Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome

BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS) associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS) and correlate with the inflammation and oxidative stress.METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP) and F2-Isoprostane.RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220) and F2-Isoprostane (r=0.023).CONCLUSION: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane.KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane

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High-Sensitivity C-Reactive Protein and the Metabolic Syndrome

The Metabolic Syndrome ◽

10.1007/978-1-60327-116-5_9 ◽

2008 ◽

pp. 167-188

Author(s):

Yiqing Song ◽

Simin Liu ◽

Joann E. Manson

Keyword(s):

Metabolic Syndrome ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

The Metabolic Syndrome

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Effect ofBifidobacterium lactisHN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome

British Journal Of Nutrition ◽

10.1017/s0007114518001861 ◽

2018 ◽

Vol 120 (6) ◽

pp. 645-652 ◽

Cited By ~ 5

Author(s):

Luciana J. Bernini ◽

Andréa N. Colado Simão ◽

Cínthia H. B. de Souza ◽

Daniela F. Alfieri ◽

Liliane G. Segura ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Inflammatory Markers ◽

Healthy Subjects ◽

Antioxidant Defenses ◽

Beneficial Effects ◽

The Metabolic Syndrome ◽

Inflammatory State ◽

Baseline Values ◽

And Oxidative Stress

AbstractBeneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects ofBifidobacterium lactisHN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0·02 andP=0·03, respectively), hydroperoxides (P=0·02 andP=0·01, respectively) and IL-6 levels (P=0·02). Increases in adiponectin (P=0·04) and nitric oxide metabolites (NOx,P=0·001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0·002). In conclusion,B. lactisHN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.

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Leptin, Adiponectin, and High-Sensitivity C-Reactive Protein in Relation to the Metabolic Syndrome in Urban South African Blacks With and Without Coronary Artery Disease

Metabolic Syndrome and Related Disorders ◽

10.1089/met.2008.0080 ◽

2009 ◽

Vol 7 (3) ◽

pp. 243-248 ◽

Cited By ~ 18

Author(s):

Lucas Ntyintyane ◽

Vanessa Panz ◽

Frederick J. Raal ◽

Geoffrey Gill

Keyword(s):

Coronary Artery Disease ◽

Metabolic Syndrome ◽

Coronary Artery ◽

South African ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein ◽

The Metabolic Syndrome ◽

Urban South ◽

Artery Disease

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Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome

Mediators of Inflammation ◽

10.1155/2007/93573 ◽

2007 ◽

Vol 2007 ◽

pp. 1-8 ◽

Cited By ~ 17

Author(s):

Juha Saltevo ◽

Mauno Vanhala ◽

Hannu Kautiainen ◽

Esko Kumpusalo ◽

Markku Laakso

Keyword(s):

Metabolic Syndrome ◽

Receptor Antagonist ◽

Interleukin 1 ◽

High Sensitivity ◽

Population Based ◽

C Reactive Protein ◽

Reactive Protein ◽

Interleukin 1 Receptor Antagonist ◽

The Metabolic Syndrome ◽

Hs Crp

This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to subjects with MetS. If MetS was present according to both IDF and NCEP criteria, BMI, waist, triglycerides, hs-CRP, and IL-1Ra were significantly higher compared to subjects who had MetS according to either only IDF or only NCEP criteria. The hs-CRP, IL-1Ra, and adiponectin linearly correlated with the number of the components of MetS according to both definitions. Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of MetS. Individuals who had MetS according to both criteria had the most adverse changes in cardiovascular risk factors.

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