scholarly journals Typology of the human organism system adaptation

2017 ◽  
Vol 25 (3) ◽  
pp. 362-372 ◽  
Author(s):  
Yu. A. Shatyr ◽  
S. V. Bulatetsky ◽  
I. V. Ulesikova ◽  
I. G. Mulik ◽  
E. V. Nazarova
Keyword(s):  
Functional Properties ◽  
Stress Reactivity ◽  
Background Level ◽  
High Reactivity ◽  
Exercise Stress ◽  
Human Organism ◽  
Low Level ◽  
System Adaptation ◽  
Specific Reactivity ◽  
High Level

Transition to personalized medicine requires the systematization of possible scenarios of the human organism individual adaptation to exogenous shocks. Objective: To identify and typology sustainable adaptation options to extreme environmental factors, taking into account individual, genetically determined functional properties of the human organism. As the object of the study, 146 people of both sexes were involved, 18-23 years of age. The work was performed in accordance with Articles 5, 6 and 7 of "The Universal Declaration on Bioethics and Human Rights" with the informed consent registration. As a result of complex theoretical and experimental researches the typology of the human organism system adaptation to extreme exogenous influences is designed. At the same time, stable combinations of functional properties phenotypic manifestations for individuals with high, medium and low level of general non-specific reactivity are systematized. Revealed expressed specific manifestations of the variation pulsometry main indicators depending on the individual level of general non-specific reactivity of an organism, where the prevalence of the sympathetic component of the autonomic nervous system is characteristic for people with high reactivity level and parasympathetic – for individuals with a low reactivity level. It was determined that an emergency exercise stress in individuals with a high level of general non-specific reactivity is a risk factor for sympathicotonia that gives them increased stress reactivity. Taken studies have proved the feasibility of separation of three types of the adaptation process. 1. The syntoxic process, which is typical for low level of general non-specific reactivity. 2. An integrated process inherent to the medium level of reactivity. 3. Catatoxic process, which is typical for a high level of general non-specific reactivity of an organism. The proposed typology is based on the account: the background level of general non-specific reactivity; specificity and speed of adaptation development; vegetative balance; dynamics of nociceptive sensitivity; psycho-emotional state of a person. Using the developed typology allows to individualize an assessment, forecasting and correction of the functional organism state that will provide personalization of health-support a person in high ambient load.

scholarly journals New insights into genotype–phenotype correlation in individuals with different level of general non-specific reactivity of an organism

2016 ◽  
Vol 13 (4) ◽  
pp. 33-42 ◽  
Author(s):  
Alexander Mulik ◽  
Valery Novochadov ◽  
Alexander Bondarev ◽  
Sofya Lipnitskaya ◽  
Irina Ulesikova ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Genetic Basis ◽  
Pain Threshold ◽  
Molecular Mechanisms ◽  
Human Organism ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Specific Reactivity ◽  
High Level ◽  
Very High

Summary The objective of the study was to investigate the genetic basis of general non-specific reactivity of an organism. Systematic search in PubMedCentral, PDB, KEGG and SNP databases identified a set of genes and their polymorphisms that can determine pain sensitivity and therefore the level of general non-specific reactivity of the human organism. Six SNPs were selected for genotyping kit design; 230 healthy volunteers were enrolled in the study. It was revealed that very high pain threshold was associated with allele A in rs1851048 and allele C in rs6777055. High level of general non-specific reactivity of an organism was associated with allele G in rs2562456 (OR=1.804, CI=1.139-2.857, p=0.011) and allele C in rs6923492 (OR=1.582, CI=1.071-2.335, p=0.021). Low level of general non-specific reactivity of an organism was associated with allele T in rs6923492 (OR=0.351, CI=0.154-0.799, p=0.010). A set of genes and single-nucleotide polymorphisms associated with the pain sensitivity and indirectly with the level of general non-specific reactivity of human organism were determined. The identified correlations reveal some molecular mechanisms of general non-specific reactivity of an organism variability and can guide further research in this area.

SIGNIFICANCE OF THE HYPOTHERMIA LEVEL FOR NEUROPHYSIOLOGICAL REACTIONS OF HUMAN ORGANISM TO EXPERIMENTAL WHOLE-BODY COOLING

2020 ◽  
Vol 54 (5) ◽  
pp. 57-64
Author(s):  
D.B. Demin ◽  
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
External Auditory Meatus ◽  
Total Sample ◽  
Whole Body ◽  
Human Organism ◽  
Low Level ◽  
Body Cooling ◽  
Whole Body Cooling ◽  
High Level

