Treatment of inflammatory diseases of the pelvic organs, due to mixed infection

2016 ◽  
pp. 134-143
Author(s):  
O. V. Romashchenko ◽  
◽  
S. V. Vozianova ◽  
A.V. Rudenko ◽  
L.F. Yakovenko ◽  
...  
Keyword(s):  
Mixed Infection ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Immune Defense ◽  
Laboratory Diagnostics ◽  
Simultaneous Treatment ◽  
Local Immunity ◽  
Etiological Factors ◽  
Pelvic Organs ◽  
Anti Inflammatory

Today the marked increase in the frequency of inflammatory diseases of the pelvic organs (IDPO) caused by sexually transmitted infections (STIs). And among the factors is dominated by numerous microbial associations (mixed infection) in 65-70% of cases detect Chlamydia, gonorrhea, Trichomonas, Molykote. The advantage of latent flow IDPO caused by these factors is one of the reasons for untimely and inadequate treatment of the inflammatory process of the genital organs and the formation of a range of violations of reproductive health of women. The aim of the study: the rationale for differentiated approaches to the treatment of chronic IDPO caused by mixed infection. Materials and methods. A survey of 72 women aged 18 to 37 years with IDPO with disease duration from 2 to 11 years. According to etiological factors and clinical course of HSTMT allocated groups were examined: First, the core group of 38 women with HSTMT caused by mixed infection in combination with Chlamydia, Molicutas; the SECOND main group - 34 patients with HSTMT caused by mixed infection in combination with Trichomonas. Results. Studies have shown that chronic inflammatory diseases of the genital organs in women are predominantly polietiologichesky nature; the latter determines the characteristics of the disease and its consequences. According to clinical and preclinical guidelines inflammatory diseases of the genital organs, caused by mixed infection, defined by differentiated approaches to the choice-stage anti-inflammatory therapy. Conclusion. Among the factors contributing to the effectiveness of treatment of inflammatory diseases of the genital organs, caused by mixed infection, should be highlighted: 1. Early diagnosis of the disease. 2. Identification and remediation of all sources of infection. 3. Compliance with phasing of conducting anti-inflammatory therapy. 4. The restoration of microbiocenosis of intestines, vagina, urethra with the use of the drug Laktovit Forte. 5. The correction of immunological disorders, the recovery of local immune defense. 6. Examination and the simultaneous treatment (if necessary) partner (partners). 7. Clinical, microbiological control of effectiveness of the treatment for 3 months; immunological control after 3, 6 months after treatment. Introduction to practical healthcare system of reasonable effective treatments for VSAT based on objective results of clinical and laboratory diagnostics, account etiological factors, state of systemic and local immunity, pathogenesis mechanisms of development of inflammatory process will contribute to the prevention of its chronicity and relapse. Key words: inflammatory diseases of the pelvic organs, mixed infection, treatment, Tiflox, Meratin.

LOCAL IMMUNE STATUS AND ETIOLOGICAL FACTORS IN PARATONSILLITIS

2019 ◽  
Vol 25 (3) ◽  
pp. 78-86
Author(s):  
T.V. Zolotova ◽  
◽  
A.G. Volkov ◽  
P.A. Kondrashov ◽  
◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Immunoglobulin A ◽  
Secretory Iga ◽  
Control Group ◽  
Local Immunity ◽  
Immunomodulatory Agents ◽  
Etiological Factors ◽  
Streptolysin O ◽  
Bacterial Lysates ◽  
Antigenic Load

