Prevention of Complications Arising after Tooth Extraction

2021 ◽  
Vol 5 (9) ◽  
pp. 101-105
Author(s):  
Oleksii Tymofieiev ◽  
Viktoriia Ripa ◽  
Diana Havlytiuk ◽  
Marta Sokoliuk ◽  
Lesia Kolisnichenko
Keyword(s):  
Analgesic Effect ◽  
Tooth Extraction ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Anti Inflammatory ◽  
Tooth Extractions

The study involved 67 patients with acute odontogenic inflammatory diseases of the jaws were examined. All examined patients underwent tooth extraction, which caused the development of an acute inflammatory process. We have determined the effectiveness of treatment of patients with the drug “Givalex,” which was used to prevent inflammatory post-extraction complications in patients with acute odontogenic inflammatory diseases. Based on the examinations of patients, it was proved that the multicomponent preparation “Givalex” used for oral baths after tooth extractions has an expressed antiseptic, anti-inflammatory and analgesic effect, as well as a deodorizing effect.

STUDY OF SPECIFIC PHARMACOLOGICAL ACTIVITY OF SODIUM SALT (4-О-Β-GLUCOPYRANOSYLOXY)-BENZOIC ACID

2016 ◽  
Vol 78 (6-8) ◽  
Author(s):  
Smirnov Ivan ◽  
Murashko Tatyana ◽  
Ivanov Alex ◽  
Bondarev Alex ◽  
Udut Vladimir
Keyword(s):  
Benzoic Acid ◽  
Analgesic Activity ◽  
Sodium Salt ◽  
Analgesic Effect ◽  
Inflammatory Diseases ◽  
Peptic Ulcers ◽  
Chronic Inflammatory Diseases ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Chronic inflammatory diseases of various genesis are prevalent today. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain and inflammation, but their long-term use is associated with complications in the gastrointestinal tract, including peptic ulcers. We synthesized a molecule of sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid. This substance has diuretic and anti-inflammatory activities. It should be noted that most of NSAIDs has analgesic effect. In this connection, the aim of this study was to evaluate the analgesic activity of sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid. We studied analgesic effect in the test “acetic writhing”. Sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid significantly reduces the number of writhing by 14 units during the experiment, as an alternative criterion percent of animals with analgesia was 42.6%. Thus, in the test "acetic writhing" revealed the presence of the analgesic activity have developed drug average severity. 

scholarly journals . Full-scale testing of biologically active additive “Ivlaxinˮ in patients with acute inflammatory diseases

2019 ◽  
Vol 48 (2) ◽  
pp. 143-150
Author(s):  
Евгения Лобач ◽  
Evgeniya Lobach ◽  
Андрей Вековцев ◽  
Andrey Vekovtsev ◽  
Дмитрий Никитюк ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Blood Analysis ◽  
Biologically Active ◽  
Standards Of Care ◽  
Control Group ◽  
Shortness Of Breath ◽  
Therapeutic Treatment ◽  
Anti Inflammatory

Clinical tests were carried out in the representative group of patients with focal left-sided pneumonia (5 men and 7 women aged 18–41). Special-use product was included in in-patient department patients’ diet: 2 tablets in the first intake, then 1 tablet 4 times a day. Course of treatment was 21 days. Biologically active dietary supplement was prescribed together with general therapeutic treatment according to generally accepted standards of care. Control group included 15 patients randomized depending on sex and age who took only medicine. The author measured body temperature, studied the results of general blood tests, determined the level of C-reactive protein and seromucoids, performed R-graphy of lungs, electrocardiogram before and after treatment, analyzed clinical symptoms (cough, type of expectoration, shortness of breath). Composition of the special-use product was scientifically justified taking pharmacological characteristics of its ingredients and their active agents into account. Introduction of the biologically active dietary supplement in addition to the prescribed therapeutic treatment gave positive effect in relation to the inflammatory process: the patients could easier clear their throats from expectoration, coughed less frequently, and had less intense shortness of breath. It was evident that symptoms of disease recrudescence decreased. It appeared in the decreased intensity and length of fever. In case of acute respiratory viral infection the biologically active dietary supplement had antipyretic activity due to the anti-exudative effect of its ingredients. The author determined the anti-inflammatory effect and reduction of acute intoxication symptoms taking the results of general blood analysis into account. Patients who took special-use product had lower values of an inflammatory process marker – seromucoids. Tissues restored easily. The tested product has anti-inflammatory, antipyretic and analgesic properties. It can be used in complex treatment of acute inflammatory diseases and recrudescence of chronic inflammatory processes.

