scholarly journals Adjuvant treatment of colorectal cancer

2002 ◽  
Vol 49 (2) ◽  
pp. 15-18
Author(s):  
J.A. Wils
Keyword(s):  
Colorectal Cancer ◽  
Adjuvant Treatment ◽  
Large Scale ◽  
New Drugs ◽  
Morbidity And Mortality ◽  
The Past ◽  
The Future ◽  
The Usa

Colorectal cancer is a leading cause of morbidity and mortality, with approximately 300,000 new cases and 200,000 related deaths in Europe and the USA each year. Adjuvant treatment of colorectal cancer is now widely accepted and can reduce mortality with approximately 10%. This can be considered as one of the major achievements in oncology from the past decade. Current results will be discussed and strategies for the future will be outlined, including on-going or planned large-scale trials with new drugs and approaches.

scholarly journals Database thinking and deep description: designing a digital archive of the National Synchrotron Light Source

2019 ◽  
Vol 34 (Supplement_1) ◽  
pp. i46-i57
Author(s):  
Robert Crease ◽  
Elyse Graham ◽  
Jamie Folsom
Keyword(s):  
Phase Transition ◽  
Large Scale ◽  
Materials Science ◽  
Digital Tools ◽  
Digital Archive ◽  
Big Science ◽  
National Synchrotron Light Source ◽  
The Past ◽  
The Usa ◽  
Synchrotron Light

Abstract Over the past few years, research carried out at large-scale materials science facilities in the USA and elsewhere has undergone a phase transition that affected its character and culture. Research cultures at these facilities now resemble ecosystems, comprising of complex and evolving interactions between individuals, institutions, and the overall research environment. The outcome of this phase transition, which has been gradual and building since the 1980s, is known as the New (or Ecologic) Big Science [Crease, R. and Westfall, C. (2016). The new big science. Physics Today, 69: 30–6]. In this article, we describe this phase transition, review the practical challenges that it poses for historians, review some potential digital tools that might respond to these challenges, and then assess the theoretical implications posed by “database history’.

COMBINING DEFAULT LOGIC DATABASES

1994 ◽  
Vol 03 (03) ◽  
pp. 319-348 ◽  
Author(s):  
CHITTA BARAL ◽  
SARIT KRAUS ◽  
JACK MINKER ◽  
V. S. SUBRAHMANIAN
Keyword(s):  
Knowledge Representation ◽  
Knowledge Base ◽  
Large Scale ◽  
Future Generation ◽  
Knowledge Bases ◽  
Default Logic ◽  
Integrity Constraints ◽  
Specialized Knowledge ◽  
The Past ◽  
The Future

During the past decade, it has become increasingly clear that the future generation of large-scale knowledge bases will consist, not of one single isolated knowledge base, but a multiplicity of specialized knowledge bases that contain knowledge about different domains of expertise. These knowledge bases will work cooperatively, pooling together their varied bodies of knowledge, so as to be able to solve complex problems that no single knowledge base, by itself, would have been able to address successfully. In any such situation, inconsistencies are bound to arise. In this paper, we address the question: "Suppose we have a set of knowledge bases, KB1, …, KBn, each of which uses default logic as the formalism for knowledge representation, and a set of integrity constraints IC. What knowledge base constitutes an acceptable combination of KB1, …, KBn?"

scholarly journals Winter hydrometeorological extreme events modulated by large scale atmospheric circulation in southern Ontario

2019 ◽  
Author(s):  
Olivier Champagne ◽  
Martin Leduc ◽  
Paulin Coulibaly ◽  
M. Altaf Arain
Keyword(s):  
Atmospheric Circulation ◽  
Extreme Events ◽  
Large Scale ◽  
Internal Variability ◽  
Southern Ontario ◽  
Future Evolution ◽  
The Past ◽  
The Future ◽  
High Flows ◽  
Large Scale Atmospheric Circulation

