scholarly journals Effect of 1,6-Hexamethylene Diisocyanate Exposure on Peak Flowmetry in Automobile Paint Shop Workers in Iran

2010 ◽  
Vol 61 (2) ◽  
pp. 183-189 ◽  
Author(s):  
Siyamak Pourabedian ◽  
Abdullah Barkhordari ◽  
Ehsanallah Habibi ◽  
Masoud Rismanchiyan ◽  
Mohsen Zare
Keyword(s):  
Occupational Exposure ◽  
Peak Expiratory Flow ◽  
Inhalation Exposure ◽  
Threshold Limit Value ◽  
Hexamethylene Diisocyanate ◽  
Paint Shop ◽  
Limit Value ◽  
Automobile Body ◽  
Flow Inhalation ◽  
Expiratory Flow

Effect of 1,6-Hexamethylene Diisocyanate Exposure on Peak Flowmetry in Automobile Paint Shop Workers in IranThe aim of this study was to investigate the effects of occupational exposure to 1,6-hexamethylene diisocyanate (HDI) on peak flowmetry in automobile body paint shop workers in Iran. We studied a population of 43 car painters exposed to HDI at their workplaces. Peak expiratory flow was tested for one working week, from the start to the end of each shift. Air was sampled and HDI analysed in parallel, according to the OSHA 42 method.Daily and weekly HDI exposure averages were (0.42±0.1) mg m-3 and (0.13±0.05) mg m-3, respectively.On painting days, 72 % of workers showed more than a 10 % variation in peak expiratory flow. Inhalation exposure exceeded the threshold limit value (TLV) ten times over. This strongly suggests that HDI affected the peak flowmetry in the studied workers.

EXPERIMENTAL SUBSTANTIATION OF THE MAXIMUM ALLOWABLE CONCENTRATION OF DIOCTYL TEREPHTHALATE IN THE AIR OF THE WORKING AREA

2020 ◽  
pp. 34-38
Author(s):  
A. S. Radilov ◽  
S. A. Solntseva ◽  
I. E. Shkaeva ◽  
S. A. Dulov ◽  
E. V. Vivulanets ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Functional State ◽  
Hematological Parameters ◽  
Inhalation Exposure ◽  
Threshold Limit Value ◽  
Maximum Allowable Concentration ◽  
Limit Value ◽  
Threshold Limit ◽  
The Central Nervous System

Toxicity and hazard assessment of dioctyl terephthalate (DOTP) was performed in acute, subacute, and chronic experiments, and its principal toxicometry parameters were determined.It was found that on single exposure DOTP exhibits low toxicity and hazard. No resorptive and irritant effects on skin and mucous membrane of eyes were detected in animal experiments. The single inhalation exposure threshold limit value was set at 300 mg/m3, based on the results of monitoring of the functional state of the central nervous system and myocardium and hematological parameters.Thirty-day subacute experiments (oral administration, inhalation exposure, and skin applications) revealed no accumulation of the compound.Four-month chronic exposure to DOTP aerosols (concentration 96,8 mg/m3) caused disorder of the functional state of the central nervous system and myocardium, changes in the hematological and biochemical parameters, gas and acid-base status of the blood, and morphological changes in the lungs and heart. Embryotoxic, genotoxic and gonadotoxic effects were not detected.The chronic inhalation exposure threshold limit value for DOTP (Limch) was set at 18,6 mg/m3, and the concentration of 3,4 mg/m3 was found to be ineffective.The maximum allowable concentration of DOTP in the air of the working area was set at 3,0 mg/m3, hazard class 3.

Exploring a new method for the biological monitoring of plastic workers exposed to the vinyl chloride monomer

2016 ◽  
Vol 32 (12) ◽  
pp. 1921-1926
Author(s):  
Mansour Rezazadeh Azari ◽  
Raana Tayefeh-Rahimian ◽  
Mohamad Javad Jafari ◽  
Hamid Souri ◽  
Yasser Shokoohi ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Biological Monitoring ◽  
Vinyl Chloride ◽  
Occupational Safety ◽  
Statistical Significance ◽  
Threshold Limit Value ◽  
Exhaled Breath ◽  
Vinyl Chloride Monomer ◽  
Manufacturing Plants ◽  
Limit Value

Vinyl chloride monomer (VCM) is widely used in the production of polyvinyl chloride (PVC) plastics. VCM is recognized as a confirmed human and animal carcinogenic compound. Recent studies have reported poor health of plastic workers, even having exposure at concentrations below the permissible limit to VCM. There has not been any study regarding exposed workers to VCM in Iran. Similarly, no information exists as to the biological monitoring of such workers. The main purpose of this study was to conduct a thorough occupational and biological monitoring of Iranian plastic workers exposed to VCM. A total of 100 workers from two plastic manufacturing plants (A and B) in Tehran along with 25 unexposed workers as controls were studied. The personal monitoring of all nonsmoking workers exposed to VCM at two plastic manufacturing plants (A and B) was performed in the morning shift (8 a.m. to 4 p.m.) according to the National Institute For Occupational Safety And Health method no. 1007. Biological monitoring of workers was carried out through collection of exhaled breath of all exposed and control workers in Tedlar bags and with a subsequent analysis using gas chromatography–flame ionization detector. Not only the mean occupational exposure of workers to VCM at plant A was higher than the respective threshold limit value but also the statistical significance was higher than workers at plant B. Similarly, VCM concentration in exhaled breath of workers at plant A was also statistically significantly higher than at plant B. Correlation of occupational exposure of all workers to vinyl chloride with its concentration in exhaled breath was statistically significant. This is the first study on biological monitoring for exposed plastic workers to VCM using exhaled breath. On the basis of the results in this study, a novel method of biological monitoring of plastic workers was proposed.

