Impact of Etanercept on Vitamin D Status and Vitamin D-binding Protein in Bio-naïve Patients with Psoriasis

High levels of serum vitamin D-binding protein have been shown previously in patients with psoriasis compared with healthy controls; a possible role in inflammation is implied. The primary objective of this study was to investigate the impact of 24-week etanercept treatment on vitamin D status and vitamin D-binding protein in patients with psoriasis. The secondary aim was to explore whether pre-treatment vitamin D levels could predict the treatment effect. A prospective observational study was performed, including 20 patients with psoriasis and 15 controls. Serum samples i.a. were analysed for vitamin D metabolites, vitamin D-binding protein and highly sensitive C-reactive protein. Baseline levels of vitamin D-binding protein were higher in patients with self-reported arthropathy than in those without. After 24 weeks’ treatment, an improvement in psoriasis was noted, as was a decrease in highly sensitive C-reactive protein. Vitamin D-binding protein decreased in those with self-reported arthropathy. Higher baseline levels of vitamin D were associated with partly faster and greater improvement in psoriasis. Vitamin D-binding protein may have an inflammatory biomarker role.

Download Full-text

Alteration of Serum 25(OH) Vitamin D, Vitamin D Binding Protein, and C-reactive Protein Levels in Acute Leukemia Patients

Clinical Laboratory ◽

10.7754/clin.lab.2018.180412 ◽

2018 ◽

Vol 64 (09/2018) ◽

Cited By ~ 1

Author(s):

Liejun Jiang ◽

Xiaomei Zhang ◽

Yanyun Chen ◽

Xiaocong Huo ◽

Shuang Deng ◽

...

Keyword(s):

Vitamin D ◽

Acute Leukemia ◽

Binding Protein ◽

Vitamin D Binding Protein ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

25 Oh Vitamin D

Download Full-text

Circulating vitamin D binding protein levels are not associated with relapses or with vitamin D status in multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458513500552 ◽

2013 ◽

Vol 20 (4) ◽

pp. 433-437 ◽

Cited By ~ 17

Author(s):

Joost Smolders ◽

Evelyn Peelen ◽

Mariëlle Thewissen ◽

Paul Menheere ◽

Jan Damoiseaux ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Binding Protein ◽

High Dose ◽

Vitamin D Metabolites ◽

Vitamin D Status ◽

Vitamin D Binding Protein ◽

Vitamin D Metabolism ◽

Physiological Range ◽

High Dose Vitamin

Background: A low vitamin D status has been associated with multiple sclerosis (MS). Most circulating vitamin D metabolites are bound to vitamin D binding protein (DBP). Objectives: The purpose of this study was to explore whether there is an association between MS and DBP. Methods: We compared DBP concentrations in blood samples of controls ( n = 30) and subjects with relapsing–remitting MS (RRMS) during remission ( n = 29) and relapse ( n = 15). Furthermore, we explored correlations of DBP with 25- hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D levels (1,25(OH)2D), and the effect of high-dose vitamin D3 supplementation on DBP levels in RRMS patients ( n = 15). Results: DBP-concentration did not differ between the sub-groups measured, and there was no correlation between DBP and vitamin D metabolite concentration within the physiological range. Upon supplementation of high doses vitamin D3, DBP concentration remained unaltered. After supplementation, serum 1,25(OH)2D( R = 0.517, p = 0.049), but not 25(OH)D, correlated positively with DBP. Conclusions: We found no association between DBP, MS, and vitamin D status within the physiological range. After high - dose vitamin D supplementation, DBP concentrations may be relevant for vitamin D metabolism.

Download Full-text

Distribution and Determinants of Vitamin D-Binding Protein, Total, “Non-Bioavailable”, Bioavailable, and Free 25-Hydroxyvitamin D Concentrations among Older Adults

Nutrients ◽

10.3390/nu13113982 ◽

2021 ◽

Vol 13 (11) ◽

pp. 3982

Author(s):

Anna Zhu ◽

Sabine Kuznia ◽

Tobias Niedermaier ◽

Bernd Holleczek ◽

Ben Schöttker ◽

...

