Cosolvents Impact on some Properties of the Solutions and the Films of Succinamide Chitosan

The article deals with the method of the medical purpose materials creation with the controlled physico-chemical and mechanical deformation properties on the basis of water-soluble derivative of amino polysaccharide chitosan – succinamide chitosan. The essence of the method is the macromolecules aggregation processes regulation in the initial solutions by the injection of organic cosolvents – acetone and ethanol. It has been stated that in a mixed solvent succinamide chitosan molecules are not in the form of the isolated macromolecular balls but as the macromolecules interacting (aggregated) systems. It has been proved that the presence of cosolvents decreases the polymer macromolecule links capability to interact with an enzyme and increases physico-mechanical characteristics of the film materials.

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Amorphous and Crystalline Particulates: Challenges and Perspectives in Drug Delivery

Current Pharmaceutical Design ◽

10.2174/1381612822666161107162109 ◽

2017 ◽

Vol 23 (3) ◽

pp. 350-361 ◽

Cited By ~ 5

Author(s):

Hisham Al-Obaidi ◽

Mridul Majumder ◽

Fiza Bari

Keyword(s):

Crystal Engineering ◽

Drug Carrier ◽

Solid Dispersions ◽

Chemical Properties ◽

Pharmaceutical Product ◽

Water Soluble ◽

Amorphous Form ◽

Physico Chemical ◽

Water Soluble Drugs ◽

Amorphous Drug

Crystalline and amorphous dispersions have been the focus of academic and industrial research due to their potential role in formulating poorly water-soluble drugs. This review looks at the progress made starting with crystalline carriers in the form of eutectics moving towards more complex crystalline mixtures. It also covers using glassy polymers to maintain the drug as amorphous exhibiting higher energy and entropy. However, the amorphous form tends to recrystallize on storage, which limits the benefits of this approach. Specific interactions between the drug and the polymer may retard this spontaneous conversion of the amorphous drug. Some studies have shown that it is possible to maintain the drug in the amorphous form for extended periods of time. For the drug and the polymer to form a stable mixture they have to be miscible on a molecular basis. Another form of solid dispersions is pharmaceutical co-crystals, for which research has focused on understanding the chemistry, crystal engineering and physico-chemical properties. USFDA has issued a guidance in April 2013 suggesting that the co-crystals as a pharmaceutical product may be a reality; but just not yet! While some of the research is still oriented towards application of these carriers, understanding the mechanism by which drug-carrier miscibility occurs is also covered. Within this context is the use of thermodynamic models such as Flory-Huggins model with some examples of studies used to predict miscibility.

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Silica Monolith for the Removal of Pollutants from Gas and Aqueous Phases

Molecules ◽

10.3390/molecules26051316 ◽

2021 ◽

Vol 26 (5) ◽

pp. 1316

Author(s):

Vanessa Miglio ◽

Chiara Zaccone ◽

Chiara Vittoni ◽

Ilaria Braschi ◽

Enrico Buscaroli ◽

...

Keyword(s):

Rhodamine B ◽

Water Solution ◽

Synthesis Method ◽

Textural Properties ◽

Adsorption Properties ◽

Water Soluble ◽

Silica Monoliths ◽

Physico Chemical ◽

Gaseous Toluene ◽

Mcm 41

This study focused on the application of mesoporous silica monoliths for the removal of organic pollutants. The physico-chemical textural and surface properties of the monoliths were investigated. The homogeneity of the textural properties along the entire length of the monoliths was assessed, as well as the reproducibility of the synthesis method. The adsorption properties of the monoliths for gaseous toluene, as a model of Volatile Organic Compounds (VOCs), were evaluated and compared to those of a reference meso-structured silica powder (MCM-41) of commercial origin. Silica monoliths adsorbed comparable amounts of toluene with respect to MCM-41, with better performances at low pressure. Finally, considering their potential application in water phase, the adsorption properties of monoliths toward Rhodamine B, selected as a model molecule of water soluble pollutants, were studied together with their stability in water. After 24 h of contact, the silica monoliths were able to adsorb up to the 70% of 1.5 × 10−2 mM Rhodamine B in water solution.

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Microscopic and Phytochemical analysis of Desmodium velutinum (Willd) DC and Desmodium gangeticum (L.) DC. Panchanga powder

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00517 ◽

2021 ◽

pp. 2950-2956

Author(s):

Jigyasa Pathak ◽

Aswathi M. P. ◽

B. R. Patel ◽

Harisha C. R. ◽

Shukla Vinay J.

