Age-related response of IL-4/Luc/CNS-1 transgenic miceto phthalic anhydrideexposure

Age-related changes are associated with susceptibility to infection, malignancy, autoimmunity, response to vaccination and wound healing. To investigate the relationship of several pathological phenotypes of allergic inflammationto age, alterations in theIL-4 derived luciferase signal and general phenotype biomarkers were measured in young (2-month-old) and old (12-month-old) IL-4/Luc/CNS-1 transgenic (Tg) mice with phthalic anhydride (PA)-induced allergic inflammationfor 2 weeks. There was no difference in the ear phenotypes and thickness between young and old mice, although these levels were higher in the PA-treated group thantheacetone-olive oil (AOO)-treated group. The luciferase signal was detected in the mesenteric lymph node (ML), thymus and pancreas of both young and old PA-treated mice, but showed a greater increasein old Tg mice (exceptin thethymus). Agreaterincrease inthe epidermal thickness and dermal thickness was measured in old PA-treated mice than young PA-treated mice, while total mast cell number remainedconstant in both groups. Furthermore, the concentration of IgE was greater in young PA-treated mice than in old PA-treated mice,as wasthe expression of VEGF and IL-6. Taken together, theresults of this study showed that an animal?s age is an important factor that must be considered when PA-induced allergic inflammation in IL-4/Luc/CNS-1 Tg mice areinvestigated to screen for allergens and therapeutic compounds.

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Cognitive Factors Mediate the Relation Between Age and Flight Path Maintenance in General Aviation

Aviation Psychology and Applied Human Factors ◽

10.1027/2192-0923/a000102 ◽

2016 ◽

Vol 6 (2) ◽

pp. 81-90 ◽

Cited By ~ 4

Author(s):

Kathleen Van Benthem ◽

Chris M. Herdman

Keyword(s):

Cognitive Functioning ◽

Flight Path ◽

General Aviation ◽

Cognitive Factors ◽

Pilot Performance ◽

Pilot Error ◽

Age Related ◽

And Performance ◽

Relationship Of ◽

The Relationship

Abstract. Identifying pilot attributes associated with risk is important, especially in general aviation where pilot error is implicated in most accidents. This research examined the relationship of pilot age, expertise, and cognitive functioning to deviations from an ideal circuit trajectory. In all, 54 pilots, of varying age, flew a Cessna 172 simulator. Cognitive measures were obtained using the CogScreen-AE ( Kay, 1995 ). Older age and lower levels of expertise and cognitive functioning were associated with significantly greater flight path deviations. The relationship between age and performance was fully mediated by a cluster of cognitive factors: speed and working memory, visual attention, and cognitive flexibility. These findings add to the literature showing that age-related changes in cognition may impact pilot performance.

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The relationship between the age of Schistosoma mansoni cercariae and their ability to penetrate and infect the mammalian host

Parasitology ◽

10.1017/s0031182000083001 ◽

1983 ◽

Vol 87 (3) ◽

pp. 481-492 ◽

Cited By ~ 10

Author(s):

J. Ruth Lawson ◽

R. A. Wilson

Keyword(s):

Schistosoma Mansoni ◽

Stratum Corneum ◽

Mass Mortality ◽

Mammalian Host ◽

Energy Reserves ◽

Age Related ◽

Abdominal Route ◽

Relationship Of ◽

The Relationship ◽

Related Mortality

SummaryThe ability of the cercariae of Schistosoma mansoni to penetrate the tails of mice was shown to remain constant throughout their lives. However, their capacity to establish themselves and then reach maturity decreased as they aged. The abdominal route of penetration produced consistently higher maturation rates than the tail route. Significantly different maturation rates were obtained by modifying the standard tail infection technique. Evidence is presented that age-related mortality of schisto-somula occurs within 24 h of penetration and may be associated with the exhaustion of energy reserves during the penetration of the stratum corneum. The relationship of this age-related mortality to ‘mass mortality’ is discussed.

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Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves

10.1101/2021.06.09.447677 ◽

2021 ◽

Author(s):

Lea L. Backhausen ◽

Juliane H. Froehner ◽

Herve Lemaitre ◽

Eric Artiges ◽

Marie-Laure Paillere-Martinot ◽

...

