GREEN ANALYTICAL METHOD FOR QUANTIFICATION OF SECNIDAZOLE IN TABLETS BY FOURIER-TRANSFORM INFRARED SPECTROSCOPY (FTIR)

Secnidazole is a medicine widely used in the treatment of bacterial and protozoal diseases. The free sale of this drug allows its easy access to the population and for this reason, the studies that involve the analysis of the quality control of this drug are extremely important to keep the results safe and reliable. Considering the great pharmacotherapeutic application of secnidazole and the great importance of developing new analytical methods that contribute to the environmen, the study was based on the development and validation of a new sustainable analytical method by Fourier-transform infrared spectroscopy (FT-IR) to identify and quantify secnidazole tablets. The method was duly validated according to the ICH guidelines, presenting precision, accuracy, selectivity, robustness and linearity in the concentration range of 0.5-1.3 mg/pellet. The application of this method in addition to being safe and reliable is highly favorable from an economic point of view since there is a significant reduction in the use of production costs as solvents and raw material, being fast and simple and can also be applied to other medicines.

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Fourier Transform Infrared Spectroscopy in Oral Cancer Diagnosis

International Journal of Molecular Sciences ◽

10.3390/ijms22031206 ◽

2021 ◽

Vol 22 (3) ◽

pp. 1206

Author(s):

Rong Wang ◽

Yong Wang

Keyword(s):

Cancer Research ◽

Fourier Transform ◽

Infrared Spectroscopy ◽

Oral Cancer ◽

Fourier Transform Infrared Spectroscopy ◽

Diagnostic Tool ◽

Unmet Need ◽

Fourier Transform Infrared ◽

The United States ◽

Easy Access

Oral cancer is one of the most common cancers worldwide. Despite easy access to the oral cavity and significant advances in treatment, the morbidity and mortality rates for oral cancer patients are still very high, mainly due to late-stage diagnosis when treatment is less successful. Oral cancer has also been found to be the most expensive cancer to treat in the United States. Early diagnosis of oral cancer can significantly improve patient survival rate and reduce medical costs. There is an urgent unmet need for an accurate and sensitive molecular-based diagnostic tool for early oral cancer detection. Fourier transform infrared spectroscopy has gained increasing attention in cancer research due to its ability to elucidate qualitative and quantitative information of biochemical content and molecular-level structural changes in complex biological systems. The diagnosis of a disease is based on biochemical changes underlying the disease pathology rather than morphological changes of the tissue. It is a versatile method that can work with tissues, cells, or body fluids. In this review article, we aim to summarize the studies of infrared spectroscopy in oral cancer research and detection. It provides early evidence to support the potential application of infrared spectroscopy as a diagnostic tool for oral potentially malignant and malignant lesions. The challenges and opportunities in clinical translation are also discussed.

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The Degree of Deacetylation Chitosan Various Marine Shells

10.31227/osf.io/wh9an ◽

2018 ◽

Author(s):

sinardi ◽

Prayatni Soewondo ◽

Suprihanto Notodarmojo ◽

cynthia radiman

Keyword(s):

Fourier Transform ◽

Infrared Spectroscopy ◽

Natural Product ◽

Fourier Transform Infrared Spectroscopy ◽

Ir Spectrum ◽

Fourier Transform Infrared ◽

Raw Material ◽

Natural Coagulant ◽

Degree Of Deacetylation ◽

The Fourier Transform

Chitosan is a natural product derived from biopolymers such as chitin and cellulose and is found in the exoskeleton of marine sources. Chitosan was produced through 3 subsequent processes i.e. deproteination, demineralization and deacetylation.The aim of this study is to determine degree of deacetylation chitosan. The degree of deacetylation was calculated from IR spectrum using the Fourier Transform Infrared spectroscopy (FTIR). The degree of deacetylation of chitosan from Penaeusmonodon, Scylla sp, and Mytilus virdis linneausshells, were 89.05%, 87.64%, and 77.80%. Marine shells used as raw material of chitosan and enhancement degree of deacetylation potential to be used as natural coagulant.

