scholarly journals Botanical Agents for the Treatment of Nonmelanoma Skin Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jillian W. Millsop ◽  
Raja K. Sivamani ◽  
Nasim Fazel
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
The United States ◽  
Nonmelanoma Skin Cancer ◽  
Surgical Removal ◽  
Chemopreventive Agents ◽  
Treatment And Prevention ◽  
Skin Cancers ◽  
United States Standard ◽  
Nonmelanoma Skin Cancers

Nonmelanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma, are common neoplasms worldwide and are the most common cancers in the United States. Standard therapy for cutaneous neoplasms typically involves surgical removal. However, there is increasing interest in the use of topical alternatives for the prevention and treatment of nonmelanoma skin cancer, particularly superficial variants. Botanicals are compounds derived from herbs, spices, stems, roots, and other substances of plant origin and may be used in the form of dried or fresh plants, extracted plant material, or specific plant-derived chemicals. They possess multiple properties including antioxidant, anti-inflammatory, and immunomodulatory properties and are, therefore, believed to be possible chemopreventive agents or substances that may suppress or reverse the process of carcinogenesis. Here, we provide a review of botanical agents studied for the treatment and prevention of nonmelanoma skin cancers.

Dermatology

2016 ◽  
pp. 297-314
Author(s):  
Carilyn N. Wieland
Keyword(s):  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
The United States ◽  
Non Hodgkin Lymphoma ◽  
Exposed Skin ◽  
Skin Cancers ◽  
Clinical Presentations ◽  
History Of ◽  
Nonmelanoma Skin Cancers

Nonmelanoma skin cancers (basal cell carcinoma, squamous cell carcinoma) are the most common malignancies in the United States. Both basal cell and squamous cell carcinomas commonly occur on sun-exposed skin areas. The strongest risk factors for melanoma are a family history of melanoma, multiple benign or atypical nevi, and a previous melanoma. Cutaneous T-cell lymphoma is a non-Hodgkin lymphoma characterized by expansion of malignant T cells within the skin. The most common clinical presentations are mycosis fungoides and Sézary syndrome.

scholarly journals Nonmelanoma skin cancer in the population of the city of Belgrade in the period 1999-2011

2015 ◽  
Vol 143 (5-6) ◽  
pp. 290-295 ◽  
Author(s):  
Goran Videnovic ◽  
Dragan Miljus ◽  
Danijela Ilic ◽  
Dragan Krasic ◽  
Snezana Zivkovic
Keyword(s):  
Skin Cancer ◽  
Incidence Rate ◽  
Squamous Cell ◽  
Basal Cell ◽  
Nonmelanoma Skin Cancer ◽  
Skin Carcinoma ◽  
Skin Cancers ◽  
Nonmelanoma Skin Cancers ◽  
The City ◽  
Squamous Cell Skin Carcinoma

Introduction. Nonmelanoma skin cancers in the literature are mainly related to basal cell and squamous cell skin carcinoma. Objective. The aim of the study was to determine the trend in the incidence of histological types of nonmelanoma skin cancers in the population of the city of Belgrade from 1999 to 2011. Methods. From the Serbian National Cancer Registry we extracted all recorded cases of skin cancer in Belgrade from January 1st 1999 to December 31st 2011. Incidence rates were standardized by the method of direct standardization with the world population as the standard population. Trends and annual percentage change (APC) of incidence rate were calculated by performing joinpoint regression analyses. Results. Incidence rate of nonmelanoma skin cancer showed significantly increasing trend between 1999 and 2006 with APC of 8.6% (95% CI: 5.6-11.7), basal cell carcinoma increased with APC of 8.4% (95% CI: 5.2-11.6) and squamous cell skin carcinoma with APC of 9.33% (95% CI: 5.7-13.1). The incidence increased with age for both men and women, especially after the age of 60. Conclusion. Our results showed a continuously increasing incidence trend of both basal cell and squamous cell skin carcinomas in the population of the city of Belgrade between 1999 and 2011. Adequate primary and secondary prevention would certainly be successful in reducing this type of cancer in the future.

scholarly journals Nonmelanoma Facial Skin Cancer: A Review of Diagnostic Strategies, Surgical Treatment, and Reconstructive Techniques

