scholarly journals Analysis of inner ear potassium recycling genes as potential factors associated with tinnitus

Author(s):  
Małgorzata Pawełczyk ◽  
Elżbieta Rajkowska ◽  
Piotr Kotyło ◽  
Adam Dudarewicz ◽  
Guy Camp ◽  
...  

Abstract

Author(s):  
Yuan Fang ◽  
Amy van Grieken ◽  
Irene N. Fierloos ◽  
Dafna A. Windhorst ◽  
Harrie Jonkman ◽  
...  

Abstract Background A high parenting self-efficacy (PSE) has been associated with positive parenting and positive child development. However, there is limited and inconsistent information on factors associated with PSE. Objective To investigate factors associated with PSE in parents of children aged 0–7 years old, and to explore whether the associations were different between mothers and fathers. Methods We performed a cross-sectional analysis of the baseline data from a prospective cohort study: the CIKEO study. A total of 1012 parents (mean age = 33.8, SD = 5.0) completed self-reported measure of PSE and 18 potential factors associated with PSE. Results Multivariable models revealed that lower parenting stress, fewer child behavior problems, better eating behavior, better parental and child general health, a smaller number of children living in the household, higher perceived level of social support and having a migration background were associated with higher levels of PSE (p < 0.05). The association between family functioning and PSE differed between mothers and fathers (p for interaction = 0.003): with beta and 95% confidence interval being: 1.29 (− 2.05, 0.87), and 0.23 (− 0.46, 3.29), respectively. Conclusions A range of parental, child and social-contextual factors in relation to PSE were identified. The patterns of associations for most of the factors were similar among mothers and fathers. However, the association between family functioning and PSE might differ for mothers and fathers. Our findings are relevant for tailoring and implementing successful interventions and effective policy making in child care. Trial registration Netherlands National Trial Register number NL7342. Date of registration: 05-November-2018, retrospectively registered.


2000 ◽  
Vol 57 (3) ◽  
pp. 538-547 ◽  
Author(s):  
Jennifer L Klug ◽  
Janet M Fischer

Acidification causes profound changes in species composition in aquatic systems. We conducted mesocosm experiments in three northern Wisconsin lakes (Trout Lake, Little Rock - Reference, Little Rock - Treatment) to test how different phytoplankton communities respond to acidification. Major differences exist among these lakes in water chemistry and phytoplankton community composition. In each lake, three pH treatments (control, press (sustained pH 4.7), and pulse (alternating pH 4.7 and ambient pH)) were maintained for 6 weeks. We observed a striking increase in species in the genus Mougeotia in all systems. Mougeotia is a filamentous green alga often found in acidified lakes. The magnitude of the Mougeotia increase differed among lakes and treatments, and we used an autoregressive model to identify potential factors responsible for these differences. Our results suggest that biotic factors such as competition with other algae played a relatively minor role in regulating Mougeotia dynamics. Instead, pH and abiotic factors associated with changes in pH (e.g., dissolved inorganic carbon) were important predictors of Mougeotia dynamics.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yehong Zhou ◽  
Junjie Zhang ◽  
Wenwen Wu ◽  
Man Liang ◽  
Qiang-Song Wu

Abstract Background There are no pharmacological interventions currently available to prevent the transmission of SARS-CoV-2 or to treat COVID-19. The development of vaccines against COVID-19 is essential to contain the pandemic. we conducted a cross-sectional survey of Shanghai residents to understand residents’ willingness to be vaccinated with any future COVID-19 vaccines and take measures to further improve vaccination coverage. Methods We conducted a cross-sectional survey using self-administered anonymous questionnaires from 1 July to 8 September 2020. The main outcome was willingness of participants, and any children or older individuals living with them, to receive future COVID-19 vaccines. Logistic regression analyses were used to explore potential factors associated with vaccination willingness. Results A total of 1071 participants were asked about their willingness to receive future COVID-19 vaccines, for themselves and at least 747 children and 375 older individuals (≥60 years old) living with them. The highest proportion of expected willingness to vaccinate was among participants (88.6%), followed by children (85.3%) and older individuals (84.0%). The main reasons for reluctance to vaccinate among 119 participants were doubts regarding vaccine safety (60.0%) and efficacy (28.8%). Participants with a self-reported history of influenza vaccination were more likely to accept COVID-19 vaccines for themselves [adjusted odds ratio (OR) = 1.83; 95% confidence interval (CI): 1.19–2.82], their children (adjusted OR = 2.08; 95%CI: 1.30–3.33), and older individuals in their household (adjusted OR = 2.12; 95%CI: 1.14–3.99). Participants with older individuals in their families were less willing to vaccinate themselves (adjusted OR = 0.59; 95%CI: 0.40–0.87) and their children (adjusted OR = 0.58; 95%CI: 0.38–0.89). Conclusions Participants were more reluctant to accept COVID-19 vaccines for older individuals living with them. The presence of older individuals in the home also affected willingness of participants and their children to be vaccinated.


2018 ◽  
Vol 66 (2) ◽  
pp. 587-600 ◽  
Author(s):  
Christoforos Hadjichrysanthou ◽  
Kevin McRae-McKee ◽  
Stephanie Evans ◽  
Frank de Wolf ◽  
Roy M. Anderson ◽  
...  