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Karakterisasi Nitroselulosa dari Pulp Larut Bambu Beema dan Bambu Industri

JURNAL SELULOSA ◽

10.25269/jsel.v9i01.241 ◽

2019 ◽

Vol 9 (01) ◽

pp. 25

Author(s):

Frederikus Tunjung Seta ◽

Susi Sugesty ◽

Reynaldo Biantoro

Keyword(s):

Fourier Transform ◽

Infrared Spectroscopy ◽

Chemical Composition ◽

Nitrogen Content ◽

Fourier Transform Infrared Spectroscopy ◽

Fourier Transform Infrared ◽

Dissolving Pulp ◽

Raw Material ◽

Ftir Analysis ◽

Bamboo Pulp

Saat ini Indonesia masih mengandalkan impor nitroselulosa sebagai bahan baku propelan. Tujuan penelitian ini adalah mencari komposisi optimum pembuatan nitroselulosa untuk propelan dari bahan baku pulp larut bambu Beema dan Industri sebagai alternatif dari pulp larut kayu. Sebelum proses nitrasi, pulp larut bambu Beema dan bambu Industri mengalami proses perlakuan awal dengan menggunakan willey mill, pulp larut kemudian diayak dan diambil pulp dengan ukuran kurang dari 60 mesh. Pada proses nitrasi, perbandingan bahan kimia yang digunakan adalah formula 1 (HNO3:HNO3 Fumming:H2SO4= 2,5:1:9,5), formula 2 (HNO3:HNO3 Fumming:H2SO4= 3:1:7,5), dan formula 3 (HNO3:HNO3 Fumming:H2SO4= 1:1:1,6). Hasil yang didapatkan pada penelitian ini pulp larut dari bahan baku bambu Beema dengan formula 3 mampu mendapatkan kadar nitrogen tertinggi (12,97%). Analisis Fourier-transform infrared spectroscopy (FTIR) menunjukkan adanya gugus nitro dan pada uji bakar juga menunjukkan bahwa nitroselulosa dapat terbakar dengan cepat. Akan tetapi, nilai kelarutan dalam aseton dan eter-alkohol nitroselulosa dari kedua jenis bambu menunjukkan bahwa distribusi kadar nitrogen pada proses nitrasi masih belum memenuhi standar.Kata kunci: bambu, kadar nitrogen, nitroselulosa, pulp larut, propelanCharacterization of Nitrocellulose from Beema Bamboo and Industrial Bamboo Dissolving PulpAbstractCurrently, Indonesia still relies on imports of nitrocellulose as a propellant raw material. The objective of this research is to determine the optimum composition of nitrocellulose making for propellant from Beema bamboo pulp and Industrial bamboo pulp as an alternative of dissolving pulp from wood. Prior to the nitration process, both dissolving pulp of Beema bamboo and industrial undergo a pretreatment process using willey mill, the pulp then sieved and taken with a size less than 60 mesh. In the nitration process, the chemical composition used is formula 1 (HNO3: HNO3 Fumming: H2SO4 = 2.5: 1: 9.5), formula 2 (HNO3: HNO3 Fumming: H2SO4 = 3: 1: 7,5) and the formula 3 (HNO3: HNO3 Fumming: H2SO4 = 1: 1: 1,6). Result showed that dissolving pulp from Beema bamboo with third formula get the highest nitrogen content (12,97%). Fourier-transform infrared spectroscopy (FTIR) analysis showed that all of the nitrocellulose have nitro group and with burning test also proved that nitrocellulose can be rapidly burdened. However, the solubility of nitrocellulose in acetone and ethers-alcohols indicates that the distribution of nitrogen content in the nitration process is not meet the standard yet. Keywords: bamboo, nitrogen content, nitrocellulose, dissolving pulp, propellant

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