scholarly journals Target motion management in breast cancer radiation therapy

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Elham Piruzan ◽  
Naser Vosoughi ◽  
Seied Rabi Mahdavi ◽  
Leila Khalafi ◽  
Hojjat Mahani
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Real Time ◽  
Imaging Modality ◽  
The Body ◽  
Target Motion ◽  
Particle Therapy ◽  
High Dose ◽  
Time Motion ◽  
Intrafractional Motion

Abstract Background Over the last two decades, breast cancer remains the main cause of cancer deaths in women. To treat this type of cancer, radiation therapy (RT) has proved to be efficient. RT for breast cancer is, however, challenged by intrafractional motion caused by respiration. The problem is more severe for the left-sided breast cancer due to the proximity to the heart as an organ-at-risk. While particle therapy results in superior dose characteristics than conventional RT, due to the physics of particle interactions in the body, particle therapy is more sensitive to target motion. Conclusions This review highlights current and emerging strategies for the management of intrafractional target motion in breast cancer treatment with an emphasis on particle therapy, as a modern RT technique. There are major challenges associated with transferring real-time motion monitoring technologies from photon to particles beams. Surface imaging would be the dominant imaging modality for real-time intrafractional motion monitoring for breast cancer. The magnetic resonance imaging (MRI) guidance and ultra high dose rate (FLASH)-RT seem to be state-of-the-art approaches to deal with 4D RT for breast cancer.

Correlation Between Toxicity and Dosimetric Parameters in Patients Treated with Adjuvant Intensity-Modulated Radiation Therapy for Breast Cancer: The Results of a Prospective Study.

2020 ◽  
Author(s):  
David Pasquier ◽  
Benoit Bataille ◽  
Florence Le Tinier ◽  
Raoudha Bennadji ◽  
Hélène Langin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Late Onset ◽  
Univariate Analysis ◽  
Intensity Modulated Radiation Therapy ◽  
Conservative Surgery ◽  
High Dose ◽  
Total Mastectomy ◽  
Intensity Modulated ◽  
A Prospective Study

Abstract Background. In the treatment of breast cancer, intensity-modulated radiation therapy (IMRT) reportedly reduces the high-dose irradiation of at-risk organs and decreases the frequency of adverse events (AEs). Comparisons with conventional radiotherapy have shown that IMRT is associated with lower frequencies of acute and late-onset AEs. Here, we extended a prospective, observational, single-center study of the safety of IMRT to a second investigating center. Methods. Patients scheduled for adjuvant IMRT after partial or total mastectomy were given a dose of 50 Gy (25 fractions of 2 Gy over five weeks), with a simultaneous integrated boost in patients having undergone conservative surgery. Results. 300 patients were included in the study, and 288 were analyzed. The median follow-up period was 2.1 years. Most AEs were mild. The most common AEs were skin-related - mainly radiodermatitis (in 266 patients (92.4%)) and hyperpigmentation (in 178 (61.8%)). Smoking (odds ratio) [95%CI] = 2.10 [1.14–3.87]; p = 0.017), no prior chemotherapy (0.52 [0.27–0.98]; p = 0.044), and D98% for subclavicular skin (1.030 [1.001–1.061]; p = 0.045) were associated with grade ≥ 2 acute AEs. In a univariate analysis, the mean dose, (p < 0.0001), D2% (p < 0.0001), D50% (p = 0.037), D95% (p = 0.0005), D98% (p = 0.0007), V30Gy (p < 0.0001), and V45Gy (p = 0.0001) were significantly associated with grade ≥ 1 acute esophageal AEs. In a multivariate analysis, D95% for the skin (p < 0.001), D98% for the subclavicular skin and low D95% for the internal mammary lymph nodes were associated with grade ≥ 1 medium-term AEs. Conclusions. The safety profile of adjuvant IMRT after partial or total mastectomy is influenced by dosimetric parameters. Trial registration: ClinicalTrials.gov NCT02281149

Inflammatory breast cancer: a review.

1992 ◽  
Vol 10 (6) ◽  
pp. 1014-1024 ◽  
Author(s):  
I A Jaiyesimi ◽  
A U Buzdar ◽  
G Hortobagyi
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Natural History ◽  
Inflammatory Breast Cancer ◽  
Survival Rates ◽  
Autologous Bone Marrow ◽  
High Dose ◽  
Combined Modality ◽  
History Of ◽  
Disease Free

PURPOSE The natural history of inflammatory breast cancer and the recent advances in its management were reviewed. DESIGN The English medical literature from 1924 to 1990 was reviewed using the Cancerline and Medline retrieval systems, and through a manual review of bibliographies of identified articles. RESULTS The majority of patients with inflammatory breast cancer treated only with local therapies died 18 to 24 months after diagnosis. A combined modality approach with chemotherapy, surgery, and radiation therapy has improved disease-free and overall survival rates for inflammatory breast cancer. Approximately 35% to 55% of patients treated with combined modality regimens remain disease-free and alive at 5 years. CONCLUSION Induction combination chemotherapy administered with radiation therapy, mastectomy, both, or with additional chemotherapy favorably alters the natural history of inflammatory breast cancer. New drug combinations and high-dose chemotherapy with autologous bone marrow support are being evaluated to improve further patient survival.