Keyword(s):

Sex Differences ◽

Brain Development ◽

Adolescent Psychopathology ◽

Control Procedure ◽

Structural Development ◽

Age Related ◽

Subcortical Regions ◽

Relationship Of ◽

First Time ◽

The Relationship

Adolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist in psychopathology, which might be mirrored in underlying sex differences in structural development. However, previous studies showed inconsistencies in subcortical trajectories and potential sex differences. Therefore, we aimed to investigate the subcortical structural trajectories and their sex differences across adolescence using for the first time a single cohort design, the same quality control procedure, software and a general additive mixed modeling approach. We investigated two large European sites from ages 14 to 24 with 503 participants and 1408 total scans from France and Germany as part of the IMAGEN project including four waves of data acquisition. We found significantly larger volumes in males versus females in both sites and across all seven subcortical regions. Sex differences in age-related trajectories were observed across all regions in both sites. Our findings provide further evidence of sex differences in longitudinal adolescent brain development of subcortical regions and thus might eventually support the relationship of underlying brain development and different adolescent psychopathology in boys and girls.

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Power Vector Analysis of Corneal Astigmatism among Chinese over Fifty Years Old: a retrospective cross-sectional study

10.21203/rs.3.rs-17216/v1 ◽

2020 ◽

Author(s):

Yilin Pang ◽

Xiaoguang Cao ◽

Xianru Hou ◽

Li Yuan ◽

Yongzhen Bao

Keyword(s):

Axial Length ◽

Linear Trend ◽

Linear Regression Analysis ◽

Corneal Astigmatism ◽

Vector Analysis ◽

Cross Sectional ◽

Age Related ◽

Relationship Of ◽

The Relationship ◽

Cataract Patients

Abstract Background: To investigate the relationship between corneal astigmatism and age, axial length (AL) among Chinese over fifty years old. Methods: This study enrolled 1,082 right eyes of age-related cataract patients over 50 years old in the clinic of Peking University People’s Hospital, Beijing, China. Axial length, magnitude and meridian of anterior corneal astigmatism were measured by IOLMaster. Restricted cubic splines and Spearman rank correlation coefficients were used to investigate the relationship of the magnitude of cornea astigmatism to age and AL. Power vector analysis method and linear regression analysis were used to assess the relationship of the meridian of astigmatism to age and AL. Results: For this study , mean age, AL, and corneal astigmatism value were 72.45 ±9.28 years, 23.90±1.93mm, and 1.12±0.74D, respectively. The magnitude of corneal astigmatism was 0.75D or higher in 63.8% eyes. The magnitude of corneal astigmatism increased with age after 65 years old. This correlation was statistically significant when AL was between 22.00mm and 26.00mm. The vector value in J 0 was inversely correlated with age. The mean vector value change from with-the-rule (WTR) to against-the-rule (ATR) corneal astigmatism was 0.22D/10 years during 50-65 years old and 0.15D/10 years during 65-85 years old, and was 0.22D/10 years in male and 0.12D/10 years in female, respectively. Conclusions: A large proportion of elderly Chinese cataract patients over 50 years old have corneal astigmatism more than 0.75D . There was a non-linear trend from WTR astigmatism towards ATR astigmatism with age, which was more obvious in elder age and in male. When AL is between 22.00mm and 26.00mm, the magnitude of corneal astigmatism increases with age after 65 years old.

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Age-related decline in executive function as a hallmark of cognitive ageing in primates: an overview of cognitive and neurobiological studies

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2019.0618 ◽

2020 ◽

Vol 375 (1811) ◽

pp. 20190618 ◽

Cited By ~ 3

Author(s):

Agnès Lacreuse ◽

Naftali Raz ◽

Daniel Schmidtke ◽

William D. Hopkins ◽

James G. Herndon

Keyword(s):

Executive Function ◽

Age Differences ◽

Cognitive Processes ◽

Life Histories ◽

Primate Species ◽

Cognitive Ageing ◽

Age Related ◽

Relationship Of ◽

The Relationship ◽

Ageing Brain

Executive function (EF) is a complex construct that reflects multiple higher-order cognitive processes such as planning, updating, inhibiting and set-shifting. Decline in these functions is a hallmark of cognitive ageing in humans, and age differences and changes in EF correlate with age-related differences and changes in association cortices, particularly the prefrontal areas. Here, we review evidence for age-related decline in EF and associated neurobiological changes in prosimians, New World and Old World monkeys, apes and humans. While EF declines with age in all primate species studied, the relationship of this decline with age-related alterations in the prefrontal cortex remains unclear, owing to the scarcity of neurobiological studies focusing on the ageing brain in most primate species. In addition, the influence of sex, vascular and metabolic risk, and hormonal status has rarely been considered. We outline several methodological limitations and challenges with the goal of producing a comprehensive integration of cognitive and neurobiological data across species and elucidating how ageing shapes neurocognitive trajectories in primates with different life histories, lifespans and brain architectures. Such comparative investigations are critical for fostering translational research and understanding healthy and pathological ageing in our own species. This article is part of the theme issue ‘Evolution of the primate ageing process’.

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