scholarly journals Oral Administration of Zolpidem Tartrate in an Abuse-deterrent Formulation Versus an Immediate Release Formulation in Beagle Dogs

2021 ◽  
pp. 1-6
Author(s):  
Amina Vazda ◽  
Wei Xia ◽  
Håkan Engqvist
Keyword(s):  
Controlled Release ◽  
Oral Administration ◽  
Chemical Properties ◽  
Immediate Release ◽  
Prescription Drug Abuse ◽  
Pharmacokinetic Analysis ◽  
Beagle Dogs ◽  
Release Formulation ◽  
Physical And Chemical ◽  
Plasma Profile

Objective: The continuing rise of prescription drug abuse has greatly necessitated the development of an abuse-deterrent formulation. Geopolymers are a promising base for drug design as they allow for tuneable drug release and possess superior physical and chemical properties compared with conventional pharmaceutical excipients.Methods: Geopolymer pellets containing zolpidem tartrate were administrated orally to beagle dogs as a controlled-release formulation with the commercial immediate-release product, Stilnoct® tablets, as the control.Results: The administration of zolpidem tartrate as immediate-release tablets demonstrated an elevated immediate release plasma profile and the zolpidem tartrate in the geopolymers demonstrated a controlled-release plasma profile. The pharmacokinetic analysis demonstrated that immediate-release tablet administration generated much higher plasma concentration when compared with geopolymer pellets administration for zolpidem tartrate. On the other hand, the geopolymer formulation prolonged the time of drug release.Conclusion: Oral administration of zolpidem tartrate in geopolymer pellets demonstrated a controlled-release plasma profile.

scholarly journals Preparation andIn Vitro/In VivoEvaluation of Vinpocetine Elementary Osmotic Pump System

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Meiying Ning ◽  
Yue Zhou ◽  
Guojun Chen ◽  
Xingguo Mei
Keyword(s):  
Citric Acid ◽  
Controlled Release ◽  
Elimination Rate ◽  
Immediate Release ◽  
Osmotic Pump ◽  
Prolonged Release ◽  
Time Curve ◽  
Release Formulation ◽  
Pump System ◽  
Controlled Release Tablets

Preparation andin vitroandin vivoevaluation of vinpocetine (VIN) elementary osmotic pump (EOP) formulations were investigated. A method for the preparation of VIN elementary osmotic pump tablet was obtained by adding organic acid additives to increase VIN solubility. VIN was used as the active pharmaceutical ingredient, lactose and mannitol as osmotic agent. Citric acid was used as increasing API solubility and without resulting in the API degradation. It is found that the VIN release rate was increasing with the citric acid amount at a constant range. Cellulose acetate 398-3 was employed as semipermeable membrane containing polyethylene glycol 6000 and diethyl-o-phthalate as pore-forming agent and plasticizer for controlling membrane permeability. In addition, a clear difference between the pharmacokinetic patterns of VIN immediate release and VIN elementary osmotic pump formulations was revealed. The area under the plasma concentration-time curve after oral administration of elementary osmotic pump formulations was equivalent to VIN immediate release formulation. Furthermore, significant differences found for mean residence time, elimination half-life, and elimination rate constant values corroborated prolonged release of VIN from elementary osmotic pump formulations. These results suggest that the VIN osmotic pump controlled release tablets have marked controlled release characters and the VIN osmotic pump controlled release tablets and the normal tablets were bioequivalent.

Comparative Efficacy of a Once-Daily Controlled-Release Formulation of Glipizide and Immediate-Release Glipizide in Patients With NIDDM

Diabetes Care ◽  
1994 ◽  
Vol 17 (12) ◽  
pp. 1460-1464 ◽  
Author(s):  
M. Berelowitz ◽  
C. Fischette ◽  
W. Cefalu ◽  
D. S. Schade ◽  
T. Sutfin ◽  
...  
Keyword(s):  
Controlled Release ◽  
Immediate Release ◽  
Comparative Efficacy ◽  
Release Formulation ◽  
Once Daily ◽  
Controlled Release Formulation

Technologies in Bilayer Tablet Manufacturing: A Review

2021 ◽  
pp. 253-258
Author(s):  
Mayuri B. Patil ◽  
Priyanka M. Salve ◽  
Shital V. Sonawane ◽  
Avish D. Maru ◽  
Jayshree S. Bhadane ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Immediate Release ◽  
Successful Development ◽  
Release Formulation ◽  
The Past ◽  
Bilayer Tablet ◽  
Release Drug ◽  
Tablet Manufacturing ◽  
The Cost

Bilayer tablet is a recent time for the successful development of controlled release formulation along with various quality to provide a way of the successful drug delivery system. Over the past 30 years stated that the cost and complications involved in marketing new drug entities have increased, with consequent recognition of therapeutic advantages of controlled drug delivery, greater attention has been concentration on development of sustained or controlled release drug delivery systems. Bilayer tablet it is used in the different aspect for anti-inflammatory and analgesic. Bilayer tablet incidental release of two drugs in combination, separate two incompatible substance and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is enhancing beneficial technology to control the shortcoming of the single layered tablet. There is various application used in the bilayer tablets.

Mucoadhesive Pellets for Drug Delivery Applications: A Critical Review

2020 ◽  
Vol 8 (2) ◽  
pp. 153-167
Author(s):  
Inderbir Singh ◽  
Gayatri Devi ◽  
Bibhuti Ranjan Barik ◽  
Anju Sharma ◽  
Loveleen Kaur
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Chemical Properties ◽  
Immediate Release ◽  
Physical And Chemical Properties ◽  
Mucoadhesive Polymers ◽  
Mucoadhesive Polymer ◽  
Physical And Chemical ◽  
And Chemical Properties

Pellets are spherical shaped multiparticulate drug delivery systems with size ranging between 0.5-2.0 mm. Free flow, good mechanical properties, improved physical and chemical properties of powder, and stability are some advantages of pellets. Mucoadhesive pellets could be developed by using appropriate concentration and type of mucoadhesive polymer. Mucoadhesive pellets can be used for delivery of drugs to gastric, colonic, and vaginal regions. Immediate release, sustained/controlled release and implantable delivery could be incorporated using mucoadhesive pellets. Reproducibility, ease of scalability, quality control checks and significant mechanical strength are some advantages making pellets widely acceptable by pharmaceutical industry. In the present review, mucoadhesion process and theories, mucoadhesive polymers, pelletization process, evaluation of pellets and reported research/patents on mucoadhesive pellets for delivery of different categories of drugs have been presented.

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