Research on the Application of Motion Capture of Kinect Technology in the Sport Training

2014 ◽  
Vol 926-930 ◽  
pp. 2714-2717
Author(s):  
Quan Wei Shi
Keyword(s):  
Real Time ◽  
Motion Capture ◽  
The Body ◽  
Sports Training ◽  
The Real ◽  
Sport Training ◽  
Time Motion ◽  
Development Costs ◽  
Graphics Rendering ◽  
Rendering Engine

For the real-time motion capture in the sport training to analysis and study, this paper adopts Kinect technology and the development of sports training combined with. Kinect somatosensory the camera as the system core, the body movements, facial expressions capture system in development costs, operating results and the development efficiency has the optimal balance point. The purpose of this research is based on the OGRE graphics rendering engine, using 3DSMAX and open source code, the design and implementation of Kinect somatosensory camera and 3DSMAX, OGRE combination of game action, motion capture system based on. This system provides an important help for realizing the real-time motion capture in the sports training, can be used in the field of sports training.

Real-Time Motion Capture for a Human Body using Accelerometers

Robotica ◽  
2001 ◽  
Vol 19 (6) ◽  
pp. 601-610 ◽  
Author(s):  
Jihong Lee ◽  
Insoo Ha
Keyword(s):  
Real Time ◽  
Motion Capture ◽  
Human Body ◽  
Degrees Of Freedom ◽  
Low Cost ◽  
Human Motion ◽  
The Body ◽  
Sensor Data ◽  
Time Motion ◽  
Gravity Acceleration

In this paper we propose a set of techniques for a real-time motion capture of a human body. The proposed motion capture system is based on low cost accelerometers, and is capable of identifying the body configuration by extracting gravity-related terms from the sensor data. One sensor unit is composed of 3 accelerometers arranged orthogonally to each other, and is capable of identifying 2 rotating angles of joints with 2 degrees of freedom. A geometric fusion technique is applied to cope with the uncertainty of sensor data. A practical calibration technique is also proposed to handle errors in aligning the sensing axis to the coordination axis. In the case where motion acceleration is not negligible compared with gravity acceleration, a compensation technique to extract gravity acceleration from the sensor data is proposed. Experimental results not only for individual techniques but also for human motion capturing with graphics are included.

scholarly journals A Critical Review of Radiation Therapy: From Particle Beam Therapy (Proton, Carbon, and BNCT) to Beyond

2021 ◽  
Vol 11 (8) ◽  
pp. 825
Author(s):  
Yoshitaka Matsumoto ◽  
Nobuyoshi Fukumitsu ◽  
Hitoshi Ishikawa ◽  
Kei Nakai ◽  
Hideyuki Sakurai
Keyword(s):  
Radiation Therapy ◽  
Nuclear Reactions ◽  
Ion Beam ◽  
Multidisciplinary Treatment ◽  
Treatment Strategies ◽  
Particle Beam ◽  
Particle Therapy ◽  
High Dose ◽  
Therapeutic Effects ◽  
Particle Beam Therapy

In this paper, we discuss the role of particle therapy—a novel radiation therapy (RT) that has shown rapid progress and widespread use in recent years—in multidisciplinary treatment. Three types of particle therapies are currently used for cancer treatment: proton beam therapy (PBT), carbon-ion beam therapy (CIBT), and boron neutron capture therapy (BNCT). PBT and CIBT have been reported to have excellent therapeutic results owing to the physical characteristics of their Bragg peaks. Variable drug therapies, such as chemotherapy, hormone therapy, and immunotherapy, are combined in various treatment strategies, and treatment effects have been improved. BNCT has a high dose concentration for cancer in terms of nuclear reactions with boron. BNCT is a next-generation RT that can achieve cancer cell-selective therapeutic effects, and its effectiveness strongly depends on the selective 10B accumulation in cancer cells by concomitant boron preparation. Therefore, drug delivery research, including nanoparticles, is highly desirable. In this review, we introduce both clinical and basic aspects of particle beam therapy from the perspective of multidisciplinary treatment, which is expected to expand further in the future.

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