Treatment of inflammatory diseases of the pelvic organs, due to mixed infection

2016 ◽  
pp. 134-143
Author(s):  
O. V. Romashchenko ◽  
◽  
S. V. Vozianova ◽  
A.V. Rudenko ◽  
L.F. Yakovenko ◽  
...  
Keyword(s):  
Mixed Infection ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Immune Defense ◽  
Laboratory Diagnostics ◽  
Simultaneous Treatment ◽  
Local Immunity ◽  
Etiological Factors ◽  
Pelvic Organs ◽  
Anti Inflammatory

Today the marked increase in the frequency of inflammatory diseases of the pelvic organs (IDPO) caused by sexually transmitted infections (STIs). And among the factors is dominated by numerous microbial associations (mixed infection) in 65-70% of cases detect Chlamydia, gonorrhea, Trichomonas, Molykote. The advantage of latent flow IDPO caused by these factors is one of the reasons for untimely and inadequate treatment of the inflammatory process of the genital organs and the formation of a range of violations of reproductive health of women. The aim of the study: the rationale for differentiated approaches to the treatment of chronic IDPO caused by mixed infection. Materials and methods. A survey of 72 women aged 18 to 37 years with IDPO with disease duration from 2 to 11 years. According to etiological factors and clinical course of HSTMT allocated groups were examined: First, the core group of 38 women with HSTMT caused by mixed infection in combination with Chlamydia, Molicutas; the SECOND main group - 34 patients with HSTMT caused by mixed infection in combination with Trichomonas. Results. Studies have shown that chronic inflammatory diseases of the genital organs in women are predominantly polietiologichesky nature; the latter determines the characteristics of the disease and its consequences. According to clinical and preclinical guidelines inflammatory diseases of the genital organs, caused by mixed infection, defined by differentiated approaches to the choice-stage anti-inflammatory therapy. Conclusion. Among the factors contributing to the effectiveness of treatment of inflammatory diseases of the genital organs, caused by mixed infection, should be highlighted: 1. Early diagnosis of the disease. 2. Identification and remediation of all sources of infection. 3. Compliance with phasing of conducting anti-inflammatory therapy. 4. The restoration of microbiocenosis of intestines, vagina, urethra with the use of the drug Laktovit Forte. 5. The correction of immunological disorders, the recovery of local immune defense. 6. Examination and the simultaneous treatment (if necessary) partner (partners). 7. Clinical, microbiological control of effectiveness of the treatment for 3 months; immunological control after 3, 6 months after treatment. Introduction to practical healthcare system of reasonable effective treatments for VSAT based on objective results of clinical and laboratory diagnostics, account etiological factors, state of systemic and local immunity, pathogenesis mechanisms of development of inflammatory process will contribute to the prevention of its chronicity and relapse. Key words: inflammatory diseases of the pelvic organs, mixed infection, treatment, Tiflox, Meratin.

Approaches to Treatment of Infections of Lower Urinary Tracts in Women of Reproductive Age

2017 ◽  
pp. 81-92
Author(s):  
O.V. Romashchenko ◽  
◽  
V.M. Grygorenko ◽  
V.V. Biloholovska ◽  
L.O. Lebid ◽  
...  
Keyword(s):  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Clinical Analysis ◽  
Reproductive Age ◽  
Gardnerella Vaginalis ◽  
Urinary System ◽  
Reproductive Systems ◽  
Women Of Reproductive Age ◽  
Anti Inflammatory ◽  
Lower Urinary

Infections of urinary tracts (IUT) occupy a priority place both in the level of their outspread and the emergence of recurrences of the disease in ambulatory and stationary practice of a doctor; they are conditioned by inflammatory process, mostly of bacterial genesis, developed in different anatomic parts of urinary system – from fascia renalis to external urethral opening and often combined with pelvic inflammatory diseases. Purpose of research: to evaluate the effectiveness of complex therapy of chronic recidivating cystitis in combination with pelvic inflammatory diseases in women of reproductive age. Materials and Methods. A complex clinical and microbiological examination of 39 women aged from 18 to 39 having chronic reccurent cystitis in combination with pelvic inflammatory diseases in the observation dynamics (before and after the course of anti-inflammatory therapy with the inclusion of Tiflox and probiotic Lactovit Forte) was carried out. Results. As a result of the carried out research the symptomatic development of chronic reccurent cystitis at the background of latent development of pelvic inflammatory diseases was established. In the etiological spectre of chronic reccurent cystitis there were more often microorganisms (mostly E.coli – 82.1%) in the monoculture of critical and high number of microbs, and in 17 (43.5%) mixt-infection was established. Concordance when establishing Chlamydia (7.7%), Mycoplasmas (5.1%), Ureaplasmas (10.3%), Candida (33.4%), and Gardnerella vaginalis (10.3%) both in the biomaterial from urethra and genitals in comparison with the spectre of clinical characteristics certified the presence of interconnection of urinary and reproductive systems, which has to be considered when conducting complex anti-inflammatory therapy. Conclusion. Treatment of chronic reccurent cystitis should be conducted considering the heaviness and level of changes in the inflammatory process both from the side of urinary and reproductive systems in a single context. Only after the clinical analysis of all factors in combination it is possible to determine the tactics of treatment of infections of urinary system in women of reproductive age with the prescription of grounded and adequate therapy. Key words: infections of lower urinary tracts, pelvic inflammatory diseases, women of reproductive age, diagnostics, treatment of acute and chronic recurrent cystitis, Tiflox, Lactovit Forte.