Paratonsillitis is one of the most common purulent inflammatory diseases, considered as a manifestation of chronic tonsillitis. The aim of the work is to study the state of local immunity by the level of immunoglobulin A in saliva in patients with paratonsillitis and its changes in the treatment process, to determine the level of antistreptolysin-O in serum, as well as to study the etiological factors of paratonsillites in the microbiological assessment of the species composition of flora in smears from the cavity of paratonsillar abscess. Under our observation there were 152: 32 healthy people and 120 patients with paratonsillitis under abecedarian or abscess stage. It was found that in patients with paratonsillitis there is a significant (p<0.001) decrease in the level of secretory immunoglobulin A in saliva, which indicates a violation of local immunity and requires correction. The level of antibodies to streptolysin-O in the serum of patients with paratonsillitis was significantly - 10.25 times higher than in healthy individuals in the control group, which confirms the high streptococcal antigenic load. The results of microbiological examination of smears from the abscess cavity indicated the release of the most frequent pathogens of paratonsillites - Streptococcus β-haemolythicus, Streptococcus Pneumoniae and Staphylococcus Aureus, with bacterial associations prevailing (63.5%). After a course of antimicrobial therapy, supplemented with immunomodulatory agents in the form of bacterial lysates, there was an increase in the level of secretory IgA in saliva in 10-30 days in 3.3-4.5 times. At the same time, the level of antistreptolysin-O significantly decreased. In patients receiving immunomodulatory therapy in the form of bacterial lysates in the complex treatment of paratonsillitis, for the period of observation of 6 months, there was a decrease in the frequency of relapses of the disease by 2 times.

scholarly journals . Full-scale testing of biologically active additive “Ivlaxinˮ in patients with acute inflammatory diseases

2019 ◽  
Vol 48 (2) ◽  
pp. 143-150
Author(s):  
Евгения Лобач ◽  
Evgeniya Lobach ◽  
Андрей Вековцев ◽  
Andrey Vekovtsev ◽  
Дмитрий Никитюк ◽  
...  
Keyword(s):  
Dietary Supplement ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Blood Analysis ◽  
Biologically Active ◽  
Standards Of Care ◽  
Control Group ◽  
Shortness Of Breath ◽  
Therapeutic Treatment ◽  
Anti Inflammatory

Clinical tests were carried out in the representative group of patients with focal left-sided pneumonia (5 men and 7 women aged 18–41). Special-use product was included in in-patient department patients’ diet: 2 tablets in the first intake, then 1 tablet 4 times a day. Course of treatment was 21 days. Biologically active dietary supplement was prescribed together with general therapeutic treatment according to generally accepted standards of care. Control group included 15 patients randomized depending on sex and age who took only medicine. The author measured body temperature, studied the results of general blood tests, determined the level of C-reactive protein and seromucoids, performed R-graphy of lungs, electrocardiogram before and after treatment, analyzed clinical symptoms (cough, type of expectoration, shortness of breath). Composition of the special-use product was scientifically justified taking pharmacological characteristics of its ingredients and their active agents into account. Introduction of the biologically active dietary supplement in addition to the prescribed therapeutic treatment gave positive effect in relation to the inflammatory process: the patients could easier clear their throats from expectoration, coughed less frequently, and had less intense shortness of breath. It was evident that symptoms of disease recrudescence decreased. It appeared in the decreased intensity and length of fever. In case of acute respiratory viral infection the biologically active dietary supplement had antipyretic activity due to the anti-exudative effect of its ingredients. The author determined the anti-inflammatory effect and reduction of acute intoxication symptoms taking the results of general blood analysis into account. Patients who took special-use product had lower values of an inflammatory process marker – seromucoids. Tissues restored easily. The tested product has anti-inflammatory, antipyretic and analgesic properties. It can be used in complex treatment of acute inflammatory diseases and recrudescence of chronic inflammatory processes.

scholarly journals An impact of the combined drug containing antimicrobial, antiprotozoal, antifungal and glucocorticoid agents on local immunity in women with bacterial vaginosis and non-specific vaginitis

2021 ◽  
Vol 11 (3) ◽  
pp. 549-555
Author(s):  
O. M. Bokach ◽  
M. S. Murasheva ◽  
M. S. Selkova ◽  
K. V. Storozheva ◽  
S. V. Chepanov ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Inflammatory Cytokine ◽  
Randomized Clinical Trials ◽  
Inflammatory Diseases ◽  
Vaginal Mucosa ◽  
Vaginal Smears ◽  
Local Immunity ◽  
Therapeutic Concept ◽  
Frequent Relapses ◽  
Anti Inflammatory

