Negative predictive value of F-18-FDG coincidence PET in patients with Hodgkin's disease and a residual mass after therapy: a retrospective diagnostic test study

Background: Thyroid carcinoma generally has a good prognosis. The main focus of current research on thyroid carcinoma is to increase the accuracy of preoperative diagnosis of thyroid nodules. When the result of fine needle aspiration biopsy (FNAB) is indeterminate, clinicians often have doubts in determining the surgical management. Objective: Protein BRAF expression analysis can help improve the accuracy of FNAB and optimize the management of differentiated thyroid carcinoma. Methods: This study is a diagnostic test performed from October 2016 at Sanglah General Hospital with 38 patients as subjects who fulfilled the inclusion criteria. Data is being presented in descriptive form before diagnostic test is done to determine sensitivity, specificity, positive predictive value, negative predictive value and the accuracy of immunocytochemistry test for BRAF on indeterminate thyroid nodule. Results: Thirty-eight samples met the inclusion criteria during the study period. Three samples were male (7.9%) and 35 samples (92.1%) were female. The mean age of the sample was 45.21 years (SD ±10.910 years) with ages ranging from 23 to 66 years. Of the 12 samples undergoing isthmolobectomy, 7 samples (58.4%) were determined to be malignant from histopathological results. The sensitivity value of BRAF immunocytochemistry test is 45.45% with a specificity value of 81.25%, a positive predictive value of 76.92%, a negative predictive value of 52% and an accuracy of 60.50%. Analysis of the receiver operator (ROC) curve shows the area under the curve (AUC) of 63.4% with a confidence interval of 45.5–81.2%. Conclusion: Immunocytochemistry BRAF test have a reliable diagnostic value and can be taken into consideration in the preoperative diagnosis of thyroid malignancies.

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Utility of the methylated SEPT9 test for the early detection of colorectal cancer: a systematic review and meta-analysis of diagnostic test accuracy

BMJ Open Gastroenterology ◽

10.1136/bmjgast-2019-000355 ◽

2020 ◽

Vol 7 (1) ◽

pp. e000355 ◽

Cited By ~ 5

Author(s):

Rohit Hariharan ◽

Mark Jenkins

Keyword(s):

Colorectal Cancer ◽

Systematic Review ◽

Early Detection ◽

Positive Predictive Value ◽

Negative Predictive Value ◽

Diagnostic Test ◽

Predictive Value ◽

Meta Analysis ◽

Test Accuracy ◽

Sensitivity Specificity

BackgroundCirculating tumour DNA from colorectal cancer (CRC) is a biomarker for early detection of the disease and therefore potentially useful for screening. One such biomarker is the methylated SEPT9 (mSEPT9) gene, which occurs during CRC tumourigenesis. This systematic review and meta-analysis aims to establish the sensitivity, specificity and accuracy of mSEPT9 tests for the early diagnosis of CRC.MethodsA systematic search of the relevant literature was conducted using Medline and Embase databases. Data were extracted from the eligible studies and analysed to estimate pooled sensitivity, specificity and diagnostic test accuracy.ResultsBased on 19 studies, the pooled estimates (and 95% CIs) for mSEPT9 to detect CRC were: sensitivity 69% (62–75); specificity 92% (89–95); positive likelihood ratio 9.1 (6.1–13.8); negative likelihood ratio 0.34 (0.27–0.42); diagnostic OR 27 (15–48) and area under the curve 0.89 (0.86–0.91). The test has a positive predictive value of 2.6% and negative predictive value of 99.9% in an average risk population (0.3% CRC prevalence), and 9.5% (positive predictive value) and 99.6% (negative predictive value) in a high-risk population (1.2% CRC prevalence).ConclusionThe mSEPT9 test has high specificity and moderate sensitivity for CRC and is therefore a potential alternative screening method for those declining faecal immunochemical test for occult blood (FIT) or other screening modalities. However, it is limited by its poor diagnostic performance for precancerous lesions (advanced adenomas and polyps) and its relatively high costs, and little is known about its acceptability to those declining to use the FIT.

