scholarly journals Functional Constipation Frequency in Children Diagnosed with Autism Spectrum Disorder

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Çağatay Günay ◽  
Hasret Ayyildiz Civan ◽  
Semra Yılmaz
Keyword(s):  
Autism Spectrum Disorder ◽  
Adolescent Psychiatry ◽  
Functional Constipation ◽  
Child And Adolescent ◽  
Autism Spectrum ◽  
Child And Adolescent Psychiatry ◽  
Spectrum Disorder ◽  
The Other ◽  
Significant Difference ◽  
Severe Autism

 Aim: In our study, we aimed to determine the frequency of functional constipation in children diagnosed with autism spectrum disorders by child and adolescent psychiatry and mental health.Materials and Methods: Between September 2017 and September 2018, children with autism spectrum disorder who applied to BakırköySadiKonuk Education and Research Hospital Child and Adolescent Psychiatry Outpatient Clinic were evaluated by means of childhood autism rating scale (CARS). A total of 108 patients were evaluated with the Roman IV criteria and the frequency of functional constipation was investigated.Results: A total of 108 cases, 87% (n = 94) male and 13% (n = 14) female, were studied. The ages of the patients were between 2 and 15 years and the mean age was 6.89 ± 2.76. Organic constipation was not detected in patients with constipation and all of them were diagnosed as functional constipation. There was no statistically significant difference between the rates of functional constipation in cases according to gender. The incidence of functional constipation in males was significantly higher in patients with severe autism than in those with mild to moderate autism. “Two or fewer defecations in the toilet per week” criteria was found significantly higher in girls than in boys. No significant difference was found for the other five criteria according to gender. Each of the six criteria of the Rome IV criteria were found to be significantly higher in patients with severe autism than those with mild to moderate autism according to CARS scores. One of the Roman IV criteria, “History of large diameter stools that may obstruct the toilet” was found significantly higher in patients aged nine years and older. No significant correlation was found between the other criteria and age groups.Conclusion: All of the six criteria of the Roman IV criteria were significantly higher in cases with severe autism according to CARS, compared to those with mild to moderate autism.

scholarly journals Functional Constipation Frequency in Children Diagnosed with Autism Spectrum Disorder

Konselor ◽  
2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Çağatay Günay ◽  
Hasret Ayyıldız Civan ◽  
Semra Yılmaz ◽  
Didem Gülcü Taşkın
Keyword(s):  
Autism Spectrum Disorder ◽  
Adolescent Psychiatry ◽  
Functional Constipation ◽  
Child And Adolescent ◽  
Autism Spectrum ◽  
Child And Adolescent Psychiatry ◽  
Spectrum Disorder ◽  
The Other ◽  
Significant Difference ◽  
Severe Autism

Aim: In our study, we aimed to determine the frequency of functional constipation in children diagnosed with autism spectrum disorders by child and adolescent psychiatry and mental health.Materials and Methods: Between September 2017 and September 2018, children with autism spectrum disorder who applied to BakırköySadiKonuk Education and Research Hospital Child and Adolescent Psychiatry Outpatient Clinic were evaluated by means of childhood autism rating scale (CARS). A total of 108 patients were evaluated with the Roman IV criteria and the frequency of functional constipation was investigated.Results: A total of 108 cases, 87% (n = 94) male and 13% (n = 14) female, were studied. The ages of the patients were between 2 and 15 years and the mean age was 6.89 ± 2.76. Organic constipation was not detected in patients with constipation and all of them were diagnosed as functional constipation. There was no statistically significant difference between the rates of functional constipation in cases according to gender. The incidence of functional constipation in males was significantly higher in patients with severe autism than in those with mild to moderate autism. “Two or fewer defecations in the toilet per week” criteria was found significantly higher in girls than in boys. No significant difference was found for the other five criteria according to gender. Each of the six criteria of the Rome IV criteria were found to be significantly higher in patients with severe autism than those with mild to moderate autism according to CARS scores. One of the Roman IV criteria, “History of large diameter stools that may obstruct the toilet” was found significantly higher in patients aged nine years and older. No significant correlation was found between the other criteria and age groups.Conclusion: All of the six criteria of the Roman IV criteria were significantly higher in cases with severe autism according to CARS, compared to those with mild to moderate autism.

