40-Year Trends in Skin Cancer in British Columbia, Canada, 1973 to 2003

2012 ◽  
Vol 16 (2) ◽  
pp. 83-91 ◽  
Author(s):  
David I. Mclean ◽  
Norm Phillips ◽  
Youwen Zhou ◽  
Richard Gallagher ◽  
Tim K. Lee
Keyword(s):  
British Columbia ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Incidence Rate ◽  
Incidence Rates ◽  
Cutaneous Malignant Melanoma ◽  
Skin Cancers ◽  
Canadian Population ◽  
Novel Method ◽  
Over Time

Background: Skin cancer is common in North America. Incidence rate trends are potentially important in the assessment of the effects of measures to increase sun awareness in the population as well as measures to reduce sun damage. Objective: To determine the incidence of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and cutaneous malignant melanoma (CMM) in a geographically defined Canadian population over a 40-year period. Methods: Data were obtained from the BC Cancer Registry for the calendar years 1973, 1983, 1993, and 2003. Results: Age-standardized incidence rates increased significantly from 1973 to 2003 for BCC, SCC, and CMM. Limitations: The ethnic makeup of British Columbia has changed over time, and a novel method of accounting for the effect of this on skin cancer rates is presented. Conclusion: The incidence rate for skin cancers continued to rise in British Columbia, but there appears to have been a decline in the incidence of CMM and BCC in the youngest cohorts.

scholarly journals Epidemiology and Trends of Skin Cancers in Guilan Province, Iran During 2010-2014

2021 ◽  
Vol 29 (4) ◽  
pp. 154-165
Author(s):  
Abbas Darjani ◽  
◽  
Narges Alizadeh ◽  
Kaveh Gharaei Nejad ◽  
Hojat Eftekhari ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Incidence Rate ◽  
Age Groups ◽  
World Health ◽  
Cross Sectional ◽  
Skin Cancers ◽  
Geographical Regions ◽  
The World ◽  
Guilan Province

Background: Skin cancer is the most common type of cancer in the world. Pattern of skin cancer is different in various geographical regions, depending on the genetic and environmental factors. Objective: This study aims to investigate the incidence rate of skin cancer and its trends in Guilan province of Iran during 2010-2014. Materials and Methods: In this descriptive cross-sectional study, the five-year data related to all cases of skin cancer recorded for Guilan Province during 2010-2014 were used. The age-sex incidence of skin cancer was standardized using the standard population of the World Health Organization. The age-standardized incidence rate of skin cancers including Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC) and Melanoma was calculated, and then its trends were evaluated. Results: A total of 1664 cases with skin cancer, 1014 men and 650 women, were reported in the province from 2010 to 2014. Incidence of skin cancer was higher in men. BCC was the most common skin cancer. The most common site for BCC was face and scalp, and for SCC it was the lip. Melanoma was mostly occurred on acral regions. The incidence of skin cancer had a rising trend and had raised in all age groups. Conclusion: There is an increasing trend of skin cancers in Guilan Province. Therefore, planning for detection, prevention and control of its risk factors is necessary.

scholarly journals Detailed head localization and incidence of skin cancers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marta Fijałkowska ◽  
Mateusz Koziej ◽  
Bogusław Antoszewski
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Vertical Dimension ◽  
Surgical Department ◽  
Surface Areas ◽  
Common Cancer ◽  
Skin Cancers ◽  
Sex Type ◽  
Cancer Subtype ◽  
The Face

AbstractSkin cancers are the most common neoplasms; frequently, they localize on the face. The aim of paper is to present the incidence of skin tumors in a single center from 2017 to 2019, describe trends in its frequency and find relations between neoplasms and sex, type of cancer, and its size. An analysis of histopathological files from the surgical department between 2017 and 2019 was calculated. These items were selected: sex, age, type of skin cancer, subtype of basal cell carcinoma (BCC), grading of squamous cell carcinoma (SCC), localization and dimensions of the tumor. The study sample consisted of 387 cases. BCC was the most common cancer and its nodular type was the most frequent. In older patients, the vertical dimension of excised carcinoma was significantly larger. Moreover, this connection was detected only in women compared to men. There were statistically significant differences between dimensions of the skin cancer and sex. In men group, skin cancers had statistically higher vertical dimensions and larger surface areas. On the face and head, BCC more often localizes in the nasal area, while SCC on the auricle. It has been demonstrated that the older the patient, the larger the vertical dimension of the tumor. As such, tumor size is larger in men than in women, as women usually see their physicians sooner than men: cosmetic concerns are more important to them.

