelet deposition was measured by scintillation camera imaging for one hour. The results after oral administration of suloctidil (100 mg/kg/d in two divided doses) were not different from control studies. Moreover, concurrent heparin anticoagulation did not affect 111In-platelet deposition compared with control data. In contrast, ticlopidine (20 mg/ kg/d) significantly decreased platelet deposition that was reduced further by the addition of heparin.Chronic arterial-thromboembolism was initiated by segments of polyurethane (Biomer) cannula introduced into chronic arteriovenous shunts. Thrombus formation by the polyurethane cannula was measured as 111In-platelet turnover (corrected for removal of senescent platelets). Cannula platelet consumption was unaffected by suloctidil (20 mg/kg/d given in two divided doses for two days preceding and throughout the period of platelet survival measurement). In contrast, dipyridamole (10 mg/ kg/d) and sulfinpyrazone (100 mg/kg/d) completely interrupted cannula platelet consumption.We conclude that suloctidil probably has little or no effect on platelet-dependent thrombus formation.

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