scholarly journals EFEK SINERGIS KLOROKUIN DAN N-ACETYL CYSTEINE TERHADAP PENURUNAN PARASITEMIA DAN PENURUNAN KADAR MALONDYALDEHYDE ERITROSIT MENCIT YANG DIINFEKSI PLASMODIUM BERGHEI

2016 ◽  
Vol 20 (1) ◽  
pp. 6
Author(s):  
Agustin Iskandar ◽  
Sudjari Sudjari
Keyword(s):  
Body Weight ◽  
Global Health ◽  
Experimental Research ◽  
Plasmodium Berghei ◽  
Synergic Effect ◽  
The World ◽  
Parasitemia Level ◽  
Acetyl Cysteine ◽  
Combined Drugs ◽  
Global Health Problem

Malaria is still a global health problem around the world particularly in Indonesia. Chloroquine is one of the anti-malarial drugs which is still used in Indonesia. The aim of this research is to know the synergic effect of Chloroquine and N-Acetyl Cysteine towards parasitemia and erythrocyte malondyaldehyde levels in mice infected with Plasmodium berghei. This was an experimental research using Plasmodium berghei and BALB/c strain mice, 6−8 weeks old, with body weight 20−30 grams. After infected with Plasmodium berghei, the mice were divided into eight (8) groups: control, chloroquine, NAC 0.25 mg/gBb; NAC 0.5 mg/gBb; NAC 1 mg/gBb and combined drugs of chloroquine and NAC 0.25 mg/gBb; NAC 0.5 mg/gBb; NAC 1 mg/gBb. On the 3rd, 5th, and 7th day after treatment, the mice were killed and their parasitemia and Malondialdehyde (MDA) levels were measured. By using MANOVA and Tukey HSD test, a signifi cant difference in parasitemia level was found between the control and chloroquine group, as well as the control and combined drug groups. In the NAC groups, there was no decrease. The decrease of MDA level began on the 7th day. It can be concluded that there was a synergic effect between the chloroquine and N-Acetyl Cysteine in decreasing parasitemia and malondyaldehyde levels in mice BALB/c infected with Plasmodium berghei.

scholarly journals Modality analysis in Joe Biden’s speech delivered on the anniversary of the Covid-19 shutdown

2021 ◽  
Vol 6 (2) ◽  
pp. 60-70
Author(s):  
Inggita Pramesti Ayuningtyas
Keyword(s):  
Discourse Analysis ◽  
Global Health ◽  
Health Problem ◽  
The Self ◽  
Functional Grammar ◽  
Systemic Functional Grammar ◽  
The World ◽  
Global Health Problem

Covid-19 has been global health problem and become the concern of global leaders in the world. One of them is Joe Biden, current president of American. He delivered his speech on Anniversary Covid-19 Shutdown on March 11, 2021. The clauses in his speech contain modality. Modality is included in interpersonal meaning where language is used to encode interaction between the speaker and the hearer. This research aims to analyze the type of modality used by Biden in his speech and utilize it to find his self-representation. The research uses Systemic Functional Grammar (SFG) in term of modality analysis as the tool and discourse analysis as the approach. The finding shows that three types of modalities found; inclination, probability and obligation. The self-representation of Biden found are being visionary, being determined, showing sadness, being powerful, and showing respect.   DOI: 10.26905/enjourme.v6i2.6531

scholarly journals Pendampingan Mitigasi dan Adaptasi Perilaku Baru di Masa Pandemi Covid-19 Melalui Gerakan Masyarakat Menggunakan Masker (GEMAS), Penggunaan Antiseptik dan Desinfektan di Kabupaten Bombana, Sulawesi Tenggar

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Nuralifah ◽  
Ruslin ◽  
Andi Nafisah Tendri Adjeng ◽  
Yuni Aryani Koedoes ◽  
Nur Fitriana Muhammad Ali
Keyword(s):  
Population Density ◽  
Global Health ◽  
Community Service ◽  
Public Knowledge ◽  
Hand Sanitizer ◽  
The People ◽  
Number Of Patients ◽  
The World ◽  
Global Health Problem

COVID-19 causes worldwide panic and become a global health problem so that it is declared as pandemic since December 2019. Indonesia is a country with 4th population density in the world. The level of spread of COVID-19 patients in Indonesia may be more than countries with smaller populations. South East Sulawesi has confirmed 484 of COVID-19 cases. One of the highest areas with the number of patients is Bombana Regency. The purpose of community service carried out by lecturers and students from Halu Oleo University was to strengthen the role of the people of Bombana Regency in mitigating and adapting to the COVID-19 pandemic. Activities in community service included education and socialization of GEMAS, antiseptics, and disinfectants which were carried out offline (door to door) and online. As well as the distribution of masks and spray hand sanitizer for free. Through this activity, it can be expected to increase public knowledge and awareness in using masks, antiseptics, and disinfectants properly to face COVID-19 pandemic.