scholarly journals Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression

Cancers ◽  
2021 ◽  
Vol 13 (17) ◽  
pp. 4362
Author(s):  
Alessandra Pecora ◽  
Justine Laprise ◽  
Manel Dahmene ◽  
Mélanie Laurin
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Cancer Biology ◽  
Rho Gtpase ◽  
Signaling Networks ◽  
Molecular Events ◽  
Skin Cancers ◽  
Cancer Initiation ◽  
Cytoskeletal Dynamics ◽  
Genetic Perturbations

Skin cancers are the most common cancers worldwide. Among them, melanoma, basal cell carcinoma of the skin and cutaneous squamous cell carcinoma are the three major subtypes. These cancers are characterized by different genetic perturbations even though they are similarly caused by a lifelong exposure to the sun. The main oncogenic drivers of skin cancer initiation have been known for a while, yet it remains unclear what are the molecular events that mediate their oncogenic functions and that contribute to their progression. Moreover, patients with aggressive skin cancers have been known to develop resistance to currently available treatment, which is urging us to identify new therapeutic opportunities based on a better understanding of skin cancer biology. More recently, the contribution of cytoskeletal dynamics and Rho GTPase signaling networks to the progression of skin cancers has been highlighted by several studies. In this review, we underline the various perturbations in the activity and regulation of Rho GTPase network components that contribute to skin cancer development, and we explore the emerging therapeutic opportunities that are surfacing from these studies.

Surgical Management of Melanoma and Other Skin Cancers

2015 ◽  
Author(s):  
Jennifer A. Wargo ◽  
Kenneth Tenabe
Keyword(s):  
Lymph Node ◽  
Surgical Treatment ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Stage Iv ◽  
Stage Iii ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Stage Iv Melanoma ◽  
Melanoma Skin

The prevalence of malignant skin cancers has increased significantly over the past several years. Approximately 1.2 million cases of non-melanoma skin cancer are diagnosed per year. More alarming, up to 80,000 cases of melanoma are diagnosed per year, an incidence that has been steadily increasing, with a lifetime risk of 1 in 50 for the development of melanoma. The disturbing increase in the incidence of both non-melanoma skin cancer and melanoma can largely be attributed to the social attitude toward sun exposure. The clinical assessment and management of skin lesions can be challenging. This review describes the assessment process, including thorough history and examination; the need for possible biopsy; and excision criteria. Specific types of skin cancer are distinguished and include basal cell carcinoma; squamous cell carcinoma; and melanoma; and for each type the incidence; epidemiology; histologic subtypes; diagnosis; and both surgical and non-surgical treatments are provided. Stages I-IV of melanoma are detailed, with prognostic factors described. Surgical treatment for stages I and II include description of the margins of excision and sentinel lymph node biopsy. The surgical treatment of Stage III melanoma further includes therapeutic lymph node dissection and isolated limb perfusion. Adjuvant therapies are also presented and include radiotherapy and chemotherapy. The additional treatment of metastasectomy for Stage IV melanoma is described. For both Stage III and IV melanoma, the study of vaccines to host immune cells is reported. For Stage IV melanoma, the text also describes immunotherapy treatment. Operative procedures specific to superficial and deep groin dissections are outlined. This review contains 9 figures, 3 tables, and 96 references.

scholarly journals Expression profiles of proton-sensing G-protein coupled receptors in common skin tumors

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Wybke Klatt ◽  
Susanne Wallner ◽  
Christoph Brochhausen ◽  
Judith A. Stolwijk ◽  
Stephan Schreml
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Skin Tumors ◽  
Solid Cancer ◽  
Tissue Samples ◽  
Skin Cancers ◽  
Common Skin

Abstract The proton-sensing GPCRs (pH-GPCRs) GPR4 (GPR19), TDAG8 (GPR65, T-cell death associated gene 8), OGR1 (GPR68, ovarian cancer GPCR1), and G2A (GPR132, G2 accumulation protein) are involved in sensing and transducing changes in extracellular pH (pHe). Extracellular acidification is a central hallmark of solid cancer. pH-GPCR function has been associated with cancer cell proliferation, adhesion, migration and metastasis, as well as with modulation of the immune system. Little is known about the expression levels and role of pH-GPCRs in skin cancer. To better understand the functions of pH-GPCRs in skin cancer in vivo, we examined the expression-profiles of GPR4, TDAG8, OGR1 and G2A in four common skin tumors, i.e. squamous cell carcinoma (SCC), malignant melanoma (MM), compound nevus cell nevi (NCN), basal cell carcinoma (BCC). We performed immunohistochemistry and immunofluorescence staining on paraffin-embedded tissue samples acquired from patients suffering from SCC, MM, NCN or BCC. We show the expression of pH-GPCRs in four common skin cancers. Different expression patterns in the investigated skin cancer types indicate that the different pH-GPCRs may have distinct functions in tumor progression and serve as novel therapeutic targets.

