Comparison of accuracy in three versions of simplified sequential organ failure assessment scores to predict prognosis of septic patients

Background: Evidence shows that simplified SOFA scoring system has better clinical practice. Objective: This study aimed to compare the scores acquired with the simplified sequential organ failure assessment (sSOFA), simplified organ dysfunction criteria optimized for electronic health records (eSOFA), and simplified and accurate sequential organ failure assessment (sa-SOFA) for their accuracies in predicting the prognosis of septic patients. Methods: This retrospective observational study was conducted at three major academic hospitals. Clinical data from 574 patients diagnosed with sepsis following the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)were retrospectively retrieved and analyzed. Scores from the quick sequential organ failure assessment (qSOFA) and sequential organ failure assessment (SOFA) were used as reference scores. The area under the receiver operating characteristic curve (AUROC) was used to compare the accuracies of eSOFA, sSOFA, and sa-SOFA scores in predicting in-hospital mortality. Results: AUROC analysis demonstrated the predictability of the five scoring systems for sepsis surveillance, listed in descending order as: sa-SOFA,0.790 (95% confidence interval [CI]: 0.754-0.822); SOFA, 0.774 (95% CI: 0.738-0.808); eSOFA,0.729 (95% CI: 0.691-0.765); sSOFA,0.681 (95% CI: 0.641- 0.719); and qSOFA,0.618(95% CI: 0.577-0.658). Moreover, sa-SOFA and SOFA scores (Z= 1.950, p = 0.051) did not significantly differ from each other in discriminatory power, but the sa-SOFA score had a higher power than either the sSOFA or eSOFA scores (p values <0.001). Conclusion: sa-SOFA showed the highest accuracy in predicting in-hospital fatality of septic patients when compared with sSOFA and eSOFA.

Download Full-text

Analisis Hubungan Sequential Organ Failure Assessment (Sofa) Score Dengan Mortalitas Pasien Sepsis

Jurnal Kesehatan Andalas ◽

10.25077/jka.v9i2.1221 ◽

2020 ◽

Vol 9 (2) ◽

pp. 168

Author(s):

Agustin Iskandar ◽

Fran Siska

Keyword(s):

Septic Shock ◽

Sequential Organ Failure Assessment ◽

Organ Failure ◽

Sofa Score ◽

Area Under The Curve ◽

International Consensus ◽

The Third ◽

Failure Assessment ◽

Sepsis And Septic Shock

Sepsis merupakan kondisi disfungsi organ mengancam nyawa yang diakibatkan oleh disregulasi sistem imun pejamu terhadap infeksi dan Sequential Organ Failure Assessment (SOFA) score merupakan suatu skoring untuk menilai kegagalan organ terkait sepsis. Peningkatan SOFA score diasosiasikan dengan outcome pasien yang lebih buruk. Tujuan: Menganalisis korelasi SOFA score dengan mortalitas pada pasien sepsis. Metode: Desain penelitian adalah kohort prospektif yang dilakukan di RSU Dr Saiful Anwar dari Maret 2018 hingga Juni 2019. Kriteria diagnosis sepsis ditegakkan berdasarkan The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Perhitungan SOFA score dilakukan dalam 2 hari pertama perawatan pasien sepsis di rumah sakit. Analisis data dilakukan pada p < 0,05. Hasil: Didapatkan 85 pasien sepsis dengan luaran meninggal sebanyak 72,94% sedangkan 28,06% membaik. Terdapat perbedaan bermakna antara SOFA score yang meninggal dan yang hidup (p=0,015). SOFA score dipakai untuk memprediksi kematian, didapatkan area under the curve (AUC) 0,74 (p=0,009), dengan cut off point optimum 7. Pada total SOFA score lebih tinggi dari sama dengan 7, didapatkan RR= 3.8, p=0.028. SOFA score merupakan parameter untuk menilai kegagalan organ pada pasien sepsis, dimana total SOFA score yang lebih tinggi dikaitkan dengan peningkatan risiko kematian. Simpulan: SOFA score pada kelompok yang meninggal lebih tinggi daripada yang sembuh. Pasien sepsis dengan SOFA score lebih besar sama dengan 7 memiliki risiko 3,8 kali lebih besar untuk meninggal.Kata kunci: risiko kematian, sepsis, SOFA score

Download Full-text

Comparison of Systemic Inflammatory Response Syndrome and quick Sequential Organ Failure Assessment scores in predicting bacteremia in the emergency department

Acute Medicine & Surgery ◽

10.1002/ams2.654 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Katsuyuki Furuta ◽

Hiroaki Akamatsu ◽

Ryuichi Sada ◽

Kyohei Miyamoto ◽

Shunsuke Teraoka ◽

...