Use of Phosphatidylcholine in the Treatment of Localized Fat Deposits. Results and expectations

2017 ◽  
Vol 68 (7) ◽  
pp. 1438-1441 ◽  
Author(s):  
Sorin Berbece ◽  
Dan Iliescu ◽  
Valeriu Ardeleanu ◽  
Alexandru Nicolau ◽  
Radu Cristian Jecan
Keyword(s):  
World Health Organisation ◽  
Normal Weight ◽  
World Health ◽  
Basic Substance ◽  
Physical Exercises ◽  
Fat Deposits ◽  
The World ◽  
The Common ◽  
Global Health Problem ◽  
Over Time

Obesity represents a global health problem. According to the latest studies released by the World Health Organisation (WHO), 1.7 billion currently in excess of normal weight individuals, of which approx. 75% are overweight (body mass index - BMI 25 to 30). The common form of excess adipose tissue manifestation in overweight individuals is localized fat deposits with high (abdominal) or low (buttocks and thighs) disposition. Although the overweight can be corrected relatively easy by changing behavioral habits or food, a constant physical exercises program or following a diet food are not accessible to all through the efforts of will, financial and time involved. Several methods have been studied and tested over time to eliminate more or less invasive fat deposits with varying efficacy and adverse effects. Chemical lipolysis using phosphatidylcholine as the basic substance was initially used in hypercholesterolemia and its complications and was rapidly adopted in mesotherapy techniques for the treatment of fat deposits. This study reveals the results obtained using Dermastabilon on a sample of 16 patients, the time allocated to treatment and discomfort being minimal, and rapid and notable results. There were no side effects.

scholarly journals Osmium–arene complexes with high potency towards Mycobacterium tuberculosis

Metallomics ◽  
2021 ◽  
Vol 13 (4) ◽  
Author(s):  
James P C Coverdale ◽  
Collette S Guy ◽  
Hannah E Bridgewater ◽  
Russell J Needham ◽  
Elizabeth Fullam ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Global Health ◽  
Mechanism Of Action ◽  
Health Problem ◽  
Normal Lung ◽  
Lung Cells ◽  
Redox Mechanism ◽  
Human Lung Cells ◽  
Half Sandwich ◽  
Global Health Problem

Abstract The treatment of tuberculosis (TB) poses a major challenge as frontline therapeutic agents become increasingly ineffective with the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). To combat this global health problem, new antitubercular agents with novel modes of action are needed. We have screened a close family of 17 organometallic half-sandwich Os(II) complexes [(arene)Os(phenyl-azo/imino-pyridine)(Cl/I)]+Y– containing various arenes (p-cymene, biphenyl, or terphenyl), and NMe2, F, Cl, or Br phenyl or pyridyl substituents, for activity towards Mtb in comparison with normal human lung cells (MRC5). In general, complexes with a monodentate iodido ligand were more potent than chlorido complexes, and the five most potent iodido complexes (MIC 1.25–2.5 µM) have an electron-donating Me2N or OH substituent on the phenyl ring. As expected, the counter anion Y (PF6–, Cl–, I–) had little effect on the activity. The pattern of potency of the complexes towards Mtb is similar to that towards human cells, perhaps because in both cases intracellular thiols are likely to be involved in their activation and their redox mechanism of action. The most active complex against Mtb is the p-cymene Os(II) NMe2-phenyl-azopyridine iodido complex (2), a relatively inert complex that also exhibits potent activity towards cancer cells. The uptake of Os from complex 2 by Mtb is rapid and peaks after 6 h, with temperature-dependence studies suggesting a major role for active transport. Significance to Metallomics Antimicrobial resistance is a global health problem. New advances are urgently needed in the discovery of new antibiotics with novel mechanisms of action. Half-sandwich organometallic complexes offer a versatile platform for drug design. We show that with an appropriate choice of the arene, an N,N-chelated ligand, and monodentate ligand, half-sandwich organo–osmium(II) complexes can exhibit potent activity towards Mycobacterium tuberculosis (Mtb), the leading cause of death from a single infectious agent. The patterns of activity of the 17 azo- and imino-pyridine complexes studied here towards Mtb and normal lung cells suggest a common redox mechanism of action involving intracellular thiols.

Investigation of therapeutic potential of three endemic Cirsium species for global health problem obesity

2021 ◽  
Vol 141 ◽  
pp. 243-254
Author(s):  
Sila Ozlem Sener ◽  
Ufuk Ozgen ◽  
Seyda Kanbolat ◽  
Nuriye Korkmaz ◽  
Merve Badem ◽  
...  
Keyword(s):  
Global Health ◽  
Health Problem ◽  
Therapeutic Potential ◽  
Global Health Problem

scholarly journals ‘Choking the national demos’: research partnerships and the material constitution of global health

2021 ◽  
Vol 17 (1) ◽  
pp. 122-127
Author(s):  
John Harrington
Keyword(s):  
Human Rights ◽  
Global Health ◽  
Access To Medicines ◽  
Functional Health ◽  
Essential Medicines ◽  
World Health ◽  
Moral Principle ◽  
International Human Rights Law ◽  
Health Law ◽  
The World

By foregrounding a widened view of the rule of law in transnational legal processes, the works under discussion in this symposium can support innovative critical perspectives on global health law –a field that has gained wide attention due to the spread of COVID-19 around the world (Lander, 2020; Bhatt, 2020). Legal and socio-legal scholars in the decade and a half before the pandemic worked on locating global health law and articulating its underlying principles. Lawrence Gostin's 2014 monograph offers a synoptic view centred on international institutions (e.g. the World Health Organization, World Trade Organization, UN Human Rights Council) and problems (e.g. infectious-disease response, tobacco control), along with an elaboration of its normative basis in universal moral principle and international human rights law (Gostin, 2014). Struggles over access to essential medicines and intellectual property in the early 2000s are, for example, represented in terms of the right to health constraining international trade law. Andreas Fischer-Lescano and Guenther Teubner's 2004 reading is oriented more by social theory than by doctrinal or ethical frames (Fischer-Lescano and Teubner, 2004, pp. 1006, 1008). A functional health regime has ‘differentiated out’, they observe, and operates as a discrete communication system across borders, albeit one that is threatened by the preponderant economic system. On this model, the battle for access to medicines amounts to ensuring, via human rights guarantees, that the rationality of the health system is not replaced by that of its economic rival in legal and policy communications (Fischer-Lescano and Teubner, 2004, pp. 1030, 1046).

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