scholarly journals Seftarolin, Antibiotik Baru dengan Aktivitas Anti-MRSA: Sebuah Kajian Efektivitas, Keamanan, dan Biaya Penggunaan

2020 ◽  
Vol 6 (1) ◽  
pp. 160-180
Author(s):  
Steven Victoria Halim ◽  
Eko Setiawan
Keyword(s):  
Staphylococcus Aureus ◽  
Medical Practice ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Efficacy And Safety ◽  
Medical Field ◽  
Antibiotic Resistant ◽  
Methicillin Resistant ◽  
New Antibiotics ◽  
Multiple Antibiotics

A growing problem in the medical field is the development of antibiotic resistant pathogens. One reason this development is so important is that in recent years there is a shortage of new antibiotics in development to combat resistant pathogens. It worths to mention that while 19 new antibiotics were released in the period 1980 to 1984, this had dropped to just three in the period 2005 to 2009. Ironically, the shortage of new antibiotics occur in the era where growing number of pathogens develop resistance to multiple antibiotics that previously effectively used to treat the infections. As a consequent, it is essential that the efficacy of last resort antibiotics, including the new antibiotics, be maintained as long as possible. Ceftaroline is a new antibiotic in Indonesia market which has methicillin-resistant Staphylococcus aureus activity and it belongs to the cephalosporins. Further understanding related to basic profile of ceftaroline, efficacy and safety, cost, and place in therapy is needed to optimize the responsible used of ceftaroline in daily medical practice

scholarly journals Mersaquinone, A New Tetracene Derivative from the Marine-Derived Streptomyces sp. EG1 Exhibiting Activity against Methicillin-Resistant Staphylococcus aureus (MRSA)

Antibiotics ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 252 ◽  
Author(s):  
Min Cheol Kim ◽  
Reiko Cullum ◽  
Ali M. S. Hebishy ◽  
Hala A. Mohamed ◽  
Ahmed H. I. Faraag ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
2D Nmr ◽  
North Coast ◽  
Spectroscopic Techniques ◽  
Methicillin Resistant ◽  
Streptomyces Sp ◽  
The North ◽  
Societal Challenges ◽  
New Antibiotics

New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a new tetracene derivative, named Mersaquinone (1), and the known Tetracenomycin D (2), Resistoflavin (3) and Resistomycin (4) have been isolated from the organic extract of the marine Streptomyces sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone (1) was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone (1) showed antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 3.36 μg/mL.

scholarly journals Detection of Methicillin-Resistant Staphylococcus aureus Strains Resistant to Multiple Antibiotics and Carrying the Panton-Valentine Leukocidin Genes in an Algiers Hospital

2006 ◽  
Vol 50 (3) ◽  
pp. 1083-1085 ◽  
Author(s):  
Nadjia Ramdani-Bouguessa ◽  
Michèle Bes ◽  
Hélène Meugnier ◽  
Françoise Forey ◽  
Marie-Elisabeth Reverdy ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Panton Valentine Leukocidin ◽  
Valentine Leukocidin ◽  
Multiple Antibiotics

ABSTRACT Forty-five Panton-Valentine leukocidin (PVL)-positive, methicillin-resistant Staphylococcus aureus strains were isolated in Algeria between 2003 and 2004; 18 isolates were isolated in the community and 27 in a hospital. Five PVL-positive hospital isolates were resistant to multiple antibiotics, including ofloxacin and gentamicin for three isolates.

scholarly journals Evolutionary GEM: The Evolution of Methicillin-resistant Staphylococcus aureus

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Jaiden Tu ◽  
Patricia M. Gray
Keyword(s):  
Public Health ◽  
Staphylococcus Aureus ◽  
Horizontal Gene Transfer ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Rapid Evolution ◽  
Public Health Issue ◽  
Major Public Health Issue ◽  
Methicillin Resistant ◽  
Gene Variation ◽  
New Antibiotics

