scholarly journals Costs of the Metabolic Syndrome in Elderly Individuals: Findings from the Cardiovascular Health Study

Diabetes Care ◽  
2007 ◽  
Vol 30 (10) ◽  
pp. 2553-2558 ◽  
Author(s):  
L. H. Curtis ◽  
B. G. Hammill ◽  
M. A. Bethel ◽  
K. J. Anstrom ◽  
J. S. Gottdiener ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Elderly Individuals ◽  
The Metabolic Syndrome

scholarly journals OB2 THE COST OF THE METABOLIC SYNDROME IN THE ELDERLY: FINDINGS FROM THE CARDIOVASCULAR HEALTH STUDY

2007 ◽  
Vol 10 (3) ◽  
pp. A19
Author(s):  
LH Curtis ◽  
BG Hammill ◽  
MA Bethel ◽  
KJ Anstrom ◽  
JS Gottdiener ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
The Metabolic Syndrome ◽  
The Cost

Abstract 1957: The Carboxyterminal Telopeptide of Procollagen type I and Procollagen type III Aminoterminal Peptide (PIIINP) are Strong Predictors of Cardiovascular Morbidity and Mortality in the Elderly; The Cardiovascular Health Study

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Eddy Barasch ◽  
John S Gottdiener
Keyword(s):  
Prognostic Value ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Type I ◽  
Elderly Individuals ◽  
Procollagen Type ◽  
Procollagen Type I ◽  
Cv Disease ◽  
Carboxyterminal Telopeptide

Background: The fibrillar myocardial extracellular matrix is mainly composed of type I and III fibrillar collagen and their turnover are reflected in the serum level of carboxyl-terminal propeptide type I (PIP) and procollagen type III aminoterminal peptide (PIIINP). The prognostic value of these biomarkers in elderly individuals with heart failure (HF) or other cardiovascular disease (CVD) and in healthy subjects is largely unknown. Aim: To determine the predictive value of PIP, its degradation metabolite, carboxyterminal telopeptide of procollagen type I (CTIP), and PIIINP serum level for the incident CV morbidity and mortality in a nested case control study of community-dwelling elderly individuals enrolled in the Cardiovascular Health Study (CHS). Methods: In 880 participants (ppts) enrolled in the CHS (mean age 77 ± 6 yrs, 52 % males, 79 % white), 310 with HF, 287 controls (no HF but other CVD) and 283 healthy ppts, serum levels of PIIINP, PIP and CTIP were measured by radioimmunoassay. The number of incident CV disease and death were recorded. Wilcoxon rank sum test, Kruskal-Wallis test, and Cox proportional hazards regression were used as appropriate. Results: Age, gender and race and fully adjusted analyses are presented in the table : Conclusions: In this large elderly cohort, there is a strong association between CTIP, PIIINP and incident CVD and death. Elevated CTIP level increases the risk of death more than 50% and of symptomatic PVD by almost two-fold. Whereas PIIINP has a lower predictive power than CTIP, PIP was not associated with incident CVD or death. Serum CTIP and PIIINP have a good prognostic value for both incident CVD and death in elderly individuals with or without known CV disease.

scholarly journals Correlates of aortic stiffness in elderly individuals: a subgroup of the cardiovascular health study

2002 ◽  
Vol 15 (1) ◽  
pp. 16-23 ◽  
Author(s):  
R. H. Mackey ◽  
K. Sutton-Tyrrell ◽  
P. V. Vaitkevicius ◽  
P. A. Sakkinen ◽  
M. F. Lyles ◽  
...  
Keyword(s):  
Aortic Stiffness ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Elderly Individuals

Abstract 1198: The Relation Between Age and Serum Markers of Collagen Turnover in Healthy Elderly Individuals; The Cardiovascular Health Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Eddy Barasch ◽  
John S Gottdiener ◽  
Jing Han ◽  
Gerard P Aurigemma ◽  
Dalane W Kitzman ◽  
...  
Keyword(s):  
Cardiovascular Health ◽  
Collagen Type ◽  
Collagen Type I ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Type I ◽  
Entire Study ◽  
Elderly Individuals ◽  
Carboxyl Terminal

Background: Significant changes in the cardiac anatomy, morphology and function occur with aging. Increased collagen deposition in the myocardial matrix has been associated with prevalent heart failure (HF) in the elderly. The relation between age with serum level of procollagen type III aminoterminal peptide-PIIINP-, carboxyl-terminal propeptide type I -PIP-, reflecting collagen synthesis, and carboxyl-terminal telopeptide of collagen type I -CITP-marker of collagen type I degradation, is largely unknown in healthy free-living elderly individuals. Aim: To determine the relation between age with serum biomarkers of fibrosis (SBF) in a large group of community-dwelling elderly individuals. Methods: In 880 participants (ppts), mean age 77 ± 6 yrs, 52 % males, 79 % white, enrolled in the Cardiovascular Health Study, serum levels of PIIINP, PIP and CITP were measured; 179 had HF with normal LVEF (DHF), 131 had HF with LVEF < 55% (SHF), 287 controls (no HF), and 283 healthy ppts. Kruskal-Wallis test, one-way ANOVA, chi-square test and Spearman correlation were performed as appropriate. Results: SFB values and the main demographic variables are displayed in the table . The association between age with the 3 SBF for the entire study population were: PIP: r = 0.13 (p <0.0001), CITP: r = 0.13, p < 0.0001, PIIINP: r = 0.04, p = 0.20. For the individuals groups, the associations were: PIP with DHF (r = 0.25, p=0.001), CITP with DHF (r = 0.15, p =0.05), controls (r= 0.27, p < 0.0001) and healthy control groups (r = 0.19, p = 0.001). PIIINP was associated with age only in the control group (r = 0.12, p = 0.04). No association was found between age and SBF in the SHF group.

Metabolic Syndrome and Cardiovascular Disease in Older People: The Cardiovascular Health Study

2006 ◽  
Vol 54 (9) ◽  
pp. 1317-1324 ◽  
Author(s):  
Ann Marie McNeill ◽  
Ronit Katz ◽  
Cynthia J. Girman ◽  
Wayne D. Rosamond ◽  
Lynne E. Wagenknecht ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Older People ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study
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