2019 ◽  
Vol 12 ◽  
pp. 117955061986527 ◽  
Author(s):  
Ido Badash ◽  
Orr Shauly ◽  
Christopher G Lui ◽  
Daniel J Gould ◽  
Ketan M Patel
Keyword(s):  
Surgical Treatment ◽  
Skin Cancer ◽  
Treatment Options ◽  
The United States ◽  
Diagnostic Strategies ◽  
Skin Cancers ◽  
The Face ◽  
Nonmelanoma Skin Cancers ◽  
Frequent Exposure ◽  
Reconstructive Techniques

Nonmelanoma skin cancer is the most common form of cancer in the United States, and the face is a common area for skin cancer development due to its frequent exposure to the sun. This article focuses on the surgical management of facial nonmelanoma skin cancers, including diagnostic considerations, biopsy techniques, and staging. In addition, we discuss surgical treatment options, including indications, techniques, outcomes, and facial reconstruction following tumor excision.

scholarly journals Use of Tanning Beds and Incidence of Skin Cancer

2012 ◽  
Vol 30 (14) ◽  
pp. 1588-1593 ◽  
Author(s):  
Mingfeng Zhang ◽  
Abrar A. Qureshi ◽  
Alan C. Geller ◽  
Lindsay Frazier ◽  
David J. Hunter ◽  
...  
Keyword(s):  
High School ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Dose Response ◽  
The United States ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Tanning Beds ◽  
Skin Cancers ◽  
Tanning Bed

PurposeWe sought to evaluate the risk effect of tanning bed use on skin cancers among teenage and young adults. We also expected to determine whether a dose-response relationship was evident.Patients and MethodsWe observed 73,494 female nurses for 20 years (from 1989 to 2009) in a large and well-characterized cohort in the United States and investigated whether frequency of tanning bed use during high school/college and at ages 25 to 35 years were associated with a risk of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. We used Cox proportional hazards models and carefully adjusted for host risk factors, ultraviolet index of residence, and sun exposure behaviors at a young age.ResultsDuring follow-up, 5,506 nurses were diagnosed with BCC, 403 with SCC, and 349 with melanoma. The multivariable-adjusted hazard ratio (HR) of skin cancer for an incremental increase in use of tanning beds of four times per year during both periods was 1.15 (95% CI, 1.11 to 1.19; P < .001) for BCC, 1.15 (95% CI, 1.01 to 1.31; P = .03) for SCC, and 1.11 (95% CI, 0.97 to 1.27; P = .13) for melanoma. Compared with tanning bed use at ages 25 to 35 years, we found a significantly higher risk of BCC for use during high school/college (multivariable-adjusted HR for use more than six times per year compared with no use was 1.73 during high school/college v 1.28 at ages 25 to 35 years; P for heterogeneity < .001).ConclusionOur data provide evidence for a dose-response relationship between tanning bed use and the risk of skin cancers, especially BCC, and the association is stronger for patients with a younger age at exposure.

Presurgical Curettage Improves Accuracy for Nonmelanoma Skin Cancer Excision

2019 ◽  
Vol 23 (6) ◽  
pp. 617-623
Author(s):  
Matthew J. Lin ◽  
Danielle P. Dubin ◽  
Cerrene N. Giordano ◽  
Hooman Khorasani ◽  
David A. Kriegel
Keyword(s):  
Skin Cancer ◽  
Frozen Section ◽  
Normal Skin ◽  
Surgical Margin ◽  
Nonmelanoma Skin Cancer ◽  
Skin Cancers ◽  
Frozen Section Analysis ◽  
Skin Cancer Surgery ◽  
Nonmelanoma Skin Cancers ◽  
Section Analysis