Inflammatory diseases of the vagina related to imbalanced microflora composition represent one of the most common gynecological diseases primarily dealt with by obstetrician/gynecologists. Such diseases markedly worsen female patient quality of life as well as affect female reproductive system resulting both in altered fertility and adverse pregnancy outcomes. By now, multiple therapeutic and preventive protocols have been proposed to manage such diseases, but insufficient therapeutic efficacy and frequent relapses require further investigations. The aim of the study was to evaluate an effect of the drug Elgyna (Wertex, Russia) consisting of antibacterial, antifungal and glucocorticoid agents on local immunity in females with bacterial vaginosis and nonspecific vaginitis. For this, there were examined and treated 24 females enrolled to the study, who underwent gynecological examination (speculum and bimanual vaginal examination), cervical epithelium microscopy, and calculating karyopicnotic index. Special attention was paid to quantifying level of cytokines IL-6, IL-10, TNFα in vaginal smears before and after therapy with the drug Elgyna. It was found that by the end of the therapy course vaginally administered Elgyna resulted in significantly ameliorated clinical symptoms and normalized microscopic parameters of vaginal discharge. Moreover, this drug consisting of antibacterial, antifungal and glucocorticoid agents did not suppress vaginal epithelium proliferation, but lowered production of pro-inflammatory cytokine TNFα in vaginal smears and shifted toward anti-inflammatory cytokine production. This evidence pathogenetically justifies administration of the drug Elgyna in females with bacterial vaginosis and nonspecific vaginitis as an anti-inflammatory medicine. Efficacy and safety of the two-step therapeutic approach consisting of antibacterial therapy followed by vaginal microbiota recovery for treating inflammatory diseases of vaginal mucosa were confirmed in multiple randomized clinical trials. We envision that such therapeutic concept might be added with a third component implying correction of local vaginal immunity aimed at normalizing the balance between pro- and anti-inflammatory cytokines.

scholarly journals Anti-inflammatory and immunomodulating effects of the bacterial lysate in the in vivo models of aseptic lymphadenitis and pneumococcal pneumonia

2020 ◽  
Vol 22 (1) ◽  
pp. 111-122
Author(s):  
K. L. Kryshen ◽  
A. E. Kukharenko ◽  
A. S. Vichare ◽  
E. A. Gaidai ◽  
A. A. Kryshen ◽  
...  
Keyword(s):  
Immune Response ◽  
Lymph Node ◽  
Therapeutic Dose ◽  
Pneumococcal Pneumonia ◽  
Inflammatory Diseases ◽  
Immune Defense ◽  
Control Group ◽  
Infectious Agents ◽  
Bacterial Lysate ◽  
Anti Inflammatory

Bacterial lysates may produce immunoregulatory effects in the inflammatory diseases that are not directly caused by infectious agents; they may also stimulate the immune response against pathogens which are not a part of the lysate composition. Imudon® is a polyvalent bacterial lysate that is available in orodispersible tablets. However, the influence of this drug product on aseptic inflammation and immune defense against the infectious agents, the antigens of which are not contained in this preparation have not been studied so far. The aim of this study, therefore, was to determine the anti-inflammatory and immunomodulating effects of Imudon® using the models of aseptic lymphadenitis (in Wistar rats) and pneumococcal pneumonia (in Balb/c mice), i.e., the conditions not related to the specific components of the bacterial lysate. Lymphadenitis was induced in rats by administration of λ-carrageenan into a cervical lymph node via an open operative approach. Whereas pneumonia was induced in mice by administering Streptococcus pneumoniae suspension intranasally. The choice of pneumococcus was determined by the absence of pneumococcal antigens in Imudon®, i.e., it cannot be a direct inducer of adaptive immune response against pneumococcal infection. Imudon® was administered intragastrically as a crushed tablet suspension following a therapeutic-preventive regimen (for 14 days daily until the induction of inflammation and for 3 [in the lymphadenitis model] or 5 days [in the model of pneumonia] in three doses thereafter). In the lymphadenitis model, Imudon® demonstrated both local and systemic anti-inflammatory responses manifested in the reduced number of circulating leucocytes and lower TNFα levels and by ameliorated histological features of inflammation in the operated lymph node. In rats, the anti-inflammatory effect was most pronounced when the product was administered at a dose of 2.2 mg/kg (equivalent to a human therapeutic dose) and 6.6 mg/kg. In the model of pneumonia, administration of Imudon® at 4.44 mg/kg (equivalent to a human therapeutic dose) and 13.32 mg/kg demonstrated a trend towards increased survival rate as compared to the control group. On Day 5 after infection Imudon® (4.44 and 13.32 mg/kg) decreased significantly the severity of inflammation and bacterial titer in the lungs. The titer of anti-pneumococcal immunoglobulins A in the bronchoalveolar lavage fluid were found to be higher in the Imudon® treated group (13.32 mg/kg) compared to control group. The results of this study showed high antiinflammatory and immunomodulatory activities of Imudon® and provided an insight into the mechanisms that underlie the clinical effects of this drug in various inflammatory diseases.

