Loco-regional Hyperthermia Delivery: Patient-specific set-up Procedures for Treatment Optimisation

2020 ◽  
Author(s):  
J. Crezee ◽  
R. Zweije ◽  
H.P. Kok
Keyword(s):  
Patient Specific ◽  
Regional Hyperthermia ◽  
Treatment Optimisation ◽  
Set Up

scholarly journals Vascular flow simulations using SimVascular and OpenFOAM

2021 ◽  
Author(s):  
Swetha Yogeswaran ◽  
Fei Liu
Keyword(s):  
Fluid Dynamics ◽  
Blood Flow ◽  
Open Source ◽  
Open Source Software ◽  
Flow Analysis ◽  
Coarctation Of The Aorta ◽  
Patient Specific ◽  
Specific Information ◽  
Imaging Data ◽  
Set Up

AbstractApplications of computational fluid dynamics (CFD) techniques to aid in the diagnosis and treatment of cardiovascular disease have entered the research domain in recent years, due to their ability to provide valuable patient-specific information without risks associated with highly invasive procedures. SimVascular [1] [2] is an open-source software which allows streamlined processing and CFD blood flow analysis of medical imaging data. OpenFOAM [3] is a proven open-source software which allows for versatile modeling of various fluid dynamics phenomena. In this study, both SimVascular and OpenFOAM simulations are set up with identical computational mesh, similar numerical schemes, boundary conditions, and material properties, to model blood flow in the coronary artery of a 10 year old patient with Coarctation of the Aorta (CoA) who underwent end-to-side anastomosis. Difference in the flow fields such as flow rate, pressure, vorticity, and wall shear stress between SimVascular and OpenFOAM are analyzed. Similar results are obtained in both simulations up to a certain model time, before the results become drastically different. Both the similarities and differences are documented and discussed.

scholarly journals Random and systematic set-up errors in three-dimensional conformal radiotherapy – impact on planning target volume margins: the experience of the Radiation Oncology Centre of Sassari

2013 ◽  
Vol 13 (2) ◽  
pp. 166-179
Author(s):  
Matteo Tamponi ◽  
Angela Poggiu ◽  
Maria F. Dedola ◽  
Rossella Madeddu ◽  
Antonella Carnevale ◽  
...  
Keyword(s):  
Planning Target Volume ◽  
Three Dimensional ◽  
Conformal Radiotherapy ◽  
Target Volume ◽  
Patient Specific ◽  
Geometric Uncertainties ◽  
Three Dimensional Conformal Radiotherapy ◽  
Set Up ◽  
Oncology Centre ◽  
The Impact

AbstractPurposeGeometric uncertainties limit the accuracy of three-dimensional conformal radiotherapy treatments. This study aims to evaluate typical random and systematic set-up errors and analyse the impact of no action level (NAL) correction protocol on systematic set-up errors and clinical target volume (CTV)–planning target volume (PTV) margins.Materials and methodsA total 668 pairs of orthogonal electronic portal images were compared with digitally reconstructed radiographs from computed tomography planning scans for 100 patients consecutively treated during 2011. Patients were divided into groups depending on the treated anatomical region. Patient-specific and population random and systematic set-up errors were calculated. Impact of application of NAL correction protocol on systematic set-up errors and CTV–PTV expansions were evaluated.ResultsPopulation set-up errors resulted from about 1 mm in head and neck to 2–3 mm in prostate, rectum, lung, breast and gynaecological districts. Patient-specific systematic set-up errors were higher for breast and gynaecological districts and application of NAL correction protocol gave significant reductions, even higher than 30%. Calculated CTV–PTV margins ranged from 10 mm on left–right direction for prostate to 20 mm on superior–inferior direction for lung.ConclusionsSet-up errors resulted reasonably controlled and application of NAL correction protocol could further improve the level of accuracy. However, the NAL application alone did not seem to add any substantial benefit on CTV–PTV total margins without the adoption of corrective strategies to reduce other important uncertainties limiting accuracy of three-dimensional conformal radiotherapy.