Since 1961, methicillin-resistant Staphylococcus aureus (MRSA) has evolved through both single locus gene variation and horizontal gene transfer. By the late 1970s, the emergence of new SCCmec allotypes marked the beginning of a worldwide MRSA pandemic. The continuous and rapid evolution of MRSA, in response to new antibiotics, remains a major public health issue worldwide.

scholarly journals Synthesis of Antibacterial Nisin-Peptoid Hybrids Using Click Methodology

2018 ◽  
Author(s):  
Hannah L. Bolt ◽  
Laurens H.J. Kleijn ◽  
Nathaniel I. Martin ◽  
Steven L. Cobb
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Peptides ◽  
Antibacterial Agents ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Lipid Ii ◽  
New Antibiotics

Antimicrobial peptides and structurally related peptoids offer potential for the development of new antibiotics. However, progress has been hindered by challenges presented by poor in vivo stability (peptides) or lack of selectivity (peptoids). Herein, we have developed a process to prepare novel hybrid antibacterial agents that combine both linear peptoids (increased in vivo stability compared to peptides) and a nisin fragment (lipid II targeting domain). The hybrid nisin-peptoids prepared were shown to have low µM activity (comparable to natural nisin) against methicillin-resistant Staphylococcus aureus.

Community-Acquired Methicillin-Resistant Staphylococcus Aureus Infections in Otolaryngology

1992 ◽  
Vol 107 (3) ◽  
pp. 434-437 ◽  
Author(s):  
Ron D. Gottlieb ◽  
Mahendra K. Shah ◽  
David C. Perlman ◽  
Charles P. Kimmelman
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Therapy ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Intravenous Drug ◽  
Intravenous Drug Use ◽  
Methicillin Resistant ◽  
Mrsa Strains ◽  
Hospital Acquired ◽  
Susceptibility And Resistance ◽  
Multiple Antibiotics

Soon after the introduction of methicillin, strains of Staphylococcus aureus resistant to methicillin were reported. Methicillin-resistant Staphylococcus aureus (MRSA) has become a common hospital pathogen, often resistant to multiple antibiotics, while causing significant morbidity and mortality. Community-acquired MRSA infections have been infrequently documented. Most reports have been associated with intravenous drug abuse. This report reviews 15 patients with community-acquired MRSA infections of the head and neck. None admitted to intravenous drug use. Additionally, no patient was known to be a healthcare worker. The MRSA strains showed antibiotic susceptibility and resistance profiles different from typical hospital-acquired MRSA isolates. All but one infection resolved with adequate surgical or appropriate antibiotic therapy. Clinicians should become aware of the possibility of community-acquired MRSA in the patient who has had continued infection despite antibiotic therapy.

Antibiotic Resistance, the Horrendous Consequences of Bacterial Sex

2021 ◽  
pp. 111-116
Author(s):  
Thomas E. Schindler
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Resistance ◽  
Resistance Genes ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Methicillin Resistant ◽  
Postwar Japan ◽  
Resistant Genes ◽  
Rapid Emergence ◽  
Multiple Antibiotics

This chapter reviews how bacterial sex explains the rapid emergence of superbugs that are resistant to multiple antibiotics, the so-called MDR pathogens. Millions of years before humans evolved, bacteria invented antibiotics and the defensive molecules that make some bacteria resistant to an antibiotic. Therefore, antibiotic resistant genes pre-exist in many bacterial strains, literally lying in wait to emerge in superbugs. In postwar Japan, bacteriologists discovered the first MDR pathogens during dysentery outbreaks. Researchers demonstrated that the genes for resistance to several antibiotics were transferred by bacterial sex—from normal flora to the dysentery pathogens—all together and “at one stroke.” Methicillin was intentionally designed to treat penicillin-resistant infections. Only three years after its introduction of, hospitals began to find methicillin-resistant Staphylococcus aureus (MRSA). Gerard Wright coined the term resistome to signify “the global collection of resistance genes that have been readily available to pathogens for millennia.”

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