Approaches to Treatment of Infections of Lower Urinary Tracts in Women of Reproductive Age

2017 ◽  
pp. 81-92
Author(s):  
O.V. Romashchenko ◽  
◽  
V.M. Grygorenko ◽  
V.V. Biloholovska ◽  
L.O. Lebid ◽  
...  
Keyword(s):  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Clinical Analysis ◽  
Reproductive Age ◽  
Gardnerella Vaginalis ◽  
Urinary System ◽  
Reproductive Systems ◽  
Women Of Reproductive Age ◽  
Anti Inflammatory ◽  
Lower Urinary

Infections of urinary tracts (IUT) occupy a priority place both in the level of their outspread and the emergence of recurrences of the disease in ambulatory and stationary practice of a doctor; they are conditioned by inflammatory process, mostly of bacterial genesis, developed in different anatomic parts of urinary system – from fascia renalis to external urethral opening and often combined with pelvic inflammatory diseases. Purpose of research: to evaluate the effectiveness of complex therapy of chronic recidivating cystitis in combination with pelvic inflammatory diseases in women of reproductive age. Materials and Methods. A complex clinical and microbiological examination of 39 women aged from 18 to 39 having chronic reccurent cystitis in combination with pelvic inflammatory diseases in the observation dynamics (before and after the course of anti-inflammatory therapy with the inclusion of Tiflox and probiotic Lactovit Forte) was carried out. Results. As a result of the carried out research the symptomatic development of chronic reccurent cystitis at the background of latent development of pelvic inflammatory diseases was established. In the etiological spectre of chronic reccurent cystitis there were more often microorganisms (mostly E.coli – 82.1%) in the monoculture of critical and high number of microbs, and in 17 (43.5%) mixt-infection was established. Concordance when establishing Chlamydia (7.7%), Mycoplasmas (5.1%), Ureaplasmas (10.3%), Candida (33.4%), and Gardnerella vaginalis (10.3%) both in the biomaterial from urethra and genitals in comparison with the spectre of clinical characteristics certified the presence of interconnection of urinary and reproductive systems, which has to be considered when conducting complex anti-inflammatory therapy. Conclusion. Treatment of chronic reccurent cystitis should be conducted considering the heaviness and level of changes in the inflammatory process both from the side of urinary and reproductive systems in a single context. Only after the clinical analysis of all factors in combination it is possible to determine the tactics of treatment of infections of urinary system in women of reproductive age with the prescription of grounded and adequate therapy. Key words: infections of lower urinary tracts, pelvic inflammatory diseases, women of reproductive age, diagnostics, treatment of acute and chronic recurrent cystitis, Tiflox, Lactovit Forte.

scholarly journals EFFECT OF COMPLEX TREATMENT OF GINGIVITIS WITH THE USE OF CHEWING PHYTOSUBSTRATE IN WOMEN WITH EMERGENCIES CAUSED BY PREGNANCY ON THE CONTENT OF PROINFLAMMATORY CYTOKINES IN THE ORAL FLUID

2021 ◽  
Vol 17 (2) ◽  
pp. 68-73
Author(s):  
Sergey Chuykin ◽  
Natalia Kudashkina ◽  
Al'fiya Yashchuk ◽  
Marsel Tuigunov ◽  
Galina AKATYEVA ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Inflammatory Cytokines ◽  
Inflammatory Process ◽  
Oral Fluid ◽  
Inflammatory Diseases ◽  
Pathological Condition ◽  
Complex Treatment ◽  
Local Immunity ◽  
Tnf Α ◽  
Pro Inflammatory Cytokines

