scholarly journals Analysis Of Family Cases With Type I Diabetes Mellitus In A Group Of Pediatric Patients From Constanţa County

2012 ◽  
Vol 18 (1) ◽  
pp. 13-18
Author(s):  
Irina Franciuc ◽  
Cristina Maria Mihai ◽  
Alina Martinescu ◽  
Loredana Mariana Aftenie ◽  
Adina Honcea
Keyword(s):  
Type 1 Diabetes ◽  
Family History ◽  
Pediatric Patients ◽  
Type I Diabetes ◽  
Statistical Significance ◽  
P Value ◽  
Type I ◽  
History Of ◽  
Index Cases

AbstractThe aim of this study was to present the cases with family history of type 1 diabetes in a group of pediatric patients from the Clinic of Pediatrics, Constanta County Hospital, and to analyze the risk for relatives conferred by presence of particular DR genotypes. 8 out of 60 index cases had relatives affected with type 1 diabetes (13.33%). Of these, four had firstdegree relatives affected (6.67%) and were presented here. Although high-risk genotypes were more frequent in the group of familial cases, no association was found between DR genotype and family history of type 1 diabetes when statistical significance was tested (p value 0.119).

scholarly journals HHEX-IDE Polymorphism Is Associated with Low Birth Weight in Offspring with a Family History of Type 1 Diabetes

2009 ◽  
Vol 94 (10) ◽  
pp. 4113-4115 ◽  
Author(s):  
Christiane Winkler ◽  
Thomas Illig ◽  
Kerstin Koczwara ◽  
Ezio Bonifacio ◽  
Anette-Gabriele Ziegler
Keyword(s):  
Type 1 Diabetes ◽  
Birth Weight ◽  
Family History ◽  
Low Birth Weight ◽  
History Of

scholarly journals Health related quality of life among children with Type I diabetes, Assiut city, Egypt

2017 ◽  
Vol 7 (10) ◽  
pp. 73 ◽  
Author(s):  
Marzoka A. Gadallah ◽  
Taghreed Abdul-Aziz M. Ismail ◽  
Naglaa Saad Abdel Aty
Keyword(s):  
Quality Of Life ◽  
Type 1 Diabetes ◽  
Health Insurance ◽  
Type I Diabetes ◽  
Type I ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Objective: Health related quality of life (HRQOL) is a multidimensional construct that includes physical and psychosocial functioning, has emerged as an important outcome in pediatric population with chronic health conditions. The study objectives are to measure the quality of life among children with type I diabetes compared to healthy peers and to determine factors affecting the QOL among children with type I diabetes.Methods: Analytic cross sectional study was conducted in Sidi Galal health insurance outpatient clinic for children with type 1 diabetes mellitus and a comparison group of healthy peers was taken from other outpatient clinics. A total of four hundred and twelve children, aged from 8-18 years with type 1 diabetes and four hundred and twelve healthy peers matched in age and sex were interviewed. Three tools were used for this study: Demographic questionnaire, Socio-economic scale, and Peds QL4.0 Generic Core Scale was used to measure HRQOL.Results: The mean age of studied children was 12.9 ± 3.2. More than 60% of children with diabetes had uncontrolled glycemic level and 60% of them were in low socio-economic level. Children with diabetes had significantly lower HRQOL than healthy children in all domains. Age, glycemic control status and birth order of the diabetic children showed no significance difference regarding the QOL. Disease duration affected only the emotional function of the QOL and females showed significantly higher score regarding school functioning. Social, school and the total QOL scores were significantly higher among children with highly educated mothers while father's education affected the emotional, school and total QOL scores. Children in the middle and high social class showed significantly higher scores regarding social, school and total QOL. Presence of diabetic parent positively affected the social functioning while had negative effect on the school function of children with type I diabetes.Conclusions and recommendations: Diabetes is negatively affecting all the QOL functioning of the children. We recommend that Integrated programs between child's home, school and health insurance clinics for educating and supporting children with diabetes to improve their HRQOL.

FAMILY HISTORY OF DIABETES IS ASSOCIATED WITH INCREASED RISK OF RECURRENT DIABETIC KETOACIDOSIS IN PEDIATRIC PATIENTS

2020 ◽  
Vol 26 (3) ◽  
pp. 305-311
Author(s):  
Janaki D. Vakharia ◽  
Sungeeta Agrawal ◽  
Janine Molino ◽  
Lisa Swartz Topor
Keyword(s):  
Diabetes Mellitus ◽  
Family History ◽  
Diabetic Ketoacidosis ◽  
Pediatric Patients ◽  
Incidence Rate Ratio ◽  
Family History Of Diabetes ◽  
Increased Risk ◽  
History Of