Keyword(s):

Emergency Department ◽

Systemic Inflammatory Response Syndrome ◽

Inflammatory Response ◽

Sequential Organ Failure Assessment ◽

Organ Failure ◽

Systemic Inflammatory Response ◽

Assessment Scores ◽

Failure Assessment

Download Full-text

Prospective cohort study comparing sequential organ failure assessment and acute physiology, age, chronic health evaluation III scoring systems for hospital mortality prediction in critically ill cirrhotic patients

International Journal of Clinical Practice ◽

10.1111/j.1742-1241.2005.00634.x ◽

2005 ◽

Vol 60 (2) ◽

pp. 160-166 ◽

Cited By ~ 40

Author(s):

Y-C Chen ◽

Y-C Tian ◽

N-J Liu ◽

Y-P Ho ◽

C. Yang ◽

...

Keyword(s):

Cohort Study ◽

Hospital Mortality ◽

Sequential Organ Failure Assessment ◽

Organ Failure ◽

Prospective Cohort ◽

Scoring Systems ◽

Mortality Prediction ◽

Health Evaluation ◽

Failure Assessment ◽

Cirrhotic Patients

Download Full-text

Multicenter study of the multiple organ dysfunction syndrome in intensive care units: the usefulness of Sequential Organ Failure Assessment scores in decision making

Intensive Care Medicine ◽

10.1007/s00134-005-2640-2 ◽

2005 ◽

Vol 31 (7) ◽

pp. 927-933 ◽

Cited By ~ 90

Author(s):

L. Cabré ◽

J. Mancebo ◽

J. F. Solsona ◽

P. Saura ◽

I. Gich ◽

...

Keyword(s):

Decision Making ◽

Intensive Care ◽

Sequential Organ Failure Assessment ◽

Organ Failure ◽

Organ Dysfunction ◽

Multicenter Study ◽

Multiple Organ ◽

Multiple Organ Dysfunction ◽

Assessment Scores ◽

Failure Assessment

Download Full-text

Comparison of Thrombelastometry with Simplified Acute Physiology Score II and Sequential Organ Failure Assessment Scores for the Prediction of 30-Day Survival

Shock ◽

10.1097/shk.0b013e318204bff6 ◽

2011 ◽

Vol 35 (4) ◽

pp. 339-342 ◽

Cited By ~ 43

Author(s):

Michael Adamzik ◽

Tanja Langemeier ◽

Ulrich H. Frey ◽

Klaus Görlinger ◽

Fuad Saner ◽

...

Keyword(s):

Sequential Organ Failure Assessment ◽

Organ Failure ◽

Simplified Acute Physiology Score ◽

Acute Physiology Score ◽

Assessment Scores ◽

Failure Assessment

Download Full-text

The Association Between Sequential Organ Failure Assessment Scores and Mortality in Patients With Sepsis During the First Week: The JSEPTIC DIC Study

Journal of Intensive Care Medicine ◽

10.1177/0885066618775959 ◽

2018 ◽

Vol 35 (7) ◽

pp. 656-662 ◽

Cited By ~ 1

Author(s):

Tsuyoshi Nakashima ◽

Kyohei Miyamoto ◽

Toshio Shimokawa ◽

Seiya Kato ◽

Mineji Hayakawa

Keyword(s):

Septic Shock ◽

Severe Sepsis ◽

Hospital Mortality ◽

Sequential Organ Failure Assessment ◽

Organ Failure ◽

Sofa Score ◽

Assessment Scores ◽

Coagulation Study ◽

Failure Assessment ◽

The Relationship

Objective: Predicting prognosis is a complex process, particularly in patients with severe sepsis or septic shock. This study aimed to determine the relationship between the Sequential Organ Failure Assessment (SOFA) scores for individual organs during the first week of admission and the in-hospital mortality in patients with sepsis. Methods: This study was a post hoc evaluation of the Japan Septic Disseminated Intravascular Coagulation study and included patients admitted to 42 intensive care units in Japan for severe sepsis or septic shock, between January 2011 and December 2013. We assessed the relationship between the organ and total SOFA scores on days 1, 3, and 7 following admission and the in-hospital mortality using logistic regression analysis. Results: We evaluated 2732 patients and found the in-hospital mortality rate was 29.1%. The mean age of the patients (standard deviation) was 70.5 (14.1) years, and the major primary site of infection was the abdomen (33.6%). The central nervous system (CNS) SOFA score exhibited the strongest relationship with mortality on days 1 (adjusted odds ratio [aOR]: 1.49, 95% confidence interval [CI]: 1.40-1.59), 3 (aOR: 1.75, 95% CI: 1.62-1.89), and 7 (aOR: 1.93, 95% CI: 1.77-2.10). The coagulation SOFA scores showed a weak correlation with mortality on day 1, but a strong correlation with mortality on day 7 (aOR: 2.04, 95% CI: 1.87-2.24). Conclusions: The CNS SOFA scores were associated with mortality in patients with severe sepsis on days 1, 3, and 7 following hospitalization. The coagulation SOFA score was associated with mortality on day 7. In clinical situations, the CNS SOFA scores during the acute phase and the CNS SOFA and coagulation SOFA scores during the subsequent phases should be evaluated in order to determine patient prognosis.

Download Full-text