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Predictive value of lymphography for sites of subdiaphragmatic disease encountered at staging laparotomy in newly diagnosed Hodgkin's disease and non-Hodgkin's lymphoma.

Journal of Clinical Oncology ◽

10.1200/jco.1983.1.9.532 ◽

1983 ◽

Vol 1 (9) ◽

pp. 532-536 ◽

Cited By ~ 26

Author(s):

R A Castellino ◽

N R Dunnick ◽

D R Goffinet ◽

S R Rosenberg ◽

H S Kaplan

Keyword(s):

Predictive Value ◽

Hodgkin's Disease ◽

Hodgkin’S Lymphoma ◽

Hodgkin’S Disease ◽

Hodgkin's Lymphoma ◽

Newly Diagnosed ◽

Staging Laparotomy ◽

Non Hodgkin’S Lymphoma ◽

Non Hodgkin's Lymphoma

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Role of ascitic fluid adenosine deaminase (ADA) and serum CA-125 in the diagnosis of tuberculous peritonitis

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v40i3.25228 ◽

2015 ◽

Vol 40 (3) ◽

pp. 89-91 ◽

Cited By ~ 5

Author(s):

N Ali ◽

NC Nath ◽

R Parvin ◽

A Rahman ◽

TM Bhuiyan ◽

...

Keyword(s):

Positive Predictive Value ◽

Negative Predictive Value ◽

Diagnostic Test ◽

Ascitic Fluid ◽

Predictive Value ◽

Ca 125 ◽

Histopathological Diagnosis ◽

Diagnostic Modality ◽

Cross Sectional

This cross sectional study was carried out in the department of gastroenterology, BIRDEM, Dhaka from January 2010 to May 2011 to determine the role of ascitic fluid ADA and serum CA-125 in the diagnosis of clinically suspected tubercular peritonitis. Total 30 patients (age 39.69±21.26, 18M/12F) with clinical suspicion of tuberculosis peritonitis were included in this study after analyzing selection criteria. Laparoscopic peritoneal biopsy with histopathological diagnosis was considered gold standard against which accuracics of two biomarkers (ADA & CA-125) were compared. Cut off value of ADA and CA-125 are 24 u/l, 35 U/ml respectively. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of ADA as a diagnostic modality in tuberculos peritonitis were 87.5%, 83.33%, 95.45%, 62.5% and 86.67% respectively where as CA-125 was found to have 83.33% sensitivity, 50% specificity, 86.9% positive predictive value, 42.85% negative predictive value and 76.6% accuracy. Both biomarkers are simple, non-invasive, rapid and relatively cheap diagnostic test where as laparoscopy is an invasive procedure, costly & requires trained staff and not without risk and also not feasible in all the centre in our country. So ascitic fluid ADA and serum CA-125 are important diagnostic test for peritoneal tuberculosis.Bangladesh Med Res Counc Bull 2014; 40 (3): 89-91

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Gallium scans in the management of patients with Hodgkin's disease: a study of 101 patients.

Journal of Clinical Oncology ◽

10.1200/jco.1997.15.2.518 ◽

1997 ◽

Vol 15 (2) ◽

pp. 518-527 ◽

Cited By ~ 52

Author(s):

E Salloum ◽

D S Brandt ◽

V J Caride ◽

E Cornelius ◽

D Zelterman ◽

...

Keyword(s):