Keyword(s):

Chemical Analysis ◽

Analytical Study ◽

Water Soluble ◽

Wild Edible Plants ◽

Phytochemical Analysis ◽

Edible Plants ◽

Therapeutic Purpose ◽

Whole Plant ◽

Physico Chemical ◽

Collection Practices

Background: Desmodium velutinum (Fabaceae) is one of the wild edible plants used traditionally to treat diarrhoea, haematuria, infertility and also externally used to treat scorpion bites. Though various parts of the plant have been used for therapeutic purpose, panchanga of the plant has not been studied for its Pharmacognostical and phytochemical characteristics in detail, following scientific parameters. Hence in the present study Desmodium velutinum whole plant has been studied for its pharmacognostical and phytochemical characters and compared with commonly used species Desmodium gangeticum. Methods: Whole plant of Desmodim velutinum was collected from Paikmal, Odisha and Desmodium gangeticum was collected from Junagarh, Gujarat in the month of November 2019 following good collection practices and shade dried. Pharmacognostical study and analytical study were performed following standard pharmacopoeial procedures. Results: Whole plant (Panchanga) of former is sweetish and latter is bitter. Powder microscopy of Desmodium gangeticum showed presence of rhomboidal crystals and lignified annular and spiral vessels. Desmodium velutinum showed presence of prismatic crystals and lignified pitted vessels. Physico-chemical analysis showed higher loss on drying in Desmodium gangeticum, and higher water soluble extractive values of Desmodium velutinum. Phytochemical estimation showed the presence of Proteins, tannins, and carbohydrates in both samples. HPTLC study showed similar Rf value 0.82 and 0.94 at 254 and 0.03 and 0.41 at 366nm. Conclusion: Basing upon the analytical and microscopic similarities Desmodium velutinum may be considered as substitute of Desmodium gangeticum

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A review on conductometric studies of electrolytes in mixed solvent systems to understand ion-ion and ion-solvent interactions

Biointerface Research in Applied Chemistry ◽

10.33263/briac103.355360 ◽

2020 ◽

Vol 10 (3) ◽

pp. 5355-5360

Keyword(s):

Mixed Solvent ◽

Mixed Solvents ◽

Chemical Properties ◽

Electrolyte Solutions ◽

Molar Conductance ◽

Extensive Literature ◽

Solvent Interactions ◽

Physico Chemical ◽

Wide Range ◽

Solvent Systems

The study of ion- solvent interaction is of much importance to investigate the nature of different solutions. Measurement of electrical conductivity and evaluation of physico-chemical properties, such as molar conductance, limiting molar conductance, ion-pair association, Walden product etc. shade light on different intermolecular interactions present in electrolyte solutions. Solvation properties can be varied by mixing two or more solvents. An extensive literature survey on conductometric studies has been carried out on different electrolytes dissolved in a wide range of mixed solvent systems. The reported results show that strong solute-solute, solute-solvent and solvent-solvent interactions are responsible for the physico- chemical behavior of a solution in mixed solvents.

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Pharmacognostical, Physico-Chemical and Preliminary Phytochemical Analysis of Whole Plant of Piper Longum L.

International Journal of Research and Review ◽

10.52403/ijrr.20210860 ◽

2021 ◽

Vol 8 (8) ◽

pp. 440-449

Author(s):

Fathima Suman P ◽

Minhaj . ◽

I Arthi

Keyword(s):

Water Soluble ◽

Phytochemical Analysis ◽

Alcoholic Extract ◽

Phytochemical Screening ◽

Plant Identification ◽

Piper Longum ◽

Whole Plant ◽

Physico Chemical ◽

Physicochemical Evaluation ◽

Physicochemical Constants

This study deals with the Pharmacognostical physicochemical and phytochemical evaluation of the whole plant of Piper longum L. Pharmacognostical studies include macroscopic, microscopic and physicochemical evaluation. Physicochemical constants showed the values of total ash (10.8%), acid insoluble ash (1.3%), water soluble ash (3.2%), sulphated ash (12%), nitrated ash (1.85%), hot extraction (11.2%), water soluble extractive (4.8%), ethanol soluble extractive (12.4%), ether soluble extractive (5.6%), loss on drying (29%), swelling index (0.33) and mucilage content (0.8%) w/w. The preliminary phytochemical screening of the alcoholic extract showed presents of alkaloids, phenolic compounds, tannins, mucilage, starch, steroid and flavonoids. This study helps to development of different standard parameters of the plant which help the plant identification and authentication. Keywords: Piper longum L., Whole plant, Pharmacognostic, Phytochemical, Extract.

