scholarly journals Biologically active new Fe(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) complexes of N-(2-thienylmethylene)methanamine

2008 ◽  
Vol 73 (4) ◽  
pp. 415-421 ◽  
Author(s):  
C. Spînu ◽  
M. Pleniceanu ◽  
C. Tigae
Keyword(s):  
Schiff Base ◽  
Metal Chelates ◽  
Biologically Active ◽  
Planar Geometry ◽  
Central Metal Atom ◽  
Central Metal ◽  
Tetrahedral Geometry ◽  
Susceptibility Data ◽  
Distorted Octahedral ◽  
Elemental Analyses

Iron(II), cobalt(II), nickel (II), copper (II), zinc(II) and cadmium(II) complexes of the type ML2Cl2, where M is a metal and L is the Schiff base N- -(2-thienylmethylene)methanamine (TNAM) formed by the condensation of 2- -thiophenecarboxaldehyde and methylamine, were prepared and characterized by elemental analysis as well as magnetic and spectroscopic measurements. The elemental analyses suggest the stoichiometry to be 1:2 (metal:ligand). Magnetic susceptibility data coupled with electronic, ESR and M?ssbauer spectra suggest a distorted octahedral structure for the Fe(II), Co(II) and Ni(II) complexes, a square-planar geometry for the Cu(II) compound and a tetrahedral geometry for the Zn(II) and Cd(II) complexes. The infrared and NMR spectra of the complexes agree with co-ordination to the central metal atom through nitrogen and sulphur atoms. Conductance measurements suggest the non-electrolytic nature of the complexes, except for the Cu(II), Zn(II) and Cd(II) complexes, which are 1:2 electrolytes. The Schiff base and its metal chelates were screened for their biological activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the metal chelates were found to possess better antibacterial activity than that of the uncomplexed Schiff base.

scholarly journals Cu (II) Complex of 1- Naphthaldehyde Semicarbazone: Synthesis, Characterization, Thermal Analysis and Antibacterial Activity

2020 ◽  
pp. 1-9
Author(s):  
Dipta Sarker ◽  
Md. Faruk Hossen ◽  
Md. Kudrat-E-Zahan ◽  
Md. Masuqul Haque ◽  
Rausan Zamir ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Enterobacter Aerogenes ◽  
Carbonyl Oxygen ◽  
Molar Conductivity ◽  
Central Metal Atom ◽  
Central Metal ◽  
Tetrahedral Geometry ◽  
Magnetic Susceptibility Data ◽  
Susceptibility Data ◽  
Metal Ligand

The ligand, L is the Schiff base formed by condensation of 1- naphthaldehyde with semicarbazide and its Cu(II) complex have been synthesized and characterized by elemental and thermogravimetric analysis and molar conductivity, magnetic and spectroscopic measurements. Elemental analysis of the chelate suggests the stoichiometry is 1:1 (metal-ligand). Infrared spectra of the complex agree with the coordination to the central metal atom through the nitrogen of the azomethine (-HC=N-) group and the carbonyl oxygen atom. Magnetic susceptibility data suggest a tetrahedral geometry for the complex. ESI-MS data also supports the proposed structure of the synthesized compounds. The ligand and its copper complex have been screened for their antibacterial activity against Enterobacter aerogenes and Bacillus cereus. The metal complex were shown to possess more antibacterial activity than the uncomplexed ligand.

scholarly journals Synthesis,Characterization, biocidal, Anti-diabetic, Anti-inflammatory and Anti-Cancer(MCF-7) Studies of Schiff base ligand and its metal (II) complexes

2021 ◽  
Vol 37 (1) ◽  
pp. 58-64
Author(s):  
Karthik Somasundaram ◽  
Gomathi Thulasimani ◽  
Vedanayaki Subramaniam
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Powder Xrd ◽  
Molar Ratio ◽  
Assay Method ◽  
Planar Geometry ◽  
Tetrahedral Geometry ◽  
Metal Acetate ◽  
Elemental Analyses ◽  
Hydroxy Quinoline