Predictive Value ◽

Hodgkin's Disease ◽

Progressive Disease ◽

Residual Disease ◽

Hodgkin’S Disease ◽

Combined Modality Therapy ◽

Stage I ◽

Stage Iii ◽

Disease Stage

PURPOSE To evaluate the utility of periodic gallium (67Ga) scans in the management of patients with Hodgkin's disease. PATIENTS AND METHODS From 1990 to 1994, 101 patients treated for Hodgkin's disease (stage I to II, n = 67; stage III to IV, n = 34) had a positive 67Ga scan at the time of diagnosis. Treatment included chemotherapy in 27 patients, radiation therapy in 28, and combined modality therapy in 46. All patients underwent 67Ga scans at the time of diagnosis, near the end or just after treatment, and at periodic follow-up evaluation. RESULTS After treatment, the 67Ga scan remained positive in four patients and was interpreted as negative in 97. Among the four patients with positive scans, two died of progressive disease and two relapsed. Among the remaining 97 patients with negative 67Ga scans, 16 patients relapsed, including five with stage I to II (7.5%) and 11 with stage III to IV (34.4%) disease. The negative predictive value of posttherapy 67Ga scan was 83.5% for all patients; however, when calculated according to stage, it was 92.4% for patients with stage I to II disease and 64.5% for patients with stage III to IV disease (P < .01). CONCLUSION A positive 67Ga scan at the end of therapy is rarely seen in patients with Hodgkin's disease and should be considered a manifestation of gross residual disease. However, a negative 67Ga scan after therapy had a significantly lower predictive value in patients with stage III to IV disease compared with stage I to II disease. The predictive value of 67Ga scans, as well as newer imaging studies, should be analyzed according to pretreatment stage.

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The Kim Test

The American Journal of Sports Medicine ◽

10.1177/0363546504272687 ◽

2005 ◽

Vol 33 (8) ◽

pp. 1188-1192 ◽

Cited By ~ 134

Author(s):

Seung-Ho Kim ◽

Jun-Sic Park ◽

Woong-Kyo Jeong ◽

Seong-Kee Shin

Keyword(s):

Positive Predictive Value ◽

Negative Predictive Value ◽

Diagnostic Test ◽

Predictive Value ◽

Sudden Onset ◽

Level Of Evidence ◽

Labral Lesion ◽

Posterior Shoulder ◽

Interexaminer Reliability ◽

Test Result

Background Detection of a posteroinferior labral lesion by physical examination is often difficult. Purpose To introduce a novel diagnostic test for detecting a posteroinferior labral lesion of the shoulder. Hypothesis The Kim test can detect a posteroinferior labral lesion of the shoulder. Study Design Cohort study (diagnosis); Level of evidence, 1. Methods In 172 painful shoulders, the Kim test was compared with the jerk test and was verified by arthroscopic examination. A sudden onset of posterior shoulder pain and click with or without clunk indicated a positive test result. Results Thirty-three shoulders had a positive Kim test result, in which 24 had a posteroinferior labral lesion and 9 had a normal posteroinferior labrum. Of 139 shoulders with a negative Kim test result, 6 had a posteroinferior labral tear and 133 had a normal posteroinferior labrum. The sensitivity of the Kim test was 80%, specificity was 94%, positive predictive value was 0.73, and negative predictive value was 0.96. The interexaminer reliability between 2 examiners was 0.91. The accuracy of the jerk test in detecting a posteroinferior labral lesion was the following: sensitivity, 73%; specificity, 98%; positive predictive value, 0.88; and negative predictive value, 0.95. The location of the posterior labral lesion was predominantly posterior in 19 shoulders and predominantly inferior in 11 shoulders. The Kim test was more sensitive in detecting a predominantly inferior labral lesion, whereas the jerk test was more sensitive in detecting a predominantly posterior labral lesion. The sensitivity in detecting a posteroinferior labral lesion increased to 97% when the 2 tests were combined. Conclusion The Kim test is a reliable diagnostic test for detection of a posteroinferior labral lesion.

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Comparison between Invasive & Non-Invasive Diagnostic Evaluation of Tuberculous Peritonitis In Our Prospective

Medicine Today ◽

10.3329/medtoday.v27i2.30039 ◽

2016 ◽

Vol 27 (2) ◽

pp. 20-22

Author(s):

Md Naushad Ali ◽

Rehana Parvin ◽

Md Abul Kalam Azad ◽

AKM Mazharul Islam

Keyword(s):