scholarly journals Racial Differences in the Incidence of Colorectal Cancer

2010 ◽  
Vol 24 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Rukinder Virk ◽  
Sharlene Gill ◽  
Eric Yoshida ◽  
Simon Radley ◽  
Baljinder Salh
Keyword(s):  
Colorectal Cancer ◽  
British Columbia ◽  
Racial Differences ◽  
South Asian ◽  
Saturated Fat ◽  
Incidence Rates ◽  
Colorectal Cancers ◽  
Canadian Population ◽  
Cancer Agency ◽  
Different Populations

BACKGROUND: Colon cancer is one of the most common cancers and the second most common cause of cancer mortality in Western societies. Population screening has been introduced as a means to reducing its impact; however, there are little or no data on the incidence of this disorder in the different populations that comprise the Canadian population.OBJECTIVE: To retrospectively determine the incidence of colorectal cancer in selected racial populations of British Columbia.METHODS: The British Columbia Cancer Agency database was used to retrieve information on the incidence of cancers occurring during the years 1994 to 1998, with the British Columbia and national population censuses used to derive the age-specific and age-standardized incidence rates of colorectal cancers. Surnames were used to identify the origin of individuals from South Asian and Chinese backgrounds.RESULTS: For the Caucasian Canadian (C) population, the weighted age-standardized incidence rate ranged from 51.99 per 100,000 in 1995, to 57.68 per 100,000 in 1998. For Chinese Canadians (CC), the range was 39.2 per 100,000 in 1996, to 31.2 per 100,000 in 1998. For South Asian Canadians (SAC), the range was 7.40 per 100,000 in 1994, to 24.85 per 100,000 in 1998. The RR for the development of cancer were significantly different when comparing C versus CC (RR 1.9; 95% CI 1.58 to 2.31; P<0.001), C versus SAC (RR 7.1; 95% CI 4.20 to 12.0; P<0.0001) and CC versus SAC (RR 3.7; 95% CI 2.14 to 6.5; P<0.0001).CONCLUSIONS: Significant differences in the incidence of colorectal cancers have been defined for the first time in various racial subgroups in British Columbia. This finding may have important implications for both screening and understanding of the environmental factors influencing the biology of these lesions. Because SAC have among the highest incidence of atherosclerotic heart disease and diabetes, it suggests that unidentified genetic and/or environmental protective factors are capable of countering the traditionally recognized risk of high saturated fat intake for the development of colorectal cancer.

scholarly journals Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series of 10 Cases

2017 ◽  
Vol 9 (3) ◽  
pp. 211-216 ◽  
Author(s):  
Virginia Garofalo ◽  
Alessandra Ventura ◽  
Sara Mazzilli ◽  
Laura Diluvio ◽  
Luca Bianchi ◽  
...  
Keyword(s):  
High Risk ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Medical Device ◽  
Actinic Keratosis ◽  
Organ Transplant ◽  
Cyclooxygenase Inhibitors ◽  
Organ Transplant Recipient ◽  
Skin Cancers ◽  
Melanoma Skin

Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk of recurrence of skin lesions in AK and non-melanoma skin cancer patients. Activation of cyclooxygenase 1 and 2 enzymes plays an important role in the pathogenesis of skin cancers. Topical application of cyclooxygenase inhibitors such as diclofenac and, more recently, piroxicam has shown to reduce AK lesions in immunocompetent subjects. A medical device containing piroxicam and SPF 50+ sunscreen filters (P+SS) has been demonstrated to be effective in reducing AK lesions and improving the field of cancerization. We report the effect of P+SS, applied for 16 weeks, in a case series of 10 OTR subjects with multiple AK lesions. P+SS treatment was associated with a relevant AK lesion reduction (>75%) in 7 patients (with a complete clearance in 3 subjects) with an improvement in the field of cancerization. This medical device could be considered a promising long-term curative and preventive treatment in OTR patients at high risk of non-melanoma skin cancers.

scholarly journals Nonmelanoma skin cancer in the population of the city of Belgrade in the period 1999-2011

2015 ◽  
Vol 143 (5-6) ◽  
pp. 290-295 ◽  
Author(s):  
Goran Videnovic ◽  
Dragan Miljus ◽  
Danijela Ilic ◽  
Dragan Krasic ◽  
Snezana Zivkovic
Keyword(s):  
Skin Cancer ◽  
Incidence Rate ◽  
Squamous Cell ◽  
Basal Cell ◽  
Nonmelanoma Skin Cancer ◽  
Skin Carcinoma ◽  
Skin Cancers ◽  
Nonmelanoma Skin Cancers ◽  
The City ◽  
Squamous Cell Skin Carcinoma

