Psoriasis and autoimmune skin diseases

Introduction Presuming that psoriasis is an autoimmune skin disease, the aim of this study was to establish its association with other autoimmune skin diseases. The material was obtained at the Dermatovenereological Clinic Clinical Center Novi Sad. Material and methods This 10-year retrospective study (1990-1999) included 1743 psoriasis patients. The control group consisted of 7492 nonpsoriatic dermatological patients. Results Association of psoriasis with other dermatological diseases of autoimmune nature has been established in 13 (0.74 %) patients. The most frequent association was with lichen ruber planus in five patients, with alopecia areata and vitiligo in three patients, and in one with bullous pemphigoid and herpetiform dermatitis. Using Fisher's test no significant association was established. Discussion and conclusion According to literature data association of psoriasis with other autoimmune diseases is well known, but rare, which is in accordance with our results. The question arises whether this association is the matter of poor coexistence or the matter of genetic mutations. However, once established, these associations can further highlight the autoimmune nature of psoriasis. The research of autoimmunity would lead us to epithelial cells in thymus, and their badly learnt cognitive function about what is own, and what is not.

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Clinical analysis of cases of lichen ruber planus in the oral cavity

Clinical review for general practice ◽

10.47407/kr2021.2.6.00080 ◽

2021 ◽

Vol 2 (6) ◽

pp. 46-52

Author(s):

Irina K. Lutskaya ◽

◽

Olga G. Zinovenko ◽

Irina O. Beloivanenk ◽

◽

...

Keyword(s):

Oral Cavity ◽

Inpatient Treatment ◽

Skin Diseases ◽

Correct Diagnosis ◽

Clinical Manifestations ◽

Local Therapy ◽

Clinical Analysis ◽

General Effect ◽

Lichen Ruber ◽

Lichen Ruber Planus

The manifestation of skin diseases in the oral cavity can be detected by doctors of any profile during the interview and examination of the patient. Often, the diagnosis is carried out by a dentist. A thorough diagnostic search allows you to determine the main clinical manifestations and treatment tactics. The dentist independently prescribes local therapy. A complex general effect is recommended by a dermatologist. Severe cases require inpatient treatment. A correct diagnosis and adequate medical measures improve the general condition and the local clinical picture, as well as contribute to a stable remission of the disease.

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Effects of ETV and VPS on cognitive impairment in infants with congenital hydrocephalus: A retrospective study

European Journal of Inflammation ◽

10.1177/2058739219866095 ◽

2021 ◽

Vol 19 ◽

pp. 205873921986609

Author(s):

Wen-Yu Ji ◽

Ning Cai ◽

Ke-bai Tu ◽

Yong-Xin Wang ◽

Yan-Dong Fan ◽

...

Keyword(s):

Cognitive Impairment ◽

Retrospective Study ◽

Cognitive Function ◽

Ventriculoperitoneal Shunt ◽

Endoscopic Third Ventriculostomy ◽

Clinical Symptoms ◽

Congenital Hydrocephalus ◽

Control Group ◽

Third Ventriculostomy ◽

Developmental Quotient

This study aims to investigate the postoperative cognitive function changes of infants who underwent endoscopic third ventriculostomy (ETV) or ventriculoperitoneal shunt (VPS) for the treatment of congenital hydrocephalus. Data of 70 hydrocephalus infants and children were retrospectively analyzed. Among these patients, 20 patients underwent ETV, 27 patients underwent VPS, and 23 patients did not undergo any operation (controls). All patients were routinely cared after discharge. The Gecell Developmental Diagnostic Scale was filled for all patients at 2 weeks, 2 months, and 6 months after diagnosis. A total of 20 patients in the ETV group were followed up for 6 months. Among these patients, the clinical symptoms of 18 patients significantly improved. Results determined at 6 months after surgery in the ETV group was statistically significant, compared with the control group ( P < 0.05). Results determined at 2 and 6 months after surgery in the VPS group were statistically significant, compared with the control group ( P < 0.05). Developmental quotient (DQ) values in these two operation groups increased after the operation ( P < 0.01), and the differences were statistically significant. ETV and VPS can improve the cognitive function of infants with hydrocephalus. Improvement of cognitive function by VPS is more significant for infants.

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ACUPUNCTURE IN TREATMENT OF РАTIENTS WITH CRONIC DERMATOSES

Journal of Volgograd State Medical University ◽

10.19163/1994-9480-2020-2(74)-127-129 ◽

2020 ◽

Vol 74 (2) ◽

pp. 127-129

Author(s):

N.G. Klinova ◽

◽

I.N. Ivanova ◽

V.V. Popov ◽

V.I. Rusinov ◽

...