Profile of two hundred children with Autism Spectrum Disorder from a tertiary child and adolescent psychiatry centre

2017 ◽  
Vol 28 ◽  
pp. 51-56 ◽  
Author(s):  
John Vijay Sagar Kommu ◽  
Gayathri K.R. ◽  
Shoba Srinath ◽  
Satish Chandra Girimaji ◽  
Shekhar P. Seshadri ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Adolescent Psychiatry ◽  
Children With Autism ◽  
Child And Adolescent ◽  
Autism Spectrum ◽  
Child And Adolescent Psychiatry ◽  
Spectrum Disorder

scholarly journals Possible tics diagnosed as stereotypies in patients with severe autism spectrum disorder: a video-based evaluation

2020 ◽  
Author(s):  
Cristiano Termine ◽  
Enzo Grossi ◽  
Valentina Anelli ◽  
Ledina Derhemi ◽  
Andrea E. Cavanna
Keyword(s):  
Autism Spectrum Disorder ◽  
Rating Scale ◽  
Young Patients ◽  
Autism Spectrum ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
High Rate ◽  
Video Recordings ◽  
Significant Difference ◽  
Severe Autism

Abstract Background The association of stereotypies and tics is not rare in children with severe autism spectrum disorder (ASD). The differential diagnosis between stereotypies and tics in this patient population can be difficult; however, it could be clinically relevant because of treatment implications. Methods A total of 108 video recordings of repetitive behaviors in young patients with stereotypies in the context of ASD were reviewed by a movement disorders expert and a trainee, in order to assess the prevalence of possible co-morbid tics. The Modified Rush Videotape Rating Scale (MRVS) was used to rate tic frequency and severity. Results Out of 27 patients with stereotypies (24 males; mean age 14 years), 18 (67%) reported possible tics. The most frequently observed tics were eye blinking, shoulder shrugging, neck bending, staring, and throat clearing. The mean MRVS score was 5, indicating mild tic severity. The only significant difference between patients with tics and patients without tics was the total number of stereotypies, which was higher in the subgroup of patients without tics (p = 0.01). Conclusions Expert review of video-recordings of repetitive behaviors in young patients with ASD and stereotypies suggests the possibility of a relatively high rate of co-morbid tics. These findings need to be integrated with a comprehensive clinical assessment focusing on the diagnostic re-evaluation of heterogeneous motor manifestations.

scholarly journals The urinary biopterin in autism spectrum disorder

Pteridines ◽  
2021 ◽  
Vol 32 (1) ◽  
pp. 17-22
Author(s):  
Aleksandra Waligóra ◽  
Aleksandra Damasiewicz-Bodzek ◽  
Piotr Gorczyca ◽  
Sławomir Waligóra ◽  
Krystyna Tyrpień-Golder
Keyword(s):  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
The Other ◽  
Urine Samples ◽  
Control Group ◽  
Healthy Children ◽  
Healthy Individuals ◽  
Children With Asd ◽  
Significant Difference

Abstract Objective The aim of the study was to determine whether biopterin is present in significantly lower quantities in urine samples of patients with autism spectrum disorder (ASD) compared to healthy individuals. Methods The concentration of biopterin in urine samples was measured by ELISA using commercially available kit. The study involved 53 children aged 3–16 years with ASD and 60 healthy children aged 2–14 years. Results Significantly lower biopterin concentration was observed in autistic patients compared to the control group. However, no significant difference was observed between mild, moderate, and severe ASD. Conclusion One of the potential causes of decrease in urinary biopterin levels may be tetrahydrobiopterin (BH4) deficiency, which has extensive and serious health consequences for the nervous system. The results of measuring biopterin as a fully oxidized form of BH4 may suggest that biosynthesis or regeneration of BH4 may be decreased in children with ASD. On the other hand, decreased urinary biopterin levels in children with ASD may be due to BH4 overuse, a good regeneration process, and decreased urinary excretion; and abnormalities in BH4 metabolism appear to be related to the aetiology of ASD or may be due to ASD.

