Effects of general anesthesia and ultrasonography-guided interscalene block on pain and oxidative stress in shoulder arthroscopy: a randomized trial

Background/aim: The aim of this study was to evaluate the effects of general anesthesia and ultrasonography-guided interscalene block on pain and oxidative stress evaluated by thiol–disulphide balance and C-reactive protein levels in patients undergoing shoulder arthroscopy. Materials and methods: A total of 42 patients aged 18–75 years who were scheduled to undergo shoulder arthroscopy were randomized into interscalene block group (Group-IB, n = 20) and general anesthesia group (Group-GA, n = 22). All patients received patient-controlled analgesia during the postoperative period. Additional analgesics were administered to patients with a visual analog scale score of > 4. Native -thiol, total -thiol, disulphide and C-reactive protein levels were measured. Patients’ visual analog scale scores, morphine and additional analgesic consumption were recorded. A shift in thiol–disulphide balance toward decreased thiol and increased disulphide levels was regarded as an indicator of oxidative stress. Results: Pain level, morphine and additional analgesic consumption were higher in Group-GA. Native-thiol and total-thiol levels were higher in Group-IB postoperatively and also disulphide levels were lower at postoperative 18 hours. C-reactive protein levels were similar in both the groups. Conclusion: Interscalene block induced less oxidative stress during the postoperative period, as evaluated by thiol–disulphide balance.

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C-reactive protein levels and oxidative stress markers as predictors of spontaneous preterm birth in women from South Bulgaria

10.21175/rad.abstr.book.2021.6.7 ◽

2021 ◽

Author(s):

Iliana Koleva ◽

Yanka Karamalakova ◽

Maria Angelova ◽

Galina Nikolova

Keyword(s):

Oxidative Stress ◽

Preterm Birth ◽

Oxidative Stress Markers ◽

C Reactive Protein ◽

Spontaneous Preterm Birth ◽

Protein Levels ◽

Reactive Protein ◽

Stress Markers ◽

And Oxidative Stress

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Effects of purslane supplementation on C‐reactive protein levels and biomarkers of oxidative stress as marks for metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials

Phytotherapy Research ◽

10.1002/ptr.7182 ◽

2021 ◽

Author(s):

Ying Zhu ◽

Yubing Huang ◽

Heitor O. Santos ◽

Caio V. C. Oliveira ◽

Hui Zhou ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Metabolic Syndrome ◽

Meta Analysis ◽

Controlled Trials ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Randomized Controlled ◽

Biomarkers Of Oxidative Stress

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Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome

The Indonesian Biomedical Journal ◽

10.18585/inabj.v2i3.127 ◽

2010 ◽

Vol 2 (3) ◽

pp. 131

Author(s):

Waode Nurfina ◽

Irawan Yusuf ◽

Mansyur Arif

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Iron Status ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

The Metabolic Syndrome ◽

Metabolic Conditions ◽

Inflammatory State ◽

And Oxidative Stress

BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS) associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS) and correlate with the inflammation and oxidative stress.METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP) and F2-Isoprostane.RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220) and F2-Isoprostane (r=0.023).CONCLUSION: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane.KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane

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Patients Undergoing Myeloablative Chemotherapy and Hematopoietic Stem Cell Transplantation Exhibit Depleted Vitamin C Status in Association with Febrile Neutropenia

Nutrients ◽

10.3390/nu12061879 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1879 ◽

Cited By ~ 1

Author(s):

Anitra C. Carr ◽

Emma Spencer ◽

Andrew Das ◽

Natalie Meijer ◽

Carolyn Lauren ◽

...

Keyword(s):

Oxidative Stress ◽

Febrile Neutropenia ◽

Vitamin C ◽

Thiobarbituric Acid ◽

Thiobarbituric Acid Reactive Substances ◽

C Reactive Protein ◽

Hematopoietic Stem ◽

Reactive Protein ◽

Myeloablative Chemotherapy ◽

And Oxidative Stress

Patients undergoing myeloablative chemotherapy and hematopoietic stem cell transplantation (HSCT) experience profound neutropenia and vulnerability to infection. Previous research has indicated that patients with infections have depleted vitamin C status. In this study, we recruited 38 patients with hematopoietic cancer who were undergoing conditioning chemotherapy and HSCT. Blood samples were collected prior to transplantation, at one week, two weeks and four weeks following transplantation. Vitamin C status and biomarkers of inflammation (C-reactive protein) and oxidative stress (protein carbonyls and thiobarbituric acid reactive substances) were assessed in association with febrile neutropenia. The vitamin C status of the study participants decreased from 44 ± 7 µmol/L to 29 ± 5 µmol/L by week one (p = 0.001) and 19 ± 6 µmol/L by week two (p < 0.001), by which time all of the participants had undergone a febrile episode. By week four, vitamin C status had increased to 37 ± 10 µmol/L (p = 0.1). Pre-transplantation, the cohort comprised 19% with hypovitaminosis C (i.e., <23 µmol/L) and 8% with deficiency (i.e., <11 µmol/L). At week one, those with hypovitaminosis C had increased to 38%, and at week two, 72% had hypovitaminosis C, and 34% had outright deficiency. C-reactive protein concentrations increased from 3.5 ± 1.8 mg/L to 20 ± 11 mg/L at week one (p = 0.002), and 119 ± 25 mg/L at week two (p < 0.001), corresponding to the development of febrile neutropenia in the patients. By week four, these values had dropped to 17 ± 8 mg/L (p < 0.001). There was a significant inverse correlation between C-reactive protein concentrations and vitamin C status (r = −0.424, p < 0.001). Lipid oxidation (thiobarbituric acid reactive substances (TBARS)) increased significantly from 2.0 ± 0.3 µmol/L at baseline to 3.3 ± 0.6 µmol/L by week one (p < 0.001), and remained elevated at week two (p = 0.003), returning to baseline concentrations by week four (p = 0.3). Overall, the lowest mean vitamin C values (recorded at week two) corresponded with the highest mean C-reactive protein values and lowest mean neutrophil counts. Thus, depleted vitamin C status in the HSCT patients coincides with febrile neutropenia and elevated inflammation and oxidative stress.

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