scholarly journals An In Vivo 3D Micro-CT Evaluation of Tooth Movement After the Application of Different Force Magnitudes in Rat Molar

2009 ◽  
Vol 79 (4) ◽  
pp. 703-714 ◽  
Author(s):  
Carmen Gonzales ◽  
Hitoshi Hotokezaka ◽  
Yoshinori Arai ◽  
Tadashi Ninomiya ◽  
Junya Tominaga ◽  
...  
Keyword(s):  
Tooth Movement ◽  
Three Dimensional ◽  
Element Model ◽  
Longitudinal Change ◽  
Micro Ct ◽  
Linear Measurements ◽  
Center Of Rotation ◽  
Ct Evaluation ◽  
Space Width

Abstract Objective: To investigate the precise longitudinal change in the periodontal ligament (PDL) space width and three-dimensional tooth movement with continuous-force magnitudes in living rats. Materials and Methods: Using nickel-titanium closed-coil springs for 28 days, 10-, 25-, 50-, and 100-g mesial force was applied to the maxillary left first molars. Micro-CT was taken in the same rat at 0, 1, 2, 3, 10, 14, and 28 days. The width of the PDL was measured in the pressure and tension sides from 0 to 3 days. Angular and linear measurements were used to evaluate molar position at day 0, 10, 14, and 28. The finite element model (FEM) was constructed to evaluate the initial stress distribution, molar displacement, and center of rotation of the molar. Results: The initial evaluation of PDL width showed no statistical differences among different force magnitudes. Tooth movement was registered 1 hour after force application and gradually increased with time. From day 10, greater tooth movement was observed when 10 g of force was applied. The FEM showed that the center of rotation in the molar is located in the center of five roots at the apical third of the molar roots. Conclusion: The rat's molar movement mainly consists of mesial tipping, extrusion of distal roots, intrusion of mesial root, palatal inclination, and mesial rotation. Although the initial tooth movement after the application of different force magnitudes until day 3 was not remarkably different, 10 g of force produced more tooth movement compared with heavier forces at day 28.

Investigation of Vibration Characteristics of the Ligamentous Lumbar Spine Using the Finite Element Approach

1994 ◽  
Vol 116 (4) ◽  
pp. 377-383 ◽  
Author(s):  
Vijay K. Goel ◽  
Hosang Park ◽  
Weizeng Kong
Keyword(s):  
Finite Element ◽  
Resonant Frequency ◽  
Cyclic Load ◽  
Static Load ◽  
Three Dimensional ◽  
Element Model ◽  
Upper Body ◽  
Experimental Investigations ◽  
Flexion Extension

A nonlinear, three-dimensional finite element model of the ligamentous L4-SI segment was developed to analyze the dynamic response of the spine in the absence of damping. The effects of the upper body mass were simulated by including a mass of 40 kg on the L4 vertebral body. The modal analyses of the model indicated a resonant frequency of 17.5 Hz in axial mode and 3.8 Hz in flexion-extension mode. Accordingly, the predicted responses for the cyclic load of −400 ± 40 N applied at four different frequencies (5, 11, 16.5, and 25 Hz) were compared with the corresponding results for axial compressive static loads (−360, and −440 N). As compared to the static load cases, the predicted responses were higher for the cyclic loading. For example, the effect of cyclic load at 11 Hz was to produce significant changes (9.7 – 19.0 percent) in stresses, loads transmitted through the facets, intradiscal pressure (IDP), disk bulge, as compared to the static load predictions. The responses were found to be frequency dependent as well; supporting the in vivo observations of other investigators that the human spine has a resonant frequency. For example, the 11 Hz model (DYN11) compared to the DYN5 model showed an increase in majority of the predicted parameters. The parameters showed an increase with frequency until 17.5 Hz (resonant frequency of the model); thereafter a decrease at 25 Hz. A chronic change in these parameters, especially at the resonant frequency, beyond the “base” values may trigger the bone remodeling process leading to spinal degeneration/disorders associated with chronic vibration exposure. Future directions for extending the present model as a complement to the experimental investigations are also discussed.