Effects of hypothermia on the character of changes in central hemodynamics, heart rate variability (HRV) and EEG were studied during an experimental whole-body cooling of 30 healthy male subjects at the age of 18–20 years. The subjects were divided into 2 equal groups by the median body temperature in the total sample (34.1 °С) during cooling. The experiment consisted of 3 steps: rest at +20 °С, 10-min exposure to -20 °С in a hypothermal chamber and rewarming at +20 °С. The parameters registered at each step included EEG, blood pressure (BP), heart rate (HR) and temperature in the external auditory meatus. In the cooling chamber, body temperature lowered reliably by 1.4–3.1 °С on the average. In both groups hypothermia reduced the index of regulatory systems strain, increased total HRV power and BP, and decreased HR. During rewarming all these parameters tended to return to baseline values. Subjects with a more distinct hypothermia (33.1 °С) displayed a weakened baroreflex reaction (slight HR reduction) accompanied by a stronger vascular reaction (significant BP rise). High baroreflex stability in the subjects with low-level hypothermia (35 °С) was evidenced by a significant HR decrease in response to the BP rise. Changes in the EEG amplitude and frequency patterns during cooling declared themselves by enhancement of the subcortex regulatory activity (reliable rise in the theta-activity). Also, the alpha-activity was increased in the subjects with high-level hypothermia and decreased in 73 % of the subjects with a low-level hypothermia which points to desynchronization of the main rhythm.

scholarly journals Features of changes in physiological and psychophysiological indices, as well as of the physical efficiency of the heart, depending on the degree of neurotism in hypoxic conditions

2018 ◽  
Vol 20 (2) ◽  
pp. 16-20
Author(s):  
A A Blaginin ◽  
S N Sinelnikov ◽  
R A Dzankisov ◽  
V B Dergachev
Keyword(s):  
Heart Rate ◽  
Background Level ◽  
Low Level ◽  
Physiological Reaction ◽  
Hypoxic Conditions ◽  
Arterial Blood ◽  
Low Degree ◽  
High Level ◽  
High Degree ◽  
Different Levels

Features of hypoxia tolerability by persons with different levels of neurotism are presented. It was found that changes on physiological parameters such as heart rate, arterial pressure and saturation of arterial blood in persons with a high level of neurotism are more pronounced in conditions of hypoxia. In particular, to the 25-30th min. when they stay in altitude chamber, heart rate is enlarged by 38% (p0,01) from initial. The persons with the low level of a neyrotizm, the augmentation of heart rate doesn’t exceed 28% (p0,01). This compensatory physiological reaction helps maintain arterial blood saturation in people with high neurotism by 5,3% (p0,05) more, at people with a low degree of neurotism. However, at the same time at examinees with a high level of neurotism, in comparison with persons with the low level of a neyrotizm more expressed decrease of working capacity of a myocardium on 23,4%. In addition, in persons with a high degree of neurotism, there is a more pronounced negative dynamics of an increase in the time of a complex sensomotorny reaction to 41,57 ms (p0,05) from background level, while in persons with low neurotism only by 26,19 ms (p0,05). Thus, at assessment of an acceptability of a hypoxia, it is necessary to take into account the dependence of changes physiological and psychophysiological indicators and also physical effeciency of heart from degree neyrotizm.

Teknik Data Mining Dalam Clustering Produksi Susu Segar Di Indonesia Dengan Algoritma K-Means

2019 ◽  
Vol 1 (1) ◽  
pp. 31-39
Author(s):  
Ilham Safitra Damanik ◽  
Sundari Retno Andani ◽  
Dedi Sehendro
Keyword(s):  
Data Mining ◽  
Milk Production ◽  
Clustering Algorithm ◽  
Clustering Method ◽  
Data Mining Techniques ◽  
Low Level ◽  
Fresh Milk ◽  
Nutritional Needs ◽  
High Level ◽  
Level Cluster

Milk is an important intake to meet nutritional needs. Both consumed by children, and adults. Indonesia has many producers of fresh milk, but it is not sufficient for national milk needs. Data mining is a science in the field of computers that is widely used in research. one of the data mining techniques is Clustering. Clustering is a method by grouping data. The Clustering method will be more optimal if you use a lot of data. Data to be used are provincial data in Indonesia from 2000 to 2017 obtained from the Central Statistics Agency. The results of this study are in Clusters based on 2 milk-producing groups, namely high-dairy producers and low-milk producing regions. From 27 data on fresh milk production in Indonesia, two high-level provinces can be obtained, namely: West Java and East Java. And 25 others were added in 7 provinces which did not follow the calculation of the K-Means Clustering Algorithm, including in the low level cluster.