Keyword(s):

Older Adults ◽

Vitamin D ◽

Health Outcomes ◽

Binding Protein ◽

Vitamin D Status ◽

Linear Regression Models ◽

Vitamin D Binding Protein ◽

Hydroxyvitamin D ◽

Reactive Protein ◽

25 Hydroxyvitamin D

Background: serum 25-hydroxyvitamin D (25(OH)D) (“total 25 OH(D)”) is the most commonly used indicator of vitamin D status. However, 25(OH)D is mostly bound to the vitamin D binding protein (VDBP) or albumin in blood, and it has been suggested that the remaining bioavailable or free 25(OH)D may be more relevant for vitamin D associated health outcomes. We aimed to explore distributions and determinants of VDBP, total, bioavailable, complementary “non-bioavailable”, and free 25(OH)D in a large cohort of older adults in Germany. Methods: total 25(OH)D, VDBP, and albumin concentrations were measured in blood samples of 5899 men and women aged 50–75 years and used to calculate bioavailable (and complementary “non-bioavailable”) and free 25(OH)D concentrations. Linear regression models were used to evaluate associations of potential determinants of the various vitamin D biomarkers. Results: mean concentrations of VDBP, total, non-bioavailable, bioavailable, and free 25(OH)D were 323.6 µg/mL, 49.8 nmol/L, 43.4 nmol/L, 2.5 ng/mL, and 5.7 pg/mL, respectively. Seasonal variations were observed for all markers, with peak values in spring for VDBP and in summer for total, non-bioavailable, bioavailable, and free 25(OH)D. Consistent inverse associations were seen with age and body mass index for all markers, but divergent associations were seen with C-reactive protein. Strong variations by VDBP genotypes were seen for bioavailable and free 25(OH)D, and, in opposite direction for non-bioavailable 25(OH)D. Conclusion: commonalities and differences in determinants of various markers of vitamin D status were observed, which may help to enable a better understanding of their potential role for various vitamin D related health outcomes.

Download Full-text

Measuring Vitamin D Status in Chronic Inflammatory Disorders: How does Chronic Inflammation Affect the Reliability of Vitamin D Metabolites in Patients with IBD?

Journal of Clinical Medicine ◽

10.3390/jcm9020547 ◽

2020 ◽

Vol 9 (2) ◽

pp. 547 ◽

Cited By ~ 2

Author(s):

Aysegül Aksan ◽

Dilem Tugal ◽

Nathalena Hein ◽

Katharina Boettger ◽

Yurani Caicedo-Zea ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Vitamin D ◽

Negative Correlation ◽

Bowel Disease ◽

Binding Protein ◽

Fecal Calprotectin ◽

Vitamin D Metabolites ◽

Vitamin D Status ◽

Vitamin D Binding Protein ◽

Inflammatory Bowel

Evidence gained from recent studies has generated increasing interest in the role of vitamin D in extraskeletal functions such as inflammation and immunoregulation. Although vitamin D deficiency has been implicated in the pathophysiology of inflammatory diseases including inflammatory bowel disease (IBD), evidence as to whether vitamin D supplementation may cure or prevent chronic disease is inconsistent. Since 25OH-vitamin D (25OHD) has been suggested to be an acute-phase protein, its utility as a vitamin D status marker is therefore questionable. In this study, possible interactions of vitamin D and inflammation were studied in 188 patients with IBD, with high-sensitivity C-reactive protein (hsCRP) levels ≥ 5 mg/dL and/or fecal calprotectin ≥ 250 µg/g defined as biochemical evidence of inflammatory activity. Levels of 25OHD and vitamin D-binding protein (VDBP) were determined by ELISA, and 1,25-dihydroxyvitamin D (1,25OHD) and dihydroxycholecalciferol (24,25OHD) by LC-MS/MS. Free and bioavailable vitamin D levels were calculated with the validated formula of Bikle. Serum 1,25OH2D and vitamin D binding protein (VDBP) levels were shown to differ between the inflammatory and noninflammatory groups: patients with inflammatory disease activity had significantly higher serum concentrations of 1,25OH2D (35.0 (16.4–67.3) vs. 18.5 (1.2–51.0) pg/mL, p < 0.001) and VDBP (351.2 (252.2–530.6) vs. 330.8 (183.5–560.3) mg/dL, p < 0.05) than patients without active inflammation. Serum 24,25OH2D levels were negatively correlated with erythrocyte sedimentation rate (ESR) (−0.155, p = 0.049) while concentrations of serum 1,25OH2D correlated positively with hsCRP (0.157, p = 0.036). Correlations with serum VDBP levels were found for ESR (0.150, p = 0.049), transferrin (0.160, p = 0.037) and hsCRP (0.261, p < 0.001). Levels of serum free and bioavailable 25OHD showed a negative correlation with ESR (−0.165, p = 0.031, −0.205, p < 0.001, respectively) and hsCRP (−0.164, p = 0.032, −0.208, p < 0.001 respectively), and a moderate negative correlation with fecal calprotectin (−0.377, p = 0.028, −0.409, p < 0.016, respectively). Serum total 25OHD concentration was the only vitamin D parameter found to have no specific correlation with any of the inflammatory markers. According to these results, the traditional parameter, total 25OHD, still appears to be the best marker of vitamin D status in patients with inflammatory bowel disease regardless of the presence of inflammation.

