Hemocorrectors Based on Perfluorocarbon Gas-Transport Blood-Substituting Emulsions

Abstract Hemocorrectors based on perfluorocarbon gas-transport blood-substituting emulsions are complex multiphase systems used in the biomedical field as multifunctional drugs, in particular, as gas-transport substitutes for a blood donor. The aim of this review was to discuss their physicochemical and medico-biological properties. A number of preparations from both Russian and foreign manufacturers based on chemically inert perfluorocarbon blood-substituting emulsions of a nano-size level as hemocorrectors with a gas transport function are shown. The analysis of the effect of perfluorocarbon emulsion on the blood gas transport indicators showed that perfluorocarbon particles in the bloodstream will significantly improve the conditions of gas exchange in tissues. The most important issue is the concentration of perfluorocarbon blood-substituting emulsions. The perfluorocarbon emulsions can be considered as a means of correcting the gas transport properties of blood, increasing the reserve capacity of blood cells-red blood cells to deliver oxygen to the tissues. Taking into account all facts about perfluorocarbon hemocorrectors, it can be concluded that they can be used as universal nanocarriers for the transdermal delivery of oxygen and biologically active compounds in various fields of biomedicine and cosmetology.

Download Full-text

The Molecular Diversity Scope of Urazole in the Synthesis of Organic Compounds

Current Organic Synthesis ◽

10.2174/1570179416666190925162215 ◽

2019 ◽

Vol 16 (7) ◽

pp. 953-967 ◽

Cited By ~ 1

Author(s):

Ghodsi M. Ziarani ◽

Fatemeh Mohajer ◽

Razieh Moradi ◽

Parisa Mofatehnia

Keyword(s):

Biological Activities ◽

Biological Properties ◽

Biologically Active ◽

Microtubule Assembly ◽

Heterocyclic Molecules ◽

Biological Perspective ◽

Highly Active ◽

Anti Inflammatory ◽

High Yields ◽

Short Time

Background: As a matter of fact, nitrogen as a hetero atom among other atoms has had an important role in active biological compounds. Since heterocyclic molecules with nitrogen are highly demanded due to biological properties, 4-phenylurazole as a compound containing nitrogen might be important in the multicomponent reaction used in agrochemicals, and pharmaceuticals. Considering the case of fused derivatives “pyrazolourazoles” which are highly applicable because of their application for analgesic, antibacterial, anti-inflammatory and antidiabetic activities as HSP-72 induction inhibitors (I and III) and novel microtubule assembly inhibitors. It should be mentioned that spiro-pyrazole also has biological activities like cytotoxic, antimicrobial, anticonvulsant, antifungal, anticancer, anti-inflammatory, and cardiotonic activities. Objective: Urazole has been used in many heterocyclic compounds which are valuable in organic syntheses. This review disclosed the advances in the use of urazole as the starting material in the synthesis of various biologically active molecules from 2006 to 2019. Conclusion: Compounds of urazole (1,2,4-triazolidine-3,5-dione) are the most important molecules which are highly active from the biological perspective in the pharmaceuticals as well as polymers. In summary, many protocols for preparations of the urazole derivatives from various substrates in multi-component reactions have been reported from different aromatic and aliphatic groups which have had carbonyl groups in their structures. It is noted that several catalysts have been synthesized to afford applicable molecules with urazole scaffolds. In some papers, being environmentally friendly, short time reactions and high yields are highlighted in the protocols. There is a room to synthesize new catalysts and perform new reactions by manipulating urazole to produce biologically active compounds, even producing chiral urazole component as many groups of chiral urazole compounds are important from biological perspective.

Download Full-text

The Effect of the Type and Concentration of the Crosslinking Diene on the Gas Transport Properties of Membranes Based on Polyoctylmethylsiloxane

Membranes and Membrane Technologies ◽

10.1134/s2517751620060037 ◽

2020 ◽

Vol 2 (6) ◽

pp. 399-406

Author(s):

E. A. Grushevenko ◽

I. L. Borisov ◽

D. S. Bakhtin ◽

V. V. Volkov ◽

A. V. Volkov

Keyword(s):

Transport Properties ◽

Gas Transport ◽

Gas Transport Properties

Download Full-text

Isobornylchalcones as Scaffold for the Synthesis of Diarylpyrazolines with Antioxidant Activity

Molecules ◽

10.3390/molecules26123579 ◽

2021 ◽

Vol 26 (12) ◽

pp. 3579

Author(s):

Svetlana A. Popova ◽

Evgenia V. Pavlova ◽

Oksana G. Shevchenko ◽

Irina Yu. Chukicheva ◽

Aleksandr V. Kutchin

Keyword(s):