Determinants of Abuse of the Bodies of the Dead

2019 ◽  
pp. 71-77
Author(s):  
Margarita Khomyakova
Keyword(s):  
Low Income ◽  
Criminal Code ◽  
Value Judgments ◽  
Legal Norms ◽  
Low Level ◽  
Medical Institutions ◽  
Specific Object ◽  
The Subject ◽  
The Dead ◽  
High Level

The author analyzes definitions of the concepts of determinants of crime given by various scientists and offers her definition. In this study, determinants of crime are understood as a set of its causes, the circumstances that contribute committing them, as well as the dynamics of crime. It is noted that the Russian legislator in Article 244 of the Criminal Code defines the object of this criminal assault as public morality. Despite the use of evaluative concepts both in the disposition of this norm and in determining the specific object of a given crime, the position of criminologists is unequivocal: crimes of this kind are immoral and are in irreconcilable conflict with generally accepted moral and legal norms. In the paper, some views are considered with regard to making value judgments which could hardly apply to legal norms. According to the author, the reasons for abuse of the bodies of the dead include economic problems of the subject of a crime, a low level of culture and legal awareness; this list is not exhaustive. The main circumstances that contribute committing abuse of the bodies of the dead and their burial places are the following: low income and unemployment, low level of criminological prevention, poor maintenance and protection of medical institutions and cemeteries due to underperformance of state and municipal bodies. The list of circumstances is also open-ended. Due to some factors, including a high level of latency, it is not possible to reflect the dynamics of such crimes objectively. At the same time, identification of the determinants of abuse of the bodies of the dead will reduce the number of such crimes.

scholarly journals EXPRESS: Marketers Project Their Personal Preferences onto Consumers: Overcoming the Threat of Egocentric Decision Making

2021 ◽  
pp. 002224372199837
Author(s):  
Walter Herzog ◽  
Johannes D. Hattula ◽  
Darren W. Dahl
Keyword(s):  
Decision Making ◽  
Consumer Preferences ◽  
Research Question ◽  
Pilot Studies ◽  
Low Level ◽  
Marketing Managers ◽  
False Consensus Effect ◽  
False Consensus ◽  
High Level

This research explores how marketing managers can avoid the so-called false consensus effect—the egocentric tendency to project personal preferences onto consumers. Two pilot studies were conducted to provide evidence for the managerial importance of this research question and to explore how marketing managers attempt to avoid false consensus effects in practice. The results suggest that the debiasing tactic most frequently used by marketers is to suppress their personal preferences when predicting consumer preferences. Four subsequent studies show that, ironically, this debiasing tactic can backfire and increase managers’ susceptibility to the false consensus effect. Specifically, the results suggest that these backfire effects are most likely to occur for managers with a low level of preference certainty. In contrast, the results imply that preference suppression does not backfire but instead decreases false consensus effects for managers with a high level of preference certainty. Finally, the studies explore the mechanism behind these results and show how managers can ultimately avoid false consensus effects—regardless of their level of preference certainty and without risking backfire effects.

Exploring The Effect of Visual Information Degradation on Human Perception and Performance In A Human-Telerobot System

2020 ◽  
Vol 64 (1) ◽  
pp. 1302-1307
Author(s):  
Richard Stone ◽  
Minglu Wang ◽  
Thomas Schnieders ◽  
Esraa Abdelall
Keyword(s):  
Visual Information ◽  
Human Perception ◽  
Low Level ◽  
Hit Rate ◽  
Word Level ◽  
Level Of Automation ◽  
Significant Difference ◽  
Human Operators ◽  
And Performance ◽  
High Level

Human-robotic interaction system are increasingly becoming integrated into industrial, commercial and emergency service agencies. It is critical that human operators understand and trust automation when these systems support and even make important decisions. The following study focused on human-in-loop telerobotic system performing a reconnaissance operation. Twenty-four subjects were divided into groups based on level of automation (Low-Level Automation (LLA), and High-Level Automation (HLA)). Results indicated a significant difference between low and high word level of control in hit rate when permanent error occurred. In the LLA group, the type of error had a significant effect on the hit rate. In general, the high level of automation was better than the low level of automation, especially if it was more reliable, suggesting that subjects in the HLA group could rely on the automatic implementation to perform the task more effectively and more accurately.

scholarly journals The high-level benefits of low-level sandboxing

2020 ◽  
Vol 4 (POPL) ◽  
pp. 1-32 ◽  
Author(s):  
Michael Sammler ◽  
Deepak Garg ◽  
Derek Dreyer ◽  
Tadeusz Litak
Keyword(s):  
Low Level ◽  
High Level

Urban network of China from the perspective of population mobility: Three-dimensional co-occurrence of nodes and links

2021 ◽  
pp. 0308518X2199781
Author(s):  
Xinyue Luo ◽  
Mingxing Chen
Keyword(s):  
Three Dimensional ◽  
Geographical Distance ◽  
Two Dimensional ◽  
Population Mobility ◽  
Urban Network ◽  
Urban Networks ◽  
Low Level ◽  
Medium Level ◽  
High Level ◽  
External Connections

The nodes and links in urban networks are usually presented in a two-dimensional(2D) view. The co-occurrence of nodes and links can also be realized from a three-dimensional(3D) perspective to make the characteristics of urban network more intuitively revealed. Our result shows that the external connections of high-level cities are mainly affected by the level of cities(nodes) and less affected by geographical distance, while medium-level cities are affected by the interaction of the level of cities(nodes) and geographical distance. The external connections of low-level cities are greatly restricted by geographical distance.

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