Background Presurgical curettage before nonmelanoma skin cancer surgery may help delineate tumor subclinical extensions. Objective To determine histologically whether presurgical curettage appropriately or inappropriately changes excision specimen size. Materials and Methods One hundred fifty consecutive nonmelanoma skin cancers treated with Mohs micrographic surgery. The clinical margin (CM) was marked. Presurgical curettage was then performed and the resultant presurgical curettage margin (PCM) marked. Frozen section analysis of the CM and PCM revealed whether the curettage-induced margin change was appropriate or unnecessary. Results Presurgical curettage appropriately increased the surgical margin in 9.3% of cases, reducing the number of Mohs stages from 2 to 1. It appropriately decreased the surgical margin in 17.3% thereby conserving normal skin. In 19.4% of cases the curettage increased the margin in situations where the CM had underestimated the size of the tumor; however, in these cases, the curettage did not increase the margin sufficiently to clear the tumor. In 44.0% of cases the PCM did not change the size of the stage I specimen compared to the CM and confirmed the CM. In 10.0% of cases, preoperative curettage reduced margin accuracy by removing healthy tissue (8.0%) or underestimating tumor (2.0%). These errors were associated with eyelid location, severe background photodamage, and morpheiform/infiltrating/sclerosing basal cell carcinomas. Conclusion Presurgical curettage can improve tumor excision accuracy and efficiency. Careful tumor selection is important to optimize curette utility.

Incidence of Nonmelanoma Skin Cancer in New Brunswick, Canada, 1992 to 2001

2007 ◽  
Vol 11 (2) ◽  
pp. 45-52 ◽  
Author(s):  
Robert C. Hayes ◽  
Suzanne Leonfellner ◽  
Wilfred Pilgrim ◽  
Jian Liu ◽  
Douglas N. Keeling
Keyword(s):  
Skin Cancer ◽  
New Brunswick ◽  
Cell Carcinoma ◽  
Cancer Registry ◽  
Descriptive Analysis ◽  
The United States ◽  
Incidence Rates ◽  
Nonmelanoma Skin Cancer ◽  
Annual Number ◽  
World Standard

Background:Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), collectively referred to as nonmelanoma skin cancer (NMSC), cause significant morbidity and generate a substantial cost to the health care system. Canadian data on the incidence of NMSC are lacking.Objective:To study the incidence and characteristics of NMSC in New Brunswick, Canada (population 729,498 people in 2001), by using the Provincial Cancer Registry.Method:Data were obtained from 1992 to 2001 from the New Brunswick Provincial Cancer Registry, to which reporting of all cancers is mandatory. Multiple tumors of a given histologic type are recorded only once in the registry per individual per lifetime. A descriptive analysis of incidence rates of BCC and invasive SCC of the skin was performed in relation to gender, age, and anatomic location. The main outcome measures were the age- and sex-specific incidence rates of BCC and SCC. Age standardization was performed using the Canadian, US, and world standard populations.Results:When adjusted to the world standard population, the age-standardized incidence rates (ASIRs) per 100,000 population for BCC from 1992 through 2001 were 87 for males and 68 for females. For invasive SCC, the ASIRs per 100,000 population were 34 for males and 16 for females. There was an increasing incidence trend for both BCC and invasive SCC over the 10-year study period, with minimal change in the incidence of SCC in women. The overall ratio of BCC to invasive SCC in the population was 2.8 to 1. The approximate lifetime probabilities of developing BCC and invasive SCC were 13% and 5%, respectively.Conclusions:The incidence of NMSC in the province of New Brunswick is similar to that reported from 1973 through 1987 in the province of British Columbia, higher than those reported in most parts of Europe, and lower than all published rates in the United States and Australia. Owing to the inability of the registry to account for tumor multiplicity, the actual annual number of all NMSC lesions in this population is likely much higher.

Novel Nanolipoidal Systems for the Management of Skin Cancer

2020 ◽  
Vol 14 (2) ◽  
pp. 108-125
Author(s):  
Apoorva Singh ◽  
Nimisha
Keyword(s):  
Skin Cancer ◽  
Survival Rates ◽  
Cancer Therapeutics ◽  
The Body ◽  
Surgical Removal ◽  
The Novel ◽  
Skin Cancers ◽  
Recent Developments ◽  
Abnormal Cells ◽  
The Stability

