Effect of corvitin on oxygen homeostasis and blood gas transmitters in ischemia-reperfusion of the lower limbs

Introduction. Reperfusion-reoxygenation syndrome (RRS) after revascularization of the lower limbs in obliterating atherosclerosis of the arteries is accompanied by a violation of the oxygen transport function of the blood (OTFB) and the content of gas transmitters (GTs). Reperfusion injury affects not only the tissues of the lower limbs, but also of anatomically distant organs, which supposes that effective RRS correction is required. Aim. To study the effect of Corvitin on the OTFB parameters and the content of GT of nitrogen monoxide (NO) and hydrogen sulfide (H2S) in the venous blood of the forearm after revascularization of the lower limb in chronic atherosclerotic occlusion of the superficial femoral artery (SFA). Materials and methods. The study included 118 male patients. Revascularization of the lower limb was carried out by the method of loop endaterectomy from the SFA. Patients of group I (n=52) received traditional medication, 51 patients of group II additionally received Corvitin. In the blood from the vein of the elbow bend before the operation, on the 3rd and 8th days after it, the indices of OTFB and GTs were determined. Results. In group I, on the 3rd day after surgery, pO2 increased in relation to healthy individuals by 5.2–18.5%, while pCO2 decreased by 4.8–6.7%, depending on the stage of initial ischemia. The concentrations of NO and H2S increased by 9.2–50.1% and 9.2–21.1%, respectively. The increase in the parameters of hyperoxemia, hypocapnemia and GT after the return of blood circulation decreases with the use of Corvitin (p˂0.05). By the end of the early postoperative period, the indicators of OTFB and GT not only return to their initial values, but also do not significantly differ from the group of healthy individuals (p˃0.05). Conclusion. The use of Corvitin effectively corrects violations of OTFB and GT during ischemia-reperfusion of the lower limbs, which prevents tissue reperfusion damage.

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EFFECT OF CORVITIN ON OXYGEN TRANSPORT FUNCTION OF THE BLOOD AND GAS TRANSMITTERS IN ISCHEMIA-REPERFUSION OF THE LOVER LIMBS

Journal of the Grodno State Medical University ◽

10.25298/2221-8785-2021-19-2-194-201 ◽

2021 ◽

Vol 19 (2) ◽

pp. 194-201

Author(s):

V. N. Zasimovich ◽

◽

V. V. Zinchuk ◽

N. N. Ioskevich ◽

◽

...

Keyword(s):

Hydrogen Sulfide ◽

Oxygen Transport ◽

Lower Limb ◽

Ischemia Reperfusion ◽

Venous Blood ◽

Nitrogen Monoxide ◽

Lower Limbs ◽

Upper Limbs ◽

Transport Function ◽

Group I

Background. Ischemia-reperfusion of the lower limbs in atherosclerosis of their arteries is accompanied by impaired oxygen transport function (OTF) and the content gas transmitters (GT) of blood, which needs adequate correction. Purpose. To study the effect of corvitin on the parameters of OTF and GT of nitrogen monoxide and hydrogen sulfide in venous blood after revascularization of the lower limb in chronic atherosclerotic occlusion of the superficial femoral artery (SFA). Material and methods. Revascularization of the lower limbs in 103 patients was performed by loop endaterectomy from SFA. Patients of group I (n=52) received traditional medication support, II (n=51) - corvitin. The indices of OTFB and GT in the venous blood of the lower and upper limbs were determined before the operation, on the 3rd and 8th days after it. Results. The increase in the parameters of hyperoxemia, hypocapnemia and GT concentration in the postoperative period decreases with the use of corvitin. Conclusions. The use of corvitin reduces disturbances in OTFB and GT content during ischemia-reperfusion of the lower limbs.

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Peripheral microcircuiation in patients over 60 years with atherosclerosis of lower limb arteries

Patologiya krovoobrashcheniya i kardiokhirurgiya ◽

10.21688/1681-3472-2013-3-22-26 ◽

2015 ◽

Vol 17 (2) ◽

pp. 22

Author(s):

O. V. Kamenskaya ◽

A. S. Klinkova ◽

A. A. Karpenko ◽

A. M. Karaskov ◽

V. B. Starodubtsev ◽

...