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Status and Speciation of Silicon and Its Interaction with Physico-Chemical Properties

Asian Journal of Environment & Ecology ◽

10.9734/ajee/2021/v14i230199 ◽

2021 ◽

pp. 1-11

Author(s):

Isaiah Ufuoma Efenudu ◽

Ehi Robert Orhue ◽

Ogochukwu Jennifer Ikeh ◽

Michael Aimiesomon Erhayimwen ◽

Blessing James

Keyword(s):

Organic Matter ◽

Acidic Medium ◽

Soil Depth ◽

Chemical Properties ◽

Water Soluble ◽

Sequential Fractionation ◽

Soil Redox ◽

Parent Materials ◽

Physico Chemical ◽

Negative Effect

The effectiveness of three different extractants soil mixtures—HCl, HCl + H2S04, and DTPA-TEA, in order to determine Si from soil and the forms of Silicon as influenced by different parent materials under acidic medium. Seven forms of Silicon; namely water soluble, specifically adsorbed, oxides bound, organic matter bound, exchangeable, residual, total viz sequential fractionation. Extractable Si value established in this study was (50.0 mg kg-1), indicating negative effect on plant physiology. The physico-chemical properties decreased significantly with increase in soil depth vs soil parent materials. In addition, the forms of Si in the parent materials decreased in the pattern RES, bound residual fractions > EXC, soluble & exchangeable fractions > OM, organic matter fraction. Among the properties the silt fraction, pH & OM significantly and positively correlated with the forms of silicon, with negative correlation vs clay which maybe due to silicon adsorption by clayey fraction of the soil (redox). Therefore the soil maybe be maintained and conserved for farming activities.

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Microencapsulation of water-soluble isoflavone and physico-chemical property in milk

Archives of Pharmacal Research ◽

10.1007/bf02976702 ◽

2003 ◽

Vol 26 (5) ◽

pp. 426-431 ◽

Cited By ~ 13

Author(s):

Jin Seok Seok ◽

Jae Soon Kim ◽

Hae Soo Kwak

Keyword(s):

Chemical Property ◽

Water Soluble ◽

Physico Chemical ◽

Physico Chemical Property

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Spectrophotometric studies of molecular complex formation between water-soluble cobalt(II) Schiff base complex and nucleotides in mixed solvent systems

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2004.11.027 ◽

2005 ◽

Vol 61 (13-14) ◽

pp. 3061-3065 ◽

Cited By ~ 9

Author(s):

Davar M. Boghaei ◽

Mehrnaz Gharagozlou

Keyword(s):

Schiff Base ◽

Complex Formation ◽

Molecular Complex ◽

Mixed Solvent ◽

Schiff Base Complex ◽

Water Soluble ◽

Base Complex ◽

Molecular Complex Formation ◽

Solvent Systems

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Mechanical characteristics of stretchable electronics based on a mogul-patterned structure

Functional Materials Letters ◽

10.1142/s1793604716420121 ◽

2016 ◽

Vol 09 (06) ◽

pp. 1642012 ◽

Cited By ~ 1

Author(s):

Yeon-Ho Lee ◽

Youn-Jea Kim

Keyword(s):

Flexible Electronics ◽

Mechanical Characteristics ◽

Mechanical Deformation ◽

Von Mises Stress ◽

Structural Safety ◽

Stretchable Electronics ◽

Film Material ◽

Von Mises ◽

Nanostructured Patterns ◽

Stress And Strain Distribution

Recent progress in unconventional forms of foldable and stretchable electronics has enabled development of novel electronics. Especially, stretchable electronics have attracted much interest for applications that require reliable operation under mechanical deformation. Stretchable electrodes can be bent, stretched and compressed while maintaining good performance and structural safety. To realize flexible electronics, stretchability of devices, which requires a deeper understanding of nanoscale materials and mechanics, is needed. In this study, the mechanical characteristics of electrodes based on a mogul-pattern, which retain their electrical conductivity under mechanical deformation, were evaluated. Nanostructured patterns and thin film material were considered for stretched and bent models. The von Mises stress and strain distribution were analyzed and depicted graphically.

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