scholarly journals Ecstasy tablets intoxication with lethal autcome

2007 ◽  
Vol 64 (9) ◽  
pp. 635-638 ◽  
Author(s):  
Snezana Djordjevic ◽  
Gordana Tomasevic
Keyword(s):  
High Performance Liquid Chromatography ◽  
Case Report ◽  
High Performance ◽  
High Dose ◽  
Recreational Drug ◽  
Post Mortem ◽  
Synthetic Compound ◽  
Death Case ◽  
Spectral Detection ◽  
Minimal Concentration

Background. Ecstasy, 3,4-methylenedioxymethamphetamine (MDMA), is a synthetic compound increasingly popular as a recreational drug. Tablets known as ecstasy contain MDMA, but may also contain caffeine, ephedrine, paramethoxyamphetamine, 3,4-methylenedioxyamphetamine (MDA), amphetamine, methamphetamine, and ketamine. After absorption MDMA is metabolized to MDA, 4-hydroxy-3- metoxymetamphetamine (HMMA) and 4-hydroxy-3- metoxyamphetamine (HMA). After that HMMA and HMA are conjugated and excreted by urine. The aim of this report was to confirm by toxicological post mortem analyses of poisoned person organs that ecstasy had been the cause of his death. Case report. We reported the death of a 17-year-old boy after the ingestion of ecstasy. MDMA and metabolites were determined by multicolumn high performance liquid chromatography with UV spectral detection (HPLC-UV). Toxicological tests showed the presence of MDMA in all samples. When examining post mortem material (the organs), the highest concentrations were measured in the stomach (835,97 ?g/g) and kidney (801,14 ?g/g). The minimal concentration was in the liver (22,26 ?g/g). Conclusion. The obtained results of MDMA and its metabolites concentrations showed abuse of a high dose of ecstasy. .

scholarly journals COLCHICINA: INTOXICAÇÃO E ÓBITO, RELATO DE CASO

2004 ◽  
Vol 5 (1) ◽  
Author(s):  
P.M.K.C. GABRIEL ◽  
M.M. GABRIEL ◽  
J. ESCORSIN NETO ◽  
M. LOPES
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Case Report ◽  
High Performance ◽  
High Concentration ◽  
Emergency Ward ◽  
Death Case ◽  
Analytical Results ◽  
Mean Concentration

B. I., de 67 anos, foi internado em um hospital no interior do Estado do Paraná, apresentando dor abdominal, vômitos e diarréia intensa, vindo a falecer após 4h de internamento. Após investigação do médico sanitarista, constatou-se que a vítima havia começado tratamento com cápsulas manipuladas com o princípio ativo “colchicina”. Análise por cromatografia líquida de alta resolução (HPLC) indicou positividade para colchicina nas cápsulas, com concentração média de 63,48mg e negativo no material biológico da vítima. A intoxicação por colchicina foi confirmada através dos exames anátomo patológico, sintomatologia apresentada no período de internamento e a alta dosagem de colchicina encontrada nas cápsulas manipuladas e ainda disponíveis. COLCHICINE: INTOXICATION AND DEATH, CASE REPORT Abstract B. I., sixty-seven years old, was taken to a hospital with abdominal cramps, vomiting and intense diarrhoea; he died four hours after being admitted in the emergency ward. After some medical investigation, it became known that the patient had started a treatment with colchicine in capsules prepared by a pharmacist. The capsules and the autopsy materials were analysed by High Performance Liquid Chromatography (HPLC) and the analytical results for the capsules were positive for colchicine with mean concentration of 63,48mg/capsule; the analytical results for the autopsy materials were negative for colchicine. The fatal colchicine intoxication was confirmed by the anatomo-pathological exams carried out in the autopsy materials, by the sintomatology presented by the patient during his staying in the hospital and by the high concentration of colchicine found in the still remaining capsules.