Download Full-text

Calcium-Regulating Hormones and Minerals From Birth to 18 Months of Age: A Cross-Sectional Study. I. Effects of Sex, Race, Age, Season, and Diet on Vitamin D Status

PEDIATRICS ◽

10.1542/peds.77.6.883 ◽

1986 ◽

Vol 77 (6) ◽

pp. 883-890

Author(s):

P. Lichtenstein ◽

B. L. Specker ◽

R. C. Tsang ◽

F. Mimouni ◽

C. Gormley

Keyword(s):

Vitamin D ◽

Human Milk ◽

Binding Protein ◽

Vitamin D Metabolites ◽

Vitamin D Status ◽

Vitamin D Binding Protein ◽

Hydroxyvitamin D ◽

Dihydroxyvitamin D ◽

1,25 Dihydroxyvitamin D ◽

25 Hydroxyvitamin D

The influence of sex, race, age, season, and diet (cow's milk formula v human milk) on the vitamin D and vitamin D-binding protein status in infants less than 18 months of age was investigated in this crosssectional, prospective study of 198 infants. No differences by sex were observed in serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D, or vitamin D-binding protein concentrations. By race, black infants had significantly elevated serum 1,25-dihydroxyvitamin D levels relative to white infants. By age, vitamin D-binding protein concentrations increased with increasing age. By season, serum 25-hydroxyvitamin D concentrations were low in winter, whereas 1,25-dihydroxyvitamin D and vitamin D-binding protein were high in winter compared with summer. By diet, formula-fed infants had higher serum concentrations of all measured vitamin D metabolites and vitamin D-binding protein than human milk-fed infants. Thus, race, age, season, and diet exert, individually or in combination, different and significant effects on vitamin D metabolites; these should be considered in assessing infant vitamin D status.

Download Full-text

Faculty Opinions recommendation of Vitamin D-binding protein and vitamin D status of black Americans and white Americans.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718183980.793487526 ◽

2013 ◽

Author(s):

Joyce Popoola

Keyword(s):

Vitamin D ◽

Binding Protein ◽

Black Americans ◽

White Americans ◽

Vitamin D Status ◽

Vitamin D Binding Protein

Download Full-text

Vitamin D-binding protein: multifunctional component of blood serum

Annals of the Russian academy of medical sciences ◽

10.15690/vramn1396 ◽

2021 ◽

Vol 76 (1) ◽

pp. 103-110

Author(s):

Alexandra A. Povaliaeva ◽

Ekaterina A. Pigarova ◽

Anastasia A. Romanova ◽

Larisa K. Dzeranova ◽

Artem Y. Zhukov ◽

...