Abstract. Extreme events are widely studied across the world because of their major implications for many aspects of society and especially floods. These events are generally studied in term of precipitation or temperature extreme indices that are often not adapted for regions affected by floods caused by snowmelt. Rain on Snow index has been widely used but it neglects rain only events which are expected to be more frequent in the future. In this study we identified a new winter compound index and assessed how large-scale atmospheric circulation controls the past and future evolution of these events in the Great Lakes region. The future evolution of this index was projected using temperature and precipitation from the Canadian Regional Climate Model Large Ensemble (CRCM5-LE). These climate data were used as input in PRMS hydrological model to simulate the future evolution of high flows in three watersheds in Southern Ontario. We also used five recurrent large-scale atmospheric circulation patterns in northeastern North America and identified how they control the past and future variability of the newly created index and high flows. The results show that daily precipitation higher than 10 mm and temperature higher than 5 °C were a necessary historical condition to produce high flows in these three watersheds. In the historical period, the occurrences of these heavy rain and warm events as well as high flows were associated to two main patterns characterized by high Z500 anomalies centred on eastern Great Lakes (HP) and the Atlantic Ocean (South). These hydrometeorological extreme events will be more frequent in the near future and will still be associated to the same atmospheric patterns. The future evolution of the index will be modulated by the internal variability of the climate system as higher Z500 in the east coast will amplify the increase in the number of events, especially the warm events. The relationship between the extreme weather index and high flows will be modified in the future as the snowpack reduces and rain becomes the main component of high flows generation. This study shows the values of CRCM5-LE dataset to simulate hydrometeorological extreme events in Eastern Canada and to better understand the uncertainties associated to internal variability of climate.

scholarly journals International Community’s Approach to Western Balkans: In Search of Stability and Security

2019 ◽  
Vol 25 (85) ◽  
pp. 64-88
Author(s):  
Janez Juvan
Keyword(s):  
European Union ◽  
International Institutions ◽  
Holistic Approach ◽  
International Community ◽  
The European Union ◽  
Western Balkans ◽  
The Past ◽  
The Future ◽  
The Usa ◽  
The Stability

Abstract The article presents research on the international community’s engagement in the countries of the Western Balkans in the past and their possible approach in the future. The focus of our research is on the functioning of mechanisms through which the international community performs certain tasks in the region. These interventions are primarily political, in the form of conferences, political programmes, consultations, pressures and continuous persuasion. Economic initiatives follow afterwards. By using different reform approaches, international institutions try to improve cooperation with the European Union (EU) and countries such as the USA, Russia, Turkey and China. Our research attempts to identify possible methods and new solutions for individual cases of conflict in Western Balkans countries, especially where the international community is actively involved. On this basis, we created a more holistic approach. The application of these measures could make the necessary reforms of the future easier. Our approach emphasises all the elements of security that are essential to the stability of the region and for the prevention of conflicts in the future.

scholarly journals Predicting the Future: Art and Algorithms

2020 ◽  
Vol 18 (3) ◽  
pp. 893-911
Author(s):  
Akos Rona-Tas
Keyword(s):  
Social Life ◽  
Consumer Credit ◽  
Social Contexts ◽  
Individual Level ◽  
The Past ◽  
Predictive Algorithms ◽  
The Future ◽  
The Usa ◽  
The Individual ◽  
Political Governance

Abstract Predictive algorithms are replacing the art of human judgement in rapidly growing areas of social life. By offering pattern recognition as forecast, predictive algorithms mechanically project the past onto the future, embracing a peculiar notion of time where the future is different in no radical way from the past and present, and a peculiar world where human agency is absent. Yet, prediction is about agency, we predict the future to change it. At the individual level, the psychological literature has concluded that in the realm of predictions, human judgement is inferior to algorithmic methods. At the sociological level, however, human judgement is often preferred over algorthms. We show how human and algorithmic predictions work in three social contexts—consumer credit, college admissions and criminal justice—and why people have good reasons to rely on human judgement. We argue that mechanical and overly successful local predictions can result in self-fulfilling prophecies and, eventually, global polarization and chaos. Finally, we look at algorithmic prediction as a form of societal and political governance and discuss how it is currently being constructed as a wide net of control by market processes in the USA and by government fiat in China.

