Incidence of Nonmelanoma Skin Cancer in New Brunswick, Canada, 1992 to 2001

2007 ◽  
Vol 11 (2) ◽  
pp. 45-52 ◽  
Author(s):  
Robert C. Hayes ◽  
Suzanne Leonfellner ◽  
Wilfred Pilgrim ◽  
Jian Liu ◽  
Douglas N. Keeling
Keyword(s):  
Skin Cancer ◽  
New Brunswick ◽  
Cell Carcinoma ◽  
Cancer Registry ◽  
Descriptive Analysis ◽  
The United States ◽  
Incidence Rates ◽  
Nonmelanoma Skin Cancer ◽  
Annual Number ◽  
World Standard

Background:Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), collectively referred to as nonmelanoma skin cancer (NMSC), cause significant morbidity and generate a substantial cost to the health care system. Canadian data on the incidence of NMSC are lacking.Objective:To study the incidence and characteristics of NMSC in New Brunswick, Canada (population 729,498 people in 2001), by using the Provincial Cancer Registry.Method:Data were obtained from 1992 to 2001 from the New Brunswick Provincial Cancer Registry, to which reporting of all cancers is mandatory. Multiple tumors of a given histologic type are recorded only once in the registry per individual per lifetime. A descriptive analysis of incidence rates of BCC and invasive SCC of the skin was performed in relation to gender, age, and anatomic location. The main outcome measures were the age- and sex-specific incidence rates of BCC and SCC. Age standardization was performed using the Canadian, US, and world standard populations.Results:When adjusted to the world standard population, the age-standardized incidence rates (ASIRs) per 100,000 population for BCC from 1992 through 2001 were 87 for males and 68 for females. For invasive SCC, the ASIRs per 100,000 population were 34 for males and 16 for females. There was an increasing incidence trend for both BCC and invasive SCC over the 10-year study period, with minimal change in the incidence of SCC in women. The overall ratio of BCC to invasive SCC in the population was 2.8 to 1. The approximate lifetime probabilities of developing BCC and invasive SCC were 13% and 5%, respectively.Conclusions:The incidence of NMSC in the province of New Brunswick is similar to that reported from 1973 through 1987 in the province of British Columbia, higher than those reported in most parts of Europe, and lower than all published rates in the United States and Australia. Owing to the inability of the registry to account for tumor multiplicity, the actual annual number of all NMSC lesions in this population is likely much higher.

scholarly journals Botanical Agents for the Treatment of Nonmelanoma Skin Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jillian W. Millsop ◽  
Raja K. Sivamani ◽  
Nasim Fazel
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
The United States ◽  
Nonmelanoma Skin Cancer ◽  
Surgical Removal ◽  
Chemopreventive Agents ◽  
Treatment And Prevention ◽  
Skin Cancers ◽  
United States Standard ◽  
Nonmelanoma Skin Cancers

Nonmelanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma, are common neoplasms worldwide and are the most common cancers in the United States. Standard therapy for cutaneous neoplasms typically involves surgical removal. However, there is increasing interest in the use of topical alternatives for the prevention and treatment of nonmelanoma skin cancer, particularly superficial variants. Botanicals are compounds derived from herbs, spices, stems, roots, and other substances of plant origin and may be used in the form of dried or fresh plants, extracted plant material, or specific plant-derived chemicals. They possess multiple properties including antioxidant, anti-inflammatory, and immunomodulatory properties and are, therefore, believed to be possible chemopreventive agents or substances that may suppress or reverse the process of carcinogenesis. Here, we provide a review of botanical agents studied for the treatment and prevention of nonmelanoma skin cancers.

Epidemiology of Skin Tumors: Data from the Cutaneous Cancer Registry in Trentino, Italy

2003 ◽  
Vol 7 (4) ◽  
pp. 300-305 ◽  
Author(s):  
Sebastiana Boi ◽  
Mario Cristofolini ◽  
Rocco Micciolo ◽  
Enzo Polla ◽  
Paolo Dalla Palma
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Cancer Registry ◽  
Personal Data ◽  
Incidence Rates ◽  
Skin Tumors ◽  
Published Data ◽  
Anatomical Site ◽  
Ratio Test ◽  
Chi Squared