scholarly journals Assessment of Occupational Exposure to Indium Dust for Indium-Tin-Oxide Manufacturing Workers

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 419
Author(s):  
Boo Wook Kim ◽  
Wonseok Cha ◽  
Sungwon Choi ◽  
Jungah Shin ◽  
Byung-Soon Choi ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Lung Disease ◽  
Tin Oxide ◽  
Indium Tin Oxide ◽  
Threshold Limit Value ◽  
Respirable Dust ◽  
Breathing Zone ◽  
Indium Concentration ◽  
Limit Value ◽  
First Case

According to recent research, indium nanoparticles (NPs) are more toxic than micro-sized particles. While cases of indium lung disease have been reported worldwide, very little research has been conducted on the occupational exposure to indium NPs. Recently, an indium-related lung disease was reported in Korea, a global powerhouse for display manufacturing. In this study, we conducted an assessment ofoccupational exposure at an indium tin oxide (ITO) powder manufacturing plant, where the first case of indium lung disease in Korea occurred. Airborne dustwas obtained from a worker’s breathing zone, and area sampling in the workplace environment was conducted using real-time monitoring devices. Personal samples were analyzed for the indium concentrations in total dust, respirable dust fraction, and NPs using personal NPs respiratory deposition samplers. The total indium concentration of the personal samples was lower than the threshold limit value recommended by the American Conference of Governmental Industrial Hygienists (ACGIH TLV), which was set as occupational exposure limit (OEL). However, the respirable indium concentration exceeded the recently set ACGIH TLV for the respirable fraction of indium dust. The concentration of indium NPs ranged between 0.003 and 0.010 × 10−2 mg/m3, accounting for only 0.4% of the total and 2.7% of the respirable indium particles. This was attributed to the aggregating of NPs at the µm sub-level. Given the extremely low fraction of indium NPs in the total and respirable dust, the current OEL values, set as the total and respirable indium concentrations, do not holistically represent the occupational exposure to indium NPs or prevent health hazards. Therefore, it is necessary to set separate OEL values for indium NPs. This study covers only the process of handling ITO powder. Therefore, follow-up studies need to be conducted on other ITO sputtering target polishing and milling processes, which typically generate more airborne NPs, to further investigate the effects of indium on workers and facilitate the necessary implementation of indium-reducing technologies.

N-Methylformamide. Documentation of proposed values of occupational exposure limits (OELs)

2021 ◽  
Vol XXXVII (1) ◽  
pp. 17-47
Author(s):  
Elżbieta Bruchajzer ◽  
Jadwiga Szymańska ◽  
Barbara Frydrych
Keyword(s):  
Occupational Exposure ◽  
Occupational Safety ◽  
Inhalation Exposure ◽  
Laboratory Animals ◽  
Exposure Limits ◽  
Short Term ◽  
Colorless Liquid ◽  
Limit Value ◽  
Hepatotoxic Effect ◽  
Term Administration

N-Methylformamide is a colorless liquid with an ammoniacal odor, used as a solvent and an intermediate for chemical reactions. There are no data on occupational exposure in Poland. N-Methylformamide is very well absorbed into the human body. The LD50 values for N-methylformamide administered to animals in various routes are similar (2600 ÷ 4000 mg/kg bw). After single or short-term administration of the compound in doses of 100 ÷ 1200 mg/kg bw. worsening symptoms of liver damage have been observed. No-observed adverse effect concentration (NOAEC) was established at 120 mg/m3 (two-week inhalation exposure in rats). Increase of hepatotoxic effect of N-methylformamide were observed at concentrations of 320 mg/m3 and 980 mg/m3. There are no data on sub-chronic, chronic and carcinogenic effects of the compound in laboratory animals. N-Methylformamide was not mutagenic and genotoxic. It caused embryotoxic and teratogenic effects. The NOAEC value (120 mg/m3) was used as the basis for determining the MAC (maximum acceptable concentration) value for N-methylformamide, and the MAC value for N-methylformamide was calculated at 3.3 mg/m3. There are no basis to determine the short-term value (STEL) and biological limit value (BLV). It has been proposed to label the compound as "Ft" (toxic for reproduction) and "skin" (skin absorption of the substance may be as important as inhalation exposure). This article discusses the problems of occupational safety and health, which are covered by health sciences and environmental engineering

EFFECT OF BODY MASS INDEX ON PEAK EXPIRATORY FLOW RATE

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
K. Subramanyam ◽  
Dr. P. Subhash Babu
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Normal Weight ◽  
The Body ◽  
Health Care Centre ◽  
Expiratory Flow ◽  
Group B

Obesity has become one of the major health issues in India. WHO defines obesity as “A condition with excessive fat accumulation in the body to the extent that the health and wellbeing are adversely affected”. Obesity results from a complex interaction of genetic, behavioral, environmental and socioeconomic factors causing an imbalance in energy production and expenditure. Peak expiratory flow rate is the maximum rate of airflow that can be generated during forced expiratory manoeuvre starting from total lung capacity. The simplicity of the method is its main advantage. It is measured by using a standard Wright Peak Flow Meter or mini Wright Meter. The aim of the study is to see the effect of body mass index on Peak Expiratory Flow Rate values in young adults. The place of a study was done tertiary health care centre, in India for the period of 6 months. Study was performed on 80 subjects age group 20 -30 years, categorised as normal weight BMI =18.5 -24.99 kg/m2 and overweight BMI =25-29.99 kg/m2. There were 40 normal weight BMI (Group A) and 40 over weight BMI (Group B). BMI affects PEFR. Increase in BMI decreases PEFR. Early identification of risk individuals prior to the onset of disease is imperative in our developing country. Keywords: BMI, PEFR.

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