scholarly journals Scale-up of Aerated Industrial Multistage Rushton Impeller Bioreactors with Complex Rheology

Author(s):  
Sören Bernauer ◽  
Mathias Schöpf ◽  
Johannes Khinast ◽  
Timo Hardiman

The power input and gas-liquid mass transfer rank among the most important industrial fermentation process parameters. The present study analyzes the power input and gas hold-up as a function of the flow regime, impeller diameter, and rheological properties in a pilot scale reactor (160 L) equipped with four Rushton impellers. This leads to four dimensionless numbers for predicting measurements in pilot and industrial bioreactors (110 and 170 m3) with a standard deviation of 7 % to 29 %. This is unparalleled for the underlying aerated and non-Newtonian fermentation broths. Several existing correlation equations are discussed to be dissatisfying (up to 130 % deviation), and might be sufficiently valid only within scale or for small scaling factors. The introduced approach predicts adequately accurate over three orders of magnitude. Based on these encouraging results, we identified the Galilei number and the power concept as the central elements in combination with the consequent dimensional analysis for an efficient scaling betweeen pilot and industrial scale.

2014 ◽  
Vol 604 ◽  
pp. 216-219 ◽  
Author(s):  
Marina Sokolova ◽  
Andris Putnins ◽  
Imants Kreicbergs ◽  
Janis Locs

Within current research calcium phosphates were synthesized by wet chemical precipitation method in laboratory and pilot scale reactor. The aim of this work was to study the influence of main technological parameters of wet chemical precipitation synthesis and scale-up of laboratory synthesis. The results showed that it is possible to obtain calcium phosphates with different and reproducible phase compositions such as hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP) and biphasic calcium phosphates (HAp/β-TCP) in pilot scale reactor. Using the method developed it was possible to increase the product yield more than 30 times compared to formerly used laboratory scale method.


Energy ◽  
2021 ◽  
Vol 219 ◽  
pp. 119604
Author(s):  
Francesco Parrillo ◽  
Filomena Ardolino ◽  
Gabriele Calì ◽  
Davide Marotto ◽  
Alberto Pettinau ◽  
...  

2017 ◽  
Vol 11 (1) ◽  
pp. 16-25 ◽  
Author(s):  
Rebecca Faschian ◽  
Ilyas Eren ◽  
Steven Minden ◽  
Ralf Pörtner

Fixed-bed processes, where cells are immobilized within macroporous carriers, are a promising alternative to processes with suspended cells. A scale-up concept is presented in order to evaluate the performance as part of process design of fixed-bed processes. Therefore,Lactococcus lactiscultivation in chemostat and batch mode was compared to fixed bed cultures on three different scales, the smallest being the downscaledMultifermwith 10 mL fixed bed units, the second a 100 mL fixed-bed reactor and the third a pilot scale reactor with 1 L fixed bed volume. As expected, the volume specific lactate productivity of all cultivations was dependent on dilution rate. In suspension chemostat culture a maximum of 2.3 g·L-1·h-1was reached. Due to cell retention in the fixed-beds, productivity increased up to 8.29 g·L-1·h-1at a dilution rate of D = 1.16 h-1(corresponding to 2.4·µmax) on pilot scale. For all fixed bed cultures a common spline was obtained indicating a good scale-up performance.


2020 ◽  
Vol 6 ◽  
pp. 496-502 ◽  
Author(s):  
Mohammed El Ibrahimi ◽  
Ismail Khay ◽  
Anas El Maakoul ◽  
Mohamed Ould Moussa ◽  
Abdelwahed Barkaoui ◽  
...  

2005 ◽  
Vol 48 (spe) ◽  
pp. 243-248 ◽  
Author(s):  
Delmira Beatriz Wolff ◽  
Juan Carlos Ochoa ◽  
Etienne Paul ◽  
Rejane Helena Ribeiro da Costa

This work investigated the nitrification in a hybrid moving bed pilot scale reactor, which used a low density recycled plastic support material for biomass growth. The filling rate was 20% of its working volume (22L). The feeding and recirculation outflow was 45L/day. The reactor operated at a temperature of 16ºC, in two phases, according to the sludge retention time (SRT): A phase was 10 days and B phase was 3 days (average values). The applied average volumetric nitrogen and organic loads were 0.16KgTKN/m3.day and 1kgCOD/m³.day, respectively. The results showed an average nitrogen removal of 95% and average COD removal of 89%, in both A and B phases. Nitrogen removal rates were independents of the SRT.


Author(s):  
W A Rizal ◽  
R Maryana ◽  
D J Prasetyo ◽  
A Suwanto ◽  
S K Wahono

2017 ◽  
Vol 114 ◽  
pp. 5381-5392 ◽  
Author(s):  
Paola Librandi ◽  
Giulia Costa ◽  
Ana Carolina Bello de Souza ◽  
Stefano Stendardo ◽  
Aderval Severino Luna ◽  
...  

2017 ◽  
Vol 12 (3) ◽  
pp. 706-716 ◽  
Author(s):  
Yugo Takabe ◽  
Fumitake Nishimura ◽  
Ryosuke Suzuki ◽  
Yasuhiro Asada ◽  
Yumeto Utsunomiya ◽  
...  

Wastewater reuse using soil aquifer treatment (SAT) is a rational and realistic solution in countries and regions with limited freshwater resources. The behaviour and removal of perfluoroalkyl carboxylic acids (PFCAs) under long hydraulic retention times (HRTs) in SAT may warrant further investigation. In this study, actual treated effluent from a wastewater treatment plant (WWTP) was continuously treated using a pilot-scale SAT reactor with a designed HRT of 30 days, located in the WWTP; PFCA removal characteristics were investigated based on a 14-month monitoring period. Continuous SAT reactor operations were accomplished for 30 months under the designed HRT (28 days, as calculated by a tracer test); stable treatments were achieved during the period, represented by dissolved organic matter removal from 3.94 mgC/L to 0.701 mgC/L. Removal of PFCAs by SAT under an HRT of 28 days was found to be difficult, as indicated by perfluorooctanoic acid level from 18.4 to 19.0 ng/L. In addition, PFCA concentrations may be increased after SAT, probably due to the influences of PFCA precursors; this is indicated by the increase in perfluorononanoic acid from 11.6 to 14.1 ng/L. Based on the guideline values, further removal of PFCAs in SAT-treated effluent may be required.


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