Keyword(s):

Atopic Dermatitis ◽

Chronic Urticaria ◽

Skin Diseases ◽

Lichen Ruber ◽

Lichen Ruber Planus ◽

Effect Of Therapy ◽

Chronic Skin ◽

Chronic Skin Diseases ◽

Selection Of

The article is devoted to reflexotherapy of patients with different dermatoses. The experience of treatment with acupuncture of chronic skin diseases in reflexotherapy room is analised. The selection of acupuncture meridians and points in dermatological patients is proposed. The results of acupuncture of patients with lichen ruber planus, atopic dermatitis, eczema, chronic urticaria, prurigo, psoriasis of palms and soles, lichen ruber pillaris Devergy are discussed. Effect of therapy on basis of psychosomatic nature is explained.

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On the question of Lichen ruber

Kazan medical journal ◽

10.17816/kazmj58173 ◽

1930 ◽

Vol 26 (7) ◽

pp. 91-97

Author(s):

I. A. Kugushev ◽

M. B. Potashnik

Keyword(s):

Skin Diseases ◽

Lichen Ruber ◽

Lichen Ruber Planus

The group of lichenoid skin diseases still occupies the attention of dermatologists. Different forms of papules belong to the group of lichen papules: Lichen ruber planus, acuminatus, verrucosus, obtusus, corneus pemphigoides, atrophicans and others. skin. This applies in particular to the subdivision of the forms Lichen ruber planus, Lichen acuminatus et verrucosus.

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Pattern of Skin Diseases in Patients Visiting Universal College of Medical Sciences-Teaching Hospital (UCMS-TH) from the Three Districts of Terai Region in Nepal

Journal of Universal College of Medical Sciences ◽

10.3126/jucms.v2i3.11820 ◽

2014 ◽

Vol 2 (3) ◽

pp. 3-8

Author(s):

Y Poudyal ◽

SL Rajbhandari

Keyword(s):

Drug Reaction ◽

Retrospective Study ◽

Teaching Hospital ◽

Alopecia Areata ◽

Skin Disease ◽

Skin Diseases ◽

Medical Sciences ◽

Geographic Factors ◽

Sexually Transmitted ◽

Number Of Patients

INTRODUCTION: The pattern of skin disease varies from country to country and in various regions within same country due to differences in socioeconomic and geographic factors. This study aimed to determine the pattern of skin disease from the three districts of Terai region in Nepal. MATERIALAND METHODS: This was retrospective study done from the hospital OPD patient's record of Universal college of Medical Sciences & Teaching Hospital (UCMS-TH), from 1st September 2011 to 31st August 2012. Patients from Rupandehi, Nawalparasi and Kapilvastu districts were taken. The diagnosis were entered in 15 categories like Acne, Alopecia Areata, Dermatophytosis, Drug reaction, Eczema, Leprosy, Lichen Planus, Melasma, Psoriasis, Pyoderma, Scabies, sexually transmitted diseses (STI), Urticaria, Viral infection and Vitiligo. Any diagnosis not in these categories, was kept at “Other” category. Monthly trend of disease was also analysed.RESULT: Total number of patients from Rupandehi, Kapilvastu and Nawalparasi districts were 12446 (89.3%), 661 (4.7%), 836 (6%) respectively. Dermatophytosis was the commonest 2003 (16.1%) in Rupandehi district, it was second in number in Nawalparasi and Kapilvastu. Eczema was the commonest in Kapilvastu and Nawalparasi district with 103 (15.6%) and 136 (16.3%) respectively. Eczema was second in number in Rupandehi district. Acne was third in number in Rupandehi and Nawalparasi but vitiligo was third common dermatosis recorded in Kapilvastu district.CONCLUSION: Dermatophytosis and Eczema are the most common dermatologic disorders in Terai region.DOI: http://dx.doi.org/10.3126/jucms.v2i3.11820 Journal of Universal College of Medical Sciences Vol.2(3) 2014: 3-8

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Effects of Cancer, Chemotherapy and Cytokines on Subjective and Objective Cognitive Functioning Among Patients with Breast Cancer

Cancers ◽

10.3390/cancers13112576 ◽

2021 ◽

Vol 13 (11) ◽

pp. 2576

Author(s):

Vincent Chin-Hung Chen ◽

Chin-Kuo Lin ◽

Han-Pin Hsiao ◽

Bor-Show Tzang ◽

Yen-Hsuan Hsu ◽

...

