Serum concentrations of calcium, phosphorus, magnesium, and calciotropic hormones in donkeys

2006 ◽  
Vol 229 (4) ◽  
pp. 565-565
Author(s):  
Ignacio Lopez ◽  
Jose C. Estepa ◽  
Francisco J. Mendoza ◽  
Mariano Rodriguez ◽  
Escolastico Aguilera-Tejero
2006 ◽  
Vol 67 (8) ◽  
pp. 1333-1336 ◽  
Author(s):  
Ignacio Lopez ◽  
Jose C. Estepa ◽  
Francisco J. Mendoza ◽  
Mariano Rodriguez ◽  
Escolastico Aguilera-Tejero

2017 ◽  
Vol 30 (6) ◽  
pp. 485 ◽  
Author(s):  
Ana Pires ◽  
Luis Sobrinho ◽  
Hugo Gil Ferreira

Introduction: A simple data filtering process together with some basic concepts of control theory applied to electronically stored clinical data were used to identify some of the pathophysiological mechanisms underlying the perturbations of the calcium/phosphorus homeostasis in chronic kidney disease.Material and Methods: Retrospective data (a set per patient of serum single value concentrations of creatinine, calcium, phosphorus, parathormone, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D) from 2507 patients with stable chronic kidney disease not on renal replacement therapy were studied. The variables were paired and subjected sequentially to a moving average and partioned into frequency classes. The plots were interpreted using the concept of a feedback loop comprising two branches of opposite sign and of set point of the loop. The set point for each pair of variables is displaced in the course of the disease and this displacement indicates which of the two factors involved (the serum concentrations of calcium or parathormone, for example) is primarily affected.Results: This analysis showed that in the course of the development of chronic kidney disease the relationships between the observed variables progressed following a monotonous, a biphasic or a triphasic pattern.Discussion: As chronic kidney disease progresses, calcium/phosphorus metabolism regulation evolves through different phases. Later, there is a progressive loss of the parathyroid gland sensitivity to the control by the serum concentrations of calcium and phosphorus. The sensitivity to the inhibitory action of 1,25-dihydroxyvitamin D decreases monotonously but never releases the gland.Conclusion: The clinical data analysis used permits to illustrate the underlying pathophysiological mechanisms.


2016 ◽  
Vol 37 (3) ◽  
pp. 1415
Author(s):  
Lara Reis Gomes ◽  
Renata Dias Rodrigues ◽  
Rafael Rocha de Souza ◽  
Amanda Bizare ◽  
João Gabriel Knychala Faria ◽  
...  

This study aimed to evaluate the physiological variations in the serum biochemical profile of neonate (3-5 days old) Senepol and crossbreed Holstein x Gir calves in Uberlândia, state of Minas Gerais, Brazil, and to compare values between breeds and sexes. In total, 168 healthy Senepol (n = 80, 28 females and 52 males) and crossbred Holstein x Gir (n = 88, 49 females and 39 males) calves were evaluated. From each animal, approximately 5 mL of blood was collected by jugular venipuncture into a sterile tube without anticoagulant to obtain serum. Serum concentrations of total protein, albumin, creatinine, urea, total cholesterol, triglycerides, calcium, and phosphorus; and the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, and gamma-glutamyl transferase (GGT) were determined on a automated multichannel analyzer. There were significant differences (p < 0.05) in serum concentrations for total protein, globulin, albumin/globulin ratio (A:G), creatinine, urea, phosphorus, calcium/phosphorus ratio (Ca:P), AST, and GGT between Senepol calves and crossbred Holstein x Gir calves, but no significant differences in serum concentrations were observed between male and female calves for either breed (p > 0.05). It was concluded that the serum biochemistry profile of newborn Senepol and crossbred Holstein x Gir calves was affected by differences in colostrum intake management and breed characteristics. Also, no differences in blood parameters were observed between male and female calves.


2020 ◽  
Vol 36 (5) ◽  
Author(s):  
Roberta de Lima Santos ◽  
Renata Dias Rodrigues ◽  
Lara Reis Gomes ◽  
Amanda Bizare ◽  
Wilson Junior Oliveira ◽  
...  

The objective of this work was to evaluate the proteins, minerals, metabolites, and serum enzymes profile in Quarter Mile equines subjected to training for Team Penning competitions by comparing the results before and after training. The animals were from the Agricultural Exhibition Park of Uberlândia (CAMARU), in Uberlândia in the State of Minas Gerais, Brazil. These animals perform constant periodic training with an average duration of two and a half hours per training. Blood samples from twenty male and female equines were collected at the beginning and end of a 45-day interval and then analyzed. A 5 mL blood sample from each animal was collected before and after training by a jugular external venipuncture, and the samples were placed in a tube—without anticoagulant and containing separator gel—to obtain the serum. The components analyzed were: total proteins, albumin, globulins, albumin to globulin ratio (A:G), total and ionized calcium, phosphorus, calcium to phosphorus ratio (Ca:P), cholesterol, triglycerides, creatinine, urea, alkaline phosphatase, ɤ-glutamyl transferase, lactate dehydrogenase (LDH), aspartate amino transferase (AST), alanine aminotransferase (ALT) and creatine kinase (CK). Statistical differences were observed with higher values after exercise for total calcium, ionized calcium, Ca: P ratio, creatinine and ALT and decreased concentrations were found for globulins, phosphorus, cholesterol and triglycerides. Despite the changes observed in the serum concentrations of some elements after exercises, it was concluded that the animals were in adequate physical condition to perform the proposed physical exercises.


