scholarly journals Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives

2011 ◽  
Vol 61 (4) ◽  
pp. 447-455 ◽  
Author(s):  
Soni Singh ◽  
Sujata Bhat
Keyword(s):  
Antimicrobial Activity ◽  
Low Cost ◽  
Aromatic Aldehydes ◽  
Dilution Method ◽  
Phenylpropionic Acid ◽  
Antimicrobial Potential ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Vinyl Derivatives

Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity in vitro by the serial dilution method. Many of these molecules displayed potent antibacterial and antifungal activities. The ease of synthesis from low-cost starting materials along with potent antimicrobial activity of these molecules provide the lead for further improvement of activity and reflect the possibility of therapeutic use.

scholarly journals Phytochemical investigation and in vitro antimicrobial activity of Richardia scabra

2016 ◽  
Vol 11 (2) ◽  
pp. 248 ◽  
Author(s):  
Kathirvel Poonkodi ◽  
Subban Ravi
Keyword(s):  
Antimicrobial Activity ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Weed Species ◽  
Antibacterial And Antifungal Activities ◽  
Agar Plug ◽  
Phytochemical Investigation ◽  
Antibacterial And Antifungal ◽  
Simple Sugar

<p class="Abstract">The present study was aimed to evaluate the phytochemical screening and antimicrobial activity of the petroleum ether and methanol extracts from the mature leaves of <em>Richardia scabra</em> from India. Disc diffusion method was used to determine the zone inhibition of the tested samples for antibacterial and agar plug method was used to determine the antifungal activity, while the microtube-dilution technique was used to determine the minimum inhibitory concentration. Both extracts showed significant antibacterial and antifungal activities when tested against 10 bacterial and four fungal strains. The minimum inhibitory concentrations of the methanol extract of<em> R. scabra</em> ranged between 12.5–100 μg/mL for bacterial strains. Alkaloids, steroids, flavonoids, fatty acids, terpenoids and simple sugar were detected as phytoconstituents of extracts. To the best of our knowledge, this is the first report against antimicrobial activity of common weed species <em>R. scabra</em> found in India.</p><p> </p>

scholarly journals Synthesis and Antimicrobial Activity of Some Chalcone Derivatives

2008 ◽  
Vol 5 (3) ◽  
pp. 461-466 ◽  
Author(s):  
Y. Rajendra Prasad ◽  
A. Lakshmana Rao ◽  
R. Rambabu
Keyword(s):  
Aqueous Solution ◽  
Antimicrobial Activity ◽  
Potassium Hydroxide ◽  
Room Temperature ◽  
Antimicrobial Agents ◽  
Aromatic Aldehydes ◽  
Plate Method ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of potassium hydroxide and ethanol at room temperature. The synthesized compounds were characterized by means of their IR,1H-NMR spectral data and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.

scholarly journals Antibacterial and Antifungal Evaluation of Chloroflavones

2018 ◽  
Vol 10 (1) ◽  
pp. 67-76
Author(s):  
M. A. Rahim ◽  
M. M. H. Bhuiyan ◽  
M. M. Matin ◽  
M. R. Alam
Keyword(s):  
Pathogenic Bacteria ◽  
Salmonella Typhi ◽  
Aspergillus Ochraceus ◽  
Diffusion Method ◽  
Dilution Method ◽  
Significant Activity ◽  
Filter Paper Disc ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Two chloroflavones, 6 and 7 along with their corresponding chalcones, 4 and 5 have been tested for antibacterial and antifungal activities against six human pathogenic bacteria viz. Bacillus cereus (G+), Staphylococcus aureus (G+), Escherichia coli (G-), Vibrio choloriae (G-), Pseudomonas aeruginosa (G-), and Salmonella typhi (G-), and four plant as well as mold fungi viz. Aspergillus flavus, Aspergillus ochraceus, Aspergillus niger and Rhizopus spp.. The antibacterial and antifungal screens of the synthesized compounds were performed in vitro by the filter paper disc diffusion method and the poisoned food technique, respectively. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of these synthesized compounds in comparison to ampicillin were also determined by broth micro-dilution method. Some of them were found to possess significant activity, when compared to standard drugs.