A new Schiff base ligand (L1) was prepared from 3-aminoquinoline with 2, 5 dimethoxybenzaldehyde in 1:1 molar ratio. Two different co-ordination of mononuclear metal(II) complexes [(ML1) &(ML1L2)] [ M= Co(II), Ni(II), Cu(II) and Zn(II)] were synthesized & characterized. ML1wereprepared from L1 and metal acetate salts molar proportion One:Two. ML1L2 synthesized from L1, metal salts and 8-hydroxy quinoline (L2) molar ratiois 1:1:1. Elemental analyses, IR, NMR, Electronic spectra, Mass spectra, EPR, SEM and Powder XRD &molar conductivity are need to clarify the structure of synthesized metal(II) complexes. The squareplanar geometry is proposed for CuL1, NiL1, ZnL1, NiL1L2 and ZnL1L2, tetrahedral geometry for CoL1&CoL1L2 and distorted square planar geometry for CuL1L2complex. Powder XRD reveals that L1, ML1& ML1L2 have crystalline nature. Antibacterial activity of Ligand,ML1& ML1L2 were screened against bacterium Gram(+), Gram(-) &antifungal activity was determined against fungus. Theanti-inflammatory and anti-diabetic actions of the L1, CuL1 &CuL1L2complexes were studied. Theanticancer activity of L1, CuL1 and CuL1L2 were studied opposed toMCF-7 using MTT assay method.

scholarly journals Antimicrobial, Antifertility and Antiinflammatory Approach to Tetradentate Macrocyclic Complexes of Iron(II) and Manganese(II)

2002 ◽  
Vol 8 (6) ◽  
pp. 347-353 ◽  
Author(s):  
Ashu Chaudhary ◽  
D. P. Jaroli ◽  
R. V. Singh
Keyword(s):  
Molecular Weight ◽  
Reproductive Organs ◽  
Spectral Studies ◽  
Central Metal Atom ◽  
Central Metal ◽  
Testicular Sperm ◽  
Mass Spectral ◽  
Sperm Density ◽  
Elemental Analyses

Some antifertility inhibitors of 18 to 24-membered tetraazamacrocyclic complexes of iron(II) and manganese(II) have been synthesised by the template condensation using 1,3-phenylenediamine with malonic acid, succinic acid, glutaric acid and adipic acid. The reaction proceed smoothly to completion. The complexes were characterized by elemental analyses, molecular weight determinations, infrared, electronic, magnetic moment, mössbaur and mass spectral studies. The elemental analyses are consistent with the formation of the complexes [M(N4Ln)Cl2] (M = Fe(lI) or Mn(II)). All these complexes are stable and monomeric in nature as indicated by the molecular weight determinations. The spectral studies confirm the octahedral geometry around the central metal atom. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs have been examined and discussed.

scholarly journals Spectroscopic Elucidation of Some Complexes of Vanillin Semicarbazone

2021 ◽  
Vol 37 (4) ◽  
pp. 826-832
Author(s):  
Navneet Sinha ◽  
Rajnish Kumar ◽  
Vijay Pratap Singh ◽  
Deepak KUMAR ◽  
Shivadhar Sharma
Keyword(s):  
Schiff Base ◽  
Biological Activities ◽  
Free Ligand ◽  
Esr Spectra ◽  
Biologically Active ◽  
Distortion Parameter ◽  
Axial Ligands ◽  
Distorted Octahedral ◽  
Semicarbazide Hydrochloride ◽  
Uv Visible

3-Phenyl-4-methoxybenzaldehyde undergoes condensation with semicarbazide hydrochloride to form a Schiff-base i.e. 3-phenyl-4-methoxybenzaldehyde semicarbazone (abbreviated as MBS). It undergoes complexation with Vanadium(II), Manganese(II), and Copper(II). The comparison of FTIR-spectra of complexes with that of free ligand helps ascertain the coordination points of ligand through the nitrogen of –CH=N– group and oxygen of group. The axial ligands have been varied by chloride, acetate and nitrate ions. The UV/Visible and ESR spectra of complexes predicts their tetragonally distorted octahedral (D4h) symmetry. The tetragonal distortion parameter (Dt) is observed maximum for chloride while it is minimum for nitrate along z-axis. Both vanillin and semicarbazide are established biologically active compounds and hence their biological activities may be enhanced by their complexation and than a versatile field may be developed for further exploration.