Antioxidant Activity ◽

Antioxidant Properties ◽

Biological Properties ◽

High Reactivity ◽

Biologically Active ◽

Brain Lipids ◽

Wide Range ◽

Privileged Structure ◽

Vitro Model

The pyrazoline ring is defined as a “privileged structure” in medicinal chemistry. A variety of pharmacological properties of pyrazolines is associated with the nature and position of various substituents, which is especially evident in diarylpyrazolines. Compounds with a chalcone fragment show a wide range of biological properties as well as high reactivity which is primarily due to the presence of an α, β-unsaturated carbonyl system. At the same time, bicyclic monoterpenoids deserve special attention as a source of a key structural block or as one of the pharmacophore components of biologically active molecules. A series of new diarylpyrazoline derivatives based on isobornylchalcones with different substitutes (MeO, Hal, NO2, N(Me)2) was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro model Fe2+/ascorbate-initiated lipid peroxidation in the substrate containing brain lipids of laboratory mice. It was demonstrated that the combination of the electron-donating group in the para-position of ring B and OH-group in the ring A in the structure of chalcone fragment provides significant antioxidant activity of synthesized diarylpyrazoline derivatives.

Download Full-text

Synthesis and Gas-Transport Properties of Poly(1-trimethylsilyl-1-propyne)- and Poly(4-methyl-2-pentyne)-Based Chlorinated Polyacetylenes for Membrane Separation of Carbon Dioxide

Membranes and Membrane Technologies ◽

10.1134/s2517751619040048 ◽

2019 ◽

Vol 1 (4) ◽

pp. 212-219 ◽

Cited By ~ 3

Author(s):

A. A. Kossov ◽

V. Yu. Geiger ◽

S. M. Matson ◽

E. G. Litvinova ◽

V. G. Polevaya

Keyword(s):

Carbon Dioxide ◽

Transport Properties ◽

Membrane Separation ◽

Gas Transport ◽

Gas Transport Properties

Download Full-text

New poly(ether imide)s with pendant di-tert-butyl groups: Synthesis, characterization and gas transport properties

Separation and Purification Technology ◽

10.1016/j.seppur.2019.02.017 ◽

2019 ◽

Vol 217 ◽

pp. 183-194 ◽

Cited By ~ 6

Author(s):

N. Belov ◽

R. Chatterjee ◽

R. Nikiforov ◽

V. Ryzhikh ◽

S. Bisoi ◽

...

Keyword(s):

Transport Properties ◽

Gas Transport ◽

Tert Butyl ◽

Gas Transport Properties

Download Full-text

A Molecular Simulation Study of Silica/Polysulfone Mixed Matrix Membrane for Mixed Gas Separation

Polymers ◽

10.3390/polym13132199 ◽

2021 ◽

Vol 13 (13) ◽

pp. 2199

Author(s):

Khadija Asif ◽

Serene Sow Mun Lock ◽

Syed Ali Ammar Taqvi ◽

Norwahyu Jusoh ◽

Chung Loong Yiin ◽

...

Keyword(s):

Transport Properties ◽

Molecular Simulation ◽

Gas Separation ◽

Membrane Separation ◽

Gas Transport ◽

Mixed Matrix ◽

Mixed Gas ◽

Gas Transport Properties ◽

Simulation Results ◽

Mixed Gases

Polysulfone-based mixed matrix membranes (MMMs) incorporated with silica nanoparticles are a new generation material under ongoing research and development for gas separation. However, the attributes of a better-performing MMM cannot be precisely studied under experimental conditions. Thus, it requires an atomistic scale study to elucidate the separation performance of silica/polysulfone MMMs. As most of the research work and empirical models for gas transport properties have been limited to pure gas, a computational framework for molecular simulation is required to study the mixed gas transport properties in silica/polysulfone MMMs to reflect real membrane separation. In this work, Monte Carlo (MC) and molecular dynamics (MD) simulations were employed to study the solubility and diffusivity of CO2/CH4 with varying gas concentrations (i.e., 30% CO2/CH4, 50% CO2/CH4, and 70% CO2/CH4) and silica content (i.e., 15–30 wt.%). The accuracy of the simulated structures was validated with published literature, followed by the study of the gas transport properties at 308.15 K and 1 atm. Simulation results concluded an increase in the free volume with an increasing weight percentage of silica. It was also found that pure gas consistently exhibited higher gas transport properties when compared to mixed gas conditions. The results also showed a competitive gas transport performance for mixed gases, which is more apparent when CO2 increases. In this context, an increment in the permeation was observed for mixed gas with increasing gas concentrations (i.e., 70% CO2/CH4 > 50% CO2/CH4 > 30% CO2/CH4). The diffusivity, solubility, and permeability of the mixed gases were consistently increasing until 25 wt.%, followed by a decrease for 30 wt.% of silica. An empirical model based on a parallel resistance approach was developed by incorporating mathematical formulations for solubility and permeability. The model results were compared with simulation results to quantify the effect of mixed gas transport, which showed an 18% and 15% percentage error for the permeability and solubility, respectively, in comparison to the simulation data. This study provides a basis for future understanding of MMMs using molecular simulations and modeling techniques for mixed gas conditions that demonstrate real membrane separation.

Download Full-text