scholarly journals THE INFERENCE OF THE CHANGES OF AXONAL TRANSPORT OF OPTIC NERVE BY DEFORMATIONS OF LAMINA CRIBROSA

2020 ◽  
Vol 20 (10) ◽  
pp. 2040027
Author(s):  
YUSHU LIU ◽  
LIPING MA ◽  
WEI GAO ◽  
ZHICHENG LIU ◽  
SHOUXIN WANG ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Axonal Transport ◽  
Laser Scanning ◽  
Saline Water ◽  
Compressive Strain ◽  
Three Dimensional ◽  
Element Model ◽  
Lamina Cribrosa ◽  
Confocal Laser

Understanding the relationship between the changes in the axonal transport of the optic nerve (ON) and lamina cribrosa (LC) deformation will be helpful to estimate the degree of axonal transport block by measuring the LC deformation in vivo. First, the changes in the axonal transport of the ON were studied using an acute high intraocular pressure (IOP) model, which was established by perfusing saline water into the anterior chamber of cats. The IOP of cat was unilaterally elevated to and maintained at 30, 40, and 50[Formula: see text]mmHg. The axonal transport of the ON was examined by confocal laser scanning microscope. Then the deformations and stress distributions of the LC and ON were calculated using a three-dimensional finite element model of the LC microstructure including ON. The results showed axonal transport changes of ON increased with elevation of the IOPs. While Young’s modulus of the LC and ON were assumed as 0.1[Formula: see text]MPa and 0.03[Formula: see text]MPa, the numerical simulation results showed that LC had displacements of 0.02, 0.03, and 0.04[Formula: see text]mm backward at the IOPs of 30, 40, and 50[Formula: see text]mmHg, respectively. The calculated compressive strain applied to the ON were 0.0425, 0.0567, and 0.0709 under 30, 40, and 50[Formula: see text]mmHg IOP, respectively. The results of strain and stress analysis of LC and ON showed that the deformation of LC would compress the ON. The axonal transport abnormalities could be inferred by measuring the LC deformation in vivo.

scholarly journals PEG-modified gadolinium nanoparticles as contrast agents for in vivo micro-CT

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Charmainne Cruje ◽  
P. Joy Dunmore-Buyze ◽  
Eric Grolman ◽  
David W. Holdsworth ◽  
Elizabeth R. Gillies ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Blood Pool ◽  
Micro Ct ◽  
Micro Computed Tomography ◽  
Poly Ethylene

AbstractVascular research is largely performed in rodents with the goal of developing treatments for human disease. Micro-computed tomography (micro-CT) provides non-destructive three-dimensional imaging that can be used to study the vasculature of rodents. However, to distinguish vasculature from other soft tissues, long-circulating contrast agents are required. In this study, we demonstrated that poly(ethylene glycol) (PEG)-coated gadolinium nanoparticles can be used as a vascular contrast agent in micro-CT. The coated particles could be lyophilized and then redispersed in an aqueous solution to achieve 100 mg/mL of gadolinium. After an intravenous injection of the contrast agent into mice, micro-CT scans showed blood pool contrast enhancements of at least 200 HU for 30 min. Imaging and quantitative analysis of gadolinium in tissues showed the presence of contrast agent in clearance organs including the liver and spleen and very low amounts in other organs. In vitro cell culture experiments, subcutaneous injections, and analysis of mouse body weight suggested that the agents exhibited low toxicity. Histological analysis of tissues 5 days after injection of the contrast agent showed cytotoxicity in the spleen, but no abnormalities were observed in the liver, lungs, kidneys, and bladder.

Effects of corticopuncture (CP) and low-level laser therapy (LLLT) on the rate of tooth movement and root resorption in rats using micro-CT evaluation

2017 ◽  
Vol 33 (4) ◽  
pp. 811-821 ◽  
Author(s):  
Selly Sayuri Suzuki ◽  
Aguinaldo Silva Garcez ◽  
Patricia Oblitas Reese ◽  
Hideo Suzuki ◽  
Martha Simões Ribeiro ◽  
...  
Keyword(s):  
Laser Therapy ◽  
Tooth Movement ◽  
Root Resorption ◽  
Low Level Laser Therapy ◽  
Micro Ct ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Ct Evaluation

Right ventricular midwall surface motion and deformation using magnetic resonance tagging

