scholarly journals Flavonoids in prevention of diseases with respect to modulation of Ca-pump function

2011 ◽  
Vol 4 (3) ◽  
Author(s):  
Ľubica Horáková
Keyword(s):  
Pump Function ◽  
Ca Pump

scholarly journals Left atrial functional assessment and mortality in patients with severe aortic stenosis with sinus rhythm

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
João Ferreira ◽  
Valdirene Gonçalves ◽  
Patrícia Marques-Alves ◽  
Rui Martins ◽  
Sílvia Monteiro ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Left Atrial ◽  
Primary Outcome ◽  
Severe Aortic Stenosis ◽  
Heart Team ◽  
Pump Function ◽  
Volumetric Assessment ◽  
All Cause Mortality ◽  
Echocardiography Laboratory

Abstract Background Aortic valve stenosis (AS) is the most common primary valvular heart disease leading to surgical or percutaneous aortic valve replacement (AVR) in Europe and its prevalence keeps growing. While other risk factors in severe AS are well documented, little is known about the prognostic value of left atrial (LA) function in AS. Our aim is to clarify the relationship between LA function measured at severe AS diagnosis (evaluated by means of volumetric assessment) and all-cause mortality during follow-up. Methods We retrospectively evaluated patients diagnosed with severe AS for the first time at our echocardiography laboratory. We evaluated LA reservoir, conduit and pump function by measuring LA volumes at different timings of cardiac cycle. Treatment strategy was decided according to heart team consensus and patient decision. We divided patients into groups according to terciles of LA reservoir, conduit and pump function. Primary outcome was defined by the occurrence of all-cause mortality during follow-up. Results A total of 408 patients were included in the analysis, with a median follow-up time of 45 months (interquartile range 54 months). 57.9% of patients underwent AVR and 44.9% of patients registered the primary outcome during follow-up. Left atrial emptying fraction (LAEF) was the best LA functional parameter and the best overall parameter in discriminating primary outcome (AUC 0.845, 95%CI 0.81–0.88, P < 0.001). After adjustment for clinical, demographic and echocardiographic variables, cumulative survival of patients with LAEF < 37% and LAEF 37 to 53% relative to patients with LAEF ≥54% remained significantly lower (HR 13.91, 95%CI 6.20–31.19, P < 0.001 and HR 3.40, 95%CI 1.57–7.37, P = 0.002, respectively). After adjustment for AVR, excess risk of LAEF < 37% and LAEF 37 to 53% relative to LAEF ≥54% remained significant (HR 11.71, 95%CI 5.20–26.40, P < 0.001 and HR 3.59, 95%CI 1.65–7.78, P = 0.001, respectively). Conclusions In patients with a first diagnosis of severe AS, LA function, evaluated by means of volumetric assessment, is an independent predictor of all-cause mortality and a more potent predictor of death compared to classical severity parameters. These data can be useful to identify high-risk patients who might benefit of AVR.

Neuropathy, axonal Na+/K+ pump function and activity-dependent excitability changes in end-stage kidney disease

2006 ◽  
Vol 117 (5) ◽  
pp. 992-999 ◽  
Author(s):  
A KRISHNAN ◽  
R PHOON ◽  
B PUSSELL ◽  
J CHARLESWORTH ◽  
H BOSTOCK ◽  
...  
Keyword(s):  
Kidney Disease ◽  
End Stage Kidney Disease ◽  
Pump Function ◽  
End Stage ◽  
Activity Dependent

Positive charge modifications alter the ability of XIP to inhibit the plasma membrane calcium pump

1996 ◽  
Vol 271 (3) ◽  
pp. C736-C741 ◽  
Author(s):  
W. Xu ◽  
C. Gatto ◽  
M. A. Milanick
Keyword(s):  
Plasma Membrane ◽  
Positive Charge ◽  
Calcium Pump ◽  
Inhibitory Peptide ◽  
Ca Pump ◽  
Contact Points ◽  
Plasma Membrane Calcium Pump ◽  
Peptide Analogues ◽  
Positively Charged

Exchange inhibitory peptide (XIP; RRLLFYKYVYKRYRAGKQRG) is the shortest peptide that inhibits the plasma membrane Ca pump at high Ca (A. Enyedi, T. Vorherr, P. James, D. J. McCormick, A. G. Filoteo, E. Carafoli, and J. T. Penniston, J. Biol. Chem. 264: 12313-12321, 1989). Sulfosuccinimidyl acetate (SNA)-modified XIP does not inhibit the Ca pump; SNA neutralizes the positive charge on Lys at positions 7, 11, and 17. Peptide 2CK-XIP (RRLLFYRYVYRCYCAGRQKG) inhibits the pump, but the iodoacetamido-modified peptide does not inhibit. Three peptide analogues, in which 7, 11, and 17 were Ala, Cys, or Lys, inhibited about as well as XIP. SNA modification of these analogues (each with 1 Lys) did not inhibit. SNA modification of 2CK-XIP results in a peptide that does not inhibit; thus position 19 is important. Our results suggest that it is critical that position 19 be positively charged, that positions 7, 11, and 17 are important contact points between XIP and the Ca pump (with at least one positively charged), and that, whereas it is not essential that residues 12 and 14 be positive, they cannot be negative.