scholarly journals Synthesis and Antimicrobial Activity of Pyrimidine Salts with Chloranilic and Picric Acids

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
C. Mallikarjunaswamy ◽  
D. G. Bhadregowda ◽  
L. Mallesha
Keyword(s):  
Antimicrobial Activity ◽  
The Other ◽  
Spectral Studies ◽  
H Nmr ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Ft Ir ◽  
Uv Visible ◽  
Antibacterial And Antifungal

Pyrimidine salts such as 2-methyl-5-nitro-phenyl-(4-pyridin-3-yl-pyrimidin-2-yl)-amine (1) and 4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-yl-amino)-phenyl-amine (2) with chloranilic and picric acids were synthesized, and theirin vitroantibacterial and antifungal activities were evaluated. The synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, and1H NMR spectral studies. Compound2aexhibited good inhibition towards antimicrobial activity compared to the other compounds.

scholarly journals Synthesis and Biological Evaluation of 2-(3-Methyl-2-oxoquinoxalin-1(2H)-yl)-N'-(substituted phenyl-methyledene/ethylidene)acetohydrazides

2010 ◽  
Vol 7 (4) ◽  
pp. 1435-1439 ◽  
Author(s):  
Gopal Krishna Rao ◽  
R. B. Kotnal ◽  
P. N. Sanjay Pai
Keyword(s):  
Antimicrobial Activity ◽  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Aromatic Aldehydes ◽  
Biological Evaluation ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Quinoxaline Derivatives ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation

A series of quinoxaline derivatives was prepared and evaluated for antitubercular, antibacterial and antifungal activities. The title compounds were prepared by condensation of substituted aromatic aldehydes and substituted acetophenones with 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl) acetohydrazide. Structures of all these compounds were confirmed by their spectral studies. Among synthesized compounds (4r, 4t, 4u, 4wand4x) have shown good anti tubercular activity (25 µg mL-1) when compared to reference drugs pyrazinamide (10 µg mL-1) and streptomycin (7.5 µg mL-1). In this study, few derivatives showed broad spectrum of antimicrobial activity at low concentration. The MICs (Minimum inhibitory concentration) of some compounds are 2-4 µg mL-1.

In vitro Antimicrobial Activity of Plants used in Cambodian Traditional Medicine

2007 ◽  
Vol 35 (05) ◽  
pp. 867-873 ◽  
Author(s):  
Aun Chea ◽  
Marie-Caroline Jonville ◽  
Sok-Siya Bun ◽  
Michèle Laget ◽  
Riad Elias ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Traditional Medicine ◽  
Bactericidal Effect ◽  
Gram Positive Bacteria ◽  
Antibacterial And Antifungal Activities ◽  
Methanolic Extracts ◽  
Disk Diffusion Assay ◽  
Antibacterial And Antifungal ◽  
Diffusion Assay

The purpose of the present study was to screen 27 plant species used in the traditional medicine of Cambodia for in vitro antibacterial and antifungal activities. Thirty-three methanolic extracts were tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Mycobacterium smegmatis and Candida albicans. Screened by disk diffusion assay, the extracts showed antimicrobial activity especially on Gram-positive bacteria. None of the crude methanolic extracts showed activity against P. aeruginosa. Twenty-five selected extracts were evaluated using a micro-dilution test. Harrisonia perforata (roots) and Hymenodictyon excelsum (bark) exhibited a bactericidal effect against S. aureus at a concentration of 500 μg/ml. Azadirachta indica (bark), Harrisonia perforata (roots and stem) and Shorea obtusa (roots) exhibited a bactericidal effect against M. smegmatis at 250 μg/ml.