Keyword(s):

Breast Cancer ◽

Cognitive Function ◽

Cognitive Abilities ◽

Verbal Fluency ◽

Control Group ◽

Control Groups ◽

Semantic Verbal Fluency ◽

Cytokine Levels ◽

Chemotherapy Patients ◽

And Control

Background: We aimed to investigate the associations of breast cancer (BC) and cancer-related chemotherapies with cytokine levels, and cognitive function. Methods: We evaluated subjective and objective cognitive function in BC patients before chemotherapy and 3~9 months after the completion of chemotherapy. Healthy volunteers without cancer were also compared as control group. Interleukins (IL) 2, 4, 5, 6, 10, 12p70, 13, 17A, 1β, IFNγ, and TNFα were measured. Associations of cancer status, chemotherapy and cytokine levels with subjective and objective cognitive impairments were analyzed using a regression model, adjusting for covariates, including IQ and psychological distress. Results: After adjustment, poorer performance in semantic verbal fluency was found in the post-chemotherapy subgroup compared to controls (p = 0.011, η2 = 0.070); whereas pre-chemotherapy patients scored higher in subjective cognitive perception. Higher IL-13 was associated with lower semantic verbal fluency in the post-chemotherapy subgroup. Higher IL-10 was associated with better perceived cognitive abilities in the pre-chemotherapy and control groups; while IL-5 and IL-13 were associated with lower perceived cognitive abilities in pre-chemotherapy and control groups. Our findings from mediation analysis further suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Conclusions: Our findings suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Different cytokines and their interactions may have different roles of neuroinflammation or neuroprotection that need further research.

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Radiological Parameters Review for Choanal Atresia

Pediatric Reports ◽

10.3390/pediatric13020038 ◽

2021 ◽

Vol 13 (2) ◽

pp. 302-311

Author(s):

Daniela Messineo ◽

Maryia Chernikava ◽

Valeria Pasquali ◽

Serena Bertin ◽

Mario Ciotti ◽

...

Keyword(s):

Retrospective Study ◽

High Resolution ◽

Surgical Approach ◽

Choanal Atresia ◽

Point Of View ◽

Control Group ◽

Study Group ◽

Control Groups ◽

Imaging Parameters ◽

Multiplanar Imaging

(1) Background: The study aims to identify which imaging parameters are necessary for a new correct surgical approach in the study of choanal atresia, and which anatomical findings are essential for correct planning of endoscopic treatment in choanal atresia. (2) Methods: In this retrospective study, 19 patients with choanal atresia had high-resolution multiplanar imaging (14 cases aged ≤1 year and 5 cases aged 1 to 3 years) and 35 patients in the control group similarly distributed by age. Fourteen variables, the most relevant from a surgical point of view, were selected and measured. A comparison was made between the averages of the study group and the different control groups, either directly observed or selected from the literature, using Pearson’s correlation. (3) Results: In 14 out of 26 cases, the differences were statistically significant. There was a correlation between the structures assessed, such as choanal height, rostrum height, and age. (4) Conclusions: Thanks to volumetric reformatting, this work identified and provided the clinician with useful information that helped choose the correct surgical approach. Furthermore, it focused on which imaging parameters are necessary to improve the planning of the surgical correction of choanal atresia.

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Study of cognitive functions in major idiopathic interstitial pneumonias

Egyptian Journal of Bronchology ◽

10.1186/s43168-020-00046-7 ◽

2020 ◽

Vol 14 (1) ◽

Author(s):

Mohamed W. Zakaria ◽

Reem I. El-Korashy ◽

Mostafa O. Shaheen ◽

Samah Selim ◽

Kwashi J. Amum

Keyword(s):