Keyword(s):

Lower Limb ◽

High Volume ◽

The Elderly ◽

Early Postoperative Period ◽

Lower Limbs ◽

Orthostatic Test ◽

Doppler Flowmetry ◽

Functional Reserves ◽

Before And After ◽

Fontaine Classification

We investigated peripheral microcirculatory blood flow (MBF) by using laser Doppler flowmetry in 146 patients with IIB-IV stage chronic ischemia of lower limbs (CILL) according to the Pokrovsky-Fontaine classification. The objective was to study the state of peripheral MBF while carrying out functional tests in patients over 60 years with IIB-IV stage CILL before and after revascularization of lower limb arteries. When ageing, CILL patients demonstrate a decrease in the peripheral MBF baseline indicators and an increase in the quantity of defects of regulatory mechanisms and functional reserves of microcirculation, which manifest themselves as a severe paradoxical reaction of the microvasculature during an orthostatic test. In the early postoperative period the elderly patients tend to have reduced functional reserves and regulation mechanisms of MBF, with a high volume and degree of severity of MBF paradoxical reactions during an orthostatic test.

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Effect of Different Placement of Heel Rockers on Lower-Limb Joint Biomechanics in Healthy Individuals

Journal of the American Podiatric Medical Association ◽

10.7547/16-052 ◽

2018 ◽

Vol 108 (3) ◽

pp. 231-235 ◽

Cited By ~ 1

Author(s):

Maedeh Farzadi ◽

Zahra Safaeepour ◽

Hoda Nabavi ◽

Masumeh Bagherzadeh Cham ◽

Mohammad Ebrahim Mousavi

Keyword(s):

Range Of Motion ◽

Lower Limb ◽

Lower Limbs ◽

Medial Malleolus ◽

Initial Contact ◽

Healthy Individuals ◽

Peak Knee ◽

Joint Biomechanics ◽

Single Limb Support ◽

Rocker Shoes

Background: Rocker shoes are commonly prescribed to healthy and pathologic populations to decrease stress on the lower limbs. An optimal rocker shoe design must consider both toe and heel rockers. Heel rockers are as effective as toe rockers in relieving foot plantar pressures. However, most studies have focused on the position of toe rockers. The aim of this study was to assess the effect of different heel rocker apex placements on lower-limb kinetics and kinematics. Methods: Eighteen healthy females participated in this study. Three pairs of rocker shoes with rocker apex positions anterior to the medial malleolus (shoe A), at the medial malleolus (shoe B), and posterior to the medial malleolus (shoe C) were fabricated and then compared with a flat shoe (shoe D). Kinetic and kinematic data were collected, and lower-extremity joint ranges of motion and moments were calculated. Results: Ankle range of motion was increased by shoe C (P = .04) during initial contact and by shoe A (P = .02) during single-limb support. Peak knee moment was significantly larger for shoes A and B (P < .05) during single-limb support. Conclusions: Results showed that forward and backward shifting of the heel rocker apex could change the knee moment and ankle joint range of motion in the stance phase of gait. Therefore, placement of the heel rocker in a rocker-bottom shoe can be manipulated to promote the desired lower-limb motion, at least in healthy individuals.

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Prevention of subclinical deep vein thrombosis in abdominal surgeries

International Surgery Journal ◽

10.18203/2349-2902.isj20182748 ◽

2018 ◽

Vol 5 (7) ◽

pp. 2475

Author(s):

Tazeem M. D. ◽

Wasim M. D. ◽

Sabia Amin ◽

Tahmida Ali

Keyword(s):

Molecular Weight ◽

Deep Vein Thrombosis ◽

Lower Limb ◽

Low Molecular Weight Heparin ◽

Lower Limbs ◽

Low Molecular Weight ◽

Vein Thrombosis ◽

Group I ◽

Deep Vein ◽

D Dimer

Background: Deep vein thrombosis (DVT) is a common but elusive illness that can result in disability and death if not recognized and treated effectively. The reported incidence has not changed much over past couple of decades. The aim of this study was to identify the risk of deep vein thrombosis related to the number of days of immobility and the role of low molecular weight heparin in the prevention of deep vein thrombosis.Methods: A total of hundred (n=100) patients undergoing laparotomy were studied in the post-operative period between January 2014 and December 2016. Patients were divided into two groups alternatively; Group I patients did not receive any DVT prophylaxis and Group II patients were given low molecular weight heparin once a day till mobilization. From 3rdPOD, all the patients were evaluated with detailed history and lower limb examination. D-dimer study was done in all the patients and if positive then followed by Color Venous Doppler. Regular follow-ups were done weekly once for a month, every two weeks for next month and once a month thereafter, minimum for 6 months.Results: A total of hundred (n=100) patients, including 65 men and 35 women, with median age of 40 years underwent laparotomies in 2 years by a single unit. The incidence of Lower Limb DVT in Group I was 8%. The risk factors associated with DVT were sex, BMI, smoking and Malignancy. The signs and symptoms associated with DVT were swelling of lower limbs, pain and tenderness, fever and Homan’s and Moses signs. The D-dimer test results were positive in 9 patients. Color Venous Doppler identified DVT in 8 patients. On regular follow- ups, remissions of clinical symptoms were recorded and repeat Doppler scans showed recanalization in all the patients after 6 months.Conclusions: Deep Vein Thrombosis is multifactorial, and post-operative patients account for majority of cases. Early mobilization and Prophylactic Low Molecular Heparin prevents DVT in abdominal surgeries.