Introduction. Nonmelanoma skin cancers in the literature are mainly related to basal cell and squamous cell skin carcinoma. Objective. The aim of the study was to determine the trend in the incidence of histological types of nonmelanoma skin cancers in the population of the city of Belgrade from 1999 to 2011. Methods. From the Serbian National Cancer Registry we extracted all recorded cases of skin cancer in Belgrade from January 1st 1999 to December 31st 2011. Incidence rates were standardized by the method of direct standardization with the world population as the standard population. Trends and annual percentage change (APC) of incidence rate were calculated by performing joinpoint regression analyses. Results. Incidence rate of nonmelanoma skin cancer showed significantly increasing trend between 1999 and 2006 with APC of 8.6% (95% CI: 5.6-11.7), basal cell carcinoma increased with APC of 8.4% (95% CI: 5.2-11.6) and squamous cell skin carcinoma with APC of 9.33% (95% CI: 5.7-13.1). The incidence increased with age for both men and women, especially after the age of 60. Conclusion. Our results showed a continuously increasing incidence trend of both basal cell and squamous cell skin carcinomas in the population of the city of Belgrade between 1999 and 2011. Adequate primary and secondary prevention would certainly be successful in reducing this type of cancer in the future.

scholarly journals Development of Two Types of Skin Cancer in a Patient with Systemic Sclerosis: a Case Report and Overview of the Literature

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Firdevs Ulutaş ◽  
Erdem Çomut ◽  
Veli Çobankara
Keyword(s):  
Systemic Sclerosis ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Case Reports ◽  
Pulmonary Function Tests ◽  
Case Series ◽  
Skin Neoplasms ◽  
Skin Cancers ◽  
Nonspecific Interstitial Pneumonia ◽  
Diffuse Cutaneous Systemic Sclerosis

Systemic sclerosis (SSc) is an uncommon rheumatic disease in which the underlying main histopathologic feature is a thickening of the skin due to excessive accumulation of collagen in the extracellular tissue. Fibrogenesis, chronic inflammation, and ulceration may eventually promote skin neoplasms. Although nonmelanoma skin cancer (NMSC) is the most frequent type, there have been restricted case reports and case series with skin cancers in SSc patients in the literature. Herein, we describe a 78-year-old woman diagnosed with diffuse cutaneous systemic sclerosis thirteen years ago and associated nonspecific interstitial pneumonia that was successfully treated with high cumulative doses of cyclophosphamide. She developed basal cell carcinoma and squamous cell carcinoma of the skin in the follow-up. She is still on rituximab treatment with stable interstitial lung disease as indicated by pulmonary function tests and high-resolution chest computed tomography. To our knowledge and a literature search, this is the first reported patient with SSc with two types of skin cancer. In this review, we also aimed to emphasize the relationship between SSc and skin cancer, and possible risk factors for SSc-related skin cancer.

scholarly journals Bladder Cancer in Lebanon

2018 ◽  
Vol 25 (1) ◽  
pp. 107327481878935 ◽  
Author(s):  
Najla A. Lakkis ◽  
Salim M. Adib ◽  
Ghassan N. Hamadeh ◽  
Rana T. El-Jarrah ◽  
Mona H. Osman
Keyword(s):  
Risk Factors ◽  
Bladder Cancer ◽  
Skin Cancer ◽  
Incidence Rate ◽  
Age Groups ◽  
Incidence Rates ◽  
Newly Diagnosed ◽  
Occupational Risk Factors ◽  
The Third ◽  
Common Cancer

Lebanon has one of the highest estimated age-standardized incidence rate (ASR(w)) of bladder cancer (BC) worldwide. The aim of this study is to analyze the incidence rates for BC in Lebanon over a period of 7 years and to compare them to the rates in other countries. Data were obtained from the Lebanese National Cancer Registry for the currently available years 2005 to 2011. The calculated ASR(w) and age-specific rates were expressed as per 100 000 population. From 2005 to 2011, BC has been ranked as the third most common cancer in Lebanon. It accounted for 9.0% of all newly diagnosed cancer cases excluding nonmelanoma skin cancer. It ranked second in males and ninth in females. The average ASR(w) over this period was 31.2 in men and 7.3 in women. These incidence rates are among the highest worldwide across all age groups in both sexes. This study shows that the incidence of BC in Lebanon is high and it is among the highest worldwide. It is important to reduce the risk of BC through tobacco control and by decreasing exposure to avoidable environmental and occupational risk factors.

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