Keyword(s):

Vitamin D ◽

Binding Sites ◽

Binding Protein ◽

Vitamin D Metabolites ◽

Biological Functions ◽

Vitamin D Binding Protein ◽

Fatty Acid Binding ◽

Physiological Properties ◽

Steroid Binding ◽

Tumor Pathogenesis

Vitamin D-binding protein (DBP) was discovered more than half a century ago as a polymorphic serum protein and is currently characterized by a variety of physiological properties. First of all, DBP carries the bulk of vitamin D metabolites circulating in the bloodstream, while albumin is the second most important transport protein, especially in patients with a low concentration of DBP in serum. Since it was discovered that only 12% of the total circulating DBP have occupied steroid binding sites, a vigorous study of other potential biological roles of DBP was initiated: actin utilization, regulation of inflammation and innate immunity mechanisms, fatty acid binding, effects on bone metabolism and participation in the tumor pathogenesis. This review focuses on the main known biological functions of DBP.

Download Full-text

Response in Vitamin D Status after Vitamin D3Supplements in Relation to Vitamin D Binding Protein Genotype

10.1210/endo-meetings.2011.part2.p26.p2-113 ◽

2011 ◽

pp. P2-113-P2-113

Author(s):

Sunee Saetung ◽

Hataikarnn Nimitphong ◽

Suwannee Chanprasertyothin ◽

La-or Chailurkit ◽

Boonsong Ongphiphadhanakul

Keyword(s):

Vitamin D ◽

Binding Protein ◽

Vitamin D Status ◽

Vitamin D Binding Protein ◽

Protein Genotype

Download Full-text

Investigating the Role of Functional Polymorphism of Maternal and Neonatal Vitamin D Binding Protein in the Context of 25-Hydroxyvitamin D Cutoffs as Determinants of Maternal-Neonatal Vitamin D Status Profiles in a Sunny Mediterranean Region

Nutrients ◽

10.3390/nu13093082 ◽

2021 ◽

Vol 13 (9) ◽

pp. 3082

Author(s):

Spyridon N. Karras ◽

Erdinç Dursun ◽

Merve Alaylıoğlu ◽

Duygu Gezen-Ak ◽

Cedric Annweiler ◽

...

Keyword(s):

Vitamin D ◽

Mediterranean Region ◽

Binding Protein ◽

Hypovitaminosis D ◽

Vitamin D Status ◽

Vitamin D Binding Protein ◽

Hydroxyvitamin D ◽

High Prevalence ◽

25 Hydroxyvitamin D ◽

Causative Effect

Recent results indicate that dysregulation of vitamin D-binding protein (VDBP) could be involved in the development of hypovitaminosis D, and it comprises a risk factor for adverse fetal, maternal and neonatal outcomes. Until recently, there was a paucity of results regarding the effect of maternal and neonatal VDBP polymorphisms on vitamin D status during pregnancy in the Mediterranean region, with a high prevalence of hypovitaminosis D. We aimed to evaluate the combined effect of maternal and neonatal VDBP polymorphisms and different maternal and neonatal 25-hydroxyvitamin D (25(OH)D) cut-offs on maternal and neonatal vitamin D profile. Blood samples were obtained from a cohort of 66 mother–child pairs at birth. Our results revealed that: (i) Maternal VDBP polymorphisms do not affect neonatal vitamin D status at birth, in any given internationally adopted maternal or neonatal cut-off for 25(OH)D concentrations; (ii) neonatal VDBP polymorphisms are not implicated in the regulation of neonatal vitamin D status at birth; (iii) comparing the distributions of maternal VDBP polymorphisms and maternal 25(OH)D concentrations, with cut-offs at birth, revealed that mothers with a CC genotype for rs2298850 and a CC genotype for rs4588 tended to demonstrate higher 25(OH)D (≥75 nmol/L) during delivery (p = 0.05 and p = 0.04, respectively), after adjustments for biofactors that affect vitamin D equilibrium, including UVB, BMI and weeks of gestation. In conclusion, this study from Southern Europe indicates that maternal and neonatal VDBP polymorphisms do not affect neonatal vitamin D status at birth, whereas mothers with CC genotype for rs2298850 and CC genotype for rs4588 demonstrate higher 25(OH)D concentrations. Future larger studies are required to establish a causative effect of these specific polymorphisms in the attainment of an adequate (≥75 nmol/L) maternal vitamin D status during pregnancy.

Download Full-text