Taiwanese new direction in prediction of early pregnancy preeclampsia: a prospective and non-interventional study

2020 ◽  
Author(s):  
Yen-Tin Chen ◽  
Tzu-Yi Lin ◽  
Po-Jen Cheng ◽  
Kok-Seong Chan ◽  
Hui-Yu Huang ◽  
...  
Keyword(s):  
False Positive Rate ◽  
Model Performance ◽  
First Trimester ◽  
Patient Specific ◽  
Interventional Study ◽  
High Detection Rate ◽  
Maternal Characteristics ◽  
Positive Rate ◽  
Trimester Screening ◽  
Set Up

Abstract Background First trimester screening is essential to preeclampsia (PE) prevention. Fetal Medicine Foundation (FMF) model combined maternal characteristics with mean arterial pressure (MAP), uterine artery pulsatility index (UtAPI) and placental growth factor (PlGF) to estimate risk. High detection rate (DR) was observed in Asia. The study aims to evaluate performance of screening in Taiwan.Methods This was a prospective and non-interventional study between January, 2017 and June, 2018. Data was collected from 700 pregnant women at 11+ 0-13+ 6 gestational week. Maternal characteristics were recorded. MAP, UtAPI and PlGF were measured and converted into Multiple of the Median (MoM). Patient-specific risks were calculated with FMF model. Performance of screening was examined by ROC curve and DR.Results 25 women (3.57%) contracted PE, including 8 with preterm PE (1.14%). In preterm PE, mean MoM of MAP and UtAPI were higher (1.096 vs 1.000; 1.084 vs 1.035). Mean MoM of PlGF was lower (0.927 vs 1.031). DR in preterm PE achieved 12.5%, 50.0%, 50.0% and 62.5% at false-positive rate (FPR) of 5%, 10%, 15% and 20%.Conclusion FMF model showed high DR for PE in Taiwan. Integration of PE and Down screening could set up a one-step workflow.

scholarly journals Physics of Within-Tissue Wave Propagation Generated by Pulse Propagation in the Carotid Artery

2019 ◽  
Vol 9 (14) ◽  
pp. 2878
Author(s):  
Tommasin ◽  
Caenen ◽  
Verhegghe ◽  
Greenwald ◽  
Segers
Keyword(s):  
Wave Propagation ◽  
Carotid Artery ◽  
Pulse Propagation ◽  
Propagation Speed ◽  
Element Model ◽  
Skin Surface ◽  
Patient Specific ◽  
Pressure Impulse ◽  
Surface Wave Propagation ◽  
Set Up

(1) Background: We aimed to assess the validity of laser Doppler vibrometry (LDV) as an emerging method to measure the local pulse wave velocity (PWV) from skin displacement generated by the pressure pulse inside an underlying artery. (2) Methods: A finite element model representing a simplified common carotid artery embedded within a soft tissue mimicking material was used to reproduce how tissue motions due to a wave propagation along the artery radiates to the skin surface. A parametric study was set up, varying: (i) the pressure conditions inside the artery (shock and traveling pressure impulse), (ii) the arterial depth and (iii) the geometry in a patient-specific artery model. (3) Results: under all conditions, the arterial pulse induced primary and secondary waves at the skin surface; of which the propagation speed deviated from the imposed PWV (deviations between −5.0% to 47.0% for the primary wave front). (4) Conclusions: the propagation of a short pressure impulse induced complex skin displacement patterns revealing a complicated link between PWV and measured propagation speeds at the skin surface. Wave propagation at the skin level may convey information about arterial PWV, however, advanced signal analysis techniques will be necessary to extract local PWV values.