scholarly journals Associations between autism spectrum disorder and eating disorders with and without self-induced vomiting: an empirical study

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Noriko Numata ◽  
Akiko Nakagawa ◽  
Kazuko Yoshioka ◽  
Kayoko Isomura ◽  
Daisuke Matsuzawa ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Eating Disorders ◽  
Eating Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
University Hospital ◽  
Autism Spectrum Quotient ◽  
Essential Difference ◽  
Illness Duration ◽  
Significant Difference

Abstract Background Although approximately 23% of anorexia nervosa (AN) patients have concomitant autism spectrum disorder (ASD), it is clinically difficult to determine ASD coexistence in patients with eating disorders. Restrictive AN is more common in younger patients and self-induced vomiting usually appears during adolescence/young adulthood, in order to prevent gaining weight caused by overeating. However, some patients are tolerant of weight gain even if they start overeating. It is important to understand the essential difference between those who vomit and those who do not vomit. In this study, we hypothesised that the absence of self-induced vomiting may be associated with the presence of ASD and aimed to assess the presence of ASD traits in each eating disorder (EDs). Clarifying this association helps to consider the coexistence of ASD in the clinical setting and can lead to the next detailed ASD evaluation, and as a result, helps to determine the appropriate treatment and support individually. Methods We retrospectively evaluated 43 females aged 15–45 years who attended Chiba University Hospital between 2012 and 2016 using the Eating Disorder Examination Questionnaire (EDE-Q) and Autism-Spectrum Quotient (AQ) to quantify the severity of the EDs and to identify whether ASD traits were present. Results There was no difference in the AQ score between bingeing-purging type AN and restricting type AN. However, there was significant difference in the AQ score between bulimia nervosa and binge EDs (BED). Of the 4 ED subtypes, BED had the highest ASD traits. The non-vomiting group with illness duration < 4 years had a significantly higher AQ communication score than the vomiting group with illness duration ≥4 years. Conclusions There was a difference in the AQ score by the presence or absence of self-induced vomiting. The results of this study suggest an association between high scores on AQ and non-vomiting. Thus, evaluation of patients for the absence of self-induced vomiting while assessing them for EDs may help us to understand the association with ASD traits.

scholarly journals The frequency, variation, and semantic integration of co-speech gesture production in verbal adolescents diagnosed with Autism Spectrum Disorder

2020 ◽  
Author(s):  
Renáta Longauerová
Keyword(s):  
Autism Spectrum Disorder ◽  
Verbal Working Memory ◽  
Autism Spectrum ◽  
Semantic Integration ◽  
Spectrum Disorder ◽  
Frequency Variation ◽  
Animated Cartoon ◽  
Significant Difference ◽  
Gesture Production ◽  
Adolescents With Asd

Gestures play an important role in communication, but for populations with atypical language development, gestures are often an area of significant difficulty, especially for individuals with Autism Spectrum Disorder (ASD). Research on younger children with ASD show a significant delay in gesture production, as well as a complete absence of certain types of gestures. However, previous work leaves open the question of whether the frequency and variation of gesture production is impaired also in adolescents with ASD. Moreover, very little is known about the semantic integration of speech and gesture in this population. In the present study, 5 adolescents with ASD and 5 typically-developing adolescents completed a narrative task, in which they were asked to retell a story of 4 animated cartoon clips. The results show that while there is no significant difference between the two groups in the frequency of gesture production and the types of gestures they produce, the frequency of gesture production in the individuals with ASD significantly depends on their verbal working memory skills. Moreover, it seems that many impairments that were confirmed by earlier studies for ASD children in early and late childhood seem to be mere delays that get resolved over time, such as the usage of supplementary gestures.