Positive Predictive Value ◽

Negative Predictive Value ◽

Diagnostic Test ◽

Predictive Value ◽

Diagnostic Evaluation ◽

Ca 125 ◽

Histopathological Diagnosis ◽

Peritoneal Tuberculosis ◽

College Hospital ◽

Non Invasive

This cross sectional study was carried out in the department of gastroenterology, Rangpur Medical College Hospital, Rangpur from January 2014 to July 2014 to compare between Invasive & Non-Invasive Diagnostic Evaluation of Tuberculosis Peritonitis In our prospective in clinically suspected patients. Total 30 patients (age 39.69±21.26, 18M/12F) with clinical suspicion of peritoneal tuberculosis were included in this study after analyzing selection criteria. Laparoscopic peritoneal biopsy with 'histopathological' diagnosis was considered as gold standard against which accuracies non-invasive test of two biomarkers (ADA & CA-125) were compared. Cut off value of ADA and CA-125 is 24 U/l, 35 U/ml respectively. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of ADA as a diagnostic modality in peritoneal tuberculosis were 87.5%, 83.33%, 95.45%, 62.5% and 86.67% respectively whereas CA-125 was found to have 83.33% sensitivity, 50% specificity, 86.9% positive predictive value, 42.85% negative predictive value and 76.6% accuracy. Both biomarkers were simple, non-invasive, rapid and relatively cheap diagnostic test whereas laparoscopy was an invasive procedure, costly & requires trained staff and not without risk and also not feasible in the entire centre in our country. So ascitic fluid ADA and serum CA-125 was important non-invasive diagnostic test for peritoneal tuberculosis.Medicine Today 2015 Vol.27(2): 20-22

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Diagnostic Test On Modified Score Of Cesarean Section History In Placenta Accreta Index In Predicting Placenta Accreta Diagnosis In Rsup Dr M Djamil

JOURNAL OBGIN EMAS ◽

10.25077/aoj.5.2.215-230.2021 ◽

2021 ◽

Vol 5 (2) ◽

pp. 215-230

Author(s):

Widayat Widayat ◽

Andi Friadi ◽

Hafni Bacthiar

Keyword(s):

Caesarean Section ◽

Positive Predictive Value ◽

Negative Predictive Value ◽

Diagnostic Test ◽

Predictive Value ◽

Placenta Accreta ◽

High Sensitivity ◽

Kappa Score ◽

Chorionic Villi ◽

History Of

Introduction : Placenta accreta is defined as abnormal implantation of placenta villi which invades myometrium without the presence of decidua bacalis resulting in placenta that is difficult to remove. Based on the depth of invasion, placenta accreta is divided into three grades, placenta accreta, placenta increta, and placenta percreta. Placenta accreta developes if chorionic villi attaches to endometrium beyond desidua basalis. Placenta increta develops when chorionic villi invades the whole myometrium. Placenta percreta developes when chorionic villi attaches beyond myometrium reaching serous and abdominal organ. Based on clinical manifestation, placenta accreta is the common term being used. Incident of abnormal placenta invasion varies from 1 : 93.000 up to 1 : 540 pregnancy. PA incidence had increased four times from 1994 to 2002 in line with increased of caesarean section procedure. Other study showed history of caesarean section increased risk of placenta accreta up to 8,7 times. Placenta accreta index (PAI) was developed based on scoring process or various parameters assessment to help diagnose placenta accreta. The parameters including: history of caesarean section ≥ 2 times, lacunae grade, sagittal smallest myometrial thickness, anterior placenta previa and birding vessel. High PAI indicates high risk of abnormal placenta invasion based on histology.Objective : This study aims to investigate modified history of cesarean section score in placenta accreta index in predicting placenta accreta diagnosis in RSUP DR M Djamil Padang.Material and methods : This was analytical study with cross sectional design. Study population was 84 placenta accreta patients in RSUP Dr. M. Djamil Padang from 2016 to 2019. Study sample was recruited using simple random sampling technique after meeting inclusion and exclusion criteria. Statistic analysis was done using Cohen’s Kappa test. Diagnostic test including sensiticivy, specivicity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy.Result : Strenght of agreement diagnosis placenta accreta based on PAI showed Kappa score of -0,002 (Kappa score < 0,2) which indicated poor strength of agreement. Strenght of agreement diagnosis placenta accreta based on modified PAI showed Kappa score of 0,353 (Kappa score range from 0,21 to 0,40) which indicated fair strength of agreement. PAI diagnostic test yield sensitivity of 97,1%, specificity of 2,8%, positive predictive value of 48,5%, negative predictive value of 50%, and accuracy of 48,6%. Modified PAI diagnostic test yield sensitivity of 97,1%, specificity of 38,9%, positive predictive value of 60%, negative predictive value of 93,3%, and accuracy of 67,1%.Conclusion : PAI has high sensitivity, low specificity, moderate positive predictive value, moderate negative predictive value, and moderate accuration. Modified PAI has high sensitivity, moderate specificity, moderate positive predictive value, high negative predictive value, and high accuracy. PAI diagnosis has poor strength of agreement compared with pathology anatomy. Modified PAI diagnosis has fair strength of agreement compared with pathology anatomy. Modified PAI has identical sensitivity with standard PAI, meanwhile for specificity, positive predictive value, negative predictive value, and accuracy, modified PAI yields higher result compared to PAI.Keywords: Modified score of history caesarean section, placenta accreta index, Modified placenta accreta index, diagnostic test of placenta accreta diagnosis