scholarly journals Phospholemman-Phosphorylation Mediates the β-Adrenergic Effects on Na/K Pump Function in Cardiac Myocytes

2005 ◽  
Vol 97 (3) ◽  
pp. 252-259 ◽  
Author(s):  
Sanda Despa ◽  
Julie Bossuyt ◽  
Fei Han ◽  
Kenneth S. Ginsburg ◽  
Li-Guo Jia ◽  
...  
Keyword(s):  
Cardiac Myocytes ◽  
Pump Function ◽  
Adrenergic Effects

Pregnancy induced hypertension and sodium pump function in erythrocytes

1992 ◽  
Vol 99 (10) ◽  
pp. 803-807 ◽  
Author(s):  
S. MACPHAIL ◽  
T. H. THOMAS ◽  
R. WILKINSON ◽  
J. M. DAVISON ◽  
W. DUNLOP
Keyword(s):  
Sodium Pump ◽  
Pregnancy Induced Hypertension ◽  
Pump Function ◽  
Induced Hypertension

scholarly journals The highly conserved extracellular peptide, DSYG(893-896), is a critical structure for sodium pump function

2004 ◽  
Vol 271 (19) ◽  
pp. 3821-3831 ◽  
Author(s):  
Susanne Becker ◽  
Heike Schneider ◽  
Georgios Scheiner-Bobis
Keyword(s):  
Sodium Pump ◽  
Pump Function ◽  
Critical Structure

Electromechanical Control of Atrium Function

2009 ◽  
Author(s):  
Miroslava Svobodova ◽  
Elena S. Di Martino
Keyword(s):  
Atrial Fibrillation ◽  
Blood Flow ◽  
Cardiac Function ◽  
The Body ◽  
Pump Function ◽  
Physical Systems ◽  
Electrical Systems ◽  
Mechanical Pump

The heart is a very efficient mechanical pump whose function is to controls the blood flow in the body. Two physical systems, namely mechanical for the pumping action and electrical for the control interact within the heart. Cardiac function can only be studied if both mechanical and electrical systems are considered. In particular, we are interested in the electromechanical control of the atrium pump function which is less studied then the electromechanical control of the ventricle pump function and none the less is a crucial factor in the development of atrial fibrillation.

Abstract 12622: Western Diet for One Month Impairs Myocardial Energetics and Both Systolic and Diastolic Pump Function in the Mouse Heart

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Ivan Luptak ◽  
Aaron L Sverdlov ◽  
Aly Elezaby ◽  
Edward J Miller ◽  
David R Pimentel ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Mitochondrial Dysfunction ◽  
Systolic Function ◽  
Atp Synthesis ◽  
Contractile Reserve ◽  
31P Nmr Spectroscopy ◽  
Pump Function ◽  
High Workload ◽  
Myocardial Energetics ◽  
Intact Heart

Background and Significance: Metabolic heart disease(MHD) is common in patients with obesity, type 2 diabetes and/or metabolic syndrome. We found cardiac mitochondrial dysfunction in mice with obesity-related MHD due to consumption of a high fat high sucrose (HFHS) diet. The effects of diet-induced obesity on cardiac energetics and pump function in the intact organ are largely unknown. Hypothesis: We tested the hypothesis that cardiac mitochondrial dysfunction due to HFHS diet for one month impairs energetic and contractile reserve in the intact heart. Methods and Results: Mice were fed a HFHS or control diet (CD) for 1 month. In isolated cardiac mitochondria from HFHS-fed mice (vs. CD) the maximal rate of ATP synthesis was decreased for complex I (down by 42%; p<0.05) and II (down by 37%; p<0.05) substrates. We measured myocardial energetics in isolated perfused hearts using 31P NMR spectroscopy at baseline (450 bpm, 2 mM Ca++) and high workload (600 bpm, 4 mM Ca++) in HFHS (n=7) and CD (n=8) hearts. In HFHS-fed hearts, myocardial ATP concentration was the same at baseline (10.5±0.4 vs 10.4±0.5 mM) and high workload (7.4±0.9 vs. 7.5±0.5 mM) as that of CD hearts. However, in HFHS-fed hearts the concentration of phosphocreatine, which reflects energy reserve, was decreased at baseline (13±0.7 vs. 17.5±0.8 mM; p<0.01) and decreased further at high workload (down to 7.3±0.7; p<0.01 vs. baseline and p<0.01 vs. CD at 10.5±0.4 mM) - indicating a mismatch between ATP production and utilization. In HFHS hearts, the diastolic pressure-volume relationship was shifted upward and leftward at baseline, indicative of diastolic dysfunction. In HFHS hearts, baseline systolic function was preserved (rate pressure product 41,600±2,200 vs. 41,000±2,000 mmHg/min), but was decreased at high workload (54,800±7,200 vs. 85,300±4,300 mmHg/min; p<0.01 vs. CD), reflecting an impaired contractile reserve. Conclusion: Consumption of a HFHS diet for one month causes cardiac mitochondrial dysfunction with reduced ATP synthesis leading to impaired energetic reserve in the intact heart. Diastolic dysfunction at rest and the impaired ability to increase systolic function with increased work demands may result from impaired energetics in MHD.

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