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Lumbo-Pelvic and Lower Limb Joint Kinematics in Subjects with and Without Low Back Pain: A Protocol for Systematic Review

10.21203/rs.3.rs-1164346/v1 ◽

2021 ◽

Author(s):

Fatemeh Ghasemi Dehcheshme ◽

Massoud Arab ◽

Mohammad Reza Nourbakhsh

Keyword(s):

Systematic Review ◽

Low Back Pain ◽

Back Pain ◽

Lower Limb ◽

Lower Limbs ◽

Reference List ◽

Low Back ◽

Healthy Individuals ◽

Newcastle Ottawa Scale ◽

Kinematic Assessment

Abstract Background Low back pain (LBP) is one of the leading causes of disability worldwide. While its main cause is mostly unknown, more than 80% of people experience this disorder during their lifetime .Some clinical evidence suggests that people with chronic LBP have various lower extremity movement disorders. This study aims to systematically review the literature on comparing the kinematics of the lumbopelvic region and lower limb joints in people with non-specific low back pain (NS-LBP) compared to healthy individuals. Methods/design: We will search main electronic databases (Medline/PubMed, Scopus, Embase, Web of Science, Pedro, ProQuest and Google Scholar) and two key journals (Journal of Electromyography and Kinesiology, Clinical Biomechanics). Also, the reference list of the previous systematic reviews would be hand-searched. Studies that have examined the kinematic differences in lumbopelvic or lower limbs between NS-LBP and healthy individuals will be included. We will examine the methodological quality and statistical reporting of each eligible trial using the Newcastle – Ottawa Scale (NOS). Discussion To our knowledge, this study will be the first systematic review to examine the kinematic differences of the lower limb joints and pelvic complex between healthy people and NS-LBP. Since the kinematic assessment of the lower extremities and pelvic joints during daily activities may help understand underlying factors causing LBP, it is important to evaluate the kinematic changes in these regions, during repetitive daily functions in these patients. Systematic review registration: PROSPERO (CRD42021230826)

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Lower Limb Locomotion Activity Recognition of Healthy Individuals Using Semi-Markov Model and Single Wearable Inertial Sensor

Sensors ◽

10.3390/s19194242 ◽

2019 ◽

Vol 19 (19) ◽

pp. 4242 ◽

Cited By ~ 1

Author(s):

Haoyu Li ◽

Stéphane Derrode ◽

Wojciech Pieczynski

Keyword(s):

Markov Model ◽

Activity Recognition ◽

Lower Limb ◽

Model Updating ◽

Inertial Sensor ◽

Lower Limbs ◽

Healthy Individuals ◽

Batch Mode ◽

On Line ◽

Locomotion Activity

Lower limb locomotion activity is of great interest in the field of human activity recognition. In this work, a triplet semi-Markov model-based method is proposed to recognize the locomotion activities of healthy individuals when lower limbs move periodically. In the proposed algorithm, the gait phases (or leg phases) are introduced into the hidden states, and Gaussian mixture density is introduced to represent the complex conditioned observation density. The introduced sojourn state forms the semi-Markov structure, which naturally replicates the real transition of activity and gait during motion. Then, batch mode and on-line Expectation-Maximization (EM) algorithms are proposed, respectively, for model training and adaptive on-line recognition. The algorithm is tested on two datasets collected from wearable inertial sensors. The batch mode recognition accuracy reaches up to 95.16%, whereas the adaptive on-line recognition gradually obtains high accuracy after the time required for model updating. Experimental results show an improvement in performance compared to the other competitive algorithms.

