scholarly journals Preliminary analysis of emulsion-based formulations containing pumpkin seed oil and hemp seed oil for internal use

2020 ◽  
Author(s):  
Maria-Cristina Anicescu ◽  
Cristina-Elena Dinu-Pirvu ◽  
Mihaela Violeta Ghica ◽  
Valentina Anuta ◽  
Razvan Mihai Prisada ◽  
...  
Keyword(s):  
Contact Angle ◽  
Oral Delivery ◽  
Seed Oil ◽  
Point Of View ◽  
Pumpkin Seed ◽  
Hemp Seed ◽  
Stability Point ◽  
Pumpkin Seed Oil ◽  
Adaptive Power ◽  
New Formulation

With a long tradition in pharmaceutical design, emulsions are functional formulations that can maintain their adaptive power connected with the new formulation requirements. Hence, this study proposed preliminary assays concerning the obtaining of natural emulsions for oral administration, incorporating pumpkin seed oil and hemp seed oil as oil phases, with lecithin as emulsifying agent. Using emulsification method, O/W and W/O emulsions were prepared and characterized from a stability point of view considering organoleptic parameters, conductivity properties followed by an extensive superficial analysis by fitting two different goniometric approaches like contact angle and pendant drop models. The emulsions obtained were stable, homogeneous, their properties being reflected by composition. Conductivity values confirmed the type of emulsions, completing their profile. Superficial analysis revealed that lecithin can sustain a proper stability due to a variation of surface tension values around 25 mN/m. The mean contact angle values ranging between 31.87±0.51° and 44.01±5.48° defined an adequate wettability, being correlated with the internal structure. To conclude, this preliminary study offered important data concerning the stability of some emulsions for oral delivery, accessing natural biocompatible components. On this way, it can be created multifunctional systems with nutritional value, but also special vehicles designed for drug delivery.

The antioxidant effects of pumpkin seed oil on subacute aflatoxin poisoning in mice

2011 ◽  
Vol 28 (12) ◽  
pp. 681-688 ◽  
Author(s):  
Gökhan Eraslan ◽  
Murat Kanbur ◽  
Öznur Aslan ◽  
Mürsel Karabacak
Keyword(s):  
Seed Oil ◽  
Pumpkin Seed ◽  
Pumpkin Seed Oil ◽  
Antioxidant Effects

scholarly journals Determination of sesame oil, rice bran oil and pumpkin seed oil in ternary mixtures using FTIR spectroscopy and multivariate calibrations

Food Research ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 135-142 ◽  
Author(s):  
Irnawati ◽  
S. Riyanto ◽  
S. Martono ◽  
Abdul Rohman
Keyword(s):  
Root Mean Square Error ◽  
Rice Bran ◽  
Seed Oil ◽  
Rice Bran Oil ◽  
Sesame Oil ◽  
Ftir Spectra ◽  
Ternary Mixtures ◽  
Mean Square ◽  
Pumpkin Seed ◽  
Pumpkin Seed Oil

Pumpkin seed oil (PSO), rice bran oil (RBO), sesame oil (SEO) are considered as functional oils due to its biological activities which are beneficial to human health, as a consequence, these oils had the higher price. This attracted unethical players to blend these oils with lower price oils, therefore, its authentication by analysis of purity levels of oils is very important. This study highlighted the potential application of FTIR spectroscopy and multivariate calibrations for analysis of PSO, RBO, and SEO in ternary mixtures. Individual FTIR spectra of studied oils as well as in ternary mixtures with certain compositions were scanned and pre-processed. Two multivariate calibrations of principle component regression (PCR) and partial least square regression (PLSR) were compared and used to build the prediction models at optimized FTIR spectra regions. The selection of multivariate calibrations, wavenumbers region, and FTIR spectra modes was based on the statistical parameters of highest R2 and lowest values of root mean square error of calibration (RMSEC) and root mean square error of prediction (RMSEP). The results showed that PLSR using second derivative FTIR spectra at wavenumbers region of 3100-2750 and 1500-663 cm-1 was used to predict the levels of PSO in ternary mixtures with RBO and SEO with R2 > 0.99 in calibration and validation models along with RMSEC value of 0.0054% and RMSEP of 0.0179%. FTIR spectra using the second and first derivatives at wavenumbers of 3100-650 cm-1 were used for prediction of RBO and SEO in ternary mixture with PSO, respectively. It can be concluded that FTIR spectra combined with PLSR at certain wavenumbers region are accurate as indicated by high R2 values and precise as indicated by low values of RMSEC and RMSEP for analysis of PSO, RBO and SEO in ternary mixtures.

scholarly journals Phenolics Dynamics and Infrared Fingerprints during the Storage of Pumpkin Seed Oil and Thereof Oleogel

Processes ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 1412
Author(s):  
Andreea Pușcaș ◽  
Andruța Mureșan ◽  
Floricuța Ranga ◽  
Florinela Fetea ◽  
Sevastița Muste ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Seed Oil ◽  
Intermolecular Forces ◽  
Syringic Acid ◽  
Bioactive Molecules ◽  
Pumpkin Seed ◽  
Ambient Storage ◽  
Oxidative Processes ◽  
Pumpkin Seed Oil ◽  
Cold Pressed

Cold-pressed pumpkin seed oil is a valuable source of bioactive molecules, including phenolic compounds. Oleogels are designed for trans and saturated fats substitution in foods, but also demonstrate protection and delivery of bioactive compounds. Consequently, the present work aimed to assess individual phenolic compounds dynamics and infrared fingerprints during the ambient storage of pumpkin seed oil and thereof oleogel. For oleogels production, a 5% ternary mixture of waxes, composed by 3% beewax, 1% sunflower wax and 1% rice bran wax, was used. Phenolic compounds were extracted by traditional liquid–liquid extraction, followed by HPLC-MS quantification. FTIR (400–4000 cm−1) was used for characterizing and monitoring the oxidative stability of all samples and for the evaluation of intermolecular forces between oleogelator mixtures and oil. Specific wavenumbers indicated oxidative processes in stored sample sets; storage time and sample clustering patterns were revealed by chemometrics. Isolariciresinol, vanillin, caffeic and syringic acids were quantified. The main changes were determined for isolariciresinol, which decreased in liquid pumpkin seed oil samples from 0.77 (T1) to 0.13 mg/100 g (T4), while for oleogel samples it decreased from 0.64 (T1) to 0.12 mg/100 g (T4). However, during the storage at room temperature, it was concluded that oleogelation technique might show potential protection of specific phenolic compounds such as syringic acid and vanillin after 8 months of storage. For isolariciresinol, higher amounts are registered in the oleogel (0.411 mg/100 g oil) than in the oil (0.37 mg/100 g oil) after 5 months of ambient temperature storage (T3). Oxidation processes occurred after 5 months storage for both oil and oleogel samples.

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