An efficient method for the preparation of benzyl γ-ketohexanoates

2013 ◽  
Vol 67 (4) ◽  
Author(s):  
Muhammad Iqbal ◽  
Imam Baloch ◽  
Musa Baloch
Keyword(s):  
Succinic Acid ◽  
1H Nmr ◽  
13C Nmr ◽  
Thionyl Chloride ◽  
Efficient Method ◽  
Good Yield ◽  
Acid Chlorides ◽  
Mass Measurements ◽  
Keto Esters

AbstractTwenty acid chlorides, 4-(mono/di-benzyloxy)-4-ketobutanoyl chlorides (Ia–XXa) were synthesised by the reaction of monoesters of succinic acid with thionyl chloride. The product thus obtained (4-benzyloxy-4-ketobutanoyl chlorides) was treated with diethylcadmium to convert it into the corresponding keto-esters (Ib–XXb), the mono/di-benzyl-γ-ketohexanoates, with a good yield. All the compounds thus prepared were characterised by physical, spectroscopic (UV-VIS, IR, 1H NMR, 13C NMR), and mass measurements techniques.

Synthesis of Nano Machines Based on Catenanes and Rotaxanes

2011 ◽  
Vol 110-116 ◽  
pp. 3807-3809
Author(s):  
Abdol Ghaffar Ebadi ◽  
Somayeh Alami
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Good Yield ◽  
Research Work ◽  
Macrocyclic Diamide ◽  
External Stimuli

A nanomachine is an assembly of a discrete number of supramolecular components designed to perform mechanical like movements as a consequence of appropriate external stimuli. In this research work we wish report synthesis of a part of nanomachines are based on interlocked macrocycle named rotaxanes, catenanes, pseudorataxane and knots, that Bis aza thiacrown compound (5) was synthesized by macrocyclic diamide (4) and 2, 6-dicarbonyldicholoride pyridine in dry CH2Cl2 and was refluxed in presence of Et3N in good yield. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR and elemental analysis.

scholarly journals Structure Modification of Quinine on C-9 Hydroxyl Group via Esterification Reaction

2020 ◽  
Vol 9 (1) ◽  
pp. 32-39
Author(s):  
Teni Ernawati ◽  
◽  
Minarti Minarti ◽  
Puspa Dewi Narrij Lotulung ◽  
◽  
...  
Keyword(s):  
Drug Discovery ◽  
Melting Point ◽  
1H Nmr ◽  
13C Nmr ◽  
Efficient Method ◽  
Hydroxyl Group ◽  
Esterification Reaction ◽  
Structure Modification ◽  
Carbonyl Chloride

Concept the role played by modified quinine in the asymmetric hydroxyl group inspired studies of modified quinine as chiral organic that lead to drug discovery development. A simple and efficient method for C-9 alkylation and arylation of quinine derivatives was reported. Series quinine derivatives were synthesized through the esterification of the hydroxyl group of quinine. The reaction with various alkyl and aryl carbonyl chloride resulted in the series of ester quinine derivatives. The structure of quinine derivatives was characterized by IR, melting point, UV, 1H NMR, 13C NMR, LCMS.

scholarly journals 3-(3,5-Difluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

Molbank ◽  
10.3390/m1011 ◽  
2018 ◽  
Vol 2018 (3) ◽  
pp. M1011 ◽  
Author(s):  
Naveen Kumar ◽  
Swamy Sreenivasa ◽  
Vasantha Kumar ◽  
Nadigar Mohan
Keyword(s):  
Spectral Analysis ◽  
1H Nmr ◽  
13C Nmr ◽  
High Purity ◽  
Title Compound ◽  
Good Yield ◽  
Phosphorus Oxychloride ◽  
Structure Characterization ◽  
Dimethyl Formamide

Vilsmeier–Haack reaction of (E)-1-[1-(3,5-difluorophenyl)ethylidene]-2-phenylhydrazine (1) using dimethyl formamide in excess of phosphorus oxychloride by conventional method, resulted in the synthesis of the title compound 3-(3,5-difluorophenyl)-1-phenyl-1H-pyrazole-4- carbaldehyde (2) in good yield and high purity. Structure characterization of the title compound was done by IR, 1H-NMR, 13C-NMR and HRMS spectral analysis.

