scholarly journals Effects of Change PH on The Structural and Optical Properties of Iron Oxide Nanoparticles

2021 ◽  
Vol 32 (3) ◽  
pp. 58
Author(s):  
Raad S. Sabry ◽  
Muslim A. Abid ◽  
Sarah Q. Hussein
Keyword(s):  
Particle Size ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Sem Images ◽  
Stabilizing Agents ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
Different Shapes ◽  
Inhibition Zones

Iron oxide nanoparticles were made using celery extract by chemical method with change PH. Bio-materials in celery extract synthesized the iron oxide nanoparticles by reducing iron (III) chloride (FeCl3) and then acted as both capping and stabilizing agents. The iron oxide NPs were characterized by XRD, SEM, and UV–vis techniques. The change PH affected the size, shape, and purity of iron oxide NPs. XRD results showed Crystallite size increased from 16.71nm to 21.65nm as pH was increased from 1.6 to 12. SEM images showed that the particle size of (α-Fe2O3) NPs was around 40.06 nm, while increasing PH showed different shapes in the same sample.  The particle size became approximately 45.56 and 61.22 nm. UV–vis measurements showed the energy band increased from 3.11eV to 5.11eV. The antimicrobial activity of iron oxide NPs was determined by growth inhibition zones of the negative gram bacteria E. coli, Klebsiella spp, and gram-positive bacteria S. aureus, S. epidermidis, and fungal Candida albicans. The zones for (α-Fe2O3) NPs when PH 1.6 was between (12-13) mm. The zones for (α-Fe2O3) NPs when PH 12 was a little higher between (13-15) mm.

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies

2020 ◽  
Vol 13 ◽  
Author(s):  
Selin Yılmaz ◽  
Çiğdem İçhedef ◽  
Kadriye Buşra Karatay ◽  
Serap Teksöz
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Sem Images

Backgorund: Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used for targeted drug delivery systems due to their unique magnetic properties. Objective: In this study, it’s aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery system for Gemcitabine (GEM). Methods: Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA) together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc. SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid for surface modification. Size distribution and the morphology of the synthesized nanoparticles were caharacterized by dynamic light scattering(DLS)and scanning electron microscopy(SEM), respectively. Radiolabeling yield of SPION-PLGAGEM nanoparticles were determined via Thin Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells in vitro. Results: SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles were determined as 366.6 nm by DLS, while zeta potential was found as-29 mV. SPION was successfully coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA was calculated as 4±0.16 % by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM nanoparticles were determined as 97.8±1.75 % via TLRC. Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM showed high uptake on MCF-7, whilst incorporation rate was increased for both cell lines which external magnetic field application. Conclusion: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics.

Synthesis of iron oxide nanoparticles in a continuous flow spiral microreactor and Corning® advanced flow™ reactor

2018 ◽  
Vol 7 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Prashant L. Suryawanshi ◽  
Shirish H. Sonawane ◽  
Bharat A. Bhanvase ◽  
Muthupandian Ashokkumar ◽  
Makarand S. Pimplapure ◽  
...  
Keyword(s):  
Particle Size ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Continuous Flow ◽  
Xrd Analysis ◽  
Resonance Spectroscopy ◽  
Oxide Nanoparticles ◽  
Flow Rates ◽  
Nanometer Size Range ◽  
Co Precipitation

AbstractIn the present work, synthesis of iron oxide nanoparticles (NPs) using continuous flow microreactor (MR) and advanced flow™ reactor (AFR™) has been investigated with evaluation of the efficacy of the two types of MRs. Effect of the different operating parameters on the characteristics of the obtained NPs has also been investigated. The synthesis of iron oxide NPs was based on the co-precipitation and reduction reactions using iron (III) nitrate precursor and sodium hydroxide as reducing agents. The iron oxide NPs were characterized using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy, and X-ray diffraction (XRD) analysis. The mean particle size of the obtained NPs was less than 10 nm at all flow rates (over the range of 20−60 ml/h) in the case of spiral MR, while, in the case of AFR™, the particle size of NPs was below 20 nm with no specific trend observed with the operating flow rates. The XRD and TEM analyses of iron oxide NPs confirmed the crystalline nature and nanometer size range, respectively. Further, magnetic properties of the synthesized iron oxide NPs were studied using electron spin resonance spectroscopy; the resonance absorption peak shows theg-factor values as 2.055 and 2.034 corresponding to the magnetic fields of 319.28 and 322.59 mT for MR and AFR™, respectively.

Distinguishing magnetic particle size of iron oxide nanoparticles with first-order reversal curves

2014 ◽  
Vol 116 (12) ◽  
pp. 124304 ◽  
Author(s):  
Monika Kumari ◽  
Marc Widdrat ◽  
Éva Tompa ◽  
Rene Uebe ◽  
Dirk Schüler ◽  
...  
Keyword(s):  
Particle Size ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Particle ◽  
Oxide Nanoparticles ◽  
First Order

Superparamagnetic Iron Oxide Nanoparticles for Magnetic Hipertermia: Synthesis, Surface Modification by Polyethylene Glycol and Characterization

2014 ◽  
Vol 802 ◽  
pp. 535-539 ◽  
Author(s):  
Fernanda A. Sampaio da Silva ◽  
Edwin E.G. Rojas ◽  
Sérgio Romero ◽  
Marcos Flávio de Campos
Keyword(s):  
Particle Size ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Magnetic Hyperthermia ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Biocompatible Polymer ◽  
Coprecipitation Process

Nowadays, superparamagnetic iron oxide nanoparticles are an important tool for cancer treatment, such as magnetic hyperthermia. The goal is heating diseased tissue and then tumor cells are destroyed. Magnetic nanoparticles are promising mainly because they have specific ability to reduce side effects. However, forin vivoapplications, nanoparticles need to be coated by a biocompatible material. In this work, nanoparticles are coated by PEG (biocompatible polymer). Samples were produced by coprecipitation process. Information about particle size, magnetic properties and crystallinity were obtained.

scholarly journals Droplet-based synthesis of homogeneous magnetic iron oxide nanoparticles

2018 ◽  
Vol 9 ◽  
pp. 2413-2420 ◽  
Author(s):  
Christian D Ahrberg ◽  
Ji Wook Choi ◽  
Bong Geun Chung
Keyword(s):  
Particle Size ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Size Distribution ◽  
Iron Oxide Nanoparticles ◽  
Residence Time ◽  
Medical Applications ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide

Nanoparticles have gained large interest in a number of different fields due to their unique properties. In medical applications, for example, magnetic nanoparticles can be used for targeting, imaging, magnetically induced thermotherapy, or for any combination of the three. However, it is still a challenge to obtain narrowly dispersed, reproducible particles through a typical lab-scale synthesis when researching these materials. Here, we present a droplet capillary reactor that can be used for the synthesis of magnetic iron oxide nanoparticles. Compared to conventional batch synthesis, the particles synthesized in our droplet reactor have a narrower size distribution and a higher reproducibility. Furthermore, we demonstrate how the particle size can be changed from 5.2 ± 0.9 nm to 11.8 ± 1.7 nm by changing the reaction temperature and droplet residence time in the droplet capillary reactor.

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