Introduction. Edema of pregnant women is a pathological condition in the second half of pregnancy, in which disorders of the functions of vital organs are noted and an exacerbation of chronic and sluggish inflammatory diseases occurs. Inflammatory periodontal disease and dental caries increase especially in the third trimester, and are most pronounced in complicated pregnancies. Changes in the cytokine profile in the mixed saliva of pregnant women reflect the state of local immunity and tissues of the oral cavity and indicate the participation of immunocompetent cells of the placenta and fetus in the response to the inflammatory process. Purpose: to characterize the effect of complex treatment of gingivitis with the use of a chewing phytosubstrate in women with edema caused by pregnancy on the level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in the oral fluid. Materials and methods: the level of cytokines IL-1β, IL-6, TNF-α in the oral fluid was determined before and after complex treatment of gingivitis with the inclusion of a chewing phytosubstrate in women with edema caused by pregnancy. Conclusion: Inclusion in the complex treatment of gingivitis in women with edema caused by pregnancy, a chewable phytosubstrate containing 0.1 g of dry matter extract (oak bark, alder stems, birch buds, chamomile flowers, thyme grass) and 1.0 g beeswax, has a pronounced therapeutic effect, reducing the content of pro-inflammatory cytokines in the oral fluid, which reflects the suppression of the inflammatory process.

IL-37 As a Potential Biotherapeutics of Inflammatory Diseases

2020 ◽  
Vol 21 (9) ◽  
pp. 855-863 ◽  
Author(s):  
Junhui Bai ◽  
Yukun Li ◽  
Meixiang Li ◽  
Sijie Tan ◽  
Daichao Wu
Keyword(s):  
Lupus Erythematosus ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Potential Therapeutic Target ◽  
Innate And Adaptive Immunity ◽  
Immune Mediated ◽  
Inflammatory Mechanism ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Novel Target

Interleukin-37 (IL-37) was discovered as a new member of pro-inflammatory IL-1 superfamily. However, further studies suggested that IL-37 plays a critical anti-inflammatory role in innate and adaptive immunity. IL-37 may suppress the inflammatory process via intracellular SMAD family member 3 (SMAD3) and extracellular IL-18 Receptor alpha (IL-18Rα) signaling pathway, respectively. Meanwhile, the abnormal expression of IL-37 was observed in immune-mediated inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, atherosclerosis, systemic lupus erythematosus, asthma, and multiple sclerosis, which suggest IL-37 is a potential therapeutic target for these diseases. In this review, we summarize the anti-inflammatory mechanism of IL-37 and discuss the critical roles of IL-37 in the pathogenesis of these diseases. Further studies are required to confirm the effectiveness of IL-37 as a novel target for these inflammatory diseases.

OPTIMIZATION OF DENTAL CARE FOR ELDERLY PATIENTS WITH CHRONIC APICAL PERIODONTITIS AGAINST THE BACKGROUND OF POLYMORBID PATHOLOGY

2020 ◽  
pp. 225-229
Author(s):  
Наталья Викторовна Бурягина ◽  
Светлана Гиршевна Горелик
Keyword(s):  
Elderly Patients ◽  
Inflammatory Cytokines ◽  
Dental Care ◽  
Immune Defense ◽  
Apical Periodontitis ◽  
Signal Molecules ◽  
Systematic Effect ◽  
Local Immunity ◽  
Anti Inflammatory ◽  
Pro Inflammatory Cytokines