Expanding the role of perfusionists in the era of new treatment options for cardiovascular disease

Perfusion ◽  
2003 ◽  
Vol 18 (4) ◽  
pp. 253-256 ◽  
Author(s):  
Joseph J Sistino
Keyword(s):  
Cardiovascular Disease ◽  
Treatment Options ◽  
Mail Survey ◽  
Surgical Patient ◽  
The Past ◽  
The Future ◽  
The Usa ◽  
Changing Patterns ◽  
New Treatment ◽  
New Applications

Treatment for cardiovascular disease has dramatically changed the surgical patient population over the past 10 years. Advances in medical management and interventional cardiovascular procedures have delayed surgery in many adults, and the surgical pool has begun to decrease despite an aging population. This affects perfusionists in terms of new psychological and technical challenges, and has serious consequences and implications for the future of the profession. This study will review the changing patterns of diagnosis and treatment of cardiovascular disease in the USA over the past 10 years by examining the annual surgical procedure rates and correlating them with the number of practicing perfusionists and new student graduates. The purpose of this review is to project the future employment opportunities for perfusionists. The second part of the paper will look at the alternative roles perfusionists have expanded into as a result of changes in the treatment of cardiovascular disease. The results of an e-mail survey of perfusionists will be presented to identify new applications of perfusion technology.

scholarly journals Winter hydrometeorological extreme events modulated by large-scale atmospheric circulation in southern Ontario

2020 ◽  
Vol 11 (1) ◽  
pp. 301-318 ◽  
Author(s):  
Olivier Champagne ◽  
Martin Leduc ◽  
Paulin Coulibaly ◽  
M. Altaf Arain
Keyword(s):  
Atmospheric Circulation ◽  
Extreme Events ◽  
Large Scale ◽  
Internal Variability ◽  
Southern Ontario ◽  
Future Evolution ◽  
The Past ◽  
The Future ◽  
High Flows ◽  
Large Scale Atmospheric Circulation

Abstract. Extreme events are widely studied across the world because of their major implications for many aspects of society and especially floods. These events are generally studied in terms of precipitation or temperature extreme indices that are often not adapted for regions affected by floods caused by snowmelt. The rain on snow index has been widely used, but it neglects rain-only events which are expected to be more frequent in the future. In this study, we identified a new winter compound index and assessed how large-scale atmospheric circulation controls the past and future evolution of these events in the Great Lakes region. The future evolution of this index was projected using temperature and precipitation from the Canadian Regional Climate Model large ensemble (CRCM5-LE). These climate data were used as input in Precipitation Runoff Modelling System (PRMS) hydrological model to simulate the future evolution of high flows in three watersheds in southern Ontario. We also used five recurrent large-scale atmospheric circulation patterns in north-eastern North America and identified how they control the past and future variability of the newly created index and high flows. The results show that daily precipitation higher than 10 mm and temperature higher than 5 ∘C were necessary historical conditions to produce high flows in these three watersheds. In the historical period, the occurrences of these heavy rain and warm events as well as high flows were associated with two main patterns characterized by high Z500 anomalies centred on eastern Great Lakes (HP regime) and the Atlantic Ocean (South regime). These hydrometeorological extreme events will still be associated with the same atmospheric patterns in the near future. The future evolution of the index will be modulated by the internal variability of the climate system, as higher Z500 on the east coast will amplify the increase in the number of events, especially the warm events. The relationship between the extreme weather index and high flows will be modified in the future as the snowpack reduces and rain becomes the main component of high-flow generation. This study shows the value of the CRCM5-LE dataset in simulating hydrometeorological extreme events in eastern Canada and better understanding the uncertainties associated with internal variability of climate.

Sibling Rivals

2020 ◽  
pp. 3-11
Author(s):  
Kenneth P. Miller
Keyword(s):  
Natural Resources ◽  
Large Scale ◽  
Sibling Rivalry ◽  
The Past ◽  
The Future

This chapter introduces the Texas-California sibling rivalry. All states can be considered “siblings,” but the connections between Texas and California are especially strong. The ties include common origins as territories of Spain and Mexico, Sun Belt geography, rich natural resources, vibrant economies, large-scale immigration, and comparable demographics. Moreover, in the past, Texas and California agreed on a range of political questions. In the 1990s, however, the two states began to divide. In the years since, they have hardened their partisan identities and come to advocate more sharply opposing visions of government. More than other states, California and Texas have driven our contemporary national polarization. The chapter presents the book’s central questions: Why, despite their similarities, have Texas and California divided? How have these states translated their competing visions into policy? And what does the future hold for these models—both for these two states and for the nation as a whole?

scholarly journals Personalized adjuvant treatment: go through the past to the future

2019 ◽  
Vol 11 (8) ◽  
pp. E109-E111
Author(s):  
Si-Yang Liu ◽  
Yi-Long Wu
Keyword(s):  
Adjuvant Treatment ◽  
The Past ◽  
The Future
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