Titanium(IV) Complexes of Monofunctional Bidentate Schiff Bases

1970 ◽  
Vol 25 (10) ◽  
pp. 1090-1094 ◽  
Author(s):  
S. R. Gupta ◽  
J. P. Tandon
Keyword(s):  
Molecular Weight ◽  
Schiff Base ◽  
Schiff Bases ◽  
General Type ◽  
Titanium Isopropoxide ◽  
Central Metal Atom ◽  
Central Metal ◽  
Coordination Numbers ◽  
Molar Ratios ◽  
Derivatives Of

Titanium (IV) complexes of monofunctional bidentate Schiff bases, such as salicylideneaniline, β-hydroxynaphthylideneaniline, benzylidene-o-aminophenol, benzylidene-2-hydroxyethylamine and benzylidene-2-hydroxy-n-propylamine have been prepared. The reactions between titanium isopropoxide and the Schiff bases in varying molar ratios resulted in the synthesis of several new derivatives of the general type, Ti (OPri)4-x (SB)x (where x = 1. 2. 3 or 4 and SB⊖ is the anion of the Schiff base SBH) in quantitative yields. The molecular weight determinations of some of the soluble derivatives indicate the possibility of coordination numbers five or seven for the central metal atom.

A Study on Electrochemical, Catalytic and Biological Properties of New Nickel Coordinated Schiff Base Materials

2013 ◽  
Vol 16 (2) ◽  
pp. 109-114
Author(s):  
S. Asha Jebamary ◽  
R. Antony ◽  
S. Theodore David ◽  
K. Karuppasamy ◽  
S. Thanikaikarasan ◽  
...  
Keyword(s):  
Schiff Base ◽  
Biological Activities ◽  
Biological Properties ◽  
Molar Conductance ◽  
Planar Geometry ◽  
Bacterial Strains ◽  
Molar Ratios ◽  
Base Materials ◽  
Elemental Analyses ◽  
Ft Ir

Four new Schiff bases have been derived from the condensation of acenapthoquinone and naphthylamines in 1:2 molar ratios. These Schiff base ligands were used to synthesise novel mononuclear Ni(II) complexes with square planar geometry. The ligands and the complexes have been investigated by elemental analyses, spectroscopic methods (FT-IR and UV-Vis.,), molar conductance and magnetic susceptibility studies. The electrochemical properties of Ni(II) complexes have been studied by cyclic voltammetry technique. The catalytic efficacy of the complexes has been analysed in the oxidation of toluene to benzyl alcohol, using H2O2. Biological activities of these ligands and complexes were checked against selected bacterial strains (E. coli and S. Aureus).

scholarly journals Ni (II), Cu (II) and Zn (II) Metal Chelates With Some Thiazole Derived Schiff-Bases: Their Synthesis, Characterization and Bactericidal Properties

1999 ◽  
Vol 6 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Zahid H. Chohan
Keyword(s):  
Escherichia Coli ◽  
Antibacterial Activity ◽  
Schiff Bases ◽  
Magnetic Moments ◽  
Metal Chelates ◽  
Conductivity Measurements ◽  
Octahedral Structure ◽  
Distorted Octahedral ◽  
Bactericidal Properties ◽  
Elemental Analyses

A number of thiazole derived tridentate Schiff-bases (LH) and its metal chelates of the type [M(L)2X] where M=Ni(II), Cu(II) and Zn(II), L=substituted salicylaldehyde (5-H, 5-CH3, 5-OCH3, 5-NO2 and 5-Cl) and X=CI have been synthesized and characterized with the help of elemental analyses, conductivity measurements, magnetic moments, UV-Vis, IR and NMR spectral data. An octahedral structure for Ni(II) and Zn(II) and a distorted octahedral structure for Cu(II) chelates have been proposed. All the Schiff-bases and their metal chelates have been screened for their biological activity against Escherichia coli, Staphylococcus aureous , Pseudomonas aeruginosa and Klebsiella pneumonae and in comparison, the metal chelates have been shown to possess more antibacterial activity than the uncomplexed Schiff-bases.

scholarly journals Synthesis, Characterization, and Magnetic and Thermal Studies on Some Metal(II) Thiophenyl Schiff Base Complexes