scholarly journals Synthesis and complete NMR spectral assignments of new benzylamino coumarin derivative

2020 ◽  
Vol 10 (2) ◽  
pp. 12-16
Author(s):  
Vidoslav Dekić ◽  
Niko Radulović ◽  
Milenko Ristić ◽  
Biljana Dekić ◽  
Novica Ristić
Keyword(s):  
Spectral Analysis ◽  
Ethyl Acetate ◽  
1H Nmr ◽  
Resonance Assignment ◽  
13C Nmr ◽  
Spatial Orientation ◽  
Good Yield ◽  
Coumarin Derivative ◽  
Two Dimensional ◽  
Nmr Techniques

This research involves the reaction of 4-chloro-3-nitrocoumarin and (4-methoxyphenyl)methanamine, whereby a novel coumarin derivative 4-[(4-methoxybenzyl) amino]-3-nitro-2H-chromen-2-one was obtained in good yield. The reaction was carried out in ethyl acetate, in the presence of triethylamine. Also, a detailed spectral analysis of a new coumarin derivative is presented. Resonance assignment was achieved using one( 1H NMR and 13C NMR) and two-dimensional NMR techniques (1H1H-COSY, NOESY, HSQC, and HMBC). The NOESY correlations of protons from arylamino substituent and coumarin core indicate their spatial orientation.

scholarly journals SYNTHESIS AND COMPLETE NMR SPECTRAL ASSIGNMENTS OF NEW BENZYLAMINO COUMARIN DERIVATIVE

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Vidoslav Dekić ◽  
Niko Radulović ◽  
Milenko Ristić ◽  
Biljana Dekić ◽  
Novica Ristić
Keyword(s):  
Spectral Analysis ◽  
Ethyl Acetate ◽  
1H Nmr ◽  
Resonance Assignment ◽  
13C Nmr ◽  
Spatial Orientation ◽  
Good Yield ◽  
Coumarin Derivative ◽  
Two Dimensional ◽  
Nmr Techniques

This research involves the reaction of 4-chloro-3-nitrocoumarin and (4-methoxyphenyl)methanamine, whereby a novel coumarin derivative 4-[(4-methoxybenzyl) amino]-3-nitro-2H-chromen-2-one was obtained in good yield. The reaction was carried out in ethyl acetate, in the presence of triethylamine. Also, a detailed spectral analysis of a new coumarin derivative is presented. Resonance assignment was achieved using one- (1H NMR and 13C NMR) and two-dimensional NMR techniques (1H-1H-COSY, NOESY, HSQC, and HMBC). The NOESY correlations of protons from arylamino substituent and coumarin core indicate their spatial orientation.

scholarly journals Synthesis of Polyimides derived from 2,6-diamino-4-methyl-1,3,5-triazine

2016 ◽  
Vol 13 (2) ◽  
pp. 196-209
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nmr Spectroscopy ◽  
1H Nmr ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
Second Step ◽  
Acid Chlorides ◽  
Triethyl Amine ◽  
Ft Ir

This work included synthesis of several new polymers of polyacryloyl chloride in two steps . The first step the included the reaction of N-( sub. or un sub. benzoyl and sub. or un sub. acetyl ) amidyl sub. 2,6- diamino -4-methyl-1,3,5-triazine (1-5) by condensation of many substituted acid chlorides with 2,6- diamino -4-methyl-1,3,5-triazine . While the second step included the reaction of polyacryloyl chloride with the produced compounds (1-5) in step (1) in the presence amount triethyl amine (Et3N) to obtain new polyimides (6-10). The prepared compounds were characterized by UV. , FT-IR, and some of them by 1H-NMR and 13C- NMR spectroscopy.