В статье показана оптимизированная тактика диагностики, лечения и реабилитации пациентов пожилого возраста с хроническим апикальным периодонтитом и полиморбидным гериатрическим континуумом на основании полученных нами данных о том, что при наличии у пожилых пациентов полиморбидности в полости рта увеличивается содержание провоспалительных сигнальных молекул, снижается содержание противовоспалительных, антиоксидатных молекул (пероксидаза) и пептидов с антимикробными свойствами (лизоцим, лактоферрин), что снижает эффективность местной иммунной защиты и потенциально способствует прогрессированию патологического процесса и является фактором риска воспалительных осложнений стоматологических манипуляций. Также нами доказано, что хронический апикальный периодонтит может расцениваться как полноценный участник полиморбидного гериатрического континуума, поскольку при его сочетании с соматической полиморбидной патологией в сыворотке крови увеличивается содержание провоспалительных цитокинов. Поэтому пожилым пациентам с хроническим апикальным периодонтитом кроме стандартного лечения добавляется местно иммуностимулятор иммудон, который за счет снижения уровня провоспалительных цитокинов и повышения концентрации противовоспалительных цитокинов, увеличения концентрации локальных факторов защиты, способствует повышению антибактериальной активности ротовой жидкости и поддержанию противовоспалительной цитокиновой системы на локальном уровне. А также препарат общего действия-иммуномодулятор полиоксидоний для коррекции выработки провоспалительных цитокинов, что влияет на общий иммунитет и увеличивает резистентность организма в отношении инфекций различной этиологии. При внедрении оптимизированной тактики стоматологической помощи пациентам пожилого возраста с хроническим апикальным периодонтитом на фоне полиморбидной патологии нами доказано, что у пожилых пациентов с ХАП и полиморбидностью в процессе лечения достоверно улучшается состояние общего иммунного ответа и параметры местного иммунитета, что способствует восстановлению функции зуба у 86,7% пациентов, а также сокращает сроки лечения пациентов на 30,1% The article describes optimized tactics of diagnostics, treatment and rehabilitation of elderly patients with chronic apical periodontitis and polymorbid geriatric continuum based on obtained data that in case of polymorbidity in oral cavity, the content of pro-inflammatory signal molecules, anti-inflammatory, antioxidant molecules (peroxidase) and peptides with antimicrobial properties (lysozyme, lactoferrin) increases, which reduces the effectiveness of local immune defense and potentially contributes to the progression of pathological processes and is a risk factor for dental procedures inflammatory complications. We have also proved that chronic apical periodontitis can be regarded as a full participant of the polymorbid geriatric continuum, since its combination with somatic polymorbid pathology increases the content of pro-inflammatory cytokines in the blood serum. Therefore, an immunostimulator immudon is added to the standard treatment of elderly patients with chronic apical periodontitis, which, by reducing the level of pro-inflammatory cytokines and increasing the concentration of anti-inflammatory cytokines, increasing the concentration of local protection factors, helps to increase the antibacterial activity of the oral fluid and maintain the anti-inflammatory cytokine system at the local level. As well as an immunomodulator with a systematic effect - polyoxidonium for correction of pro-inflammatory cytokines production, which affects the overall immune system and increases the body's resistance to infections of various etiologies. When implementing optimized tactics of dental care for elderly patients with chronic apical periodontitis against the background of polymorbid pathology, we proved that in elderly patients with CAP and polymorbidity, the state of the general immune response and local immunity parameters significantly improve during treatment, which contributes to the restoration of tooth function in 86.7% of patients, and also reduces the duration of treatment of patients by 30.1%

Prevention of Complications Arising after Tooth Extraction

2021 ◽  
Vol 5 (9) ◽  
pp. 101-105
Author(s):  
Oleksii Tymofieiev ◽  
Viktoriia Ripa ◽  
Diana Havlytiuk ◽  
Marta Sokoliuk ◽  
Lesia Kolisnichenko
Keyword(s):  
Analgesic Effect ◽  
Tooth Extraction ◽  
Inflammatory Process ◽  
Inflammatory Diseases ◽  
Anti Inflammatory ◽  
Tooth Extractions

The study involved 67 patients with acute odontogenic inflammatory diseases of the jaws were examined. All examined patients underwent tooth extraction, which caused the development of an acute inflammatory process. We have determined the effectiveness of treatment of patients with the drug “Givalex,” which was used to prevent inflammatory post-extraction complications in patients with acute odontogenic inflammatory diseases. Based on the examinations of patients, it was proved that the multicomponent preparation “Givalex” used for oral baths after tooth extractions has an expressed antiseptic, anti-inflammatory and analgesic effect, as well as a deodorizing effect.

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