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Bronchial and reverse pulmonary venous blood flow protect the lung from ischemia-reperfusion injury

Journal of Applied Physiology ◽

10.1152/jappl.1994.77.2.731 ◽

1994 ◽

Vol 77 (2) ◽

pp. 731-736 ◽

Cited By ~ 5

Author(s):

A. Hamvas ◽

D. P. Schuster

Keyword(s):

Blood Flow ◽

Ischemia Reperfusion Injury ◽

Ischemia Reperfusion ◽

Venous Blood ◽

Pulmonary Veins ◽

Left Lung ◽

Venous Blood Flow ◽

Bronchial Circulation ◽

Group I ◽

Lung Deflation

We used an intact in vivo canine model of pulmonary ischemia-reperfusion injury to evaluate whether the bronchial circulation or reverse pulmonary venous blood flow would protect the lung from injury during 2 h of unilateral pulmonary arterial (PA) occlusion and lung deflation. Serial measurements of regional extravascular density and transcapillary protein flux were made after reperfusion by using the quantitative imaging technique of positron emission tomography. Twenty-one animals were divided into four experimental groups. In all experimental groups, the left PA was clamped and the left lung was allowed to collapse and remain unventilated for a period of 2 h. In addition, in group I (n = 5) the left bronchial circulation was disrupted and the left pulmonary veins were clamped, in group II (n = 5) the bronchial circulation and the pulmonary veins were left intact, in group III (n = 6) the bronchial circulation was left intact but the pulmonary veins were clamped, and in group IV (n = 5) the bronchial circulation was disrupted but the pulmonary veins remained patent. The rate of protein flux in the left lung was increased only in group I (complete ischemia with lung deflation) [mean 195 x 10(-4) min-1 (range 85–453 x 10(-4) min-1) at 0.25 h and 114 x 10(-4) min-1 (range 22–200 x 10(-4) min-1) at 3 h] after reventilation and PA reperfusion (normal = 49 +/- 31 x 10(-4) min-1). Extravascular density increased significantly from 0.25 to 3 h only in group I.(ABSTRACT TRUNCATED AT 250 WORDS)

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Spinal cord anomalies in patients with anorectal malformations without severe sacral abnormalities or meningomyelocele: outcomes after expectant, conservative management

Journal of Neurosurgery Spine ◽

10.3171/2016.4.spine1641 ◽

2016 ◽

Vol 25 (6) ◽

pp. 782-789 ◽

Cited By ~ 13

Author(s):

Kristiina Kyrklund ◽

Mikko P. Pakarinen ◽

Seppo Taskinen ◽

Reetta Kivisaari ◽

Risto J. Rintala

Keyword(s):

Spinal Cord ◽

Lower Limb ◽

Functional Outcomes ◽

Bowel Function ◽

Anorectal Malformations ◽

Conus Medullaris ◽

Lower Limbs ◽

Neurological Abnormalities ◽

Urinary Tract Symptoms ◽

Male Patients

OBJECTIVE The goal of this study was to determine the significance of spinal cord anomalies (SCAs) in patients with anorectal malformations (ARMs) by comparing the outcomes for bowel function, lower urinary tract symptoms (LUTS), and lower-limb neurological abnormalities to these outcomes in patients with similar ARMs and a normal spinal cord. METHODS The spinal cord MRI records of female patients treated for vestibular and perineal fistula (VF/PF) and male patients with rectourethral fistula (RUF) at a single center between 1983 and 2006 were reviewed. Bowel function and LUTS were assessed by questionnaire. Patients with extensive sacral anomalies or meningomyelocele were excluded. RESULTS Of 89 patients (median age 15 years, range 5–29 years), MRI was available in 90% (n = 80; 40 male patients with RUF), and 80% of patients returned the questionnaire (n = 64; 31 male patients with RUF). Spinal cord anomalies were found in 34%, comprising a filum terminale lipoma in 30%, low conus medullaris in 10%, and thoracolumbar syrinx in 6%. Bowel functional outcomes between patients with SCAs (n = 23) and those with a normal spinal cord (n = 41) were not significantly different for soiling (70% vs 63%), fecal accidents (43% vs 34%), and constipation (57% vs 39%; p = not significant for all). The LUTS, including urge (65% vs 54%), urge incontinence (39% vs 24%), stress incontinence (17% vs 22%), and straining (32% vs 29%) were also comparable between groups (p = not significant for all). No patients developed lower-limb neurological abnormalities. CONCLUSIONS The results suggest that the long-term functional outcomes for patients with SCAs who had VF/PF and RUF may not differ significantly from patients with the same type of ARMs and a normal spinal cord. The results favor a conservative approach to their management in the absence of abnormal neurological findings in the lower limbs.