Objective: To determine the relationship between family history of diabetes mellitus (DM) and diabetic ketoacidosis (DKA) recurrence in youth with established type 1 diabetes mellitus (T1DM). Methods: We performed a retrospective chart review of patients with DKA admitted to a pediatric hospital between January, 2009, and December, 2014. We compared patients with recurrent (≥2 admissions) and nonrecurrent DKA (1 admission) and investigated patient level factors, including family history, that may be associated with DKA recurrence in pediatric patients with established T1DM. Results: Of the 131 subjects in the study, 51 (39%) subjects were in the recurrence group. Age ≥15 years old, public health insurance, and family history of T1DM or type 2 diabetes mellitus were associated with recurrent DKA admissions in both univariable and multivariable analyses. Family history was associated with DKA recurrence, with an incidence rate ratio of 1.5 (95% confidence interval = 1.0 to 2.3; P = .03). The association was not explained by type of familial diabetes, first degree relative status, or whether the family member lived in the household. Conclusion: Recognition that a positive family history of DM may be associated with a higher risk for DKA recurrence in patients with established T1DM may allow for targeted education and focus on a previously unidentified population at increased risk for DKA. Understanding the mechanism underlying the effect of family history of diabetes on the rates of DKA in patients with established T1DM may allow for improved identification and education of patients who may be at risk for DKA recurrence. Abbreviations: CI = confidence interval; DKA = diabetic ketoacidosis; EHR = electronic health record; IBD = inflammatory bowel disease; IRR = incidence rate ratio; T1DM = type 1 diabetes mellitus; T2DM = type 2 diabetes mellitus

Family history of type 2 diabetes is increased in patients with type 1 diabetes

2008 ◽  
Vol 82 (1) ◽  
pp. e1-e4 ◽  
Author(s):  
B. Barone ◽  
M. Rodacki ◽  
L. Zajdenverg ◽  
M.H. Almeida ◽  
C.A. Cabizuca ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Family History ◽  
History Of

scholarly journals Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

2008 ◽  
Vol 205 (13) ◽  
pp. 2953-2957 ◽  
Author(s):  
Pierre Bougnères ◽  
Alain-Jacques Valleron
Keyword(s):  
Type 1 Diabetes ◽  
Early Onset ◽  
Type I Diabetes ◽  
Metabolic Changes ◽  
Data Driven ◽  
Metabolic Phenotype ◽  
Type I ◽  
Β Cell ◽  
New Era

A new study reveals distinctive metabolic changes that precede the development of type 1 diabetes (T1D), tossing a stone into the quiet waters of T1D immunology and genetics. The causes of these metabolic changes and their relationship to autoimmunity and β cell destruction are not yet known, but the identification of a metabolic phenotype linked to susceptibility to type I diabetes may help pave the way to a new era of investigation of T1D causality.

Family history of Type 1 diabetes affects insulin secretion in patients with ‘Type 2’ diabetes

2013 ◽  
Vol 30 (5) ◽  
pp. e163-e169 ◽  
Author(s):  
V. M. Lundgren ◽  
M. K. Andersen ◽  
B. Isomaa ◽  
T. Tuomi
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Insulin Secretion ◽  
Family History ◽  
History Of

Functional defects in adenylyl cyclase signaling mechanisms of insulin and relaxin in skeletal muscles of rat with streptozotocin type 1 diabetes

2006 ◽  
Vol 1 (4) ◽  
pp. 530-544 ◽  
Author(s):  
Alexander Shpakov ◽  
Ludmila Kuznetsova ◽  
Svetlana Plesneva ◽  
Alexander Kolychev ◽  
Vera Bondareva ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Adenylyl Cyclase ◽  
Skeletal Muscles ◽  
Glycogen Synthase ◽  
Type I Diabetes ◽  
Functional Coupling ◽  
Type I ◽  
Stimulatory Action ◽  
Functional Disturbance

AbstractFunctional disturbance in the novel adenylyl cyclase signaling mechanism (ACSM) of insulin and relaxin action in rat streptozotocin (STZ) type I diabetes was studied on the basis of the authors’ conception of molecular defects in hormonal signaling systems as the main causes of endocrine diseases. Studying the functional state of molecular components of the ACSM and the mechanism as a whole, the following changes were found in the skeletal muscles of diabetic rats compared with control animals: 1) increase of insulin receptor binding due to an increase in the number of insulin binding sites with high and low affinity; 2) increase of the basal adenylyl cyclase (AC) activity and the reduction of AC-activating effect of non-hormonal agents (guanine nucleotides, sodium fluoride, forskolin); 3) reduction of ACSM response to stimulatory action of insulin and relaxin; 4) decrease of the insulin-activating effect on the key enzymes of carbohydrate metabolism, glycogen synthase and glucose-6-phosphate dehydrogenase. Hence, the functional activity of GTP-binding protein of stimulatory type, AC and their functional coupling are decreased during experimental type 1 diabetes that leads to the impairment of the transduction of insulin and relaxin signals via ACSM.

scholarly journals Increased Circulating T Follicular Helper Cells in Iranian Children with Type I Diabetes

2019 ◽  
Author(s):  
Mansour Arab ◽  
Maryam Razzaghy-azar ◽  
Zahra Salehi ◽  
Maryam Keshavarz ◽  
Ensieh Nasli-Esfahani ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Autoimmune Disease ◽  
Type I Diabetes ◽  
Type I ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper ◽  
Iranian Children

Type 1 diabetes (T1D) is an autoimmune disease resulting from the damage of pancreatic

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