1996 ◽  
Vol 271 (6) ◽  
pp. H2677-H2688 ◽  
Author(s):  
A. A. Young ◽  
Z. A. Fayad ◽  
L. Axel
Keyword(s):  
Magnetic Resonance ◽  
Right Ventricular ◽  
Mean Squared Error ◽  
Three Dimensional ◽  
Element Model ◽  
Right Ventricular Free Wall ◽  
Tissue Tagging ◽  
Magnetic Resonance Tagging ◽  
The Right

We describe a method for reconstructing the three-dimensional motion and deformation of the midwall surface of the right ventricular free wall (RVFW) using magnetic resonance tissue tagging. Tag points were defined where the tag stripes intersected the midwall contour and were tracked through systole in both short- and long-axis images. A finite-element model of the midwall surface of the RVFW was constructed to fit the midwall shape at end diastole. The model was then deformed to each subsequent frame by fitting the tag displacements and midwall contour locations. The method was applied to two human studies, a normal subject and a patient with right ventricular hypertrophy. The root mean squared error between model tag planes and tracked tag points was 0.70 mm for the normal heart (180 points) and 0.67 mm for the hypertrophic heart (52 points), both less than the image pixel size of approximately 1.0 mm. The differences in contraction patterns were visualized between the two studies. We conclude that this method allows accurate, noninvasive measurement of in vivo RVFW deformation.

scholarly journals A Novel Method to Quantify Longitudinal Orthodontic Bone Changes with In Vivo Micro-CT Data

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Chao Wang ◽  
Li Cao ◽  
Chongshi Yang ◽  
Yubo Fan
Keyword(s):  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Bone Modeling ◽  
Micro Ct ◽  
Sprague Dawley ◽  
Mineral Density ◽  
Bone Changes ◽  
Novel Method

Orthodontic tooth movement (OTM) is the result of region-specific bone modeling under a load. Quantification of this change in the alveolar bone around a tooth is a basic requirement to understand the mechanism of orthodontics. The purpose of this study was to quantify subregional alveolar bone changes during orthodontic tooth movement with a novel method. In this study, 12 Sprague-Dawley (SD) rats were used as an orthodontic model, and one side of the first upper molar was used to simulate OTM. The alveolar bone around the mesial root was reconstructed from in vivo micro-CT images and separated from other parts of the alveolar bone with two semicylinder filters. The amount and rate of OTM, bone mineral density (BMD), and bone volume (BV) around the root were calculated and compared at 5 time points. The results showed that the amount of tooth movement, BMD, and BV can be evaluated dynamically with this method. The molar moved fastest during the first 3 days, and the rate decreased after day 14. BMD decreased from day 0 to day 14 and returned from day 14 to day 28. BV deceased from day 0 to day 7 and from day 14 to day 28. The method created in this study can be used to accurately quantify dynamic alveolar bone changes during OTM.

The Finite Element Analysis of Stress in the Periodontal Ligament when Subject to Vertical Orthodontic Forces

1994 ◽  
Vol 21 (2) ◽  
pp. 161-167 ◽  
Author(s):  
A. N. Wilson ◽  
J. Middleton ◽  
M. L. Jones ◽  
N. J. McGuinness
Keyword(s):  
Finite Element ◽  
Periodontal Ligament ◽  
Tooth Movement ◽  
Root Resorption ◽  
Three Dimensional ◽  
Element Model ◽  
Vertical Movement ◽  
Optimum Level ◽  
Element Analysis ◽  
Three Dimensional Finite Element

In the past, vertical intrusive movement of teeth has been considered difficult and most routine clinical vertical movement of teeth has been confined to extrusion. It has been suggested that attempts at intrusion may result in an increased incidence of root resorption and also in occasional devitalization. The displacement and resulting stress fields associated with such treatment can be successfully studied using the finite element method. In the case being considered initial movements are known to be small; therefore, the assumption in the study that the material behaves linear-elastically is considered to be reasonable. This study of vertical tooth movement demonstrated that the maximum cervical margin stress in the periodontal ligament was 0·0046 N/mm2, whilst the highest apical stress was 0·00205 N/mm2 when intrusive and extrusive forces of 1 Newton were applied to the buccal surface of the crown of a tooth model. These stresses were evaluated in the light of previous studies and found to be within the suggested clinical optimum level. However, the periodontal stress distribution following orthodontic loading within this three-dimensional finite element model was found to be highly complex.

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