HOMOCYSTEINE LEVEL IN CHILDREN WITH CHRONIC KIDNEY DISEASE ON THE BACKGROUND OF CONGENITAL MALFORMATIONS OF THE URINARY SYSTEM

2018 ◽  
Vol 22 (1) ◽  
pp. 98-103
Author(s):  
A. M. Mambetova ◽  
A. M. Inarokova ◽  
N. N. Shabalova ◽  
A. T. Mahieva
2008 ◽  
Vol 31 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Anoop Shankar ◽  
Jie Jin Wang ◽  
Brian Chua ◽  
Elena Rochtchina ◽  
Vicki Flood ◽  
...  

Author(s):  
Albina A. Vyalkova ◽  
Svetlana A. Chesnokova ◽  
Oksana O. Ustinova ◽  
Larisa A. Gaikova

Introduction. The term «chronic kidney disease» (CKD) is used to define the outcomes of various forms of chronic progressive kidney disease, characterized by kidney damage, or a decrease in their function for three months or more, regardless of the nosological diagnosis. The aim of the work was to determine the frequency, structure, and clinical and paraclinical features of CKD in children to substantiate the principles of its management in primary health care. Results. In CKD patients, tubulointerstitial renal lesions were established to prevail (80%). Associated with congenital malformations of the urinary system, reflux uropathy, and urolithiasis in 98% of cases tubulointerstitial renal lesions are complicated by renal infection. In 8.9% of children, CKD was formed as an outcome of glomerulopathies; in 6.7% of children - with congenital and hereditary nephropathies; in 4.4% of children an outcome of a hemolytic uremic syndrome. The observed children dominated by I-II (74.3%), less often III and IV (25.7%) stages of CKD. The revealed clinical and paraclinical features of CKD in children are presented. The modern principles of early diagnosis of CKD in children and the identification of risk factors for the progression of nephropathy have been substantiated. For the diagnosis of CKD in childhood there has been created a. n algorithm, including at the outpatient stage. Authors suggested a set of measures for the prevention of nephropathy. Conclusion. For early diagnosis of CKD in childhood there was developed an algorithm based on the analysis of a complex of clinical and paraclinical, structural and functional parameters of the kidneys in combination with the parameters of endothelial function and cytokine status.


2019 ◽  
Vol 72 (4) ◽  
pp. 532-538
Author(s):  
Sergii V. Shevchuk ◽  
Kateryna P. Postovitenko ◽  
Iryna A. Iliuk ◽  
Halyna V. Bezsmertna ◽  
Yurii O. Bezsmertnyi ◽  
...  

1,, 1 2 ABSTRACT Introduction: According to present knowledge, hyperhomocysteinemia is one of the risk factors of cardio-vascular pathology. Patients with chronic kidney disease are known to develop hyperhomocysteinemia more often than those in general population. Іmportant cause of hyperhomocysteinemia is the deficiency of vitamins В6, В9 and В12 that are involved in homocysteine metabolism. Vitamins deficiency, we believe, can be one of the causes of hyperhomocysteinemia in the patients with chronic renal failure. The aim: To analyze the plasma homocysteine level in patients with chronic kidney disease and its assosiation with the levels of vitamins B6, B9, B12 in Ukraine. Materials and methods: The study involved 148 persons with different stagesis of chronic kidney disease who underwent immunoenzyme determination of total plasma homocysteine, B9, cobalamin and vitamin В6 status. Results: It was found that in ukrainian patient population with chronic kidney disease 58.7% of patients have hyperhomocysteinemia. Homocysteine level was shown to increase with the increase of chronic kidney disease stage. Supply of vitamins В6, В9 та В12 in the patients with chronic kidney disease was lower than in apparently healthy persons, but there was significant decrease of folic acid level proportionally to the increase of chronic kidney disease stage. There was close relationship between homocysteine level and folic acid status in the patients with chronic kidney disease, but it appeared to be independent on cobalamin and pyridoxin status. Conclusions: The obtained data are promising for finding effective means of correction of hyperhomocysteinemia in patients with chronic kidney disease by normalizing the vitamin status of such patients.


2020 ◽  
Vol 11 (2) ◽  
pp. 14-17
Author(s):  
Rizaldy Taslim Pinzon ◽  
Rosa De Lima Renita Sanyasi ◽  
Esdras Ardi Pramudita

Background: Chronic kidney disease (CKD) patients often have a high homocysteine level Hyperhomocystinemia considered as one of cardiovascular disease risk factor in CKD patients. Studies concern on the proportion of hyperhomocysteinemia in patients with CKD in Indonesia are very limited. Aims and Objectives: The main objective was to identify the proportion of hyperhomocysteinemia in CKD patients. Materials and Methods: This was a cross sectional study. Subjects in this study were CKD patients with routine hemodyalisis two times per week. Five mililiters venous blood was collected before the first hemodyalisis. The blood was stored into tubes contain clot activator. Homocysteine level higher than 15.39 μmol/L considered as hyperhomocysteine. Results: Total of 122 subjects included at this study. Subjects dominated by male with mean age of 51.7 years. Anemia (86.9%) and hypertension (86.1%) were the common comorbidities. Co-treatment assessed in this study i.e.: folic acid, calcium carbonat, antihypertensive agent, antidiabetic agent, antiplatelet agent, lipid lowering agent, and hematopoietic agent. The prevalence of hyperhomocysteinemia was high (89.3%) despite of the high consumption of folic acid in subjects (86.1%). Conclusion: Hyperhomocysteinemia is a common condition among CKD patients with hemodyalisis.


2015 ◽  
Vol 31 (7) ◽  
pp. 723-730 ◽  
Author(s):  
Yi-Chun Yeh ◽  
Mei-Feng Huang ◽  
Shang-Jyh Hwang ◽  
Jer-Chia Tsai ◽  
Tai-Ling Liu ◽  
...  

Author(s):  
I.S. Dryl ◽  
A.F. Shipko ◽  
T.F. Kolfbaeva ◽  
L.K. Petrenko ◽  
I.V. Zabashta

The most frequent mental changes in children can include increased anxiety, depression, aggression and anger, the existence of which may contribute to the progression of physical illness. Materials and methods. The study involved 49 children aged 7 to 17 years (mean age 12,7 ± 3,1let) with chronic kidney disease. Further assess psychological stress based on the level of anxiety, aggression, anger, and depression. Results. In assessing the level of anxiety, aggression, anger, and depression in all groups of children prevailed with the average of 73,1 ± 7% to 87,8 ± 5,1% of children in the group. At 24,3 ± 7% of children identified elevated levels of aggression, half of whom had congenital abnormalities of the urinary system. Most children 38 (86,3 ± 5,2%) level of depression was within average. Established cases of depression to improve small, moderate and significant among girls 13,5 ± 1,5years, which amounted to 13,6 ± 5,2% of children. Conclusions. The most vulnerable are children, particularly girls with chronic kidney disease on the background of congenital anomalies of the urinary system. All children with chronic kidney disease is necessary to evaluate the level of mental strain for the optimization of measures to prevent recurrence of the disease and improve the quality of life ofchildren.


2014 ◽  
Vol 27 (3) ◽  
pp. 299-305 ◽  
Author(s):  
Min-Chun Chao ◽  
Sung-Lin Hu ◽  
Hua-Shui Hsu ◽  
Lance E. Davidson ◽  
Chih-Hsueh Lin ◽  
...  

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