Metallographic and Fractographic Evaluation of 3D-Printed Titanium Samples to Eliminate Unsatisfactory Mechanical Properties

2017 ◽  
Vol 270 ◽  
pp. 212-217
Author(s):  
Michaela Fousová ◽  
Tereza Stejskalova ◽  
Dalibor Vojtěch
Keyword(s):  
Mechanical Properties ◽  
Titanium Alloy ◽  
3D Printing ◽  
Process Parameters ◽  
Patient Specific ◽  
Medical Implants ◽  
Laser Melting ◽  
Patient Specific Implants ◽  
3D Printed ◽  
Set Up

Czech company ProSpon spol. s r.o. has introduced 3D printing technology in its production in 2015. This company operates in the field of development, manufacture and distribution of medical implants and instruments for orthopedics, traumatology and surgery. Therefore, the current intention is to employ Selective Laser Melting (SLM) technology for production of complex and patient-specific implants from titanium alloy Ti-6Al-4V. Nevertheless, first series of produced test specimens suffered from very low plasticity insufficient for the intended application. The reduction in elongation was almost 7fold compared to conventionally used wrought standard. From that reason, specimens were subjected to fractographic evaluation of fracture surfaces, but also metallographic evaluation. The main cause of the identified problem turned out to be porosity originating from inappropriate set-up of the machine. After the adjustment of process parameters new series of specimens were prepared in which the porosity was already significantly lower. Consequently, mechanical properties reached higher and better values.

Vascular flow simulations using SimVascular and OpenFOAM (Preprint)

2021 ◽  
Author(s):  
Swetha Yogeswaran ◽  
Fei Liu
Keyword(s):  
Fluid Dynamics ◽  
Blood Flow ◽  
Open Source ◽  
Open Source Software ◽  
Flow Analysis ◽  
Coarctation Of The Aorta ◽  
Patient Specific ◽  
Specific Information ◽  
Imaging Data ◽  
Set Up

UNSTRUCTURED Applications of computational fluid dynamics (CFD) techniques to aid in the diagnosis and treatment of cardiovascular disease have entered the research domain in recent years, due to their ability to provide valuable patient-specific information without risks associated with highly invasive procedures. SimVascular is an open-source software which allows streamlined processing and CFD blood flow analysis of medical imaging data. OpenFOAM is a proven open-source software which allows for versatile modeling of various fluid dynamics phenomena. In this study, both SimVascular and OpenFOAM simulations are set up with identical computational mesh, similar numerical schemes, boundary conditions, and material properties, to model blood flow in the coronary artery of a 10 year old patient with Coarctation of the Aorta (CoA) who underwent end-to-side anastomosis. Difference in the flow fields such as flow rate, pressure, vorticity, and wall shear stress between SimVascular and OpenFOAM are analyzed. Similar results are obtained in both simulations up to a certain model time, before the results become drastically different. Both the similarities and differences are documented and discussed.

scholarly journals Strategies for Psychiatric Rehabilitation and their Cognitive Outcomes in Schizophrenia: Review of Last Five-year Studies

2021 ◽  
Vol 17 (1) ◽  
pp. 31-47
Author(s):  
Antonio Rampino ◽  
Rosa M. Falcone ◽  
Arianna Giannuzzi ◽  
Rita Masellis ◽  
Linda A. Antonucci ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Rehabilitation ◽  
Psychiatric Rehabilitation ◽  
Poor Response ◽  
Cognitive Outcomes ◽  
Patient Specific ◽  
Antipsychotic Treatment ◽  
Predictors Of Response ◽  
Set Up ◽  
Core Features

Background: Cognitive deficits are core features of Schizophrenia, showing poor response to antipsychotic treatment, therefore non-pharmacological rehabilitative approaches to such a symptom domain need to be identified. However, since not all patients with Schizophrenia exhibit the same cognitive impairment profile, individualized rehabilitative approaches should be set up. Objectives: We explored the last five-year literature addressing the issue of cognitive dysfunction response to rehabilitative methodologies in Schizophrenia to identify possible predictors of response and individualized strategies to treat such a dysfunction. Conclusion: A total of 76 studies were reviewed. Possible predictors of cognitive rehabilitation outcome were identified among patient-specific and approach-specific variables and a general overview of rehabilitative strategies used in the last five years has been depicted. Studies suggest the existence of multifaced and multi-domain variables that could significantly predict pro-cognitive effects of cognitive rehabilitation, which could also be useful for identifying individual-specific rehabilitation trajectories over time. An individualized rehabilitative approach to cognitive impairment in Schizophrenia is possible if taking into account both patient and approach specific predictors of outcomes.

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