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Pathogenesis of ischemia/reperfusion syndrome

Kazan medical journal ◽

10.17816/kmj2018-640 ◽

2018 ◽

Vol 99 (4) ◽

pp. 640-644 ◽

Cited By ~ 4

Author(s):

D E Kutepov ◽

M S Zhigalova ◽

I N Pasechnik

Keyword(s):

Blood Flow ◽

Lower Limb ◽

Ischemia Reperfusion ◽

Vascular Complications ◽

Limb Ischemia ◽

Biologically Active ◽

Lower Limbs ◽

Ion Pump ◽

Critical Ischemia ◽

Lower Limb Ischemia

Ischemia/reperfusion syndrome is a collective concept that combines various pathological conditions developing against the background of the restoration of the main blood flow in the organ or limb segment, which has long been subjected to ischemia or traumatic amputation. Intensive care physicians often see ischemia/reperfusion syndrome after restoration of blood supply in patients with critical ischemia of the lower limb. The rate of critical ischemia of the lower limbs ranges from 400 to 1000 cases per 1 million of the population. The number of lower limb amputations due to critical lower limb ischemia in economically developed countries is 13.7-32.3 cases per 100,000 of the population. The main etiological factors of critical lower limb ischemia are atherosclerosis of peripheral vessels and vascular complications of diabetes. The pathogenesis of ischemia/reperfusion syndrome is based on a complex of pathophysiological changes resulting from the restoration of blood flow in previously ischemic lower limb. Restoration of blood circulation leads to massive flow into the systemic bloodstream of anaerobic metabolism products, free myoglobin, biologically active substances and inflammatory mediators. The main sources of reperfusion damage are activated forms of oxygen, in particular, superoxide radical О2-, nitric oxide, lipid peroxidation products. In the conditions of primary ischemia, and then tissue reperfusion, excessive production of activated oxygen forms leads to damage of biological structures (lipids, proteins, deoxyribonucleic acid), which causes disruption of normal cell functioning or its death due to necrosis or apoptosis, ion pump dysfunction, adhesion of leukocytes and increased vascular permeability.

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STEROID METABOLISM IN THE PERFUSED HUMAN PLACENTA

Acta Endocrinologica ◽

10.1530/acta.0.0870181 ◽

1978 ◽

Vol 87 (1) ◽

pp. 181-191 ◽

Cited By ~ 6

Author(s):

Alfred S. Wolf ◽

Klaus A. Musch ◽

Werner Speidel ◽

Jürgen R. Strecker ◽

Christian Lauritzen

Keyword(s):

Venous Blood ◽

Placental Lactogen ◽

Dehydroepiandrosterone Sulphate ◽

Metabolic Capacity ◽

Loading Test ◽

Lower Range ◽

Group I ◽

High Concentrations ◽

Steroid Precursor

ABSTRACT A new model for the perfusion of human term-placentas has been developed for studies on the placental biogenesis of C-18 and C-19 steroids. For viability criteria, the glucose- and oxygen-consumption, regional perfusion control by dye-infusions or scanning after injection of 99Tc-labelled macroparticles, and the histological qualification were chosen. The recycled perfusate was investigated for the steroids oestrone (Oe1), oestradiol-17β (Oe2), oestriol (Oe3), 4-androstene-3,17-dione (A), testosterone (T), and human placental lactogen (HPL) by radioimmunoassay in controls and perfusions with the foetal steroid precursor dehydroepiandrosterone sulphate (DHA-S). In control perfusions, steroid hormones were found in constant ratios (Oe1:Oe2:Oe3:T:A = 30:1.5:100:0.35:1). Following the administration of 10 mg DHA-S for testing the metabolic capacity of the organ, high concentrations of Oe1 (90–720 ng/ml = 250–3970 % as compared to 100% pre-injection values) were found, shortly preceded by a rapid increase of A (66–1000 ng/ml = 100–16 000 %). A typical surge of T (5.3–147 ng/ml = 265–4640 %) preceded the normally slower increment of Oe2 (22–220 ng/ml = 1570–4330 %). The concentrations of Oe3 and HPL remained nearly unchanged. From different steroid patterns after DHA-S-load, two distinct responses of term-placentas could be differentiated: Group I (n=12) showed high concentrations of Oe1 (3200 ± 940 %), a small increase of T (1020 ± 500%), as well as low and delayed values of Oe2 (1660 ± 450%). In Group II (n = 5), values were high for T (3160 ± 1020%) and Oe2 (3300 ± 1110%), whereas Oe1 was found in a lower range (508 ± 302%). In contrast to in vivo findings in maternal venous blood after DHS-S injection to the mother, oestrone was found in perfusions as the main oestrogen fraction from DHA-S. Thus, the analysis of such metabolic differences might be of help in the interpretation of complex results from the DHA-S-loading test.

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