Background: A Skin Cancer Registry was established in the province of Trento in northeast Italy in 1992 with the aim of collecting data on all cutaneous tumors affecting residents. These neoplasms are responsible for considerable morbidity and utilization of the Health Service because of their high frequency and, therefore, knowledge of the exact incidence is very important in planning health policies. Registry data are also very helpful in performing studies of analytical and descriptive epidemiology. Methods: For each patient, we collected personal data, phenotypical characteristics, professional history, concurrent diseases, previous therapy or trauma, and all data regarding the tumors. Patients were interviewed in person or, less frequently, by phone. All data were verified and put in a computerized file, in a protected room. The Statistics Institute of Trento University analyzed the data. Comparison among means was performed using the analysis of variance and differences among proportions were tested by chi-squared analysis. Poisson regression and the likelihood ratio test were used to compare incidence rates. We analyze here the data regarding epiteliomas and melanoma. Results: During the study period we registered 3435 primary skin tumors in 2868 individuals. Crude incidence rates, calculated using the number of subjects (not the number of tumors), were 87.9 for basal cell carcinoma (BCC), 28.9 for squamous cell carcinoma (SCC), and 14.2 for cutaneous melanoma (CM), per 100,000 per annum. We also calculated the same figures in females and males and specific incidence rates in both sexes and evaluated the distribution of skin cancer according to sex and anatomical site. Conclusion: We report the analysis of the data collected by the Skin Cancer registry in a 6 year period and compare the data with published data in literature and with data of a previously registered melanoma file. Our results confirm the high incidence of non-melanoma skin cancers and the variation in the histological patterns of CM.

scholarly journals Photosensitizing Medications and Skin Cancer: A Comprehensive Review

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2344
Author(s):  
Elisabeth A. George ◽  
Navya Baranwal ◽  
Jae H. Kang ◽  
Abrar A. Qureshi ◽  
Aaron M. Drucker ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Risk ◽  
Cell Carcinoma ◽  
The United States ◽  
In Vivo Studies ◽  
Cancer Risk Factors ◽  
Skin Cancer Risk ◽  
Number Of Patients

(1) The incidence of skin cancer is increasing in the United States (US) despite scientific advances in our understanding of skin cancer risk factors and treatments. In vitro and in vivo studies have provided evidence that suggests that certain photosensitizing medications (PSMs) increase skin cancer risk. This review summarizes current epidemiological evidence on the association between common PSMs and skin cancer. (2) A comprehensive literature search was conducted to identify meta-analyses, observational studies and clinical trials that report on skin cancer events in PSM users. The associated risks of keratinocyte carcinoma (squamous cell carcinoma and basal cell carcinoma) and melanoma are summarized, for each PSM. (3) There are extensive reports on antihypertensives and statins relative to other PSMs, with positive and null findings, respectively. Fewer studies have explored amiodarone, metformin, antimicrobials and vemurafenib. No studies report on the individual skin cancer risks in glyburide, naproxen, piroxicam, chlorpromazine, thioridazine and nalidixic acid users. (4) The research gaps in understanding the relationship between PSMs and skin cancer outlined in this review should be prioritized because the US population is aging. Thus the number of patients prescribed PSMs is likely to continue to rise.

scholarly journals Molecular Approach to Cutaneous Squamous Cell Carcinoma: From Pathways to Therapy

2020 ◽  
Vol 21 (4) ◽  
pp. 1211
Author(s):  
Elisabetta Palazzo ◽  
Maria I. Morasso ◽  
Carlo Pincelli
Keyword(s):  
United States ◽  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
The United States ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Molecular Approach

Cutaneous squamous cell carcinoma (cSCC) represents the second most frequent skin cancer, recently showing a rapid increase in incidence worldwide, with around >1 million cases/year in the United States and 2500 deaths [...]

scholarly journals Basal Cell Carcinoma in a Child

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Samet Vasfi Kuvat ◽  
Zuhal Gücin ◽  
Barış Keklik ◽  
Gülzade Özyalvaçlı ◽  
Karaca Başaran
Keyword(s):  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Safety Margin ◽  
Nonmelanoma Skin Cancer ◽  
Pathologic Examination ◽  
Pigmented Lesion

Basal cell carcinoma is the most commonly seen nonmelanoma skin cancer which is rarely encountered in the childhood period. An 11-year old child was admitted to our clinic due to an erythematous and a slightly pigmented lesion with a3×4 cm diameter on his posterior scalp. Macroscopically, the lesion was excised with a 10 mm safety margin. Pathologic examination revealed a basal cell carcinoma. No symptoms or signs of a syndrome were observed both in the patient and his family.