Fixed eruption due to quinine in tonic water: A case report with high-performance liquid chromatography and ultraviolet A analyses

2013 ◽  
Vol 40 (8) ◽  
pp. 629-631 ◽  
Author(s):  
Aoi Ohira ◽  
Sayaka Yamaguchi ◽  
Takuya Miyagi ◽  
Yu-ichi Yamamoto ◽  
Satoshi Yamada ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Case Report ◽  
High Performance ◽  
Ultraviolet A ◽  
Tonic Water

Detection of Bromisovalum from the Bone Marrow of Skeletonized Human Remains: A Case Report with a Comparison between Gas Chromatography/Mass Spectrometry (GC/MS) and High-Performance Liquid Chromatography/Mass Spectrometry (LC/MS)

1997 ◽  
Vol 37 (3) ◽  
pp. 248-253 ◽  
Author(s):  
H Maeda ◽  
S Oritani ◽  
K Nagai ◽  
T Tanaka ◽  
N Tanaka
Keyword(s):  
Mass Spectrometry ◽  
Bone Marrow ◽  
Gas Chromatography ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Gas Chromatography Mass Spectrometry ◽  
Post Mortem ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry

We report a case of totally skeletonized human remains in which a considerable amount of a hypnotic, bromisovalum (bromovalerylurea), was detected from the bone marrow. The unknown skeletal remains were found in a bush, together with empty vials of bromisovalum and a water bottle. The body was identified as a 46-year-old male, who had died about seven months previously. There was no evidence of trauma. The dried bone marrow of both femurs was separately collected and toxicologically analysed by gas chromatography/mass spectrometry (GC/MS) and high-performance liquid chromatography/mass spectrometry (LC/MS). Bromisovalum was identified from the femurs. The concentration along with the circumstantial evidence suggested possible contribution of bromisovalum to the fatality. However, a considerable quantitative difference was observed between the left and right femur, showing significant post-mortem interference to toxicological evidence. The result showed that multiple sampling at least would be required for quantitative evaluation of post-mortem toxicological evidence. Moreover, the diagnostic value should also be considered with caution in relation to the blood to bone marrow ratio of each drug concentration.

scholarly journals How much is too much? A case report of nutritional supplement use of a high-performance athlete

2011 ◽  
Vol 105 (12) ◽  
pp. 1724-1728 ◽  
Author(s):  
Anja Carlsohn ◽  
Michael Cassel ◽  
Karsten Linné ◽  
Frank Mayer
Keyword(s):  
Case Report ◽  
Nutrient Intake ◽  
High Performance ◽  
Daily Intake ◽  
Nutritional Supplement ◽  
High Energy ◽  
High Dose ◽  
Supplement Use ◽  
Micronutrient Intake ◽  
Dietary Nutrient

Although dietary nutrient intake is often adequate, nutritional supplement use is common among elite athletes. However, high-dose supplements or the use of multiple supplements may exceed the recommended daily allowance (RDA) of particular nutrients or even result in a daily intake above tolerable upper limits (UL). The present case report presents nutritional intake data and supplement use of a highly trained male swimmer competing at international level. Habitual energy and micronutrient intake were analysed by 3 d dietary reports. Supplement use and dosage were assessed, and total amount of nutrient supply was calculated. Micronutrient intake was evaluated based on RDA and UL as presented by the European Scientific Committee on Food, and maximum permitted levels in supplements (MPL) are given. The athlete's diet provided adequate micronutrient content well above RDA except for vitamin D. Simultaneous use of ten different supplements was reported, resulting in excess intake above tolerable UL for folate, vitamin E and Zn. Additionally, daily supplement dosage was considerably above MPL for nine micronutrients consumed as artificial products. Risks and possible side effects of exceeding UL by the athlete are discussed. Athletes with high energy intake may be at risk of exceeding UL of particular nutrients if multiple supplements are added. Therefore, dietary counselling of athletes should include assessment of habitual diet and nutritional supplement intake. Educating athletes to balance their diets instead of taking supplements might be prudent to prevent health risks that may occur with long-term excess nutrient intake.

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