Porównanie aktywności wyciągów z liści Passiflora alata, P. caerulea i P. incarnata wobec wybranych drobnoustrojów klinicznych

2018 ◽  
Vol 19 (2) ◽  
Author(s):  
Marcin Ożarowski ◽  
Bogdan Kędzia ◽  
Małgorzata Kania-Dobrowolska ◽  
Justyna Baraniak ◽  
Agnieszka Gryszczyńska ◽  
...  
Keyword(s):  
Acanthamoeba Castellanii ◽  
Cultivated Plants ◽  
Dilution Method ◽  
Minimal Bactericidal Concentration ◽  
Microsporum Gypseum ◽  
Phytochemical Study ◽  
Antibacterial And Antifungal Activities ◽  
Serial Dilution Method ◽  
Antibacterial And Antifungal

Introduction. In recent years, researchers have shown increasing interest in species of the Passiflora genus due to their potential biological and pharmacological properties. These species are an agronomically important crops and are used commercially in the fruit industry of South America. During of collection of fruits from cultivated plants, the leaves are removed. This plant material may be used for medicinal purposes. Our previous studies showed that crude extracts from leaves of P. alata, P. caerulea and P. incarnata contained various secondary metabolites such as phenolics, flavonoids, terpenoids. Moreover extract of P. alata showed the most effective activities against Acanthamoeba castellanii strain in vitro. Aim. The aim of our study was to evaluate and to compare the antibacterial and antifungal activities of the crude alcoholic extracts from leaf of P. alata, P. caerulea and P. incarnata. Material and methods. There was measurement of the minimal inhibitory concentration (MIC), the minimal bactericidal concentration (MBC), and the minimal fungicidal concentration (MFC) of the extracts by serial dilution method. Results. The results showed that the most active extracts against Enterococcus faecalis (ATCC 8040) were as follows from: P. incarnata = P. alata (MIC = 10.0 mg/ml, MBC >10.0 mg/ml) > P. caerulea (MIC = 10.0 mg/ml, MBC > 20.0 mg/ml); against Escherichia coli (PZH 026B6): P. incarnata (MIC = 10.0 mg/ml, MBC > 10.0 mg/ml) > P. caerulea (MIC = 10.0 mg/ml, MBC = 20.0 mg/ml) > P. alata (MIC = 10.0 mg/ml, MBC > 20.0 mg/ml); against Staphylococcus aureus (ATCC 6538P): P. incarnata (MIC = 2.5 mg/ml, MBC > 5.0) > P. caerulea (MIC = 5.0 mg/ml, MBC > 10.0) > P. alata (MIC = 10.0 mg/ml, MBC > 10.0); against Candida albicans (PCM 1409PZH): P. caerulea (MIC = 7.5 mg/ml, MBC = 15.0 mg/ml), P. incarnata (MIC = 10.0 mg/ml, MBC > 10.0 mg/ml), P. alata (MIC = 15.0 mg/ml, MBC > 20.0 mg/ml); against Microsporum gypseum K1: P. incarnata = P. caerulea = P. alata (MIC = 5.0 mg/ml, MBC = 5.0 mg/ml). Phytochemical study showed that the highest concentration of phenolic compounds was shown in extract of P. alata > P. caerulea > P. incarnata. Conclusions. Due to the fact that low antimicrobial activity has been demonstrated for raw extracts, there is a need for further studies of fractionated extracts and isolated compounds to assess their activity.

Antimicrobial Activity of Essential Oil from Pinus yunnanensis Franch.var tenuifolia Growing in China

2012 ◽  
Vol 430-432 ◽  
pp. 438-442 ◽  
Author(s):  
Yu Hong Tian ◽  
Zi Li ◽  
Shi Hua Wu ◽  
Qiong Huang
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Gas Chromatography Mass Spectrometry ◽  
Disc Diffusion ◽  
Bacterial Strains ◽  
Antibacterial And Antifungal Activities ◽  
Pinus Yunnanensis ◽  
Agar Dilution ◽  
Antibacterial And Antifungal