40-Year Trends in Skin Cancer in British Columbia, Canada, 1973 to 2003

2012 ◽  
Vol 16 (2) ◽  
pp. 83-91 ◽  
Author(s):  
David I. Mclean ◽  
Norm Phillips ◽  
Youwen Zhou ◽  
Richard Gallagher ◽  
Tim K. Lee
Keyword(s):  
British Columbia ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Incidence Rate ◽  
Incidence Rates ◽  
Cutaneous Malignant Melanoma ◽  
Skin Cancers ◽  
Canadian Population ◽  
Novel Method ◽  
Over Time

Background: Skin cancer is common in North America. Incidence rate trends are potentially important in the assessment of the effects of measures to increase sun awareness in the population as well as measures to reduce sun damage. Objective: To determine the incidence of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and cutaneous malignant melanoma (CMM) in a geographically defined Canadian population over a 40-year period. Methods: Data were obtained from the BC Cancer Registry for the calendar years 1973, 1983, 1993, and 2003. Results: Age-standardized incidence rates increased significantly from 1973 to 2003 for BCC, SCC, and CMM. Limitations: The ethnic makeup of British Columbia has changed over time, and a novel method of accounting for the effect of this on skin cancer rates is presented. Conclusion: The incidence rate for skin cancers continued to rise in British Columbia, but there appears to have been a decline in the incidence of CMM and BCC in the youngest cohorts.

scholarly journals Investigating epidemiologic trends and the geographic distribution of patients with anal squamous cell carcinoma throughout Canada

2020 ◽  
Vol 27 (3) ◽  
Author(s):  
L. Cattelan ◽  
F. M. Ghazawi ◽  
M. Le ◽  
E. Savin ◽  
A. Zubarev ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Anal Cancer ◽  
Squamous Cell ◽  
Demographic Data ◽  
Cancer Registries ◽  
The United States ◽  
Incidence Rates ◽  
Anal Squamous Cell Carcinoma ◽  
Incidence And Mortality

Background Anal cancer is a rare disease, constituting 0.5% of new cancer cases in the United States. The most common subtype is squamous cell carcinoma (scc). Studies in several developed nations have reported on an increasing incidence of anal cancer in recent decades, and various risk factors pertaining to the pathogenesis of the disease have been identified, including infection with the human papillomavirus, tobacco use, and immunosuppression. The epidemiology and distribution of anal scc throughout Canada remain poorly understood, however. Methods Using 3 population-based cancer registries, a retrospective analysis of demographic data across Canada for 1992–2010 was performed. The incidence and mortality for anal scc was examined at the levels of provinces, cities, and the forward  sortation area (FSA) component (first 3 characters) of postal codes. Results During 1992–2010, 3720 individuals were diagnosed with anal scc in Canada; 64% were women. The overall national incidence rate was 6.3 cases per million population per year, with an average age at diagnosis of 60.4 years. The incidence increased over time, with significantly higher incidence rates documented in British Columbia and Nova Scotia (9.3 cases per million population each). Closer examination revealed clustering of cases in various urban centres and self-identified lgbtq communities in Toronto, Montreal, and Vancouver. Discussion This study provides, for the first time, a comprehensive analysis of the burden of anal scc in Canada, identifying susceptible populations and shedding light onto novel avenues of research to lower the incidence of anal cancer throughout the country.

Skin Cancer (Basal Cell Carcinoma, Squamous Cell Carcinoma, and Malignant Melanoma): New Cases, Treatment Practice, and Health Care Costs in New Brunswick, Canada, 2002–2010

2014 ◽  
Vol 18 (5) ◽  
pp. 320-331 ◽  
Author(s):  
Wilfred Pilgrim ◽  
Robert Hayes ◽  
Dana W. Hanson ◽  
Bin Zhang ◽  
Bonnie Boudreau ◽  
...  
Keyword(s):  
Health Care ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
New Brunswick ◽  
Cell Carcinoma ◽  
Health Care Costs ◽  
Basal Cell ◽  
Treatment Practice ◽  
Treatment Practices ◽  
Care Costs

Background: In Canada, there is no formal process for registering nonmelanoma skin cancer (NMSC); thus, the epidemiology, treatment practices, and associated health costs are not well known. Objectives: To investigate trends in new cases of skin cancer, treatment practices, and health care costs in New Brunswick, Canada. Methods: Data were extracted from the Provincial Cancer Registry and New Brunswick administrative health databases for 2002–2010. Results: New cases: Basal Cell Carcinoma (BCC) was the most common skin cancer diagnosed, and incidence rates significantly increased between 1992 and 2010. Treatment practice: Dermatologists managed the majority (45%) of the overall skin cancer treatments. Health care costs: NMSC accounted for ˜80% of the health care costs for skin cancer and was dominated by BCC. Conclusions: Development of best practice treatment guidelines for NMSC in New Brunswick would improve future health care efficiencies, and standard protocols for registering new cases of NMSC in Canada would strengthen surveillance and reporting capacity.

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