Synthesis and Biological Evaluation of Various New Substituted 1,3,4-oxadiazole-2-thiols

2008 ◽  
Vol 59 (4) ◽  
Author(s):  
Gabriela Laura Almajan ◽  
Stefania Felicia Barbuceanu ◽  
Ioana Saramet ◽  
Mihaela Dinu ◽  
Cristian Vasile Doicin ◽  
...  
Keyword(s):  
Biological Activity ◽  
Plant Growth ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Biological Evaluation ◽  
Ethyl Chloroacetate ◽  
Low Concentrations ◽  
Synthesis And Biological Evaluation

5-[4-(4X-phenylsulfonyl)phenyl]-1,3,4-oxadiazole-2-thiols, X=H, Cl, Br, reacted with ethyl chloroacetate to give S-alkylated compounds. Aminomethylation of the thione form of oxadiazoles yielded N(3)-derivatives. All the products have been characterized by elemental analysis, IR, 1H-NMR and 13C-NMR. The plant-growth regulating effects of the title compounds were examined. From the biological activity results, we found that most compounds showed weak stimulatory activities at low concentrations.

Synthesis and Spectral Characterization of New S-Alkylated 1,2,4-Triazoles as Potential Biological Agents

2017 ◽  
Vol 68 (10) ◽  
pp. 2436-2439
Author(s):  
Stefania Felicia Barbuceanu ◽  
Laura Ileana Socea ◽  
Constantin Draghici ◽  
Elena Mihaela Pahontu ◽  
Theodora Venera Apostol ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spectral Data ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Ethyl Bromide ◽  
Spectral Characterization ◽  
Basic Medium ◽  
Phenacyl Bromide

In the work we presented the behavior of 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(n-propyl)-2H-1,2,4-triazole-3(4H)-thiones (X= Cl or Br) with some alkylation agents. Thus, new S-alkylated 1,2,4-triazole derivatives were synthesized by reaction of the corresponding 1,2,4-triazole-3-thione derivatives with different �-halogenated compounds (ethyl bromide, ethyl chloroacetate or phenacyl bromide), in basic medium. The structures of synthesized compounds were elucidated by spectral data (1H-NMR, 13C-NMR, mass spectrometry) and elemental analysis.

Benzimidazole Derivatives as Potential Antimicrobial and Antiulcer Agents: A Mini Review

2019 ◽  
Vol 19 (16) ◽  
pp. 1292-1297 ◽  
Author(s):  
Ali Mohd Ganie ◽  
Ayaz Mahmood Dar ◽  
Fairooz Ahmad Khan ◽  
Bashir Ahmad Dar
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
1H Nmr ◽  
13C Nmr ◽  
Benzimidazole Derivatives ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Biological Screening ◽  
Elemental Analyses ◽  
Characterization Studies

:Here in we report the number of strategies for the synthesis of differently substituted benzimidazole derivatives. The protocols involved in the syntheses of these derivatives were one-pot or multi-component. The characterization studies of these derivatives were carried by using different spectroscopic techniques (1H NMR, 13C NMR and MS) and elemental analyses. The biological screening studies revealed that these benzimidazole derivatives show potential antibacterial as well as antifungal behavior. These benzimidazole derivatives not only depicted potential antiulcer properties but also showed moderate to good anticancer/cytotoxic behavior against different cancer cell lines.

The Electron Effect of Aromatic Group: Control Conformation of 2-Aromatic Cyclododecanone Derivatives

2020 ◽  
Vol 24 (10) ◽  
pp. 1139-1147
Author(s):  
Yang Mingyan ◽  
Wang Daoquan ◽  
Wang Mingan
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Nmr Spectra ◽  
Coupling Constants ◽  
The Other ◽  
Repulsive Interaction ◽  
X Ray Diffraction ◽  
X Ray ◽  
Electron Effect ◽  
Group Control

2-Phenylcyclododecanone and 2-cyclohexylcyclododecanone derivatives were synthesized and characterized by 1H NMR, 13C NMR, HR-ESI-MS and X-ray diffraction. Their preferred conformations were analyzed by the coupling constants in the 1H NMR spectra and X-ray diffraction, which showed the skeleton ring of these derivatives containing [3333]-2-one conformation, and the phenyl groups were located at the side-exo position of [3333]-2-one conformation due to the strong π-π repulsive interaction between the π- electron of benzene ring and π-electron of carbonyl group. The cyclohexyl groups were located at the corner-syn or the side-exo position of [3333]-2-one conformation depending on the hindrance of the other substituted groups. The π-π electron effect played a crucial role in efficiently controlling the preferred conformation of 2-aromatic cyclododecanone and the other 2-aromatic macrocyclic derivatives with the similar preferred square and rectangular conformations.

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