2016 ◽  
Vol 99 (7) ◽  
pp. 5535-5544 ◽  
Author(s):  
V. Tsiamadis ◽  
G. Banos ◽  
N. Panousis ◽  
M. Kritsepi-Konstantinou ◽  
G. Arsenos ◽  
...  

2021 ◽  
Vol 17 (5) ◽  
pp. 385-392
Author(s):  
N.V. Karlovich ◽  
T.V. Mokhort

Background. Secondary hyperparathyroidism (SHPT) is universal complication of chronic kidney disease (CKD), the likelihood of which increases as renal function decreases. Currently, SHPT is considered in the context of mineral and bone disorders associated with CKD. Mineral and bone disorders associated with CKD include, in addition to SHPT, disorders of calcium-phosphorus metabolism, bone pathology and metastatic calcification, which determine poor outcomes of the disease. The purpose of the study was to evaluate the serum concentrations of fibroblast growth factor (FGF) 23 and Klotho protein in patients with various stages of CKD and their relationship with SHPT, vitamin D levels, and calcium-phosphorus metabolism in patients with varying degrees of decreased renal function. Materials and methods. Serum concentrations of FGF 23, Klotho protein, parathyroid hormone (PTH), 25(OH)D, calcium and phosphorus were evaluated in 229 patients with various stages of chronic kidney disease and in 40 people without signs of CKD. Results. It has been shown that individuals with CKD are characterized by overproduction of humoral phosphatonin FGF 23 and Klotho deficiency, which increase as renal failure worsens. A significant relationship was established between FGF 23 and the levels of PTH and blood phosphorus; Klotho protein — with the patient’s age and serum vitamin D. An early marker of disorders in the FGF 23-Klotho system is a decrease in the Klotho protein concentration, which occurs in the early stages of CKD and is aggravated with the progression of renal failure. A statistically significant overproduction of FGF 23 associated with secondary hyperparathyroidism was registered in patients with glomerular filtration rate less than 35 ml/min/1.73 m2. Conclusions. An early marker of disorders in the FGF 23-Klotho system is a decrease in the concentration of the Klotho protein, which occurs in the early stages of CKD and is aggravated with the progression of renal fai-lure. The relationship between Klotho deficiency and the formation of SHPT has not been found. As kidney function decreases, excess production of PTH and FGF 23 appears and increases, hyperphosphatemia progresses. This proves the pathogenetic relationship between the formation of SHPT and the overproduction of humoral phosphatonin FGF 23, since it is this glomerular filtration rate that determines the growth of PTH above the upper limit of the general population reference interval.


2009 ◽  
Vol 40 (2) ◽  
pp. 302-305 ◽  
Author(s):  
Michele Miller ◽  
Tai C. Chen ◽  
Michael F. Holick ◽  
Susan Mikota ◽  
Ellen Dierenfeld

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mohsen Bakhtiyari ◽  
Mehrdad Fathei ◽  
Keyvan Hejazi

Background: Osteoporosis is the most common disorder of bone and mineral metabolism. This disease is associated with decreased bone density and loss of bone microstructure, leading to increased fragility and risk of bone fractures. Objectives: The aim of this study was to evaluate the effect of eight weeks of aerobic interval training on the serum concentrations of alkaline phosphatase, osteocalcin, and parathyroid hormone in middle-aged men. Methods: This was a quasi-experimental study of 24 men, who were divided into two groups of control (n = 12) and aerobic interval training (n = 12). Training performed during eight weeks, three times a week, each session for 45 to 60 minutes. Blood samples were analyzed for the concentrations of calcium, phosphorus, alkaline phosphatase, osteocalcin, and parathyroid hormone before and after completion of the training program. Paired samples t-test and analysis of covariance (ANCOVA) were run to analyze the data (P ≤ 0.05). Results: Weight and body mass index decreased significantly, and the maximum oxygen consumption at the end of the training program increased significantly in the experimental group. Eight weeks of aerobic exercise led to a significant increase in the amounts of calcium (P = 0.001), phosphorus (P = 0.001), alkaline phosphatase (P = 0.001), osteocalcin (P = 0.001), and parathyroid hormone (P = 0.001) in the experimental group. Conclusions: It can be stated that eight weeks of aerobic interval training may be effective in preventing osteoporosis by reducing body composition indices and increasing calcium, phosphorus, alkaline phosphatase, osteocalcin, and serum parathyroid hormone in inactive men.


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