The in vitro antimicrobial activity of the essential oil from needles of Pinus yunnanensis Franch.var tenuifolia was investigated. The essential oil was obtained by hydro-distillation and analyzed by gas chromatography-mass spectrometry (GC-MS) method. The major compound of the essential oil was α-pinene (22.542%), followed by β-caryophyllene (16.636%), 1,2,4a,5,8,8a-hexahydro-4,7-dimethyl-1-(1-methylethyl)-naphthalene (5.085%), β-cubebene (4.779%), elixene (4.442%), α-cadinol (3.528%),α-caryophyllene (3.459%) and limonene (3.428%). The antimicrobial activity of oil was evaluated by using disc diffusion and agar dilution methods, respectively. The results indicated that the essential oil held moderate antimicrobial activity against tested microorganisms. The essential oil did not differ remarkably in its antibacterial and antifungal activities. The minimum inhibitory concentrations (MICs) were 40 ml/l for bacterial strains, and 80 ml/l for fungal strains.

Evaluation of In vitro Antimicrobial and In vivo Cytotoxic Properties of Peroxo Coordination Complexes of Mg(II), Mn(II), Fe(II) & Ni(II)

1970 ◽  
Vol 3 (1) ◽  
Author(s):  
Kudrat E Zahan ◽  
MD. Shamin Hossain ◽  
Shuranjan Sarkar ◽  
Md. Mukhlesur Rahman ◽  
Md. Akhter Farooque ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Cytotoxic Activity ◽  
Full Text ◽  
Brine Shrimp ◽  
Coordination Complexes ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Six newly synthesized nickel peroxo coordination complexes, [Mg2(2-ap)2(O2)(OH), A], [Mn(2-ap) (ED)(O2), B], [Fe(2-ab)(ED)(O2), C], [Fe(2-ap)(ED)(O2), D], [Ni2(2-ab)2(O2)(OH), E] and [Ni2(2-ap)2(O2)(OH), F] showed significant antibacterial and antifungal activities. The minimum inhibitory concentrations (MIC) of these compounds were found in the range of 8-128 µg/ml. Among these compounds, F showed maximum cytotoxicity (LC50 = 3.62 µg/ml) in brine shrimp lethality bioassay. Key words: Peroxo coordination complexes; Antimicrobial activity; antifungal activity; cytotoxic activity. Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Design, Synthesis, and Antibacterial and Antifungal Activities of Novel Trifluoromethyl and Trifluoromethoxy Substituted Chalcone Derivatives

2020 ◽  
Vol 13 (11) ◽  
pp. 375
Author(s):  
Surendra Babu Lagu ◽  
Rajendra Prasad Yejella ◽  
Richie R. Bhandare ◽  
Afzal B. Shaik
Keyword(s):  
Antimicrobial Activity ◽  
Bacillus Subtilis ◽  
Fungal Infections ◽  
Normal Liver ◽  
Dilution Method ◽  
Spectroscopic Techniques ◽  
Normal Liver Cell ◽  
Olefinic Carbon ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Despite the availability of many drugs to treat infectious diseases, the problems like narrow antimicrobial spectrum, drug resistance, hypersensitivities and systemic toxicities are hampering their clinical utility. Based on the above facts, in the present study, we designed, synthesized and evaluated the antibacterial and antifungal activity of novel fluorinated compounds comprising of chalcones bearing trifluoromethyl (A1–A10) and trifluoromethoxy (B1–B10) substituents. The compounds were characterized by spectroscopic techniques and evaluated for their antimicrobial activity against four pathogenic Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Bacillus subtilis) bacterial and fungal (Candida albicans and Aspergillus niger) strains. In this study, the compounds with trifluoromethoxy group were more effective than those with trifluoromethyl group. Among the 20 fluorinated chalcones, compound A3/B3 bearing an indole ring attached to the olefinic carbon have been proved to possess the most antimicrobial activity compared to the standard drugs without showing cytotoxicity on human normal liver cell line (L02). Further, the minimum inhibitory concentration (MIC) for A3/B3 was determined by serial tube dilution method and showed potential activity. These results would provide promising access to future study about the development of novel agents against bacterial and fungal infections.

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