IL-37 As a Potential Biotherapeutics of Inflammatory Diseases

2020 ◽  
Vol 21 (9) ◽  
pp. 855-863 ◽  
Author(s):  
Junhui Bai ◽  
Yukun Li ◽  
Meixiang Li ◽  
Sijie Tan ◽  
Daichao Wu
Keyword(s):  
Lupus Erythematosus ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Potential Therapeutic Target ◽  
Innate And Adaptive Immunity ◽  
Immune Mediated ◽  
Inflammatory Mechanism ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Novel Target

Interleukin-37 (IL-37) was discovered as a new member of pro-inflammatory IL-1 superfamily. However, further studies suggested that IL-37 plays a critical anti-inflammatory role in innate and adaptive immunity. IL-37 may suppress the inflammatory process via intracellular SMAD family member 3 (SMAD3) and extracellular IL-18 Receptor alpha (IL-18Rα) signaling pathway, respectively. Meanwhile, the abnormal expression of IL-37 was observed in immune-mediated inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, atherosclerosis, systemic lupus erythematosus, asthma, and multiple sclerosis, which suggest IL-37 is a potential therapeutic target for these diseases. In this review, we summarize the anti-inflammatory mechanism of IL-37 and discuss the critical roles of IL-37 in the pathogenesis of these diseases. Further studies are required to confirm the effectiveness of IL-37 as a novel target for these inflammatory diseases.

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

scholarly journals New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Ioana-Mirela Vasincu ◽  
Maria Apotrosoaei ◽  
Sandra Constantin ◽  
Maria Butnaru ◽  
Liliana Vereștiuc ◽  
...  
Keyword(s):  
Analgesic Effect ◽  
Visceral Pain ◽  
Biological Effects ◽  
Maximum Effect ◽  
Tail Flick ◽  
Paw Edema ◽  
Cell Viability Assay ◽  
Thermal Nociception ◽  
Analgesic Effects ◽  
Anti Inflammatory

Abstract Background Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially for anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-one scaffold is an important heterocycle, which is associated with different biological effects such as anti-inflammatory and analgesic, antioxidant, antiviral, antiproliferative, antimicrobial etc. The present study aimed to evaluated the toxicity degree and the anti-inflammatory and analgesic effects of new 1,3-thiazolidine-4-one derivatives of ibuprofen. Methods For evaluation the toxicity degree, cell viability assay using MTT method and acute toxicity assay on rats were applied. The carrageenan-induced paw-edema in rat was used for evaluation of the anti-inflammatory effect while for analgesic effect the tail-flick test, as thermal nociception in rats and the writhing assay, as visceral pain in mice, were used. Results The toxicological screening, in terms of cytotoxicity and toxicity degree on mice, revealed that the ibuprofen derivatives (4a-n) are non-cytotoxic at 2 μg/ml. In addition, ibuprofen derivatives reduced carrageenan-induced paw edema in rats, for most of them the maximum effect was recorded at 4 h after administration which means they have medium action latency, similar to that of ibuprofen. Moreover, for compound 4d the effect was higher than that of ibuprofen, even after 24 h of administration. The analgesic effect evaluation highlighted that 4 h showed increased pain inhibition in reference to ibuprofen in thermal (tail-flick assay) and visceral (writhing assay) nociception models. Conclusions The study revealed for ibuprofen derivatives, noted as 4 m, 4 k, 4e, 4d, a good anti-inflammatory and analgesic effect and also a safer profile compared with ibuprofen. These findings could suggest the promising potential use of them in the treatment of inflammatory pain conditions.

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