Cognitive Impairment ◽

Cognitive Function ◽

Cognitive Dysfunction ◽

Mini Mental State Examination ◽

Mmse Score ◽

Control Group ◽

Healthy Individuals ◽

Co Morbidity ◽

Impaired Lung Function ◽

State Examination

Abstract Background Cognitive dysfunction in idiopathic interstitial pneumonia (IIP) is an important clinical co-morbidity that is associated with impaired lung function. The aim of the work is to assess cognitive function in major IIP and to find out the relation between cognitive dysfunction and the oxygenation parameters. Results Fifty individuals were involved in the study; 30 patients with major IIP and 20 healthy individuals. Patients with IIP had significantly lower mini mental state examination (MMSE) score compared to the control group (P < 0.001). Wechsler Deterioration Index (WDI) revealed that 33.3% (n = 10) of the patients with IIP had sure cognitive impairment and 26.6% (n = 8) had ongoing cognitive deterioration. Patients with idiopathic pulmonary fibrosis (IPF) had lower cognitive function than other IIP. Conclusion There is an impairment of cognitive function in patients with major IIP, particularly in IPF, as measured by WDI and MMSE. Further large studies are needed to assess the possible predictors of cognitive impairment and their effects on the patients’ outcome.

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Effect of Baduanjin exercise intervention on cognitive function and quality of life in women with breast cancer receiving chemotherapy: study protocol of a randomized controlled trial

Trials ◽

10.1186/s13063-021-05355-w ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Xiao-Lin Wei ◽

Ru-Zhen Yuan ◽

Yong-Mei Jin ◽

Shu Li ◽

Ming-Yue Wang ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Clinical Trial ◽

Cognitive Function ◽

Exercise Intervention ◽

Early Stage ◽

Early Stage Breast Cancer ◽

Pharmacological Intervention ◽

Control Group

Abstract Background More than 50% cognitive impairment was reported by cancer patients before and after medical treatment. However, there are no effective interventions to manage the cognitive problem in women with breast cancer. This pilot study was designed to evaluate the protective effect of Baduanjin exercise on cognitive function and cancer-related symptoms in women with early-stage breast cancer undergoing chemotherapy. Method A single-blinded, randomized control trial was designed. The trial will recruit 70 patients with early-stage breast cancer scheduled to receive chemotherapy from Shanghai in China. All participants will be randomly assigned to (1:1) the supervised Baduanjin group (5 times/week, 30 min each time) or the wait-list control group for 3 months. The effect of Baduanjin exercise intervention will be evaluated by outcome measures including subjective and objective cognitive function, symptoms (fatigue, depression, and anxiety), and health-related quality of life at pre-intervention (T0), 8 weeks (T1), and 12 weeks (T2). The PCI score in the FACT-Cog as the primary cognitive outcome will be reported descriptively, while effect sizes and 95% confidence intervals (CIs) will be calculated. The collected data will be analyzed by using an intention-to-treat principle and linear mixed-effects modeling. Discussion This is the first randomized clinical trial to investigate whether Baduanjin exercise will have a positive role in improving cognitive function in women with breast cancer receiving chemotherapy. If possible, Baduanjin exercise will be a potential non-pharmacological intervention to manage cognitive dysfunction and promote survivorship care among breast cancer survivors. Trial registration Chinese Clinical Trial Registry (ChiCTR) ChiCTR2000033152. Registered on 22 May 2020

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Perilla Seed Oil Enhances Cognitive Function and Mental Health in Healthy Elderly Japanese Individuals by Enhancing the Biological Antioxidant Potential

Foods ◽

10.3390/foods10051130 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1130

Author(s):

Michio Hashimoto ◽

Kentaro Matsuzaki ◽

Shahdat Hossain ◽

Tomoko Ito ◽

Harumi Wakatsuki ◽

...

Keyword(s):

Mental Health ◽

Cognitive Function ◽

Plasma Membranes ◽

Seed Oil ◽

Antioxidant Potential ◽

Control Group ◽

Healthy Elderly ◽

Age Related ◽

Elderly Japanese ◽

Perilla Seed

Oxidative stress plays an important role in age-associated cognitive decline. We recently reported that dietary intake of perilla seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of dietary PO intake on cognitive functions and mental health in healthy, elderly Japanese individuals. Seventy-five healthy volunteers aged 64–84 years were randomly divided into two groups: a control group and a PO-administered group. At baseline and at 12 months of intervention, cognitive function, mental health condition, fatty acid profile of the red blood cell plasma membranes (RBC-PM), and serum biochemical parameters were evaluated. Results showed that serum biological antioxidant potential and LNA levels in the RBC-PM at 12 months after the trial were significantly higher in the PO group compared to the control group. Further, both the cognitive function measures, as evaluated by the Frontal Assessment Battery test and the apathy scores, tended to be improved after 12 months in the PO group. Our results demonstrate that dietary PO intake enhances the antioxidant potential and prevents the age-related cognitive and mental decline in healthy elderly individuals by enhancing the blood LNA levels.

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