Author(s):  
Mashael A Alaskar ◽  
Joshua D Brown ◽  
Stacy A Voils ◽  
Scott M Vouri

Abstract Disclaimer In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose To identify the incidence of continuation of newly initiated loop diuretics upon intensive care unit (ICU) and hospital discharge and identify factors associated with continuation. Methods This was a single-center retrospective study using electronic health records in the setting of adult ICUs at a quaternary care academic medical center. It involved patients with sepsis admitted to the ICU from January 1, 2014, to June 30, 2019, who received intravenous fluid resuscitation. The endpoints of interest were (1) the incidence of loop diuretic use during an ICU stay following fluid resuscitation, (2) continuation of loop diuretics following transition of care, and (3) potential factors associated with loop diuretic continuation after transition from the ICU. Results Of 3,591 patients who received intravenous fluid resuscitation for sepsis, 39.4% (n = 1,415) were newly started on loop diuretics during their ICU stay. Among patients who transitioned to the hospital ward from the ICU, loop diuretics were continued in 33% (388/1,193) of patients. At hospital discharge, 13.4% (52/388) of these patients were prescribed a loop diuretic to be used in the outpatient setting. History of liver disease, development of acute kidney injury, being on vasopressors while in the ICU, receiving blood products, and receiving greater than 90 mL/kg of bolus fluids were significant potential factors associated with loop diuretic continuation after transition from the ICU. Conclusion New initiation of loop diuretics following intravenous fluid resuscitation in patients with sepsis during an ICU stay is a common occurrence. Studies are needed to assess the effect of this practice on patient outcomes and resource utilization.


2021 ◽  
Author(s):  
Shigui Yang ◽  
Chenyang Huang ◽  
Qingmiao Sun ◽  
Daixi JIang ◽  
Xiaobao Zhang ◽  
...  

BACKGROUND Background: Wearing a mask is one of the most effective measures to prevent COVID-19 virus infection and it is not yet clear what potential factors may be associated with facial skin problems while wearing masks. OBJECTIVE Objective: seek most suitable mask-wearing habits for public to avoid facial skin problem. METHODS Method: A cross-sectional survey was conducted through online and offline questionnaires on patterns of mask wearing and facial skin problems during COVID-19 from May 30-July 1, 2020. Multivariable regression was used to explore the potential factors associated with skin problems. We also recruited 19 subjects and compared the differences in their facial microbiomes before and after wearing masks. RESULTS Results: A total of 4385 valid questionnaires were finally analyzed and 1323 (33.1%) participants reported having facial skin problems while wearing masks. The risk factors associated with skin problems were having a history of facial skin problems (OR: 3.25, 95% CI: 2.80-3.76), facial skin allergies (OR: 1.37, 95% CI: 1.20-1.56), face washing frequency (≥3 times per day) (OR: 1.61, 95% CI: 1.07-2.43), daily sleep time <6 hours (OR: 2.38, 95% CI: 1.81-3.13), and average time spent wearing masks uninterruptedly ≥6 hours (OR: 1.67, 95% CI: 1.24-2.25). The analysis of the facial microbiome revealed that the abundance of Prevotella and Hemophilus decreased, and the functional pathway associated with cytochrome c was more predominant with the prolongation of wearing time. CONCLUSIONS Conclusion: The habit of wearing a mask and life behavior affect the occurrence of skin damage. Suitable mask types and mask-wearing habits should be recommended to avoid facial skin problems. CLINICALTRIAL NA


2020 ◽  
pp. 089826432095291
Author(s):  
Anthony Lyons ◽  
Beatrice Alba ◽  
Andrea Waling ◽  
Victor Minichiello ◽  
Mark Hughes ◽  
...  

Objectives: Volunteering is associated with positive well-being among older people, providing opportunities to stay active and socially connected. This may be especially relevant for older lesbian and gay people, who are less likely than heterosexual people to have a partner, children or support from their family of origin. Methods: Patterns of volunteering and mental, physical and social well-being were examined in a sample of 754 lesbian and gay adults in Australia aged 60 years and older who completed a nationwide survey. Results: Volunteers reported greater positive mental health than non-volunteers. Among the gay men, volunteers additionally reported higher self-rated health and social support and lower psychological distress. Both the lesbian women and gay men who volunteered for lesbian, gay, bisexual, transgender or intersex (LGBTI) organisations also reported greater LGBTI community connectedness than volunteers for non-LGBTI organisations. Discussion: These findings provide further insight into potential factors associated with the well-being of older lesbian and gay adults.


2020 ◽  
pp. tobaccocontrol-2020-055951
Author(s):  
Kosuke Kiyohara ◽  
Takahiro Tabuchi

ObjectiveWe aimed to examine the use of heated tobacco products (HTPs) in locations where cigarette smoking was not allowed, and to explore the factors associated with such use among Japanese HTP users.MethodsAn internet-based self-reported questionnaire survey was conducted in 2019 as part of the Japan Society and New Tobacco Internet Survey. The study subjects were respondents who self-reported having used HTPs in the last year. The proportions of those who had ever used or frequently used HTPs in locations where tobacco smoking was not allowed in the last year were calculated. These locations included home, restaurants and workplaces. Furthermore, potential factors associated with HTP use in such smoke-free locations were examined using multivariable logistic regression analyses.ResultsThe proportion of HTP users who had ever used HTPs in smoke-free locations in the last year was 20.7% (148/716) at home, 11.8% (128/1081) in restaurants and 11.9% (113/950) in workplaces. The proportion of those who had frequently used HTPs in those locations was 9.5% (68/716) at home, 4.8% (52/1081) in restaurants and 8.0% (76/950) in workplaces. The statistically significant factors associated with HTP use varied by location. Generally, respondents who thought HTP use was not forbidden in places where tobacco smoking is forbidden were likely to use HTPs in such locations.ConclusionIn Japan, a considerable number of people used HTPs in locations where tobacco smoking was not allowed. Policymakers should establish clear rules about use of HTPs in smoke-free environments.


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