: Skin cancer, among the various kinds of cancers, is a type that emerges from skin due to the growth of abnormal cells. These cells are capable of spreading and invading the other parts of the body. The occurrence of non-melanoma and melanoma, which are the major types of skin cancers, has increased over the past decades. Exposure to ultraviolet radiations (UV) is the main associative cause of skin cancer. UV exposure can inactivate tumor suppressor genes while activating various oncogenes. The conventional techniques like surgical removal, chemotherapy and radiation therapy lack the potential for targeting cancer cells and harm the normal cells. However, the novel therapeutics show promising improvements in the effectiveness of treatment, survival rates and better quality of life for patients. Different methodologies are involved in the skin cancer therapeutics for delivering the active ingredients to the target sites. Nano carriers are very efficient as they have the ability to improve the stability of drugs and further enhance their penetration into the tumor cells. The recent developments and research in nanotechnology have entitled several targeting and therapeutic agents to be incorporated into nanoparticles for an enhancive treatment of skin cancer. To protect the research works in the field of nanolipoidal systems various patents have been introduced. Some of the patents acknowledge responsive liposomes for specific targeting, nanocarriers for the delivery or co-delivery of chemotherapeutics, nucleic acids as well as photosensitizers. Further recent patents on the novel delivery systems have also been included here.

scholarly journals Systemic Photoprotection in Skin Cancer Prevention: Knowledge among Dermatologists

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 332
Author(s):  
Luca Fania ◽  
Francesca Sampogna ◽  
Francesco Ricci ◽  
Mariafrancesca Hyeraci ◽  
Andrea Paradisi ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Sampling Procedure ◽  
Skin Cancer Prevention ◽  
Snowball Sampling ◽  
Scientific Publications ◽  
Current State ◽  
Skin Cancers ◽  
Knowledge And Attitude ◽  
Nonmelanoma Skin Cancers

Background: Systemic photoprotection (i.e., administration of substances such as nicotinamide, carotenoids, and vitamin D) may be important to reduce photocarcinogenesis or to support long-term protection against UV irradiation. Clinical trials showed that oral nicotinamide is effective in reducing the onset of new nonmelanoma skin cancers (NMSCs), while other oral photoprotectors failed to achieve the reduction of new melanoma or NMSC formation in humans. The aim of this study was to summarize the current state of knowledge of systemic photoprotection and to evaluate the knowledge and attitude of dermatologists regarding these treatments. Methods: The survey was conducted on a sample of dermatologists recruited according to a snowball sampling procedure. The questionnaire consisted of a first part asking for characteristics of the participant and a second part with 12 specific questions on their knowledge about systemic photoprotection, particularly their knowledge of astaxanthin, β-carotene, nicotinamide, and vitamin D3. Results: One hundred eight dermatologists answered the survey. Most of them (85.2%) stated that oral photoprotectors have a role in the prevention of skin cancer, and responses mainly mentioned nicotinamide. More than half of them (54.6%) had prescribed all the considered oral photoprotectors, but the majority of them had prescribed nicotinamide, mainly for 2 to 3 months during summer, almost invariably (n = 106) associated with topical photoprotectors. Most dermatologists (>80%) were aware of scientific publications demonstrating an effect of systemic photoprotectors on NMSC. Conclusions: Most Italian dermatologists have positive views on oral photoprotection in skin cancer and are aware of the demonstrated potential of nicotinamide in the prevention of NMSCs.

scholarly journals Detailed head localization and incidence of skin cancers

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marta Fijałkowska ◽  
Mateusz Koziej ◽  
Bogusław Antoszewski
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
Vertical Dimension ◽  
Surgical Department ◽  
Surface Areas ◽  
Common Cancer ◽  
Skin Cancers ◽  
Sex Type ◽  
Cancer Subtype ◽  
The Face

AbstractSkin cancers are the most common neoplasms; frequently, they localize on the face. The aim of paper is to present the incidence of skin tumors in a single center from 2017 to 2019, describe trends in its frequency and find relations between neoplasms and sex, type of cancer, and its size. An analysis of histopathological files from the surgical department between 2017 and 2019 was calculated. These items were selected: sex, age, type of skin cancer, subtype of basal cell carcinoma (BCC), grading of squamous cell carcinoma (SCC), localization and dimensions of the tumor. The study sample consisted of 387 cases. BCC was the most common cancer and its nodular type was the most frequent. In older patients, the vertical dimension of excised carcinoma was significantly larger. Moreover, this connection was detected only in women compared to men. There were statistically significant differences between dimensions of the skin cancer and sex. In men group, skin cancers had statistically higher vertical dimensions and larger surface areas. On the face and head, BCC more often localizes in the nasal area, while SCC on the auricle. It has been demonstrated that the older the patient, the larger the vertical dimension of the tumor. As such, tumor size is larger in men than in women, as women usually see their physicians sooner than men: cosmetic concerns are more important to them.

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