scholarly journals Evaluation of circulating miRNAs and mRNAs expression patterns in autism spectrum disorder

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Amany H. Abdelrahman ◽  
Ola M. Eid ◽  
Mona H. Ibrahim ◽  
Safa N. Abd El-Fattah ◽  
Maha M. Eid ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Gene Family ◽  
Complex Disease ◽  
Expression Patterns ◽  
Normal Volunteer ◽  
Disease Diagnosis ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Expression Levels ◽  
Significant Difference

Abstract Background Autism spectrum disorder is a condition related to brain development that affects a person’s perception and socialization, resulting in problems in social interaction and communication. It has no single known cause, yet several different genes appear to be involved in autism. As a genetically complex disease, dysregulation of miRNA expression and miRNA–mRNA interactions might be a feature of autism spectrum disorder. The aim of the current study was to investigate the expression profile of circulating miRNA-128, miRNA-7 and SHANK gene family in ASD patients and to assess the possible influence of miRNA-128 and miRNA-7 on SHANK genes, which might provide an insight into the pathogenic mechanisms of ASD and introduce noninvasive molecular biomarkers for the disease diagnosis and prognosis. Quantitative real-time PCR technique was employed to determine expression levels of miRNA-128, miRNA-7 and SHANK gene family in blood samples of 40 autistic cases along with 30 age- and sex-matched normal volunteer subjects. Results Our study revealed a statistical significant upregulation of miRNA-128 expression levels in ASD cases compared to controls (p value < 0.001). A statistical significant difference in SHANK-3 expression was encountered on comparing cases to controls (p value < 0.001). However, miRNA-7 expression showed no significant difference between the studied groups. Conclusions MiRNA-128 and SHANK-3 gene are emerging players in the field of ASD. They are promising candidates as noninvasive biomarkers in autism. Future studies are needed to emphasize their pivotal role.

The Use of Mobile and Wearable Artificial Intelligence in Child and Adolescent Psychiatry – A Scoping Review (Preprint)

2021 ◽  
Author(s):  
Victoria Welch ◽  
Tom Joshua Wy ◽  
Anna Ligezka ◽  
Leslie C. Hassett ◽  
Paul E. Croarkin ◽  
...  
Keyword(s):  
Mental Health ◽  
Artificial Intelligence ◽  
Scoping Review ◽  
Adolescent Psychiatry ◽  
Child And Adolescent ◽  
Mental Health Disorders ◽  
Wearable Devices ◽  
Autism Spectrum ◽  
Child And Adolescent Psychiatry ◽  
Health Disorders

BACKGROUND Mental health disorders across the life span are a leading cause of medical disabilities. This burden is particularly significant in children and adolescents due to challenges in diagnoses and lack of precision medicine approaches. The advent and widespread adoption of wearable devices (e.g., smartwatches) that generate large volumes of passively collected data that are conducive for artificial intelligence applications to remotely diagnose and manage child and adolescent mental health disorders is promising. OBJECTIVE This study conducted a scoping review to study, characterize and identify areas of innovations with wearable devices that can augment current in-person physician assessments to individualize diagnosis and management of mental health disorders in child and adolescent psychiatry. METHODS This scoping review used PRISMA’s information as a guide. A comprehensive search of several databases from 2011 to June 25, 2021, limited to English language and excluding animal studies, was conducted. The databases included Ovid MEDLINE (R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Web of Science, and Scopus. RESULTS The initial search yielded 344 articles. 19 articles were left on the final source list for this scoping review. Articles were divided into three main groups: Studies with the main focus on Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorders (ADHD) and Internalizing disorders such as anxiety disorders. Majority of the studies used either ECG strap or wrist worn biosensor. CONCLUSIONS Our scoping review found large heterogeneity of methods and findings in artificial intelligence studies in child psychiatry. Overall, the largest gaps identified in this scoping review are the lack of randomized control trials, most available studies are pilot feasibility trials.

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