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Aderoju Amoke Osowole
Keyword(s):  
Schiff Base ◽  
Elemental Analysis ◽  
Thermal Studies ◽  
Schiff Base Complexes ◽  
Magnetic Data ◽  
Planar Geometry ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Square Planar

4-(Thiophen-3-yl)-aniline undergoes condensation with o-vanillin to form an ONS donor Schiff base, 2-methoxy-6-[(4-thiophene-3-yl-phenylimino)-methyl]-phenol, which forms complexes of the type [ML2]xH2O (where M = Mn, Co, Ni, Cu, Zn, Pd). These complexes are characterized by elemental analysis, 1H nmr, electronic, mass, and IR spectroscopies and conductance measurements. The electronic, IR and CHN data are supportive of a 4-coordinate tetrahedral geometry for Mn(II), Co(II), Ni(II), and Zn(II) complexes and square-planar geometry for Cu(II) and Pd(II) complexes, with the chromophores N2O2. The magnetic data reveals that the complexes are magnetically dilute and mononuclear with exception of the Cu(II) complex, which exhibits some anti-ferromagnetisms. The complexes are air-stable solids, and none is an electrolyte in nitro methane.

Photoluminescence properties of a cationic trinuclear zinc(II) complex with the tetradentate Schiff base ligand 6-methyl-2-({[(pyridin-2-yl)methyl]imino}methyl)phenolate

2015 ◽  
Vol 71 (10) ◽  
pp. 908-911 ◽  
Author(s):  
Young-Inn Kim ◽  
Young-Kwang Song ◽  
Daeyoung Kim ◽  
Sung Kwon Kang
Keyword(s):  
Schiff Base ◽  
Metal Cluster ◽  
Title Complex ◽  
Photoluminescence Properties ◽  
Schiff Base Ligands ◽  
Tetrahedral Geometry ◽  
Strong Emission ◽  
Tetradentate Schiff Base ◽  
Distorted Octahedral ◽  
Phenolate Ligands

Metal complexes with Schiff base ligands have been suggested as potential phosphors in electroluminescent devices. In the title complex, tetrakis[6-methyl-2-({[(pyridin-2-yl)methyl]imino}methyl)phenolato-1:2κ8N,N′,O:O;3:2κ8N,N′,O:O]trizinc(II) hexafluoridophosphate methanol monosolvate, [Zn3(C14H13N2O)4](PF6)2·CH3OH, the ZnIIcations adopt both six- and four-coordinate geometries involving the N and O atoms of tetradentate 6-methyl-2-({[(pyridin-2-yl)methyl]imino}methyl)phenolate ligands. Two terminal ZnIIcations adopt distorted octahedral geometries and the central ZnIIcation adopts a distorted tetrahedral geometry. The O atoms of the phenolate ligands bridge three ZnIIcations, forming a dicationic trinuclear metal cluster. The title complex exhibits a strong emission at 469 nm with a quantum yield of 15.5%.

scholarly journals Investigation of Metal(II)-Curcumin-Glycine Complexes : Preparation, Structural Characterization and Biological Activities

2021 ◽  
Vol 37 (2) ◽  
pp. 397-404
Author(s):  
M. Vimala Joice ◽  
P. Metilda Metilda
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activities ◽  
Metal Chelate ◽  
Bacterial Species ◽  
Molar Conductance ◽  
Metal Chelates ◽  
Magnetic Data ◽  
Planar Geometry ◽  
Tetrahedral Geometry ◽  
E Coli

A novel Schiff base obtained from curcumin and glycine was prepared and it was reacted with Co, Ni, Cu and Zn metals in order to form the stable metal complexes and characterized by elemental analysis, magnetic, molar conductance, IR, UV-Vis.,1H NMR and PXRD. The data shows that the complexes have the structure [M(II)-(cur-gly)H2O] system Electronic and magnetic data suggest a tetrahedral geometry for Co, Ni and Zn except Cu complex has a square planar geometry. The antimicrobial activity of cur-gly and its metal chelates were confirmed against the bacterial species as E. coli, P. aeruginosa, Enterococcus, B. cereus and S. aureus species. Antifungal activity was screened against C. albicans, C. parapsilosis and A. flavus. Metal chelates indicate excellent antimicrobial activity than their parent cur-gly and DNA photo cleavage activity shows that metal chelate effectively cleave the pUC 18 DNA.

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