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Perbandingan Rapid Diagnostic Test dan Pemeriksaan Mikroskopik pada Diagnosis Malaria

Kesmas National Public Health Journal ◽

10.21109/kesmas.v5i6.120 ◽

2011 ◽

Vol 5 (6) ◽

pp. 250 ◽

Cited By ~ 2

Author(s):

Lambok Siahaan

Keyword(s):

Positive Predictive Value ◽

Negative Predictive Value ◽

Diagnostic Test ◽

Rapid Diagnostic Test ◽

Parasite Density ◽

Microscopic Examination ◽

Predictive Value ◽

Blood Film ◽

Other Hand ◽

Better Than

Penelitian ini dilakukan untuk membandingkan penggunaan Rapid diagnostic test dengan pemeriksaan mikroskopik (apusan darah) dalam menegakkan diagnosis malaria. Penelitian uji diagnostik ini dilakukan di Kabupaten Nias Selatan dan Kotamadya Sabang, Sumatera Utara. Apusan darah diwarnai dengan larutan Giemsa 10% dan dibaca oleh pemeriksa yang sudah terlatih. Rapid diagnostic test dilakukan dengan menggunakan parascreen. Uji diagnostik rapid diagnostic test secara umum diperoleh hasil yaitu sensitivitas 63,8%; spesifisitas 100%; Positive Predictive Value (PPV) 100%; dan negative predictive value (NPV)93,5%. Kepadatan parasit pada rapid diagnostic test (+) dan mikroskopik (+) adalah 1.483 ± 583 parasit/μl. Sementara, kepadatan parasit pada pemeriksaan rapid diagnostic test (-) dan mikroskopik (+) adalah 621 ± 335 parasit/μl. Pemeriksaan mikroskopik masih lebih baik dibandingkandengan rapid diagnostic test, terutama pada kepadatan parasit yang rendah. Kata kunci: Malaria, pemeriksaan mikroskopik, rapid diagnostic testAbstractThe study was conducted to compare rapid diagnostic test with microscopy (blood film) to diagnose malaria disease. This diagnostic test was done in South of Nias District and Sabang District, North Sumatera. Blood film were colored with Giemsa 10% solution and examined by trained microscopists. Rapid Diagnostic Test was done based on the manual procedure. The results of diagnostic test of rapid diagnostic test were sensitivity 63,5%; specificity 100%, positive predictive value (PPV) 100%, and negative predictive value (NPV) 93,5%. The density of parasite in rapid diagnostic test (+) were 1.483 + 583 parasite/μl (1.120-2.920 parasite/μl. In other hand, the density of parasite in rapid diagnostic test (-) and microscopy were 621 + 335 parasite/ μl (120-1.160 parasite/μl). Microscopy still better than rapid diagnostic test, especially in patient with low parasite density. Keywords: Malaria, microscopic examination, rapid diagnostic test

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